Nandan Marathe, MD,1 Laura-Nanna Lohkamp, MD, MSc,1 and Michael G. Fehlings, MD, PhD
doi : 10.3171/2022.6.SPINE211011
Since its initial description, the definition of Ehlers-Danlos syndrome (EDS) has notably changed. At present, it broadly refers to disorders of the connective tissue that are heritable and have similar features including joint hypermobility, dermal dysplasia, and vascular as well as internal organ fragility. There has been no comprehensive review of spinal manifestations of EDS in the recent literature. That has led to controversies in management protocols of this so-called orphan disease.
Takayoshi Shimizu, MD, PhD, Shunsuke Fujibayashi, MD, PhD, Bungo Otsuki, MD, PhD,Koichi Murata, MD, PhD, Soichiro Masuda, MD, and Shuichi Matsuda, MD, PhD
doi : 10.3171/2022.5.SPINE22168
Residual anterior spinal cord compression (RASCC) after cervical laminoplasty, which has been confirmed on postoperative MRI, is reportedly associated with poor clinical outcomes. To date, only a few studies have described the risk factors associated with RASCC. The aim of this study was to identify the factors that can predict the occurrence of RASCC after laminoplasty for cervical spondylotic myelopathy (CSM), focusing on the location of the most stenotic segment.
Akshar H. Patel, MD,1 Sione A. Ofa, BS,1 Lacee K. Collins, BS, 2 Leland C. McCluskey Jr., MD,1 William F. Sherman, MD, MBA,1 and Mathew Cyriac, MD, MBA1
doi : 10.3171/2022.5.SPINE22415
With the use of anterior cervical discectomy and fusion (ACDF) expected to rise by 13.3% from 2020 to 2040, the increased usage of interbody cages with integral anterior fixation prompted a Centers for Medicare & Medicaid Services (CMS) review, which resulted in coding changes affecting anterior instrumentation documentation. CMS determined that Current Procedural Terminology (CPT) code 22845 should not be used to report integrated instrumentation (plate) with an interbody device, and if additional anterior instrumentation (e.g., plates and screws) is placed with an integrated interbody device, then a 59 modifier should be used. There is sparse literature examining the trends of ACDF without and with additional anterior instrumentation after the 2015 CMS audit. Therefore, this study aimed to evaluate the trends of single-level subaxial ACDF utilization from 2011 to 2019 to determine whether the 2015 CMS audit influenced the documented usage of additional anterior instrumentation.
*Richard G. Fessler, MD, PhD,1 Reza Ehsanian, MD, PhD, 2 Charles Y. Liu, PhD, MD, 3–5 Gary K. Steinberg, MD, PhD,6 Linda Jones, PT, PhD,7 Jane S. Lebkowski, PhD, 8,9 Edward D. Wirth III, MD, PhD, 8,10 and Stephen L. McKenna, MD
doi : 10.3171/2022.5.SPINE22167
The primary objective of this study was to evaluate the safety of 3 escalating doses of oligodendrocyte progenitor cells (LCTOPC1; previously known as GRNOPC1 and AST-OPC1) administered at a single time point between 21 and 42 days postinjury to participants with subacute cervical spinal cord injuries (SCIs). The secondary objective was to evaluate changes in neurological function following administration of LCTOPC1.
Mark J. Lambrechts, MD, Nicholas D. D’Antonio, BS, Brian A. Karamian, MD, Arun P. Kanhere, MD, Azra Dees, BA, Bright M. Wiafe, BS, Jose A. Canseco, MD, PhD, Barrett I. Woods, MD, I. David Kaye, MD, Jeffrey Rihn, MD, Mark Kurd, MD, Alan S. Hilibrand, MD, Christopher K. Kepler, MD, MBA, Alexander R. Vaccaro, MD, MBA, PhD, and Gregory D. Schroeder, MD
doi : 10.3171/2022.6.SPINE22435
For patients with cervical and thoracolumbar AO Spine type C injuries, the authors sought to 1) identify whether preoperative vertebral column translation is predictive of a complete spinal cord injury (SCI) and 2) identify whether preoperative or postoperative vertebral column translation is predictive of neurological improvement after surgical decompression.
Pratyush Shahi, MBBS, MS(Ortho),1 Junho Song, BS,1 Sidhant Dalal, BS,1 Dimitra Melissaridou, MD,1 Daniel J. Shinn, BS,1 Kasra Araghi, BS,1 Eric Mai, BS, 2 Evan Sheha, MD,1 James Dowdell, MD,1 Sheeraz A. Qureshi, MD, MBA,1,2 and Sravisht Iyer, MD
doi : 10.3171/2022.5.SPINE22361
The objective of this study was to assess the outcomes of minimally invasive lumbar decompression in patients ≥ 80 years of age and compare them with those of younger age groups.
