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Editors and Editorial Board.
doi : 10.1161/STR.0000000000000422
Volume 54(1) pgs. 1-289,e1-e24 January 2023
Cognitive Deficits After Stroke.
Cramer, Steven C. MD; Richards, Lorie G. PhD, OTR/L; Bernhardt, Julie PhD, OA; Duncan, Pamela PT, PhD
doi : 10.1161/STROKEAHA.122.041775
AB Cognition is a central feature of human existence and brain function. Cognitive deficits are common after stroke and may strongly impact functional outcome. Recent years have seen substantial advances in our understanding of cognitive functions in the healthy state, and this new body of knowledge promises to open new avenues for understanding and treating poststroke impairments, including cognitive deficits.
Unilateral Spatial Neglect Recovery Poststroke.
Durfee, Alexandra Zezinka PhD; Hillis, Argye E. MD
doi : 10.1161/STROKEAHA.122.041710
AB Unilateral spatial neglect (USN) is a common and disabling cognitive consequence of stroke wherein individuals demonstrate decreased response to contralesional information. Here, we provide an updated narrative review of studies that shed light on the neural mechanisms and predictors of recovery of USN.
Executive Function Poststroke: Concepts, Recovery, and Interventions.
Skidmore, Elizabeth R. PhD, OTR/L; Eskes, Gail PhD, R Psych; Brodtmann, Amy MD, PhD
doi : 10.1161/STROKEAHA.122.037946
AB Executive function is frequently impaired among people who have sustained stroke. This review provides an overview of definitions, concepts, and measures. The review also summarizes current best evidence examining executive function impairment and recovery trajectories after stroke, correlates of change over time, and emerging intervention research. Finally, this review provides recommendations for research and clinical practices, as well as priorities for future executive function research. (C) 2023 American Heart Association, Inc.
Limb Apraxias: The Influence of Higher Order Perceptual and Semantic Deficits in Motor Recovery After Stroke.
Rounis, Elisabeth MD, PhD; Binkofski, Ferdinand MD, PhD
doi : 10.1161/STROKEAHA.122.037948
AB Stroke is a leading cause of disability worldwide. Limb apraxia is a group of higher order motor disorders associated with greater disability and dependence after stroke. Original neuropsychology studies distinguished separate brain pathways involved in perception and action, known as the dual stream hypothesis.
Cognitive Recovery After Stroke: Memory.
O'Sullivan, Michael J. PhD; Li, Xuqian BPsySc; Galligan, Dana BSc; Pendlebury, Sarah T. DPhil
doi : 10.1161/STROKEAHA.122.041497
AB Memory impairment occurs in over a third of patients after symptomatic stroke. Memory deficits rarely occur in isolation but are an important component of the poststroke cognitive syndrome because of the strong relationship with the risk of poststroke dementia.
How Much Attention Do We Pay to Attention Deficits in Poststroke Aphasia?.
Varkanitsa, Maria PhD; Godecke, Erin PhD; Kiran, Swathi PhD
doi : 10.1161/STROKEAHA.122.037936
AB Although language deficits are the primary area of weakness, people with poststroke aphasia often experience challenges with nonlinguistic cognitive skills, including attention processing.
Acute Infarcts on Brain MRI Following Aortic Arch Repair With Circulatory Arrest: Insights From the ACE CardioLink-3 Randomized Trial.
Chen, Chih-Hao MD, PhD; Peterson, Mark D. MD, PhD; Mazer, C. David MD; Hibino, Makoto MD, PhD; Beaudin, Andrew E. PhD; Chu, Michael W.A. MD, MEd; Dagenais, Francois MD; Teoh, Hwee PhD; Quan, Adrian MPhil; Dickson, Jeffrey MD; Verma, Subodh MD, PhD; Smith, Eric E. MD, MPH
doi : 10.1161/STROKEAHA.122.041612
AB Background: to investigate the frequency and distribution of new ischemic brain lesions detected by diffusion-weighted imaging on brain magnetic resonance imaging after aortic arch surgery.
