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Glucocorticoid Therapy in Short Bowel Syndrome: A New Fork in the Road?
Cohran, Valeria C.
doi : 10.1097/MPG.0000000000003105
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p 1-2
Button Batteries, Convenience at a Cost
Barker, Ruth
doi : 10.1097/MPG.0000000000003160
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p 2-3
Lipids Responsible for Intestinal or Hepatic Disorder: When to Suspect a Familial Intestinal Hypocholesterolemia?
Sissaoui, Samira?,†; Cochet, Manon?,†; Poinsot, Pierre‡,§; Bordat, Claire§; Collardeau-Frachon, Sophie‡,§,||; Lachaux, Alain‡,§; Lacaille, Florence†; Peretti, Noël‡,§
doi : 10.1097/MPG.0000000000003145
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p 4-8
Familial intestinal hypocholesterolemias, such as abetalipoproteinemia, hypobetalipoproteinemia, and chylomicron retention disease, are rare genetic diseases that result in a defect in the synthesis or secretion of lipoproteins containing apolipoprotein B.
Electrogastrography Abnormalities in Pediatric Gastroduodenal Disorders: A Systematic Review and Meta-analysis
Bhat, Sameer?; Varghese, Chris?; Carson, Daniel A.?; Hayes, Tommy C.L.?; Andrews, Christopher N.†; Mousa, Hayat‡,§; O’Grady, Gregory?,||; Gharibans, Armen A.?,||
doi : 10.1097/MPG.0000000000003140
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p 9-16
Electrogastrography (EGG) is a non-invasive method of measuring gastric electrophysiology. Abnormal gastric electrophysiology is thought to contribute to disease pathophysiology in patients with gastroduodenal symptoms but this has not been comprehensively quantified in pediatric populations. This study aimed to quantify the abnormalities in gastric electrophysiology on EGG in neonatal and pediatric patients.
Glucocorticoids Improve Enteral Feeding Tolerance in Pediatric Short Bowel Syndrome With Chronic Intestinal Inflammation
Wang, Fangfang?; Gerhardt, Brandi K.†; Iwansky, Sarah N.†; Hobson, Brandy‡; Logan, Samantha‡; Mercer, David F.†; Quiros-Tejeira, Ruben E.§
doi : 10.1097/MPG.0000000000003058
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p 17-22
A group of short bowel syndrome (SBS) patients developed chronic intestinal inflammation while struggling weaning off parenteral nutrition (PN). They did not respond to standard management of SBS and food allergy. We treated them with glucocorticoids and described the outcome.
Impact of Metronidazole Treatment and Dientamoeba Fragilis Colonization on Gut Microbiota Diversity
Gotfred-Rasmussen, Helle?; Stensvold, Christen Rune?; Ingham, Anna C?cilia†; Johannesen, Thor Bech†; Andersen, Lee O’Brien?; R?ser, Dennis‡; Nielsen, Henrik Vedel?
doi : 10.1097/MPG.0000000000003096
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p 23-29
The intestinal parasite Dientamoeba fragilis is a common colonizer of children in Denmark. Metronidazole has been used to reduce gastrointestinal symptoms in children colonized with D fragilis. We aimed to identify gut microbiota changes associated with D fragilis carrier status and metronidazole treatment of D fragilis-positive children.
Maternal Psychological Factors and Onset of Functional Gastrointestinal Disorders in Offspring: A Prospective Study
Baldassarre, Maria Elisabetta?; Antonucci, Linda A.†; Castoro, Germana†; Di Mauro, Antonio?; Fanelli, Margherita‡; Grosso, Francesca Maria§; Cassibba, Rosalinda†; Laforgia, Nicola?
doi : 10.1097/MPG.0000000000003107
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p 30-36
Functional gastrointestinal disorders (FGIDs) are a heterogeneous group of conditions of unclear etiology. The biopsychosocial model approach to FGIDs posits that early-life stressors may trigger a cascade of complex interactions between genetic predisposition and risk factors eventually leading to the occurrence of FGIDs. The relationship between the psychological disposition of the mother and FGIDs occurrence is poorly understood. We conducted a study to investigate if parental psychological factors may contribute to the onset of FGIDs in offspring.
