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Topical glaucoma medications – Clinical implications for the ocular surface
Fredrik Fineide a,b,c,d,*, Neil Lagali t,u, Muhammed Yasin Adil a,b, Reiko Arita e, Miriam Kolko f,g, Jelle Vehof h,i,l, Tor P. Utheim
doi : 10.1016/j.jtos.2022.07.007
Volume 26, October 2022, Pages 19-49
Glaucoma is a leading cause of irreversible blindness. The use of topical eye drops to reduce intraocular pressure remains the mainstay treatment. These eye drops frequently contain preservatives designed to ensure sterility of the compound.
Salivary gland transplantation for dry eye disease: Indications, techniques, and outcomes
Swati Singh a,b,*, Sayan Basu a,c, Gerd Geerling
doi : 10.1016/j.jtos.2022.07.013
Volume 26, October 2022, Pages 53-62
The transplantation of salivary glands to the eye serves as a substitute for restoring tear volume in patients with severe dry eye disease. The lacrimal gland and salivary glands share similar acinar-ductal organization with some differences in the nature of secretions.
Updates in diagnostics, treatments, and correlations between oral and ocular manifestations of Sjogren's syndrome
Hassaam S. Choudhry a, Shayan Hosseini a, Hannaan S. Choudhry a, Mahnaz Fatahzadeh b, Reena Khianey c, Mohammad H. Dastjerdi
doi : 10.1016/j.jtos.2022.08.001
Volume 26, October 2022, Pages 75-87
Sjogren's syndrome (SS) is characterized as an autoimmune disorder targeting secretory glands, including the lacrimal and salivary glands, causing dry eye and dry mouth predominantly in women over the age of 40. In this review, we summarize recent advancements in SS diagnostics, treatments, and our understanding of correlations between oral and ocular manifestations of SS.
The role of sphingolipids in meibomian gland dysfunction and ocular surface inflammation
Vikram Paranjpe a, Anat Galor b,c,**, Richard Grambergs d, Nawajes Mandal
doi : 10.1016/j.jtos.2022.07.006
Volume 26, October 2022, Pages 100-110
Inflammation occurs in response to tissue injury and invasion of microorganisms and is carried out by the innate and adaptive immune systems, which are regulated by numerous chemokines, cytokines, and lipid mediators.
5-Fluorouracil in primary, impending recurrent and recurrent pterygium: Systematic review of the efficacy and safety of a surgical adjuvant and intralesional antimetabolite
Brendon W.H. Lee a,b,c,*, Amitouj S. Sidhu a,b, Ian C. Francis a,b, Minas T. Coroneo
doi : 10.1016/j.jtos.2022.08.002
Volume 26, October 2022, Pages 128-141
Pterygium is an ultraviolet-related disease characterized by an aberrant, wing-shaped and active wound-healing process. There is nothing quite as disheartening for the surgeon or patient as the recurrence of pterygium, and various adjuvants have been studied to ameliorate this.
Understanding chronic ocular surface pain: An unmet need for targeted drug therapy
Anat Galor a, Pedram Hamrah b, Sameena Haque c, Nadine Attal d, Marc Labetoulle
doi : 10.1016/j.jtos.2022.08.005
Volume 26, October 2022, Pages 148-156
Chronic ocular surface pain (COSP) may be defined as a feeling of pain, perceived as originating from the ocular surface, that persists for >3 months. COSP is a complex multifactorial condition associated with several risk factors that may significantly interfere with an individual's daily activities, resulting in poor quality of life (QoL).
The multifaceted aspects of ocular allergies: Phenotypes and endotypes
Stefano Bonini a,1, Andrea Leonardi
doi : 10.1016/j.jtos.2022.08.009
Volume 26, October 2022, Pages 174-183
Like the lung, skin, and nose, the external eye is a common target of allergic inflammation. Ocular allergy (OA) represents a collection of underestimated diseases of the eye observed in children and adults.
Emerging therapies targeting eosinophil-mediated inflammation in chronic allergic conjunctivitis
Andrew Fernandez a, Penny Asbell a, Neeta Roy
doi : 10.1016/j.jtos.2022.08.004
Volume 26, October 2022, Pages 191-196
Ocular allergy remains a significant burden to the population while the treatment for the severe, chronic forms of allergic conjunctivitis remains largely limited to non-specific immunosuppressants. Eosinophils are central to the pathophysiology and sustaining the immunologic response found in the chronic forms of ocular allergy such as vernal keratoconjunctivitis and atopic keratoconjunctivitis. Several mediators of eosinophil recruitment, chemotaxis, adhesion, activation, and survival have been identified that offer potential therapeutic targets for ocular allergy.
