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قیمت : 3,800,000 تومان- قیمت ویژه : 1,900,000تومان
Anti-Xa activity and hemorrhagic events under extracorporeal membrane oxygenation (ECMO): a multicenter cohort study
Richard Descamps, Mouhamed D. Moussa, Emmanuel Besnier, Marc-Olivier Fischer, Sébastien Preau, Fabienne Tamion, Cédric Daubin, Nicolas Cousin, André Vincentelli, Julien Goutay and Damien Du Cheyron
doi : 10.1186/s13054-021-03554-0
Critical Care 2021 25:127
Hemorrhagic events remain a major concern in patients under extracorporeal membrane oxygenation (ECMO) support. We tested the association between anticoagulation levels and hemorrhagic events under ECMO using anti-Xa activity monitoring.
Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patients
Thomas Langer, Matteo Brioni, Amedeo Guzzardella, Eleonora Carlesso, Luca Cabrini, Gianpaolo Castelli, Francesca Dalla Corte, Edoardo De Robertis, Martina Favarato, Andrea Forastieri, Clarissa Forlini, Massimo Girardis, Domenico Luca Grieco, Lucia Mirabella, Valentina Noseda, Paola Previtali
doi : 10.1186/s13054-021-03552-2
Critical Care 2021 25:128
Limited data are available on the use of prone position in intubated, invasively ventilated patients with Coronavirus disease-19 (COVID-19). Aim of this study is to investigate the use and effect of prone position in this population during the first 2020 pandemic wave.
Beyond survival: identifying what matters to survivors of critical illness
Somnath Bose, Benjamin Hoenig, Maria Karamourtopoulos, Valerie Banner-Goodspeed and Samuel Brown
doi : 10.1186/s13054-021-03565-x
Critical Care 2021 25:129
Correction to: Ventilator-associated pneumonia in critically ill patients with COVID-19
Mailis Maes, Ellen Higginson, Joana Pereira-Dias, Martin D. Curran, Surendra Parmar, Fahad Khokhar, Delphine Cuchet-Lourenço, Janine Lux, Sapna Sharma-Hajela, Benjamin Ravenhill, Islam Hamed, Laura Heales, Razeen Mahroof, Amelia Soderholm, Sally Forrest, Sushmita Sridhar
doi : 10.1186/s13054-021-03560-2
Critical Care 2021 25:130
Fast recovery of cardiac function in PIMS-TS patients early using intravenous anti-IL-1 treatment
Maria Vincenza Mastrolia, Edoardo Marrani, Giovanni Battista Calabri, Manuela L’Erario, Ilaria Maccora, Silvia Favilli, Pier Paolo Duchini, Ilaria Pagnini and Gabriele Simonini
doi : 10.1186/s13054-021-03548-y
Critical Care 2021 25:131
The prone position must accommodate changes in IAP in traumatic brain injury patients
Wojciech Dabrowski, Dorota Siwicka-Gieroba, Chiara Robba, Rafael Badenes and Manu L. N. G. Malbrain
doi : 10.1186/s13054-021-03506-8
Critical Care 2021 25:132
FDG-PET/CT in intensive care patients with bloodstream infection
Jordy P. Pijl, Mark Londema, Thomas C. Kwee, Maarten W. N. Nijsten, Riemer H. J. A. Slart, Rudi A. J. O. Dierckx, Peter H. J. van der Voort, Andor W. J. M. Glaudemans and Janesh Pillay
doi : 10.1186/s13054-021-03557-x
Critical Care 2021 25:133
2-Deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography (PET)/computed tomography (CT) is an advanced imaging technique that can be used to examine the whole body for an infection focus in a single examination in patients with bloodstream infection (BSI) of unknown origin. However, literature on the use of this technique in intensive care patients is scarce. The purpose of this study was to evaluate the diagnostic yield of FDG-PET/CT in intensive care patients with BSI.
A 5G-powered robot-assisted teleultrasound diagnostic system in an intensive care unit
Shaobo Duan, Luwen Liu, Yongqing Chen, Long Yang, Ye Zhang, Shuaiyang Wang, Liuwei Hao and Lianzhong Zhang
doi : 10.1186/s13054-021-03563-z
Critical Care 2021 25:134
Teleultrasound provides an effective solution to problems that arise from limited medical resources, a lack of local expertise, and scenarios where the risk of infection is high. This study aims to explore the feasibility of the application of a 5G-powered robot-assisted teleultrasound diagnostic system in an intensive care unit.