Blood Pressure Control Targets and Risk of Cardiovascular and Cerebrovascular Events After Intracerebral Hemorrhage.
Teo, Kay-Cheong MBBS, FHKAM; Keins, Sophia BS; Abramson, Jessica R. BA; Leung, William C.Y. MBBS, MRCP; Leung, Ian Y.H. MBBS, MRCP; Wong, Yuen-Kwun MSc; Yeung, Charming BSc; Kourkoulis, Christina BS; Warren, Andrew D. BS; Chan, Koon-Ho MD, PhD; Cheung, Raymond T.F. MD, PhD; Ho, Shu-Leong MD; Gurol, M. Edip MD, MSc; Viswanathan, Anand MD, PhD; Greenberg, Steven M. MD, PhD; Anderson, Christopher D. MD, MMSc; Lau, Kui-Kai DPhil; Rosand, Jonathan MD, MSc ,,,*; Biffi, Alessandro MD ,,,*
doi : 10.1161/STROKEAHA.122.039709
Intracerebral hemorrhage (ICH) survivors are at high risk for recurrent stroke and cardiovascular events. Blood pressure (BP) control represents the most potent intervention to lower these risks, but optimal treatment targets in this patient population remain unknown.
Covert Brain Infarction as a Risk Factor for Stroke Recurrence in Patients With Atrial Fibrillation.
Kim, Do Yeon MD; Han, Seok-Gil MD; Jeong, Han-Gil MD; Lee, Keon-Joo MD; Kim, Beom Joon MD, PhD; Han, Moon-Ku MD, PhD; Choi, Kang-Ho MD, PhD; Kim, Joon-Tae MD, PhD; Shin, Dong-Ick MD, PhD; Cha, Jae-Kwan MD, PhD; Kim, Dae-Hyun MD, PhD; Kim, Dong-Eog MD, PhD; Ryu, Wi-Sun MD, PhD; Park, Jong-Moo MD, PhD; Kang, Kyusik MD, PhD; Kim, Jae Guk MD; Lee, Soo Joo MD, PhD; Oh, Mi-Sun MD; Yu, Kyung-Ho MD, PhD; Lee, Byung-Chul MD, PhD; Park, Hong-Kyun MD; Hong, Keun-Sik MD, PhD; Cho, Yong-Jin MD, PhD; Choi, Jay Chol MD, PhD; Sohn, Sung Il MD, PhD; Hong, Jeong-Ho MD, PhD; Park, Tai Hwan MD, PhD; Lee, Kyung Bok MD, PhD; Kwon, Jee-Hyun MD, PhD; Kim, Wook-Joo MD; Lee, Jun MD, PhD; Lee, Ji Sung PhD; Lee, Juneyoung PhD; Gorelick, Philip B. MD, MPH; Bae, Hee-Joon MD, PhD
doi : 10.1161/STROKEAHA.122.038600
We aimed to evaluate covert brain infarction (CBI), frequently encountered during the diagnostic work-up of acute ischemic stroke, as a risk factor for stroke recurrence in patients with atrial fibrillation (AF).
Reperfusion Injury Is Associated With Poor Outcome in Patients With Recanalization After Thrombectomy.
Zhou, Ying MD, PhD ,*; He, Yaode MD ,*; Yan, Shenqiang MD, PhD ,*; Chen, Lin MD; Zhang, Ruoxia MD; Xu, Jinjin MD; Hu, Haitao MD, PhD; Liebeskind, David S. MD, PhD; Lou, Min MD, PhD
doi : 10.1161/STROKEAHA.122.039337
The existence of cerebral reperfusion injury in human beings remains controversial. Thus, we aimed to explore the presence of reperfusion injury in acute ischemic stroke patients with recanalization after mechanical thrombectomy and analyzed its impact on neurological outcome.
Association of Depression Onset and Treatment With Blood Pressure Control After Intracerebral Hemorrhage.