Risk Factors for Suboptimal Bowel Preparation for Colonoscopy in Pediatric Patients
Reddy, Pooja?,†; Mencin, Ali?; Lebwohl, Benjamin‡
doi : 10.1097/MPG.0000000000003114
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p e1-e6
Suboptimal bowel cleansing is common in children and can impact diagnostic and therapeutic outcomes. We aimed to identify risk factors for suboptimal bowel preparation for colonoscopy in pediatric patients.
Inpatient Pediatric Foreign Body Ingestion: National Estimates and Resource Utilization
Wood, Mary L.?; Potnuru, Paul P.†; Nair, Supriya?
doi : 10.1097/MPG.0000000000003143
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p 37-41
We generated national estimates of patient and hospitalization characteristics for pediatric inpatient admissions for foreign body ingestion (FBI) and compared these to admissions for other reasons. We further identified characteristics that were independently associated with length of stay (LOS). Finally, we hypothesized that endoscopy within 24 hours of admission was independently associated with a shorter LOS in patients admitted for FBI.
Physician Perspectives about Telemedicine: Considering the Usability of Telemedicine in Response to Coronavirus Disease 2019
Lee, Jennifer A.?,†,‡; Di Tosto, Gennaro§,||; McAlearney, Fiona A.§; Miller, Steven¶; Mezoff, Ethan?,‡; Venkatesh, Rajitha D.?,‡; Huang, Jeannie#,??; Lightdale, Jenifer R.††,‡‡; Volney, Jaclyn||; McAlearney, Ann Scheck§,||
doi : 10.1097/MPG.0000000000003149
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p 42-47
Use of telemedicine in pediatric gastroenterology has increased dramatically in response to the coronavirus disease 2019 (COVID-19) pandemic. The goal of this study was to systematically assess the usability of telemedicine in the field of pediatric gastroenterology.
Scoring Endoscopy in Pediatric Inflammatory Bowel Disease: A Way to Improve Quality
Norsa, Lorenzo?; Ferrari, Alberto†; Arrigo, Serena‡; Bramuzzo, Matteo§; Deganello Saccomani, Marco||; Di Nardo, Giovanni¶; Illiceto, Maria Teresa#; Miele, Erasmo??; Paci, Monica††; Romano, Claudio‡‡; Romeo, Erminia§§; Daperno, Marco||||; Oliva, Salvatore¶¶; on behalf of the Endoscopy group of the Italian society of pediatric Gastroenterology Hepatology and Nutrition (SIGENP)
doi : 10.1097/MPG.0000000000003090
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p 48-53
There is a large interobserver variability in evaluating mucosal lesions of inflammatory bowel disease (IBD), especially in pediatric patients. This multicenter prospective observational study aims to evaluate interobserver agreement (IOA) among pediatric endoscopists in assigning validated IBD endoscopic scores in children.
Withdrawal of Combination Immunotherapy in Paediatric Inflammatory Bowel Disease—An International Survey of Practice
Meredith, Joseph?,†; Henderson, Paul?,†; Wilson, David C.?,†; Van Limbergen, Johan‡; Wine, Eytan§; Russell, Richard K.?,†
doi : 10.1097/MPG.0000000000003098
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p 54-60
To assess current practices around the use of combination immunosuppression in paediatric inflammatory bowel disease (PIBD) with a focus on the subsequent withdrawal process.