Antibiotic treatment for dry eye disease related to meibomian gland dysfunction and blepharitis – A review
Ragnheidur R. Vernhardsdottir a,*, Morten S. Magno b,c,d,e,f, Leif Hynnekleiv b,g, Neil Lagali f,h, Darlene A. Dartt i, Jelle Vehof a,c,g,j,k, Catherine J. Jackson d, Tor P. Utheim
doi : 10.1016/j.jtos.2022.08.010
Volume 26, October 2022, Pages 211-221
Dry eye disease (DED) is among the most prevalent ophthalmic conditions but is often underdiagnosed and mistreated. Antibiotics are regularly used to treat DED caused by meibomian gland dysfunction (MGD) or blepharitis, but their use has been questioned.
Trends in using mesenchymal stromal/stem cells (MSCs) in treating corneal diseases
Jhuwala Venkatakrishnan a,b, Yusef Saeed a, Winston W-Y Kao
doi : 10.1016/j.jtos.2022.10.003
Volume 26, October 2022, Pages 255-267
Since their inception in the 1960s–70s, mesenchymal stem/stromal cells (MSCs) have gained interest because of their differentiation potential, anti-inflammatory effects, and immune-modulating properties
Alleviating experimental allergic eye disease by inhibiting pro-lymphangiogenic VEGFR3 signal
Bingsheng Lou a,1, Wanwen Wu a,1, Lei Zeng a, Weibin Zhou b, Xuan Zhang a, Xuetong Zhou a, Zheng Liu a, Keli Liu a, Xinyu Gu a, Xun Chen a, Yeqi Wang c,d, Yangxin Chen b, Xinbo Gao a, Feng Zhang
doi : 10.1016/j.jtos.2022.07.002
Volume 26, October 2022, Pages 1-12
Ocular allergy leads to acute and chronic inflammation that may deteriorate the conjunctiva and other ocular tissue. The conjunctiva is covered with abundant lymphatic vessels but how the conjunctival lymphatic system patriciates in the development of allergic eye disease (AED) remains to be elucidated.
Prevalence of neurotrophic keratopathy in patients with chronic ocular graft-versus-host disease
Rohan Bir Singh 1, Erdem Yuksel 1, Shruti Sinha, Shudan Wang, Yukako Taketani, Zala Luznik, Jia Yin, Thomas H. Dohlman, Reza Dana
doi : 10.1016/j.jtos.2022.07.001
Volume 26, October 2022, Pages 13-18
To determine the prevalence, clinical characteristics, and risk factors associated with neurotrophic keratopathy (NK) in patients with chronic ocular graft-versus-host disease (oGVHD).
Phenotypic characterization of patients developing chronic dry eye and pain after refractive surgery: A cross-sectional study
Amanda V Ì�azquez a,*, Elena MartÃnez-Plaza a, Itziar Fern Ì�andez a,b, Eva M. Sobas a, MarÃa J. Gonz Ì�alez-GarcÃa a,b, Amalia EnrÃquez-de-Salamanca a,b, Enrique Ortega a,c, Alberto L Ì�opez-Miguel a, Margarita Calonge
doi : 10.1016/j.jtos.2022.07.010
Volume 26, October 2022, Pages 63-74
To describe the clinical characteristics of patients suffering from chronic dry eye (DE) and pain after refractive surgery (RS).
Benzalkonium chloride, a common ophthalmic preservative, compromises rat corneal cold sensitive nerve activity
Evguenia Ivakhnitskaia a, Vladislav Souboch a, Valentina Dallacasagrande b, Kamila Mizerska b,c, Elizaveta Souboch a, Joy Sarkar a, Victor H. Guaiquil a, Kuei Y. Tseng d, Harumitsu Hirata b,a, Mark I. Rosenblatt
doi : 10.1016/j.jtos.2022.07.012
Volume 26, October 2022, Pages 88-96
Corneal nerves comprise the densest sensory network in the body. Dysfunction of the corneal cold sensitive neurons (CSN) is implicated in ophthalmic disorders, including Dry Eye Disease, the most common ocular surface disorder. The preservative Benzalkonium chloride (BAK) and the mydriatic agent Phenylephrine hydrochloride (PHE) are considered to be inactive at the level of the CSNs. The purpose of this study is to test the impacts of continuous exposures to BAK or PHE at their clinically used concentrations on corneal nerve structure and function.
