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Clinical Risk Score to Predict Pathogenic Genotypes in Patients With Dilated Cardiomyopathy
Luis Escobar-Lopez, MD, a,b,c Juan Pablo Ochoa, MD, P HD, a,c Ana Royuela, P HD, d Job A.J. Verdonschot, MD, PHD, e Matteo Dal Ferro, MD,c,f Maria Angeles Espinosa, MD, PHD, b,g Maria Sabater-Molina, PH D, b,c,h Maria Gallego-Delgado, MD, P HD, b,i Jose M. Larrañaga-Moreira, MD, b,j Jose M. Garcia-Pinilla, MD, PHD, b,k Maria Teresa Basurte-Elorz, MD,l José F. RodrÃguez-Palomares, MD, P HD, b,m Vicente Climent, MD, n Francisco J. Bermudez-Jimenez, MD, PHD, o MarÃa Victoria Mogollón-Jiménez, MD, p Javier Lopez, MD, PHD, b,q Maria Luisa Peña-Peña, MD, r Ana Garcia-Alvarez, MD, P HD, b,s,t Bernardo López-Abel, MD, b,u Tomas Ripoll-Vera, MD, PHD, v Julian Palomino-Doza, MD, P HD, b,w Antoni Bayes-Genis, MD, PHD, b,x Ramon Brugada, MD, PHD, b,y Uxua Idiazabal, MD, z Jesus G. Mirelis, MD, PHD, a,b,c Fernando Dominguez, MD, PHD, a,b,c Michiel T.H.M. Henkens, MD, aa Ingrid P.C. Krapels, MD, PHD, e Han G. Brunner, MD, PH D, e,bb,cc Alessia Paldino, MD, c,f Denise Zaffalon, MD,c,f Luisa Mestroni, MD, dd Gianfranco Sinagra, MD, c,f Stephane R.B. Heymans, MD, P HD, aa,ee Marco Merlo, MD, c,f Pablo Garcia-Pavia, MD, PHD
doi : 10.1016/j.jacc.2022.06.040
Volume 80, Issue 12, 20 September 2022, Pages 1115-1126
Although genotyping allows family screening and influences risk-stratification in patients with nonischemic dilated cardiomyopathy (DCM) or isolated left ventricular systolic dysfunction (LVSD), its result is negative in a significant number of patients, limiting its widespread adoption.
Genetic Testing for Dilated Cardiomyopathy: Old School Is New School
Neal K. Lakdawala, MD, a Upasana Tayal, PHD
doi : 10.1016/j.jacc.2022.07.010
Volume 80, Issue 12, 20 September 2022, Pages 1127-1129
Sacubitril/Valsartan and Frailty in Patients With Heart Failure and Preserved Ejection Fraction
Jawad H. Butt, MD, a,b Pooja Dewan, MBBS, P HD, a Pardeep S. Jhund, MBC HB, MS C, P HD, a Inder S. Anand, MD, DPHIL ,c,d Dan Atar, MD, e,f Junbo Ge, MD,g Akshay S. Desai, MD,h Luis E. Echeverria, MD, i Lars Køber, MD, DMSC ,b Carolyn S.P. Lam, MBBS, PH D, j Aldo P. Maggioni, MD,k Felipe Martinez, MD, l Milton Packer, MD,m Jean L. Rouleau, MD,n David Sim, MD, o Dirk J. Van Veldhuisen, MD, P HD, p Bojan Vrtovec, MD,q Faiez Zannad, MD, r Michael R. Zile, MD,s,t Jianjian Gong, PH D, u Martin P. Lefkowitz, MD,u Adel R. Rizkala, PHARMD, u Scott D. Solomon, MD,h John J.V. McMurray, MD
doi : 10.1016/j.jacc.2022.06.037
Volume 80, Issue 12, 20 September 2022, Pages 1130-1143
Frailty is an increasingly common problem, and frail patients are less likely to receive new pharmacologic therapies because the risk–benefit profile is perceived to be less favorable than in nonfrail patients.