Clinical Practice Survey of Repeat Endoscopy in Pediatric Inflammatory Bowel Disease in North America
Moses, Jonathan?; Sandberg, Kelly†; Winberry, Gabriel‡; Riera, Diana§; DeLozier, Sarah||; Gupta, Sandeep K.¶; Reilly, Norelle#; Park, KT??; Picoraro, Joseph#
doi : 10.1097/MPG.0000000000003100
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p 61-66
Endoscopic remission has become a standard treatment target in inflammatory bowel disease (IBD). It is unclear how widely this practice has been adopted amongst pediatric gastroenterology providers. This study determines the frequency of repeat endoscopy in pediatric IBD and evaluates for predictive baseline characteristics of providers.
Validity and Responsiveness of the Patient-reported Outcomes Measurement Information System in Children With Ulcerative Colitis
Brenner, Erica J.?; Long, Millie D.†; Mann, Courtney M.‡; Lin, Li‡; Chen, Wenli†; Reyes, Camila§; Bahnson, Kirsten M.‡; Reeve, Bryce B.‡; Kappelman, Michael D.?
doi : 10.1097/MPG.0000000000003101
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p 67-72
Patient-reported outcome measures allow children to directly report on their health and well-being. We assessed the construct validity and responsiveness of the Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric measures in children and adolescents with ulcerative colitis (UC).
Reliable Detection of Intrapulmonary Shunts Using Contrast-Enhanced Echocardiography in Children With Portal Hypertension or Portosystemic Shunt
Rock, Nathalie M.?; Beghetti, Maurice†; Tissot, Cécile†; Willi, Jean-Pierre‡; Bouhabib, Maya†; McLin, Valérie A.?; Maggio, Albane B.R.§
doi : 10.1097/MPG.0000000000003079
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p 73-79
The aim of this study was to analyze if contrast-enhanced echocardiography (CEE) is as reliable as lung perfusion scintigraphy (LPS) to detect intrapulmonary shunting (IPS) in children with portal hypertension (PHTN) or congenital/surgical portosystemic shunts (PSS) and to define the number of cardiac cycles required to exclude intrapulmonary shunting.
Applying an Age-specific Definition to Better Characterize Etiologies and Outcomes in Neonatal Acute Liver Failure
Borovsky, Kristin; Banc-Husu, Anna M.; Saul, Samantha A.; Neighbors, Katie; Kelly, Susan; Alonso, Estella M.; Taylor, Sarah A.
doi : 10.1097/MPG.0000000000003103
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p 80-85
Neonatal acute liver failure (ALF) is a rare disease with high mortality for which no standard age-specific definition exists. To advance the understanding of neonatal ALF, we characterize the etiology, presenting features, treatment, and outcomes in infants within 1 month of life.
Clinical Predictors of Morbidity and Mortality in Hospitalized Pediatric Patients With Ascites
Ingviya, Thammasin?,†,‡; Wasuwanich, Paul§,||; Scheimann, Ann O.§; Felix, Grace§; Laengvejkal, Pavis§; Vasilescu, Alexandra§; Imteyaz, Hejab§; Seaberg, Eric C.?; Karnsakul, Wikrom§
doi : 10.1097/MPG.0000000000003104
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p 86-92
Ascites is a pathologic buildup of fluid in the peritoneal cavity. Knowledge is lacking in clinical outcome in pediatric patients with ascites. We aim to identify and assess clinical variables, associated with morbidity and mortality in pediatric patients who are hospitalized with ascites.
Adult Liver Disease Prognostic Modelling for Long-term Outcomes in Biliary Atresia: An Observational Cohort Study
Jain, Vandana?; Burford, Charlotte?; Alexander, Emma C.?; Dhawan, Anil?; Joshi, Deepak†; Davenport, Mark‡; Heaton, Nigel§; Hadzic, Nedim?; Samyn, Marianne?
doi : 10.1097/MPG.0000000000003116
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p 93-98
To assess the utility of prognostic scoring systems for adolescents with biliary atresia (BA) surviving with native liver, for predicting the subsequent requirement for liver transplantation (LT).
