Journal of the American College of Cardiology




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doi : 10.1016/S0735-1097(22)06990-X

Volume 80, Issue 19, 8 November 2022, Page e161

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Contents

doi : 10.1016/S0735-1097(22)06992-3

Volume 80, Issue 19, 8 November 2022, Pages e163-e166

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Estimated Long-Term Benefit of Dapagliflozin in Patients With Heart Failure

Muthiah Vaduganathan, MD, MPH,a, * Brian L. Claggett, P HD, a, * Pardeep Jhund, MD, PHD, b Rudolf A. de Boer, MD,c Adrian F. Hernandez, MD,d Silvio E. Inzucchi, MD,e Mikhail N. Kosiborod, MD,f Carolyn S.P. Lam, MD, g Felipe Martinez, MD, h Sanjiv J. Shah, MD, i Akshay S. Desai, MD, a Daniel Lindholm, MD, P HD, j Magnus Petersson, MD, PHD, j Anna Maria Langkilde, MD, j John J.V. McMurray, b Scott D. Solomon, MD

doi : 10.1016/j.jacc.2022.08.745

Volume 80, Issue 19, 8 November 2022, Pages 1775-1784

Recent guidelines support consideration of sodium-glucose cotransporter-2 inhibitors in the long-term management of heart failure (HF) with mildly reduced or preserved ejection fraction. Patients and clinicians may be interested in the expected lifetime benefits of sodium-glucose cotransporter-2 inhibitors in this population.

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Implementing Sodium-Glucose Cotransporter-2 Inhibitor Therapy for Heart Failure: What Is the Message to DELIVER?

Michael E. Nassif, MD,a James L. Januzzi, J R , MD

doi : 10.1016/j.jacc.2022.09.008

Volume 80, Issue 19, 8 November 2022, Pages 1785-1787

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Risk Factors for In-Hospital Cardiac Arrest in Patients With ST-Segment Elevation Myocardial Infarction

Wei Gong, MD, PHD, a,b,c, * Yan Yan, MD, a,b,c, * Xiao Wang, MD,a,b,c Wen Zheng, MD,a,b,c Sidney C. Smith, J R , MD,d Gregg C. Fonarow, MD, e Louise Morgan, MSN,f Jing Liu, MD, PHD, g Dong Zhao, MD, PH D, g Changsheng Ma, MD,b,c,h Yaling Han, MD, PHD, i Gilles Montalescot, MD, PH D, j Shaoping Nie, MD, PHD, a,b,c on behalf of the CCC-ACS Investigators

doi : 10.1016/j.jacc.2022.08.797

Volume 80, Issue 19, 8 November 2022, Pages 1788-1798

In-hospital cardiac arrest (IHCA) is one of the most deleterious complications of ST-segment elevation myocardial infarction (STEMI).

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Contemporary Approaches to Reducing Morbidity and Mortality in Patients With Acute Coronary Syndromes

Graham Nichol, MD, MPH,a,b,y Amanda West, MD, MPH

doi : 10.1016/j.jacc.2022.09.009

Volume 80, Issue 19, 8 November 2022, Pages 1799-1801

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Mammalian Target of Rapamycin Inhibition in Patients With ST-Segment Elevation Myocardial Infarction

Barbara E. Stähli, MD, MPH, MBA, a, * Roland Klingenberg, MD, b, * Dik Heg, P HD, c Mattia Branca, PH D, c Robert Manka, MD, a,d Ioannis Kapos, MD,a Oliver Müggler, MD, a Andrea Denegri, MD, a Rahel Kesterke, PHD, a Florence Berger, PH D, a Julia Stehli, MD,a Alessandro Candreva, MD,a Arnold von Eckardstein, MD, e David Carballo, MD,f Christian Hamm, MD, b Ulf Landmesser, MD, g François Mach, MD,f Tiziano Moccetti, MD, h Christian Jung, MD,i Malte Kelm, MD, i Thomas Münzel, MD, j Giovanni Pedrazzini, MD,h Lorenz Räber, MD, P HD, k Stephan Windecker, MD,k Christian Templin, MD, PHD, a Christian M. Matter, MD, a Thomas F. Lüscher, MD,l,m,y Frank Ruschitzka, MD

doi : 10.1016/j.jacc.2022.08.747

Volume 80, Issue 19, 8 November 2022, Pages 1802-1814

Early inflammation following acute ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PCI) affects myocardial infarct (MI) size and left ventricular remodeling. The mammalian target of rapamycin (mTOR) is involved in the enhanced inflammatory response and its inhibition has exerted beneficial effects on MI size in preclinical models of acute MI.

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Inhibition of the Mechanistic Target of Rapamycin in Acute Myocardial Infarction∗

Jean-Claude Tardif, MD, Eric Thorin, PHD

doi : 10.1016/j.jacc.2022.08.796

Volume 80, Issue 19, 8 November 2022, Pages 1815-1817

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Air Pollution and Coronary Vasomotor Disorders in Patients With Myocardial Ischemia and Unobstructed Coronary Arteries

Massimiliano Camilli, MD,a,b, * Michele Russo, MD, P HD, a, * Riccardo Rinaldi, MD, a Andrea Caffè, MD,a Giulia La Vecchia, MD,a Alice Bonanni, BSC , PH D, a Giulia Iannaccone, MD, a Mattia Basile, MD,a Rocco Vergallo, MD, PH D, b Cristina Aurigemma, MD, PHD, b Carlo Trani, MD, a,b Giampaolo Niccoli, MD, PH D, c Filippo Crea, MD, a,b,y Rocco A. Montone, MD, PHD

doi : 10.1016/j.jacc.2022.08.744

Volume 80, Issue 19, 8 November 2022, Pages 1818-1828

Coronary vasomotor abnormalities are important causes of myocardial ischemia in patients with nonobstructive coronary artery disease (NOCAD). However, the role of air pollution in determining coronary vasomotor disorders has never been investigated.