Post-extubation oxygenation strategies in acute respiratory failure: a systematic review and network meta-analysis
Hideto Yasuda, Hiromu Okano, Takuya Mayumi, Chihiro Narita, Yu Onodera, Masaki Nakane and Nobuaki Shime
doi : 10.1186/s13054-021-03550-4
Critical Care 2021 25:135
High-flow nasal cannula oxygenation (HFNC) and noninvasive positive-pressure ventilation (NPPV) possibly decrease tracheal reintubation rates better than conventional oxygen therapy (COT); however, few large-scale studies have compared HFNC and NPPV. We conducted a network meta-analysis (NMA) to compare the effectiveness of three post-extubation respiratory support devices (HFNC, NPPV, and COT) in reducing the mortality and reintubation risk.
Comments on “Right ventricular failure in septic shock: characterization, incidence and impact on fluid responsiveness”: which parameter to assess right ventricular failure and venous congestion?
Osama Abou-Arab, Mouhamed D. Moussa, Christophe Beyls and Yazine Mahjoub
doi : 10.1186/s13054-021-03473-0
Critical Care 2021 25:136
Cerebral venous sinus thrombosis associated with thrombocytopenia post-vaccination for COVID-19
Gian Paolo Castelli, Claudio Pognani, Carlo Sozzi, Massimo Franchini and Luigi Vivona
doi : 10.1186/s13054-021-03572-y
Critical Care 2021 25:137
Iron Deficiency Defined by Hepcidin in Critically Ill Patients
Michele F. Eisenga
doi : 10.1186/s13054-021-03542-4
Critical Care 2021 25:138
Necrotizing soft-tissue infections in pediatric intensive care: a prospective multicenter case-series study
Stéphane Dauger, Renaud Blondé, Olivier Brissaud, Marie-Odile Marcoux, François Angoulvant and Michael Levy
doi : 10.1186/s13054-021-03562-0
Critical Care 2021 25:139
Longitudinal assessment of IFN-I activity and immune profile in critically ill COVID-19 patients with acute respiratory distress syndrome
Fabienne Venet, Martin Cour, Thomas Rimmelé, Sebastien Viel, Hodane Yonis, Remy Coudereau, Camille Amaz, Paul Abraham, Céline Monard, Jean-Sebastien Casalegno, Karen Brengel-Pesce, Anne-Claire Lukaszewicz, Laurent Argaud and Guillaume Monneret
doi : 10.1186/s13054-021-03558-w
Critical Care 2021 25:140
Since the onset of the pandemic, only few studies focused on longitudinal immune monitoring in critically ill COVID-19 patients with acute respiratory distress syndrome (ARDS) whereas their hospital stay may last for several weeks. Consequently, the question of whether immune parameters may drive or associate with delayed unfavorable outcome in these critically ill patients remains unsolved.
Negative drift of sedation depth in critically ill patients receiving constant minimum alveolar concentration of isoflurane, sevoflurane, or desflurane: a randomized controlled trial
Adrian-Iustin Georgevici, Theodoros Kyprianou, Jennifer Herzog-Niescery, Livia Procopiuc, Sivakkanan Loganathan, Thomas Peter Weber and Martin Bellgardt
doi : 10.1186/s13054-021-03556-y
Critical Care 2021 25:141
Intensive care unit (ICU) physicians have extended the minimum alveolar concentration (MAC) to deliver and monitor long-term volatile sedation in critically ill patients. There is limited evidence of MAC’s reliability in controlling sedation depth in this setting. We hypothesized that sedation depth, measured by the electroencephalography (EEG)-derived Narcotrend-Index (burst-suppression N_Index 0—awake N_Index 100), might drift downward over time despite constant MAC values.
Validation of the Critical-Care Pain Observation Tool-Neuro in brain-injured adults in the intensive care unit: a prospective cohort study
Céline Gélinas, Mélanie Bérubé, Kathleen A. Puntillo, Madalina Boitor, Melissa Richard-Lalonde, Francis Bernard, Virginie Williams, Aaron M. Joffe, Craig Steiner, Rebekah Marsh, Louise Rose, Craig M. Dale, Darina M. Tsoller, Manon Choinière and David L. Streiner
doi : 10.1186/s13054-021-03561-1
Critical Care 2021 25:142
Pain assessment in brain-injured patients in the intensive care unit (ICU) is challenging and existing scales may not be representative of behavioral reactions expressed by this specific group. This study aimed to validate the French-Canadian and English revised versions of the Critical-Care Pain Observation Tool (CPOT-Neuro) for brain-injured ICU patients.