Peritoneovenous Shunt for Intractable Ascites in Children: A Series of 4 Cases
Defert, Coralie?; Marret, Jean-Baptiste†; Lacaille, Florence‡; Sissaoui, Samira‡; Dupic, Laurent§; Lardy, Hubert||; Capito, Carmen?,†; Chardot, Christophe†,¶
doi : 10.1097/MPG.0000000000003131
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p e7-e10
Intractable ascites is a rare condition in children mainly caused by cirrhosis or lymphatic disorders. Internal drainage may be considered as rescue therapy. In our department, 4 patients ages from 2 months to 15 years old underwent a peritoneovenous shunt (PVS) placement between 2010 and 2020.
A Diet High in Fat and Fructose Induces Early Hepatic Mitochondrial Aging
Bramlage, Kristin S.?; Bhattacharjee, Jashdeep†; Kirby, Michelle?; Myronovych, Andriy?; Gupta, Rohun†; Gonzalez, Rosa-Maria Salazar†; Xanthakos, Stavra?; Bove, Kevin‡; Kohli, Rohit†
doi : 10.1097/MPG.0000000000003068
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p 99-102
To investigate the effect of high fructose diet on ultrastructure and content of hepatic mitochondria, we randomized 6–8 weeks old male C57Bl6/J mice to ad lib chow or high-fat-high-fructose (HF2) diet for 32 weeks. HF2-fed mice gained more weight, had higher plasma alanine aminotransferase, and fasting glucose levels and increased hepatic triglyceride content at all time points compared to chow-fed mice. HF2-fed mice had lower mitochondrial to nuclear DNA ratio compared to chow-fed mice.
Insulin Resistance as a Diagnostic Criterion for Metabolically Healthy Obesity in Children
Nso-Roca, Ana Pilar; Cortés Castell, Ernesto; Carratal? Marco, Francisco; S?nchez Ferrer, Francisco
doi : 10.1097/MPG.0000000000003097
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p 103-109
In recent years, a subgroup of individuals with obesity has been described as having a lower risk of metabolic and cardiovascular complications. These individuals have what is referred to as metabolically healthy obesity (MHO), which has a favorable metabolic profile and a lower probability of long-term complications.
The Farnesoid X Receptor Agonist Tropifexor Prevents Liver Damage in Parenteral Nutrition-fed Neonatal Piglets
Liu, Yang; Xiao, Yongtao; Chen, Shanshan; Tian, Xinbei; Wang, Weipeng; Wang, Ying; Cai, Wei
doi : 10.1097/MPG.0000000000003135
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p e11-e19
Intestinal failure-associated liver disease (IFALD) is a life-threatening complication for patients with intestinal failure who receive long-term parenteral nutrition (PN). We evaluated the effects of the farnesoid X receptor agonist tropifexor on a neonatal piglet model of IFALD fed with PN.
No Evidence for Sex-specificity in Vitamins C, E, and Fatty Acid Content of Human Milk from Healthy Polish Mothers
Zagierski, Maciej; Krukowska, Anna; Kawska, Karolina; Sznurkowska, Katarzyna; Martysiak-Zurowska, Dorota; Szlagatys-Sidorkiewicz, Agnieszka
doi : 10.1097/MPG.0000000000003136
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p e20-e25
Human milk (HM) is a complex fluid that meets the nutritional needs of infants. Its composition is associated with environmental, maternal, and fetal variables. It provides nutrients and bioactive substances, including cytokines, immunoglobulins, and constituents with antioxidative properties.
Physical Activity and Fatigue in Children With Intestinal Failure on Parenteral Nutrition
So, Stephanie; Patterson, Catherine; Betts, Zachary; Belza, Christina; Avitzur, Yaron; Wales, Paul W.
doi : 10.1097/MPG.0000000000003138
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p 110-114
With improved survival of children with intestinal failure (IF), it is important to examine the impact on long-term physical function, physical activity (PA), and fatigue and identify clinical factors that may be predictive of impairment.