Keins, Sophia BS ,,,*; Abramson, Jessica R. BA ,,,*; Mallick, Akashleena MD; Pablo Castello, Juan MD; Rodriguez-Torres, Axana MD, MPH; Popescu, Dominique PhD; Hoffman, Danielle BS; Kourkoulis, Christina BS; Gurol, M. Edip MD, MSc; Greenberg, Steven M. MD, PhD; Anderson, Christopher D. MD, MMSc; Viswanathan, Anand MD, PhD; Rosand, Jonathan MD, MSc; Biffi, Alessandro MD
Plasma sDPP4 (Soluble Dipeptidyl Peptidase-4) and Cognitive Impairment After Noncardioembolic Acute Ischemic Stroke.
You, Shoujiang MD, PhD ,,*; Bi, Yucong MD ,*; Miao, Mengyuan MD; Bao, Anran BSc; Du, Jigang MD; Xu, Tan MD, PhD; Liu, Chun-Feng MD, PhD; Zhang, Yonghong MD, PhD; He, Jiang MD, PhD; Cao, Yongjun MD, PhD; Zhong, Chongke MD, PhD
doi : 10.1161/STROKEAHA.122.040798
DPP4 (dipeptidyl peptidase-4) inhibitors have been proven to promote neuronal regeneration, reverse the development of cognitive deficits. However, the association of circulating soluble form (sDPP4 [soluble DPP4]) with poststroke cognitive impairment (PSCI) is unclear. We aimed to investigate the association between plasma sDPP4 levels and PSCI in patients with ischemic stroke.
Plasma Soluble Dipeptidyl Peptidase-4: A Possible Mechanism for Identifying and Managing Poststroke Cognitive Impairment.
Andrew, Nadine E. PhD; Srikanth, Velandai PhD
24-Hour Carotid Stent Patency and Outcomes After Endovascular Therapy: A Multicenter Study.
Allard, Julien MD; Delvoye, Francois MD; Pop, Raoul MD, PhD; Labreuche, Julien BST; Maier, Benjamin MD, MSc; Marnat, Gaultier MD; Sibon, Igor MD, PhD; Zhu, Francois MD, MSc; Lapergue, Bertrand MD, PhD; Consoli, Arturo MD; MSc; Spelle, Laurent MD, PhD; Denier, Christian MD, PhD; Richard, Sebastien MD, PhD; Piotin, Michel MD; Gory, Benjamin MD, PhD; Mazighi, Mikael MD, PhD; ETIS Investigators; Blanc, Raphael; Redjem, Hocine; Escalard, Simon; Dessilles, Jean-Philippe; Delvoye, Francois; Smajda, Stanislas; Maier, Benjamin; Solene, Hebert; Mazighi, Mikael; Obadia, Mikael; Sabben, Candice; Pierre, Seners; Igor, Raynouard; Corabianu, Ovide; de Broucker, Thomas; Manchon, Eric; Taylor, Guillaume; Maacha, Malek Ben; Thion, Laurie-Anne; Augustin, Lecler; Julien, Savatovsjy; Wang, Adrien; Evrard, Serge; Tchikviladze, Maya; Ajili, Nadia; WeisenburgerLile, David; Gorza, Lucas; Buard, Geraldine; Coskun, Oguzhan; Di Maria, Federico; Rodesh, Georges; Zimatore, Sergio; Leguen, Morgan; Gratieux, Julie; Pico, Fernando; Rakotoharinandrasana, Haja; Tassan, Philippe; Poll, Roxanna; Marinier, Sylvie; Barreau, Xavier; Berge, Jerome; Menegon, Patrice; Lucas, Ludovic; Olindo, Stephane; Renou, Pauline; Sagnier, Sharmila; Poli, Mathilde; Debruxelles, Sabrina; Rouanet, Francois; Tourdias, Thomas; Liegey, Jean-Sebastien; Briau, Pierre; Pangon, Nicolas; Coussy, Alexis; Papillon, Lisa; Papaxanthos, Jean; Detraz, Lili; Daumas-Duport, Benjamin; Alexandre, Pierre-Louis; Roy, Monica; Lenoble, Cedric; Desal, Hubert; Guillon, Benoit; de