Correction to: CXCL10 could drive longer duration of mechanical ventilation during COVID-19 ARDS
Mathieu Blot, Marine Jacquier, Ludwig-Serge Aho Glele, Guillaume Beltramo, Maxime Nguyen, Philippe Bonniaud, Sebastien Prin, Pascal Andreu, Belaid Bouhemad, Jean-Baptiste Bour, Christine Binquet, Lionel Piroth, Jean-Paul Pais de Barros, David Masson, Jean-Pierre Quenot and Pierre-Emmanuel Charles
doi : 10.1186/s13054-021-03559-9
Critical Care 2021 25:143
no abstract
Death in hospital following ICU discharge: insights from the LUNG SAFE study
Fabiana Madotto, Bairbre McNicholas, Emanuele Rezoagli, Tài Pham, John G. Laffey and Giacomo Bellani
doi : 10.1186/s13054-021-03465-0
Critical Care 2021 25:144
To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward.
A practical integrated radiomics model predicting intensive care hospitalization in COVID-19
Chiara Giraudo, Giovanni Frattin, Giulia Fichera, Raffaella Motta and Roberto Stramare
doi : 10.1186/s13054-021-03564-y
Critical Care 2021 25:145
Adverse events associated with administration of vasopressor medications through a peripheral intravenous catheter: a systematic review and meta-analysis
Victoria S. Owen, Brianna K. Rosgen, Stephana J. Cherak, Andre Ferland, Henry T. Stelfox, Kirsten M. Fiest and Daniel J. Niven
doi : 10.1186/s13054-021-03553-1
Critical Care 2021 25:146
It is unclear whether vasopressors can be safely administered through a peripheral intravenous (PIV). Systematic review and meta-analysis methodology was used to examine the incidence of local anatomic adverse events associated with PIV vasopressor administration in patients of any age cared for in any acute care environment.
Addressing gender imbalance in intensive care
Jean-Louis Vincent, Nicole P. Juffermans, Karen E. A. Burns, V. Marco Ranieri, Chryssa Pourzitaki and Francesca Rubulotta
doi : 10.1186/s13054-021-03569-7
Critical Care 2021 25:147
There is a large gender gap in critical care medicine with women underrepresented, particularly in positions of leadership. Yet gender diversity better reflects the current critical care community and has multiple beneficial effects at individual and societal levels. In this Viewpoint, we discuss some of the reasons for the persistent gender imbalance in critical care medicine, and suggest some possible strategies to help achieve greater equity and inclusion. An explicit and consistent focus on eliminating gender inequity is needed until gender diversity and inclusion become the norms in critical care medicine.
Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study
Pavan K. Bhatraju, Eric D. Morrell, Leila Zelnick, Neha A. Sathe, Xin-Ya Chai, Sana S. Sakr, Sharon K. Sahi, Anthony Sader, Dawn M. Lum, Ted Liu, Neall Koetje, Ashley Garay, Elizabeth Barnes, Jonathan Lawson, Gail Cromer, Mary K. Bray…
doi : 10.1186/s13054-021-03547-z
Critical Care 2021 25:148
Analyses of blood biomarkers involved in the host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection can reveal distinct biological pathways and inform development and testing of therapeutics for COVID-19. Our objective was to evaluate host endothelial, epithelial and inflammatory biomarkers in COVID-19.
The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study
Christian Jung, Hans Flaatten, Jesper Fj?lner, Raphael Romano Bruno, Bernhard Wernly, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Georg Wolff, Malte Kelm, Michael Beil, Sigal Sviri, Peter Vernon van Heerden, Wojciech Szczeklik, Miroslaw Czuczwar, Muhammed Elhadi
doi : 10.1186/s13054-021-03551-3
Critical Care 2021 25:149
The COVID-19 pandemic has led highly developed healthcare systems to the brink of collapse due to the large numbers of patients being admitted into hospitals. One of the potential prognostic indicators in patients with COVID-19 is frailty. The degree of frailty could be used to assist both the triage into intensive care, and decisions regarding treatment limitations. Our study sought to determine the interaction of frailty and age in elderly COVID-19 ICU patients.