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The Perils of Anthropogenic Air Pollution: When All Roads Led to Rome

Sanjay Rajagopalan, MD, a Jagat Narula, MD

doi : 10.1016/j.jacc.2022.09.015

Volume 80, Issue 19, 8 November 2022, Pages 1829-1832

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Coronary Artery Bypass Surgery Without Saphenous Vein Grafting: JACC Review Topic of the Week

Alistair Royse, MBBS, MD, a,b, * Justin Ren, BMEDS C,a, * Colin Royse, MBBS, MD,a,b,c David H. Tian, MD, PHD, d Stephen Fremes, MD, MS C, e Mario Gaudino, MD, PHD, f Umberto Benedetto, MD, P HD, g Y. Joseph Woo, MD,h Andrew B. Goldstone, MD, PH D, i Piroze Davierwala, MBBS, P HD, e,j Michael Borger, MD, PHD, j Michael Vallely, MBBS, PHD, k Christopher M. Reid, MSC , BA, PHD, l Rodolfo Rocha, MD, P HD, e David Glineur, MD, PH D, m,n Juan Grau, MD, P HD, m Richard Shaw, MD,o Hugh Paterson, MBBS, p Doa El-Ansary, BAPPSC (P HTY), PH D, a,q Stuart Boggett, BS CI, MC-BM EDS C,a Nilesh Srivastav, MBBS, a Zulfayandi Pawanis, MBBS, MB IOMEDS CI,r David Canty, MBBS, PHD, a Rinaldo Bellomo, MD, PH D

doi : 10.1016/j.jacc.2022.08.795

Volume 80, Issue 19, 8 November 2022, Pages 1833-1843

Approximately 95% of patients of any age undergoing contemporary, coronary bypass surgery will receive at least 1 saphenous vein graft (SVG). It is recognized that SVG will develop progressive and accelerated atherosclerosis, resulting in a stenosis, and in occlusion that occurs in 50% by 10 years postoperatively.

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ACC Advocacy: Engage, Influence, Advocate

Edward T.A. Fry, MD, FACC, President, American College of Cardiology Samuel O. Jones IV, MD, MPH, FACC, Chair, Health Affairs Committee Nick Morse, MBA, ACC Division Vice President, Advocacy

doi : 10.1016/j.jacc.2022.09.022

Volume 80, Issue 19, 8 November 2022, Pages 1844-1847

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Paradigm Shift to Address Cardiovascular Health at Every Stage

Valentin Fuster, MD, P HD, Editor-in-Chief, Journal of the American College of Cardiology, Justine Varieur Turco, MA, Divisional Vice President, American College of Cardiology

doi : 10.1016/j.jacc.2022.09.017

Volume 80, Issue 19, 8 November 2022, Pages 1848-1850

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Strategies to Diversify the Medical Student Training Pipeline Into Cardiology

Samip Sheth, MB, a Adriana C. Mares, MS, b Gurleen Kaur, MD

doi : 10.1016/j.jacc.2022.08.788

Volume 80, Issue 19, 8 November 2022, Pages 1851-1854

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RESPONSE: Innovative Mentorship Models Integral for Diversifying the CV Pipeline

Melvin R. Echols, MD

doi : 10.1016/j.jacc.2022.08.798

Volume 80, Issue 19, 8 November 2022, Page 1854

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Time-Varying Cardiovascular Effects of Finerenone in Diabetic Kidney Disease: Insights From FIDELIO-DKD and FIGARO-DKD Trials

Sadeer Al-Kindi, MD Issam Motairek, MD Scott Janus, MD Salil Deo, MD Mahboob Rahman, MD Ian J. Neeland, MD Sanjay Rajagopalan, MD

doi : 10.1016/j.jacc.2022.08.791

Volume 80, Issue 19, 8 November 2022, Pages 1855-1856

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The War for the Best Therapy in Coronary Artery Disease Is Far From Being Won

Nicola Gaibazzi, MD, PhD Alberto Foà, MD Luca Bergamaschi, MD Domenico Tuttolomondo, MD Carmine Pizzi, MD

doi : 10.1016/j.jacc.2022.08.792

Volume 80, Issue 19, 8 November 2022, Page e167

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Limitations of Myocardial Perfusion Imaging vs Exercise Testing for Mortality Outcome Prediction

*Wade H. Martin III, MD

doi : 10.1016/j.jacc.2022.08.794

Volume 80, Issue 19, 8 November 2022, Page e169

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Reply: Reconciling the Use of Myocardial Ischemia Testing for Selecting Patients for Coronary Revascularization

Alan Rozanski, MD Robert J.H. Miller, MD Donghee Han, MD Daniel S. Berman, MD

doi : 10.1016/j.jacc.2022.08.793

Volume 80, Issue 19, 8 November 2022, Pages e171-e172

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