Anomaly of cornea and ocular adnexa in spinster homolog 2 (Spns2) knockout mice
Shingo Yasuda a,b,*, Takayoshi Sumioka a, Masayasu Miyajima a, Hiroki Iwanishi a, Tomoya Morii a, Naoki Mochizuki c, Peter S. Reinach d,e, Winston W.Y. Kao f, Yuka Okada g, Chia-Yang Liu b, Shizuya Saika
doi : 10.1016/j.jtos.2022.08.007
Volume 26, October 2022, Pages 111-127
Spinster 2 (Spns2) is a transporter that pumps sphingosine-1-phosphate (S1P), a bioactive lipid mediator synthesized in the cytoplasm, out of cells into the inter cellular space. S1P is a signal that modulates cellular behavior during embryonic development, inflammation and tissue repair, etc.
Ocular pain in ocular graft-versus-host disease patients with neurotrophic keratopathy
Shudan Wang, Rohan Bir Singh, Erdem Yuksel, Aytan Musayeva, Shruti Sinha, Yukako Taketani, Thomas H. Dohlman *, Reza Dana
doi : 10.1016/j.jtos.2022.07.005
Volume 26, October 2022, Pages 142-147
Neurotrophic keratopathy (NK) is a degenerative disorder of the cornea characterized by decreased sensory innervation, epitheliopathy, and impaired epithelial healing. In this study, we assessed ocular pain and quality-of-life-related parameters in ocular graft-versus-host disease (oGVHD) patients with and without NK.
Density and distribution of dendritiform cells in the peripheral cornea of healthy subjects using in vivo confocal microscopy
Anam Akhlaq a,b,2, Clara Col �on c,2, Bernardo M. Cavalcanti c,2, Shruti Aggarwal c, Yureeda Qazi c, Andrea Cruzat c,d, Candice Jersey c, Douglas B. Critser e, Amy Watts c, Jill Beyer f,1, Christine W. Sindt e, Pedram Hamrah
doi : 10.1016/j.jtos.2022.07.008
Volume 26, October 2022, Pages 157-165
To establish in a large healthy cohort, dendritiform cell (DC) density and morphological parameters in the central and peripheral cornea using in vivo confocal microscopy (IVCM).
A randomized, vehicle-controlled, Phase 2b study of two concentrations of the TRPM8 receptor agonist AR-15512 in the treatment of dry eye disease (COMET-1)
David L. Wirta a,*, Michelle Senchyna b, Amber E. Lewis b, David G. Evans c, Eugene B. McLaurin c, George W. Ousler d, David A. Hollander
doi : 10.1016/j.jtos.2022.08.003
Volume 26, October 2022, Pages 166-173
Dry eye disease (DED) symptoms can negatively impact quality of life (QoL). AR-15512, a transient receptor potential melastatin 8 (TRPM8) agonist, was evaluated as a potential therapy for DED.
Therapeutic efficacy of topical blockade of substance P in experimental allergic red eye
Shudan Wang, Lingjia Liu 1,3, Tomas Blanco 3, Hongyan Ge 2, Yutong Xia, Kunpeng Pang, Yihe Chen, Reza Dana
doi : 10.1016/j.jtos.2022.08.008
Volume 26, October 2022, Pages 184-190
Allergic conjunctivitis is the most common cause leading to ocular redness (OR). Herein, using an animal model of allergic OR, we evaluated the therapeutic efficacy of topical blockade of substance P (SP) in treating red eye.
Multicenter prospective validation study for international chronic ocular graft-versus-host disease consensus diagnostic criteria
Yoko Ogawa a,*, Reza Dana b, Stella Kim c,d, Sandeep Jain e, Mark I. Rosenblatt e, Victor L. Perez f,g, Janine A. Clayton h, Monica Alves i, Eduardo Melani Rocha j, Francisco Amparo b, Kyoung Yul Seo k, Yan Wang l, Joanne Shen m, Joo Youn Oh n, Murugesan Vanathi o, Sridevi Nair o, Kyung-Sun Na p, Anjo Riemens q, Kimberly Sippel r, Matias Soifer g, Shudan Wang b, Marilia Trindade i, Mee Kum Kim n, Chang Ho Yoon n, Ryuichiro Yagi s, Ryo Hiratsuka a, Mamoru Ogawa a, Eisuke Shimizu a, Yasunori Sato t, Stephen Pflugfelder u, Kazuo Tsubota
doi : 10.1016/j.jtos.2022.09.002
Volume 26, October 2022, Pages 200-208
To validate the international chronic ocular graft-versus-host disease (GVHD) diagnostic criteria (ICCGVHD) compared to the National Institute of Health diagnostic criteria 2014 (NIH2014) for chronic ocular GVHD.