Toward the personalized and integrative management of voriconazole dosing during COVID-19-associated pulmonary aspergillosis
Brendan Le Daré, Christelle Boglione-Kerrien, Florian Reizine, Jean-Pierre Gangneux and Astrid Bacle
doi : 10.1186/s13054-021-03568-8
Critical Care 2021 25:152
Novel criteria to classify ARDS severity using a machine learning approach
Mohammed Sayed, David Ria?o and Jes?s Villar
doi : 10.1186/s13054-021-03566-w
Critical Care 2021 25:150
Usually, arterial oxygenation in patients with the acute respiratory distress syndrome (ARDS) improves substantially by increasing the level of positive end-expiratory pressure (PEEP). Herein, we are proposing a novel variable [PaO2/(FiO2xPEEP) or P/FPE] for PEEP???5 to address Berlin’s definition gap for ARDS severity by using machine learning (ML) approaches.
Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study
Jérôme Pugin, Thomas Daix, Jean-Luc Pagani, Davide Morri, Angelo Giacomucci, Pierre-François Dequin, Christophe Guitton, Yok-Ai Que, Gianluca Zani, David Brealey, Alain Lepape, Ben Creagh-Brown, Duncan Wyncoll, Daniela Silengo, Irina Irincheeva, Laurie Girard
doi : 10.1186/s13054-021-03576-8
Critical Care 2021 25:151
The early recognition and management of sepsis improves outcomes. Biomarkers may help in identifying earlier sub-clinical signs of sepsis. We explored the potential of serial measurements of C-reactive protein (CRP), procalcitonin (PCT) and pancreatic stone protein (PSP) for the early recognition of sepsis in patients hospitalized in the intensive care unit (ICU).
Ventilator-associated pneumonia in the era of COVID-19 pandemic: How common and what is the impact?
Paul-Henri Wicky, Michael S. Niedermann and Jean-François Timsit
doi : 10.1186/s13054-021-03571-z
Critical Care 2021 25:153
We reviewed similarities and differences of ventilator associated pneumonia in Sars-Cov2 infection and with other ARDS. The differences in epidemiology and outcome will be detailed. Possible explanations of differences in pathophysiology of VAP in Sarscov2 infections will be cited and discussed.
Latent class analysis to predict intensive care outcomes in Acute Respiratory Distress Syndrome: a proposal of two pulmonary phenotypes
Pedro D. Wendel Garcia, Alessio Caccioppola, Silvia Coppola, Tommaso Pozzi, Arianna Ciabattoni, Stefano Cenci and Davide Chiumello
doi : 10.1186/s13054-021-03578-6
Critical Care 2021 25:154
Acute respiratory distress syndrome remains a heterogeneous syndrome for clinicians and researchers difficulting successful tailoring of interventions and trials. To this moment, phenotyping of this syndrome has been approached by means of inflammatory laboratory panels. Nevertheless, the systemic and inflammatory expression of acute respiratory distress syndrome might not reflect its respiratory mechanics and gas exchange.
Safety profile of enhanced thromboprophylaxis strategies for critically ill COVID-19 patients during the first wave of the pandemic: observational report from 28 European intensive care units
Andrea Lavinio, Ari Ercole, Denise Battaglini, Sandra Magnoni, Rafael Badenes, Fabio Silvio Taccone, Raimund Helbok, William Thomas, Paolo Pelosi and Chiara Robba
doi : 10.1186/s13054-021-03543-3
Critical Care 2021 25:155
Critical illness from SARS-CoV-2 infection (COVID-19) is associated with a high burden of pulmonary embolism (PE) and thromboembolic events despite standard thromboprophylaxis. Available guidance is discordant, ranging from standard care to the use of therapeutic anticoagulation for enhanced thromboprophylaxis (ET). Local ET protocols have been empirically determined and are generally intermediate between standard prophylaxis and full anticoagulation. Concerns have been raised in regard to the potential risk of haemorrhage associated with therapeutic anticoagulation. This report describes the prevalence and safety of ET strategies in European Intensive Care Unit (ICUs) and their association with outcomes during the first wave of the COVID pandemic, with particular focus on haemorrhagic complications and ICU mortality.
Day-to-day progression of vital-sign circadian rhythms in the intensive care unit
Shaun Davidson, Mauricio Villarroel, Mirae Harford, Eoin Finnegan, Jo?o Jorge, Duncan Young, Peter Watkinson and Lionel Tarassenko
doi : 10.1186/s13054-021-03574-w
Critical Care 2021 25:156
Disrupted vital-sign circadian rhythms in the intensive care unit (ICU) are associated with complications such as immune system disruption, delirium and increased patient mortality. However, the prevalence and extent of this disruption is not well understood. Tools for its detection are currently limited.
