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Blood Pressure Lowering Effect of Lactobacillus-Containing Probiotic
N.P. Hardjo Lugito, R. Djuwita, A. Adisasmita and M. Simadibrata
doi : 10.37290/ijpp2641-7197
We have conducted a systematic investigation on the role of Lactobacillus on blood pressure by a meta-analysis of randomized controlled trials. The PubMed, Scopus, and Google Scholar were used to identify eligible trials from January 2000 until February 2021. Random-effects model was used to assess the treatment effect, i.e., mean difference of sysÂtolic and diastolic blood pressure.
Binding to Intestinal Epithelial Cells and Anti-Inflammatory Activity of Lactobacillus fermentum PL9988
J. Paek, B.C. Kang, H. Yang and Y. Lee
doi : 10.37290/ijpp2641-7197
Lactobacillus fermentum PL9988 was isolated from an elderly person over 80 years of age living in a Korean longevity village. Results from a previous study showed various characteristics of L. fermentum PL9988 as a probiotic, including resistance to acid and bile acid, immune-enhancing activity, adhesiveness to the intestinal cell line Caco-2, inhibition of various intestinal pathogens, antioxidation activity, and susceptibility to antimicrobials. In this study, the binding activity of L. fermentum PL9988 to the intestine was confirmed in another human intestinal cell line, HT-29, and mouse intestinal cells. The anti-inflammatory activity of L. fermentum PL9988 was examined via both in vitro and in vivo experiments. Lactobacillus fermentum PL9988 increased the amount of IL-10 and decreased the amount of TNF-α in HT-29 cells treated with LPS. Similar
Probiotic Lactobacillus plantarum IS-10506, Expression of Glial Fibrillary Acidic Protein and Platelet Endothelial Cell Adhesion Molecule-1 by Astrocytes and Endothelial Integrity: The Importance of Intestinal Microbiota as Blood Brain–Barrier Stabilizer
Reza Gunadi Ranuh, Alpha Fardah Athiyyah, Andy Darma, Wibi Riawan, Prastiya Indra Gunawan, Ingrid Suryanti Surono and Subijanto Marto Sudarmo
doi : 10.37290/ijpp2641-7197
Gut microbiota is a complex community that helps maintain the dynamic metabolic ecological balance of the brain through the gut–brain axis and keeps the blood–brain barrier structure intact. However, the knowledge of how the gut microbiÂota responds to exogenous influences on the blood–brain barrier structure remains limited.
The Effects of Probiotic and Prebiotic Administration in Children with Acute Diarrhea at Day-Care Centers
Subijanto Marto Sudarmo, Reza Gunadi Ranuh, Alpha Fardah Athiyyah, Andy Darma, Virany Diana, Boerhan Hidajat, Siti Nurul Hidayati and Anang
doi : 10.37290/ijpp2641-7197
Prevention of diarrhea needs an appropriate immune system supported by normal microbiota composition. This study aimed to determine whether probiotic or prebiotic enriched Growing-Up Milk could significantly reduce incidence of acute diarrhea. The randomized, double-blind, placebo-controlled clinical study was conducted in Surabaya, Gresik, and Sidoarjo cities, East Java–Indonesia, between July 2007 and January 2008.
Targeted Modulation of Gut Microbiota by Personalized Probiotics
P. Ryšávka, M. Kohutková-Lánová, R. NetuÅ¡il, E. PospÃÅ¡ilová, M. Hanác?ková, J. C?mielová, K. Å t’astný, I. Márová, M. Haranta and A. Bomba
doi : 10.37290/ijpp2641-7197
The current market of probiotic supplements is significantly growing although the quality and effectiveness of the commonly sold products are variable. Parameters such as the composition of each individual microbiota, strain specificity, production procedures, or storage can influence the potential positive outcome of probiotic supplements on consumers. The aim of this study was to determine changes of selected markers within the microbiota after 3 months treatment by the personal
Regulation of T Helper and Regulatory T Cells by Lactobacillus Plantarum IS-10506 Supplementation to Human Immunodeficiency Virus-Infected Children Under Antiretroviral Therapy
Reza Gunadi Ranuh, Sitti Radhiah, Khadijah Rizky Sumitro, Andy Darma, Alpha Fardah Athiyyah, Dwiyanti Puspitasari, Dominicus Husada, Anang Endaryanto, Ingrid Surono and Subijanto Marto Sudarmo
doi : 10.37290/ijpp2641-7197
Human immunodeficiency virus infection is associated with impairment of T helper 1, T helper 2, regulatory T, and T helper Type 17 homeostasis. While probiotics are widely known to improve these changes, understanding of their role on children’s immune system remains limited. In a randomized, double-blind, and placebo-controlled study conducted in Dr. Soetomo General Hospital, Surabaya from December 2012 to March 2013, we have investigated the effect of Lactobacillus plantarum IS-10506 on the regulation of T helper and regulatory T cell in children infected with human immunodeficiency virus receiving antiretroviral therapy for at least 6 months. Twenty-one human immunodeficiency virus infected children were divided into placebo and probiotic groups and L. plantarum IS-10506 was administered at a dose of 2.86 × 1010 colony forming units/day for 6 weeks. Levels of interferon-γ, interleukin-4, transforming growth factor-β, and interleukin-17 were analyzed before and after treatment as an indicator of T-cell regulation of T helper and regulatory T cells. The results show a significant increase in transforming growth factor-β level ( p = 0.003) after administration of L. plantarum IS-10506 compared to placebo with the first-line antiretroviral therapy group. There was no reported adverse effect in this study.
Subjective Evaluation Using Patient-Oriented Eczema Measure of the Clinical Effects of 1-Kestose on Atopic Dermatitis in Children: A Pilot Study
Yoshihiro Kadota, Yasuhiro Koga, Takumi Tochio and Rumiko Shibata
doi : 10.37290/ijpp2641-7197
Several objective evaluation methods are used to evaluate treatment outcomes in atopic dermatitis clinical trials. We previously demonstrated the clinical efficacy of 1-kestose, the smallest fructooligosaccharide, in the treatment of atopic dermatitis in infants using an objective evaluation method. The utility of the Patient-Oriented Eczema Measure, in which patients themselves or their guardians evaluate the pathophysiology of atopic dermatitis, has recently been reported.
Synbiotic Supplementation Facilitates Weight Loss, Improves Lipid Profile and Gut Health in Overweight and Obese Subjects
Lih-Ren Kong, Hsin-Ya Lin, Min-Shan Hsiao and Shu-Ching Wang
doi : 10.37290/ijpp2641-7197
Probiotics have been shown to assist weight loss in overweight people. This study investigated the effects of a synbiotic supplement that comprised a prebiotic and a probiotic on anthropometric and biochemical measures in overweight and obese subjects.