Recent advances in optical coherence tomography for anterior segment imaging in small animals and their clinical implications
Lisa Beckmann a, Zhen Cai a,c, Mathew Margolis b, Raymond Fang a, Ali Djalilian b, Hao F. Zhang
doi : 10.1016/j.jtos.2022.08.011
Volume 26, October 2022, Pages 222-233
Anterior segment optical coherence tomography (AS-OCT) is a rapidly evolving area of OCT imaging, providing high-resolution and non-invasive volumetric imaging of the anterior segment. This review focuses on recent advances in AS-OCT imaging in small animals, which we categorize into ultrahigh-resolution, spectroscopic, magnetomotive, polarization-sensitive, and angiographic AS-OCTs. We summarize their technical foundations, review their applications to small animal imaging, and briefly discuss their current and future clinical applications.
Imbalanced IL-37/TNF-α/CTSS signaling disrupts corneal epithelial barrier in a dry eye model in vitro
Yun Zhang a,b,1, Jin-Miao Li a,c,1, Rong Lu c, Zhao Liu a, Xin Chen a,b, Cintia S. de Paiva a, Stephen C. Pflugfelder a, De-Quan Li
doi : 10.1016/j.jtos.2022.10.001
Volume 26, October 2022, Pages 234-243
To explore novel role and molecular mechanism of a natural anti-inflammatory cytokine interleukin (IL) 37 in preventing corneal epithelial barrier disruption from hyperosmolar stress as can occur in dry eye disease.
Anti-inflammatory and wound healing potential of medicinal maggot excretions/secretions at the ocular surface
Carolina Lema a, Hasna Baidouri a, Mingxia Sun a, Susanne Pohl b, Sharon Cookson b, Rachel Redfern a,*, Alison M. McDermott
doi : 10.1016/j.jtos.2022.09.003
Volume 26, October 2022, Pages 244-254
In the skin, Lucilia sericata maggot excretions/secretions (ES) accelerate wound healing and limit inflammation. This study aimed to determine whether ES have similar beneficial effects at the ocular surface.
Induction of meibocyte differentiation by three-dimensional, matrigel culture of immortalized human meibomian gland epithelial cells to form acinar organoids
Selikem Nuwormegbe b, Na-Young Park b, Hee Joo Park b, Yeonwoo Jin a, Sun Woong Kim a,b,**,1, James V. Jester
doi : 10.1016/j.jtos.2022.10.004
Volume 26, October 2022, Pages 271-282
Recent studies have shown that two-dimensional (2D) culture of primary rabbit and immortalized human meibomian gland epithelial cells (iHMGEC) do not recapitulate normal meibocyte differentiation and fail to express critical enzymes necessary for synthesis of meibum lipids.
Automated quantification of meibomian gland dropout in infrared meibography using deep learning
Ripon Kumar Saha a, A.M. Mahmud Chowdhury a, Kyung-Sun Na b, Gyu Deok Hwang b, Youngsub Eom c, Jaeyoung Kim d, Hae-Gon Jeon e, Ho Sik Hwang b,*, Euiheon Chung
doi : 10.1016/j.jtos.2022.06.006
Volume 26, October 2022, Pages 283-294
Develop a deep learning-based automated method to segment meibomian glands (MG) and eyelids, quantitatively analyze the MG area and MG ratio, estimate the meiboscore, and remove specular reflections from infrared images.
Effects of meibomian gland dysfunction and aqueous deficiency on friction-related disease
Hyunmin Ahn a, Yong Woo Ji a, Ikhyun Jun a,b, Tae-im Kim a,b, Hyung Keun Lee a, Kyoung Yul Seo
doi : 10.1016/j.jtos.2022.02.002
Volume 26, October 2022, Pages 295-299
To evaluate the effects of meibomian gland dysfunction (MGD) and aqueous deficiency (AD) on friction-related disease (FRD).