Gaalon, Solene; Preterre, Cecile; Bracard, Serge; Anxionnat, Rene; Braun, Marc; Derelle, Anne-Laure; Tonnelet, Romain; Liao, Liang; Zhu, Francois; Schmitt, Emmanuelle; Planel, Sophie; Humbertjean, Lisa; Lacour, Jean-Christophe; Riou-Comte, Nolwenn; Voicu, Marcela; Alb, Lionel; Reitter, Marie; Brezeanu, Madalina; Masson, Agnes; Tabarna, Adriana; Podar, Iona; Macian-Montoro, Francisco; Saleme, Suzanna; Mounayer, Charbel; Rouchaud, Aymeric; Costalat, Vincent; Arquizan, Caroline; Dargazanli, Cyril; Gascou, Gregory; Lefevre, Pierre-Henri; Derraz, Imad; Riquelme, Carlos; Gaillard, Nicolas; Mourand, Isabelle; Corti, Lucas; Cagnazzo, Federico; Ter Schiphorst, Adrien; Ferre, Jean-Christophe; Raoult, Helene; Ronziere, Thomas; Lassale, Maria; Paya, Christophe; Gauvrit, Jean-Yves; Tracol, Clement; Langnier-Lemercier, Sophie
doi : 10.1161/STROKEAHA.122.039797
Management of extracranial internal carotid artery steno-occlusive lesion during endovascular therapy remains debated. Stent occlusion within 24 hours of endovascular therapy is a frequent event after acute carotid artery stenting, and we currently lack large population results.
Early Stent Patency After Endovascular Therapy for Tandem or Isolated Carotid Steno-Occlusive Disease.
Masoud, Hesham E. MD; Nguyen, Thanh N. MD; Broderick, Joseph P. MD
Hypoperfusion Intensity Ratio Is Correlated With the Risk of Parenchymal Hematoma After Endovascular Stroke Treatment.
Winkelmeier, Laurens MD; Heit, Jeremy J. MD, PhD; Adusumilli, Gautam MD; Geest, Vincent MD; Christensen, Soren PhD; Kniep, Helge MD; van Horn, Noel MD; Steffen, Paul MD; Bechstein, Matthias MD; Sporns, Peter MD; Lansberg, Maarten G. MD, PhD; Albers, Gregory W. MD; Wintermark, Max MD; Fiehler, Jens MD; Faizy, Tobias D. MD
doi : 10.1161/STROKEAHA.122.040540
Parenchymal hematoma (PH) is a major complication after endovascular treatment (EVT) for ischemic stroke. The hypoperfusion intensity ratio (HIR) represents a perfusion parameter reflecting arterial collateralization and cerebral microperfusion in ischemic brain tissue.
Redefining Disability: Patient-Reported Outcome Measures After Minor Stroke and Transient Ischemic Attack.
Olive-Gadea, Marta MD, PhD; Cano, David BS; Rodrigo-Gisbert, Marc MD; Muchada, Marian MD, PhD; Montiel, Estefania OT; Baladas, Maria OT; Sanchez-Gavilan, Ester OT; Paredes, Carolina OT; Garcia-Tornel, Alvaro MD, PhD; Rubiera, Marta MD, PhD; Requena, Manuel MD, PhD; Ribo, Marc MD, PhD; Molina, Carlos A. MD, PhD
doi : 10.1161/STROKEAHA.122.040409
term outcome assessment patients with stroke is not fully captured by usual clinical scales such as the modified Rankin Scale (mRS). Patient-reported outcome measures (PROMs) are standardized and validated assessments that consider clinical outcomes from the patient perspective.