Bedside voluntary and evoked forces evaluation in intensive care unit patients: a narrative review
Djahid Kennouche, Eric Luneau, Thomas Lapole, Jérome Morel, Guillaume Y. Millet and Julien Gondin
doi : 10.1186/s13054-021-03567-9
Critical Care 2021 25:157
Around one third of intensive care unit (ICU) patients will develop severe neuromuscular alterations, known as intensive care unit-acquired weakness (ICUAW), during their stay. The diagnosis of ICUAW is difficult and often delayed as a result of sedation or delirium. Indeed, the clinical evaluation of both Medical Research Council score and maximal voluntary force (e.g., using handgrip and/or handheld dynamometers), two independent predictors of mortality, can be performed only in awake and cooperative patients. Transcutaneous electrical/magnetic stimulation applied over motor nerves combined with the development of dedicated ergometer have recently been introduced in ICU patients in order to propose an early and non-invasive measurement of evoked force. The aim of this narrative review is to summarize the different tools allowing bedside force evaluation in ICU patients and the related experimental protocols. We suggest that non-invasive electrical and/or magnetic evoked force measurements could be a relevant strategy to characterize muscle weakness in the early phase of ICU and diagnose ICUAW.
Implications of cardiac markers in risk-stratification and management for COVID-19 patients
Pengping Li, Wei Wu, Tingting Zhang, Ziyu Wang, Jie Li, Mengyan Zhu, Yuan Liang, Wenhua You, Kening Li, Rong Ding, Bin Huang, Lingxiang Wu, Weiwei Duan, Yi Han, Xuesong Li, Xin Tang
doi : 10.1186/s13054-021-03555-z
Critical Care 2021 25:158
COVID-19 has resulted in high mortality worldwide. Information regarding cardiac markers for precise risk-stratification is limited. We aim to discover sensitive and reliable early-warning biomarkers for optimizing management and improving the prognosis of COVID-19 patients.
Elevated carboxyhaemoglobin as a novel indicator for extracorporeal membrane haemolysis and oxygenator exchange
Kenneth R. Hoffman, Aidan J. C. Burrell, Arne Diehl and Warwick Butt
doi : 10.1186/s13054-021-03582-w
Critical Care 2021 25:159
Argatroban versus heparin in patients without heparin-induced thrombocytopenia during venovenous extracorporeal membrane oxygenation: a propensity-score matched study
Christoph Fisser, Maren Winkler, Maximilian V. Malfertheiner, Alois Philipp, Maik Foltan, Dirk Lunz, Florian Zeman, Lars S. Maier, Matthias Lubnow and Thomas Müller
doi : 10.1186/s13054-021-03581-x
Critical Care 2021 25:160
During venovenous extracorporeal membrane oxygenation (vvECMO), direct thrombin inhibitors are considered by some potentially advantageous over unfractionated heparin (UFH). We tested the hypothesis that Argatroban is non-inferior to UFH regarding thrombosis and bleeding during vvECMO.
Trajectories of depression in sepsis survivors: an observational cohort study
Monique Boede, Jochen S. Gensichen, James C. Jackson, Fiene Ei?ler, Thomas Lehmann, Sven Schulz, Juliana J. Petersen, Florian P. Wolf, Tobias Dreischulte and Konrad F. R. Schmidt
doi : 10.1186/s13054-021-03577-7
Critical Care 2021 25:161
Advances in critical care medicine have led to a growing number of critical illness survivors. A considerable part of them suffers from long-term sequelae, also known as post-intensive care syndrome. Among these, depressive symptoms are frequently observed. Depressive symptom trajectories and associated factors of critical illness survivors have rarely been investigated. Study objective was to explore and compare different trajectories of depressive symptoms in sepsis survivors over 1 year after discharge from ICU.
COVID-19: spot urine rather than bronchoalveolar lavage fluid analysis?
Faeq Husain-Syed, Claudio Ronco, Thorsten Wiech, Matthias Hecker and Werner Seeger
doi : 10.1186/s13054-021-03579-5
Critical Care 2021 25:162
PEEP-induced alveolar recruitment in patients with COVID-19 pneumonia: take the right time!
Gianmaria Cammarota, Rachele Simonte and Edoardo De Robertis
doi : 10.1186/s13054-021-03573-x
Critical Care 2021 25:163
Extracorporeal membrane oxygenation in non-intubated immunocompromised patients
Klaus Stahl, Heiko Schenk, Christian Kühn, Olaf Wiesner, Marius M. Hoeper and Sascha David
doi : 10.1186/s13054-021-03584-8
Critical Care 2021 25:164