Brian J. Park, MD,1 Colin J. Gold, MD,1 David Christianson, MD,1 Nicole A. DeVries Watson, PhD, 2 Kirill V. Nourski, MD, PhD,1,3 Royce W. Woodroffe, MD,1 and Patrick W. Hitchon, MD
doi : 10.3171/2022.5.SPINE22371
Adjacent-segment disease (ASD) proximal to lumbosacral fusion is assumed to result from increased stress and motion that extends above or below the fusion construct. Sublaminar bands (SBs) have been shown to potentially mitigate stresses in deformity constructs. A similar application of SBs in lumbar fusions is not well described yet may potentially mitigate against ASD.
Matthew J. Hagan, BS,1 Albert E. Telfeian, MD, PhD,1 Rahul Sastry, MD,1 Rohaid Ali, MD,1 Kai-Uwe Lewandrowski, MD, 2 Sanjay Konakondla, MD, 3 Sean Barber, MD, 4 Kendall Lane,1 and Ziya L. Gokaslan, MD
doi : 10.3171/2022.6.SPINE22451
The aim of this study was to describe a minimally invasive transforaminal surgical technique for treating awake patients presenting with lumbar radiculopathy and compressive facet cysts.
Paul S. Page, MD, Garret P. Greeneway, MD, Simon G. Ammanuel, MD, and Daniel K. Resnick, MD
doi : 10.3171/2022.5.SPINE22504
Lumbar synovial cysts (LSCs) represent a relatively rare clinical pathology that may result in radiculopathy or neurogenic claudication. Because of the potential for recurrence of these cysts, some authors advocate for segmental fusion, as opposed to decompression alone, as a way to eliminate the risk for recurrence. The objective of this study was to create a predictive score for synovial cyst recurrence following decompression without fusion.
Elias Elias, MD, MPH, MSc,1 Shay Bess, MD, 2 Breton G. Line, BSME, 2 Virginie Lafage, PhD, 3 Renaud Lafage, MS, 4 Eric Klineberg, MD, 5 Han Jo Kim, MD, 4 Peter Passias, MD,6 Zeina Nasser, MSc, PhD,7 Jeffrey L. Gum, MD, 8 Khaled Kebaish, MD, 9 Robert Eastlack, MD,10 Alan H. Daniels, MD,11 Gregory Mundis Jr., MD,10 Richard Hostin, MD,12 Themistocles S. Protopsaltis, MD,6 Alex Soroceanu, MD,13 D. Kojo Hamilton, MD,14 Michael P. Kelly, MD,15 Munish Gupta, MD,16 Robert Hart, MD,17 Frank J. Schwab, MD, 3 Douglas Burton, MD,18 Christopher P. Ames, MD,19 Christopher I. Shaffrey, MD, 20 and Justin S. Smith, MD, PhD,1 on behalf of International Spine Study Group
doi : 10.3171/2022.6.SPINE22422
Adult cervical deformity (ACD) has high complication rates due to surgical complexity and patient frailty. Very few studies have focused on longer-term outcomes of operative ACD treatment. The objective of this study was to assess minimum 2-year outcomes and complications of ACD surgery.
Philip K. Louie, MD,1,2 Basel Sheikh Alshabab, MD,1 Michael H. McCarthy, MD, MPH,1,3 Sohrab Virk, MD,1,4 James E. Dowdell, MD,1 Michael E. Steinhaus, MD,1,5 Francis Lovecchio, MD,1 Andre M. Samuel, MD,1 Kyle W. Morse, MD,1 Frank J. Schwab, MD,1,4 Todd J. Albert, MD,1 Sheeraz A. Qureshi, MD,1 Sravisht Iyer, MD,1 Yoshihiro Katsuura, MD,1,6 Russel C. Huang, MD,1 Matthew E. Cunningham, MD, PhD,1 Yu-Cheng Yao, MD,1,7 Karen Weissmann, MD,1,8 Renaud Lafage, MSc,1,4 Virginie Lafage, PhD,1,4 and Han Jo Kim, MD
doi : 10.3171/2022.5.SPINE211537
The objective of this study was to initially validate a recent morphological classification of cervical spine deformity pathology.