Ultra-Long Transfers for Endovascular Thrombectomy-Mission Impossible?: The Australia-New Zealand Experience.
Garcia-Esperon, Carlos PhD; Wu, Teddy Y. PhD; Carraro do Nascimento, Vinicius MD; Yan, Bernard PhD; Kurunawai, Craig MD; Kleinig, Tim PhD; Selkirk, Gregory MD; Blacker, David MBBS; Barber, P. Alan PhD; Ranta, Annemarei PhD; Cervera, Alvaro PhD; Wong, Andrew PhD; Mitchell, Peter PhD; Muller, Claire PhD; Rice, Hal MBBS; De Villiers, Laetitia MBChB; Jannes, Jim PhD; Beom Hong, Jae MBBS; Bailey, Peter MBBS; Brown, Helen MB BCh; Campbell, Bruce C.V. PhD; Wilson, Duncan PhD; Fink, John PhD; Ang, Timothy MD; Bladin, Christopher MD; Phillips, Tim PhD; Hasnain, Md Golam MD; Butcher, Kenneth PhD; Miteff, Ferdinand MD; Levi, Christopher R. MD; Spratt, Neil J. PhD ,,,*; Parsons, Mark W. PhD ,,,*; on behalf of the ANZ Ultra-Long EVT Transfer Group; Chew, Beng Lim Alvin MD; Morgan, Mary MD; Collecutt, Wayne MD; Krauss, Martin MD; Tan, Aaron MD; Mahadevan, Joshua MD; Willcourt, Matthew MD; Cervera, Alvaro PhD; Bivard, Andrew PhD
doi : 10.1161/STROKEAHA.122.040480
Endovascular thrombectomy (EVT) access in remote areas is limited. Preliminary data suggest that long distance transfers for EVT may be beneficial; however, the magnitude and best imaging strategy at the referring center remains uncertain.
Physical Activity Is Inversely Associated With Severe Intracranial Stenosis in Stroke-Free Participants of NOMAS.
Yang, Dixon MD; Liu, Minghua PhD; Willey, Joshua Z. MD, MS; Khasiyev, Farid MD; Tom, Sarah E. PhD, MPH; Rundek, Tatjana MD, PhD; Cheung, Ying K. PhD; Wright, Clinton B. MD, MS; Sacco, Ralph L. MD, MS; Elkind, Mitchell S.V. MD, MS; Gutierrez, Jose MD, MPH
doi : 10.1161/STROKEAHA.122.039660
Although protective in secondary stroke prevention of intracranial arterial stenosis (ICAS), it is uncertain if the benefits of leisure time physical activity (LTPA) extend to asymptomatic ICAS or extracranial carotid stenosis (ECAS).
Physical Inactivity Is a Risk Factor for Cardiovascular Stenosis in Stroke-Free People.
Sunnerhagen, Katharina S. MD, PhD
Incidence of Cerebral Venous Thrombosis: A Population-Based Study, Systematic Review, and Meta-Analysis.
Zhou, Lily W. MD, MS; Yu, Amy Y.X. MD, MSc; Ngo, Long PhD; Hill, Michael D. MD, MSc; Field, Thalia S. MD, MHSc
doi : 10.1161/STROKEAHA.122.039390
Studying the baseline incidence of cerebral venous thrombosis (CVT) prior to COVID-19 and the limitations of how this has been previously reported in the literature will help improve understanding of this disease and how risks may have changed in the post-COVID era.
Clinical, Neuroimaging, and Genetic Markers in Cerebral Amyloid Angiopathy-Related Inflammation: A Systematic Review and Meta-Analysis.