Health-Related Quality of Life and Distress of Parents of Children With Avoidant Restrictive Food Intake Disorder
Krom, Hilde; van Oers, Hedy A.; van der Sluijs Veer, Liesbeth; van Zundert, Suzanne M.C.; Otten, Marie-Anne G.M.; Haverman, Lotte; Benninga, Marc A.; Kindermann, Angelika
doi : 10.1097/MPG.0000000000003150
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p 115-124
Health-related quality of life (HRQOL) of children with avoidant restrictive food intake disorder (ARFID) is impaired.
Receptor-binding Domain Severe Acute Respiratory Syndrome Coronavirus 2-specific Antibodies in Human Milk From Mothers With Coronavirus Disease 2019 Polymerase Chain Reaction or With Symptoms Suggestive of Coronavirus Disease 2019
Demers-Mathieu, Veronique; DaPra, Ciera; Fels, Shawn; Medo, Elena
doi : 10.1097/MPG.0000000000003158
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p 125-128
This study aims to compare the receptor-binding domain (RBD) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibody titers in human milk between mothers with a confirmed coronavirus disease 2019 (COVID-19) polymerase chain reaction (PCR) test and mothers with viral symptoms suggestive of COVID-19.
Diagnosis, Management, and Prevention of Button Battery Ingestion in Childhood: A European Society for Paediatric Gastroenterology Hepatology and Nutrition Position Paper
Mubarak, Amani; Benninga, Marc A.; Broekaert, Ilse; Dolinsek, Jernej; Homan, Matja?; Mas, Emmanuel; Miele, Erasmo; Pienar, Corina; Thapar, Nikhil; Thomson, Mike; Tzivinikos, Christos; de Ridder, Lissy
doi : 10.1097/MPG.0000000000003048
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p 129-136
Button batteries (BB) remain a health hazard to children as ingestion might lead to life-threatening complications, especially if the battery is impacted in the esophagus. Worldwide initiatives have been set up in order to prevent and also timely diagnose and manage BB ingestions.
Gastric Xanthoma: An Incidental and Unusual Finding
Abu-Alreesh, Sarah; Rosen, Danya; Nalbantoglu, ILKe; Arbizu, Ricardo A.
doi : 10.1097/MPG.0000000000003085
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p e26
Jejunopericardiac Fistula in a Patient With Colonic Interposition and a Gastrojejunostomy Tube
Saad, Michelle; Rellinger, Eric; Garrison, Aaron; Oliveira, Stephanie; Johnson, Neil; Putnam, Philip
doi : 10.1097/MPG.0000000000003088
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p e26
Acute Liver Failure in a Sickle Cell Patient
Maji, Prabir; Malik, Rohan
doi : 10.1097/MPG.0000000000003141
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p e27
Response to: Acute Liver Failure in a Sickle Cell Patient
Rizvi, Syed Ahsan; Pandey, Akash
doi : 10.1097/MPG.0000000000003142
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p e27-e28
Adaptation to the Reality of Latin America of the NASPGHAN/ESPGHAN 2016 Guidelines on the Diagnosis, Prevention, and Treatment of Helicobacter pylori Infection in Pediatrics
Harris, Paul R.; Lucero, Yalda; Pierre, Reinaldo
doi : 10.1097/MPG.0000000000003156
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p e28
Re: Diagnosis, Management, and Prevention of Button Battery Ingestion in Childhood: An ESPGHAN Position Paper
Dikkers, Frederik G.; Ebels, Tjark
doi : 10.1097/MPG.0000000000003121
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p e29
Reply to “Re: Diagnosis, Management, and Prevention of Button Battery Ingestion in Childhood: An ESPGHAN Position Paper”
de Ridder, Lissy; Benninga, Marc A.
doi : 10.1097/MPG.0000000000003122
Journal of Pediatric Gastroenterology and Nutrition: July 2021 - Volume 73 - Issue 1 - p e29