Frailty, Risk, and Heart Failure Care: Commission or Omission?∗
George A. Heckman, MD, MS C, a,b Kenneth Rockwood, MD
doi : 10.1016/j.jacc.2022.07.007
Volume 80, Issue 12, 20 September 2022, Pages 1144-1146
Cumulative Systolic Blood Pressure Load and Cardiovascular Risk in Patients With Diabetes
Nelson Wang, MD, a,b,c Katie Harris, PH D, a Pavel Hamet, PHD, d Stephen Harrap, PHD, e Giuseppe Mancia, P HD, f Neil Poulter, PHD, g Bryan Williams, PHD, g Sophia Zoungas, PH D, h Mark Woodward, P HD, a John Chalmers, PHD, a Anthony Rodgers, P HD
doi : 10.1016/j.jacc.2022.06.039
Volume 80, Issue 12, 20 September 2022, Pages 1147-1155
Standard measures of blood pressure (BP) do not account for both the magnitude and duration of exposure to elevated BP over time.
Cumulative Blood Pressure Measurement for Cardiovascular Disease Prediction: Promise and Pitfalls
Donald M. Lloyd-Jones, MD, S CM
doi : 10.1016/j.jacc.2022.07.012
Volume 80, Issue 12, 20 September 2022, Pages 1156-1158
Clinical Predictors of Recurrent Supraventricular Tachycardia in Infancy
Judson A. Moore, MD,a Sara B. Stephens, MPH,a Naomi J. Kertesz, MD,b Danyelle L. Evans, MD,a Jeffrey J. Kim, MD,a Taylor S. Howard, MD, a Tam Dan Pham, MD,a Santiago O. Valdés, MD, a Caridad M. de la Uz, MD, c Tia T. Raymond, MD, d Shaine A. Morris, MD, MPH,a Christina Y. Miyake, MD, MS
doi : 10.1016/j.jacc.2022.06.038
Volume 80, Issue 12, 20 September 2022, Pages 1159-1172
Data regarding recurrence risk among infants with supraventricular tachycardia (SVT) are limited.
Care of the Infant With Supraventricular Tachycardia: Toward a Better Paradigm
Ronald J. Kanter, MD
doi : 10.1016/j.jacc.2022.07.008
Volume 80, Issue 12, 20 September 2022, Pages 1173-1176
Heart Failure With Preserved Ejection Fraction as an Exercise Deficiency Syndrome: JACC Focus Seminar 2/4
Andre La Gerche, MBBS, P HD, a,b,c Erin J. Howden, P HD, a Mark J. Haykowsky, P HD, a,d Gregory D. Lewis, MD, e Benjamin D. Levine, MD, f,g Jason C. Kovacic, MBBS, PHD
doi : 10.1016/j.jacc.2022.07.011
Volume 80, Issue 12, 20 September 2022, Pages 1177-1191
Across differing spectrums of cardiac function and cardiac pathologies, there are strong associations between measures of cardiorespiratory fitness and burden of symptoms, quality of life, and prognosis.
Harmonization of the American College of Cardiology/American Heart Association and European Society of Cardiology/European Society of Hypertension Blood Pressure/Hypertension Guidelines: Comparisons, Reflections, and Recommendations
Paul K. Whelton, MB, MD, MSRobert M. Carey, MDGiuseppe Mancia, MDReinhold Kreutz, MDJoshua D. Bundy, PBryan Williams, MD
doi : 10.1016/j.jacc.2022.07.005
Volume 80, Issue 12, 20 September 2022, Pages 1192-1201
The 2017 American College of Cardiology/American Heart Association and 2018 European Society of Cardiology/European Society of Hypertension clinical practice guidelines for management of high blood pressure/hypertension are influential documents.
Intraoperative Residual Lesion Score Predicts Predischarge Major Residual Lesions and Reinterventions Following Congenital Heart Surgery
Aditya Sengupta, MD Kimberlee Gauvreau, ScD Katherine Kohlsaat, BS Steven D. Colan, MD Jane W. Newburger, MD, MPH Pedro J. Del Nido, MD Meena Nathan, MD, MPH
doi : 10.1016/j.jacc.2022.07.009
Volume 80, Issue 12, 20 September 2022, Pages 1202-1204