Theodorou, Aikaterini MD; Palaiodimou, Lina MD; Malhotra, Konark MD; Zompola, Christina MD; Katsanos, Aristeidis H. MD; Shoamanesh, Ashkan MD; Boviatsis, Efstathios MD; Dardiotis, Efthimios MD; Spilioti, Martha MD; Sacco, Simona MD; Werring, David J. PhD; Cordonnier, Charlotte MD, PhD; Alexandrov, Andrei V. MD; Paraskevas, George P. MD; Tsivgoulis, Georgios MD, PhD
doi : 10.1161/STROKEAHA.122.040671
There are limited data regarding the prevalence of distinct clinical, neuroimaging and genetic markers among patients diagnosed with cerebral amyloid angiopathy-related inflammation (CAA-ri).
Optimal Cerebral Perfusion Pressure and Brain Tissue Oxygen in Aneurysmal Subarachnoid Hemorrhage.
Megjhani, Murad PhD ,,*; Weiss, Miriam MD ,,*; Ford, Jenna MD; Terilli, Kalijah BA; Kastenholz, Nick Cand Med; Nametz, Daniel BS; Kwon, Soon Bin PhD; Velazquez, Angela MD; Agarwal, Sachin MD, MPH; Roh, David J. MD; Conzen-Dilger, Catharina MD; Albanna, Walid MD; Veldeman, Michael MD, PhD; Connolly, E. Sander Jr MD; Claassen, Jan MD; Aries, Marcel MD, PhD; Schubert, Gerrit A. MD; Park, Soojin MD
doi : 10.1161/STROKEAHA.122.040339
Targeting a cerebral perfusion pressure optimal for cerebral autoregulation (CPPopt) has been gaining more attention to prevent secondary damage after acute neurological injury.
Subarachnoid Hemorrhage During Pregnancy and Puerperium: A Population-Based Study.
Korhonen, Aino BcM; Verho, Liisa MD; Aarnio, Karoliina MD, PhD; Rantanen, Kirsi MD; Saaros, Anna MD; Laivuori, Hannele MD, PhD; Gissler, Mika PhD; Tikkanen, Minna MD, PhD; Ijas, Petra MD, PhD
doi : 10.1161/STROKEAHA.122.039235
Pregnancy-related subarachnoid hemorrhage (pSAH) is rare, but it causes high mortality and morbidity. Nevertheless, data on pSAH are limited. The objectives here were to examine the incidence trends, causes, risk factors, and outcomes of pSAH in a nationwide population-based cohort study in Finland covering 30 years.
Anti-Epileptic Drug Target Perturbation and Intracranial Aneurysm Risk: Mendelian Randomization and Colocalization Study.
Bakker, Mark K. PhD ,*; van Straten, Tijmen BSc ,*; Chong, Michael PhD; Pare, Guillaume MD, MSc, FRCPc; Gill, Dipender BMBCh, PhD; Ruigrok, Ynte M. MD, PhD
doi : 10.1161/STROKEAHA.122.040598
In a genome-wide association study of intracranial aneurysms (IA), enrichment was found between genes associated with IA and genes encoding targets of effective anti-epileptic drugs.
Early and Delayed Infarct Growth in Patients Undergoing Mechanical Thrombectomy: A Prospective, Serial MRI Study.
Hernandez-Perez, Maria MD, PhD; Werner, Mariano MD; Remollo, Sebastian MD; Martin, Carlota BS; Cortes, Jordi PhD; Valls, Adrian MD; Ramos, Anna MD; Dorado, Laura MD, PhD; Serena, Joaquin MD, PhD; Munuera, Josep MD, PhD; Puig, Josep MD, PhD; Perez de la Ossa, Natalia MD, PhD; Gomis, Meritxell MD, PhD; Carbonell, Jaime MD; Castano, Carlos MD, PhD; Munoz-Narbona, Lucia PhD; Palomeras, Ernest MD, PhD; Domenech, Sira MD; Massuet, Anna MD; Terceno, Mikel MD, PhD; Davalos, Antoni MD, PhD; Millan, Monica MD, PhD
doi : 10.1161/STROKEAHA.122.039090
We studied the evolution over time of diffusion weighted imaging (DWI) lesion volume and the factors involved on early and late infarct growth (EIG and LIG) in stroke patients undergoing endovascular treatment (EVT) according to the final revascularization grade.