Dae-Woong Ham, MD,1 Ho-Joong Kim, MD, 2 Sang-Min Park, MD, 2 Se Jin Park, MD, 2 Jiwon Park, MD, 3 and Jin S. Yeom, MD
doi : 10.3171/2022.5.SPINE211528
Changes in the thoracolumbar angle (TLA) would play a pivotal role in the reciprocal changes following spine realignment surgery, thereby leading to the development of proximal junctional kyphosis (PJK). This study aimed to investigate the association between TLA and the development of PJK following adult spinal deformity surgery.
Tomohiro Banno, MD, PhD,1 Yu Yamato, MD, PhD,1 Hiroki Oba, MD, 2 Tetsuro Ohba, MD, PhD, 3 Tomohiko Hasegawa, MD, PhD,1 Go Yoshida, MD, PhD,1 Hideyuki Arima, MD, PhD,1 Shin Oe, MD, PhD,1 Koichiro Ide, MD, PhD,1 Tomohiro Yamada, MD, PhD,1 Jun Takahashi, MD, PhD, 2 Hirotaka Haro, MD, PhD, 3 and Yukihiro Matsuyama, MD, PhD
doi : 10.3171/2022.5.SPINE22385
Persistent coronal imbalance (PCI) can develop postoperatively. In this study, the authors aimed to clarify the risk factors and clinical impact of PCI after posterior spinal fusion (PSF) in idiopathic scoliosis (IS) patients with a major thoracolumbar/lumbar (TL/L) curve.
Lindsay D. Orosz, MS, PA-C,1 Fenil R. Bhatt, BS, 2 Ehsan Jazini, MD, 2 Marcel Dreischarf, PhD, 3 Priyanka Grover, MS, 3 Julia Grigorian, BA,1 Rita Roy, MD,1 Thomas C. Schuler, MD, 2 Christopher R. Good, MD, 2 and Colin M. Haines, MD2
doi : 10.3171/2022.5.SPINE22109
The analysis of sagittal alignment by measuring spinopelvic parameters has been widely adopted among spine surgeons globally, and sagittal imbalance is a well-documented cause of poor quality of life. These measurements are time-consuming but necessary to make, which creates a growing need for an automated analysis tool that measures spinopelvic parameters with speed, precision, and reproducibility without relying on user input. This study introduces and evaluates an algorithm based on artificial intelligence (AI) that fully automatically measures spinopelvic parameters.
Ken Porche, MD, and Daniel J. Hoh, MD
*Weihua Chu, MD,1 Xin Chen, BA,1 Zexian Wen, MA, 2 Xingsen Xue, MA,1 Guangjian He, BA,1 Hongyan Zhang, MA,1 Jingjing Liu, MA,1 Yang Zhang, BA,1 Hua Feng, MD,1 and Jiangkai Lin, MD
doi : 10.3171/2022.3.SPINE211437
Tarlov cysts (TCs) are a common cystic entity in the sacral canal, with a reported prevalence between 1.5% and 13.2%; 10%–20% of patients are symptomatic and need appropriate clinical intervention. However, the choice of treatment remains controversial. The goal of this study was to describe a new microsurgical sealing technique for symptomatic sacral TCs (SSTCs) as well as its long-term outcomes.
Barry Ting Sheen Kweh, MBBS(Hons),1–3 Jin W. Tee, MBBS, MD, FRACS,1,2,4 F. Cumhur Oner, MD, PhD, 5 Klaus J. Schnake, MD,6,7 Emiliano N. Vialle, MD, MSc, 8 Frank Kanziora, MD, PhD, 9 Shanmuganathan Rajasekaran, MCh, PhD, FRCS,10 Marcel Dvorak, MD, FRCSC,11 Jens R. Chapman, MD,12 Lorin M. Benneker, MD,13 Gregory Schroeder, MD,14 and Alexander R. Vaccaro, MD, PhD, MBA14
doi : 10.3171/2022.5.SPINE211468
The purpose of this study was to describe the genesis of the AO Spine Sacral and Pelvic Classification System in the context of historical sacral and pelvic grading systems.
Paul S. Page, MD, Garret P. Greeneway, MD, Wendell B. Lake, MD, Nathaniel P. Brooks, MD, Darnell T. Josiah, MD, Amgad S. Hanna, MD, and Daniel K. Resnick, MD
doi : 10.3171/2022.6.SPINE22551
Extension fractures in the setting of diffuse idiopathic skeletal hyperostosis (DISH) represent highly unstable injuries. As a result, these fractures are most frequently treated with immediate surgical fixation to limit any potential risk of associated neurological injury. Although this represents the standard of care, patients with significant comorbidities, advanced age, or medical instability may not be surgical candidates. In this paper, the authors evaluated a series of patients with extension DISH fractures who were treated with orthosis alone and evaluated their outcomes.
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