Spontaneous acinar and ductal regrowth after meibomian gland atrophy induced by deletion of FGFR2 in a mouse model
Xiaowei Yang a, Xingwu Zhong a,b,*, Andrew JW. Huang c, Lixing W. Reneker
doi : 10.1016/j.jtos.2021.11.005
Volume 26, October 2022, Pages 300-309
We have demonstrated that deletion of fibroblast growth factor receptor 2 gene (Fgfr2) leads to Meibomian gland (MG) atrophy in an inducible conditional knockout mouse model, referred as Fgfr2CKO. Herein, we investigated whether MG spontaneously recovers after atrophy in this model.
Alteration in meibum lipid composition and subjective symptoms due to aging and meibomian gland dysfunction
Tomo Suzuki a,b,*, Koji Kitazawa a, Yuko Cho a,b, Masataka Yoshida c, Takashi Okumura c, Atsushi Sato c, Shigeru Kinoshita
doi : 10.1016/j.jtos.2021.10.003
Volume 26, October 2022, Pages 310-317
To investigate the alteration in lipid composition of meibum, objective clinical signs, and subjective symptoms associated with aging and meibomian gland (MG) dysfunction (MGD).
Profile of tear lipid mediator as a biomarker of inflammation for meibomian gland dysfunction and ocular surface diseases: Standard operating procedures
Yohannes Abere Ambaw a,b,g, Dhayan Parresh Timbadia e, Manfred Raida b, Federico Torta a,b, Markus R. Wenk a,b, Louis Tong
doi : 10.1016/j.jtos.2020.09.008
Volume 26, October 2022, Pages 318-327
Human tear is a biological fluid rich in lipids that is increasingly collected in clinical and biological research. The repertoire of small lipids or lipid mediators (often termed eicosanoids or oxylipins) found in human tear provides insight into metabolism of fatty acids and physiology of the ocular surface and Meibomian glands.
Eyelid blood vessel and meibomian gland changes in a sclerodermatous chronic GVHD mouse model
Fan Yang a,b,h, Isami Hayashi a,c, Shinri Sato a, Yumiko Saijo-Ban a, Mio Yamane a, Masaki Fukui a, Eisuke Shimizu a, Jingliang He d, Shinsuke Shibata e, Shin Mukai f, Kazuki Asai a, Mamoru Ogawa a, Yuqing Lan b, Qingyan Zeng g, Akito Hirakata c, Kazuo Tsubota a,i,**, Yoko Ogawa
doi : 10.1016/j.jtos.2021.10.006
Volume 26, October 2022, Pages 328-341
To investigate pathological changes in blood vessels and meibomian glands (MGs) in the eyelids of sclerodermatous chronic graft-versus-host disease (cGVHD) model mice.
Drug-induced pemphigoid: Clinical presentation, diagnosis, and management of gliptin-associated cicatrizing conjunctivitis
Anahita KateMariya B. DoctorSayan Basu
doi : 10.1016/j.jtos.2022.07.004
Volume 26, October 2022, Pages 50-52
Subconjunctival triamcinolone injection for infectious necrotizing scleritis
Matthew C. Santos, Grace L. Paley, Fouad El Sayyad, Eric L. Sollenberger, Andrew J.W. Huang
doi : 10.1016/j.jtos.2022.07.009
Volume 26, October 2022, Pages 97-99
The genus decision: Potential impact on ophthalmic pharmaceuticals
Gary D. Novack PhDKristin Williams, J.D.
doi : 10.1016/j.jtos.2022.08.006
Volume 26, October 2022, Pages 342-344
Expedited regulatory product approval in the time of COVID-19
Gary D. Novack PhD
doi : 10.1016/j.jtos.2022.05.007
Volume 26, October 2022, Pages 345-348
Redefining ocular drug delivery
Allisa J. SongJennifer S. StegerAlan L. Robin
doi : 10.1016/j.jtos.2022.09.001
Volume 26, October 2022, Pages 197-199
Optimising the method for visualising mouse meibomian gland using eyelid whole-mount lipid staining
Yuki Hamada1, Lena Sasaki1, Hikari Uehara Tomo SuzukiShigeru KinoshitaKento Otsuka, Akio KiharaYoshiaki Yamaguchi, Takahito Miyake, Masao Doi
doi : 10.1016/j.jtos.2022.10.002
Volume 26, October 2022, Pages 268-270
Readership awareness series - Paper 1: Ghost authorship
Mohammad Javed Ali,
doi : 10.1016/j.jtos.2022.07.011
Volume 26, October 2022, Pages 209-210