Cost-Effectiveness of Endovascular Treatment in Large Vessel Occlusion Stroke With Mild Prestroke Disability: Results From the HERMES Collaboration.
Ospel, Johanna M. MD, PhD ,,,*; Kunz, Wolfgang G. MD ,*; McDonough, Rosalie V. MD ,,*; van Zwam, Wim MD, PhD; Pinckaers, Floor MD; Saver, Jeffrey L. MD, PhD; Hill, Michael D. MD; Demchuk, Andrew M. MD; Jovin, Tudor G. MD; Mitchell, Peter MD; Campbell, Bruce C.V. MD, PhD; White, Phil MD; Muir, Keith MD; Achit, Hamza MD; Bracard, Serge MD; Brown, Scott PhD; Goyal, Mayank MD, PhD; for the HERMES Investigators
doi : 10.1161/STROKEAHA.121.038407
The clinical and economic benefit of endovascular treatment (EVT) in addition to best medical management in patients with stroke with mild preexisting symptoms/disability is not well studied.
Therapeutic Benefits of Adropin in Aged Mice After Transient Ischemic Stroke via Reduction of Blood-Brain Barrier Damage.
Yang, Changjun PhD; Liu, Lei PhD; Lavayen, Bianca P. MS; Larochelle, Jonathan BA; Gunraj, Rachel E. BA; Butler, Andrew A. PhD; Candelario-Jalil, Eduardo PhD
doi : 10.1161/STROKEAHA.122.039628
Adropin is a peptide encoded by the energy homeostasis-associated gene (Enho) that is highly expressed in the brain. Aging and stroke are associated with reduced adropin levels in the brain and plasma.
Cerebroprotective Role of N6-Methyladenosine Demethylase FTO (Fat Mass and Obesity-Associated Protein) After Experimental Stroke.
Chokkalla, Anil K. PhD; Jeong, Soomin MS; Mehta, Suresh L. PhD; Davis, Charles K. PhD; Morris-Blanco, Kahlilia C. PhD; Bathula, Saivenkateshkomal BS; Qureshi, Simran S. BS; Vemuganti, Raghu PhD
doi : 10.1161/STROKEAHA.122.040401
FTO (fat mass and obesity-associated protein) demethylates N6-methyladenosine (m6A), which is a critical epitranscriptomic regulator of neuronal function. We previously reported that ischemic stroke induces m6A hypermethylation with a simultaneous decrease in FTO expression in neurons.
Chemical Exchange Saturation Transfer Magnetic Resonance Imaging for Longitudinal Assessment of Intracerebral Hemorrhage and Deferoxamine Treatment at 3T in a Mouse Model.
Lai, Joseph H.C. BEng; Liu, Jiaxin PhD; Yang, Tian MS; Huang, Jianpan PhD; Liu, Yang MS; Chen, Zilin MPhil; Lee, Youngjin PhD; Leung, Gilberto K.K. MS, PhD; Chan, Kannie W.Y. PhD
doi : 10.1161/STROKEAHA.122.040830
Noninvasive imaging of molecular alterations after intracerebral hemorrhage (ICH) could provide valuable information to guide and monitor treatments. Chemical exchange saturation transfer (CEST) magnetic resonance imaging has demonstrated promises in identifying proliferation, necrosis, and changes in cellularity in brain tumors. Here, we applied CEST magnetic resonance imaging to monitor molecular changes in hematoma without and with treatment noninvasively over 2 weeks at 3T using endogenous contrast.
Impact of Decompressive Craniectomy on Hemorrhagic Transformation in Malignant Ischemic Stroke in Mice.
Borha, Alin MD, MSc; Lebrun, Florent MSc; Touze, Emmanuel MD, PhD; Emery, Evelyne MD, PhD; Vivien, Denis PhD; Gaberel, Thomas MD, PhD
doi : 10.1161/STROKEAHA.122.041365
Endovascular thrombectomy has changed the management of ischemic stroke. The reperfusion can however lead to a hemorrhagic transformation (HT). Decompressive craniectomy (DC) is a surgical procedure used for malignant ischemic stroke.
Beyond the Limits of Visual Learning: Prediction of Time From Onset From Noncontrast CT of Acute Ischemic Stroke.
Chen, Yutong BA ,,*; Mayerhofer, Ernst MD ,,,*; Parodi, Livia PhD; Harloff, Andreas MD; Batra, Puneet PhD; Rosand, Jonathan MD MSc; Anderson, Christopher D. MD, MMSc
Three-Dimensional Vascular Maps of the Thalamus.
Antoniello, Daniel MD; Fernandez-Torres, Jenelys BS
Lest We Forget: Stroke due to Cysticercal Arteritis.
Agarwal, Ayush DM; Garg, Divyani DM; Vishnu, Venugopalan Y. DM; Garg, Ajay MD; Srivastava, M.V. Padma DM
Focal Severe Stenosis of the Artery of Percheron Revealed by Conventional Angiography in Bilateral Thalami Infarction.
Jeong, Soo MD; Ha, Sang Hee MD, PhD; Chang, Jun Young MD, PhD; Kim, Bum Joon MD, PhD
Therapies Targeting Stroke Recovery.
Richards, Lorie G. PhD; Cramer, Steven C. MD
doi : 10.1161/STROKEAHA.122.041729
AB Stroke recovery therapeutics include many classes of intervention and numerous treatment targets. Stroke is a very heterogeneous disease. As such, stroke recovery therapeutics benefit from a personalized medicine approach that considers intersubject differences, such as in infarct location or stroke severity, when assigning treatment.
Pharmacogenomics in Stroke and Cardiovascular Disease: State of the Art.
Ross, Stephanie MSc, PhD; Krebs, Kristi MSc, PhD; Pare, Guillaume MD, MSc; Milani, Lili PhD
doi : 10.1161/STROKEAHA.122.037717
AB There is considerable interindividual variability in the response to antiplatelet and anticoagulant therapies, and this variation may be attributable to genetic variants. There has been an increased understanding of the genetic architecture of stroke and cardiovascular disease, which has been driven by advancements in genomic technologies and this has raised the possibility of more targeted pharmaceutical treatments.
mTOR (Mammalian Target of Rapamycin): Hitting the Bull's Eye for Enhancing Neurogenesis After Cerebral Ischemia?.
Gao, Jiale PhD; Yao, Mingjiang PhD; Chang, Dennis PhD; Liu, Jianxun PhD
doi : 10.1161/STROKEAHA.122.040376
AB Ischemic stroke remains a leading cause of morbidity and disability around the world. The sequelae of serious neurological damage are irreversible due to body's own limited repair capacity.
Improving Large Animal Ischemic Stroke Models for Translational Studies in the Era of Recanalization.
Li, Shen MD, PhD; Fisher, Marc MD
doi : 10.1161/STROKEAHA.122.041354
AB Recanalization therapy with endovascular procedures has led to significant advances in the treatment of acute ischemic stroke. Animal models have been the basis for enhancing the development of novel treatments and therapeutic modalities.
The CASSISS Randomized Clinical Trial.
Turan, Tanya N. MD, MSCR; Psychogios, Marios-Nikos MD
doi : 10.1161/STROKEAHA.122.041096
AB The CASSISS trial (China Angioplasty & Stenting for Symptomatic Intracranial Severe Stenosis), recently published in JAMA, is the most recent of several randomized controlled trials that have failed to show a benefit of percutaneous angioplasty and stenting over medical therapy for the prevention of stroke due to intracranial atherosclerotic stenosis.
Clinical Fellowship in a Foreign Country: Benefits, Challenges, Tips for Success.
Gadama, Yohane MBBS, MSc; Kamtchum-Tatuene, Joseph MD, PhD
