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Gender Disparity in Asian-Pacific Countries: An Analysis of the ASTREG-WIT-KT Registry.
Han, Miyeun MD 1; Wong, Germaine MBBS, PhD 2; Kute, Vivek B. MD 3; Nakagawa, Yuki MD 4; Wang, Hsu-Han MD 5; Arakama, Mel Hatra MD 6; Jeong, Jong Cheol MD 7; Cho, Yun Yung BS 8,9; Thwin, Khin Thida MD 10; Chapman, Jeremy MD, FRCP 11; Sapir-Pichhadze, Ruth MD 12; Mannon, Roslyn B. MD 13; Ahn, Curie MD 1; Kim, Yeong Hoon MD 14; Steering Committee Members of ASTREG-WIT-KT
doi : 10.1097/TP.0000000000004223
Volume 107(1) pgs. 1-282,e1-e44 January 2023
A First Step Toward a Cross-tissue Atlas of Immune Cells in Humans.
Cippa, Pietro E. MD, PhD 1; Mueller, Thomas F. MD 2
Registry of the International Society of Uterus Transplantation: First Report.
Brannstrom, Mats MD, PhD 1; Tullius, Stefan G. MD 2; Brucker, Sara MD 3; Dahm-Kahler, Pernilla MD, PhD 1; Flyckt, Rebecca MD 4; Kisu, Iori MD 5; Andraus, Wellington MD 6; Wei, Li MD 7; Carmona, Francisco MD 8; Ayoubi, Jean-Marc MD 9; Scollo, Paolo MD 10; Weyers, Steven MD 11; Fronek, Jiri MD 12
doi : 10.1097/TP.0000000000004286
Uterus transplantation (UTx) is a novel type of transplantation to treat infertility in women with an absent or nonfunctioning uterus. The International Society of Uterus Transplantation (ISUTx) has developed a registry to monitor worldwide UTx activities while serving as a repository for specific research questions.
Lung Transplantation for COVID-19-related Lung Disease: Clinical Experience and Call for a Global Registry.
Weder, Max M. MD 1; Aslam, Saima MD, MS 2; Ison, Michael G. MD, MS 3
COVID-19 Vaccines and Solid Organ Transplantation: More Doses, More Protection.
Safa, Kassem MD 1,2; Kotton, Camille Nelson MD 3,4
The Potential Clinical Application of Induced Tolerogenic Macrophages.
Xu, Hong MD 1; Suire, Colby PhD 1; Ildstad, Suzanne T. MD 1,2
Donor-derived Cell-free DNA Measurement in Kidney Transplant Patients Without Allograft Dysfunction: More Evidence and More Questions.
Gupta, Gaurav MD 1; Tanriover, Bekir MD, MPH, MBA, FAST 2
Understanding Current Limitations to Exercise Interventions After Liver Transplantation.
Thuluvath, Avesh J. MD, MS 1,2; Lai, Jennifer C. MD, MBA 3
The Molecular Microscope Diagnostic System: Assessment of Rejection and Injury in Heart Transplant Biopsies.
Halloran, Philip F. MD, PhD 1; Madill-Thomsen, Katelynn S. PhD 1
doi : 10.1097/TP.0000000000004323
AB This review describes the development of the Molecular Microscope Diagnostic System (MMDx) for heart transplant endomyocardial biopsies (EMBs). MMDx-Heart uses microarrays to measure biopsy-based gene expression and ensembles of machine learning algorithms to interpret the results and compare each new biopsy to a large reference set of earlier biopsies.
Diagnostic Potential of Minimally Invasive Biomarkers: A Biopsy-centered Viewpoint From the Banff Minimally Invasive Diagnostics Working Group.
Huang, Edmund MD 1; Mengel, Michael MD 2; Clahsen-van Groningen, Marian C. MD, PhD 3,4,5; Jackson, Annette M. PhD 6
doi : 10.1097/TP.0000000000004339
AB With recent advances and commercial implementation of minimally invasive biomarkers in kidney transplantation, new strategies for the surveillance of allograft health are emerging.
Mammalian Target of Rapamycin Inhibitors and Kidney Function After Thoracic Transplantation: A Systematic Review and Recommendations for Management of Lung Transplant Recipients.
Schmucki, Katja MSc 1,2; Hofmann, Patrick MD 1,2; Fehr, Thomas MD 2,3; Inci, Ilhan MD 3,4; Kohler, Malcolm MD 1,3; Schuurmans, Mace M. MD, FCCP 1,3
doi : 10.1097/TP.0000000000004336
Chronic kidney disease (CKD) after lung transplantation is common and limits the survival of transplant recipients. The calcineurin inhibitors (CNI), cyclosporine A, and tacrolimus being the cornerstone of immunosuppression are key mediators of nephrotoxicity.
Do Treg Speed Up with CARs? Chimeric Antigen Receptor Treg Engineered to Induce Transplant Tolerance.
Kaljanac, Marcell MSc 1; Abken, Hinrich 1
doi : 10.1097/TP.0000000000004316
AB Adoptive transfer of regulatory T cells (Treg) can induce transplant tolerance in preclinical models by suppressing alloantigen-directed inflammatory responses; clinical translation was so far hampered by the low abundance of Treg with allo-specificity in the peripheral blood. In this situation, ex vivo engineering of Treg with a T-cell receptor (TCR) or chimeric antigen receptor (CAR) provides a cell population with predefined specificity that can be amplified and administered to the patient.
Regulatory T Cells: Liquid and Living Precision Medicine for the Future of VCA.
Kauke-Navarro, Martin MD 1,2; Knoedler, Samuel 2,3; Panayi, Adriana C. MD 2; Knoedler, Leonard 4,5; Noel, Olivier F. MD, PhD 1; Pomahac, Bohdan MD 1
doi : 10.1097/TP.0000000000004342
AB Transplant rejection remains a challenge especially in the field of vascularized composite allotransplantation (VCA). To blunt the alloreactive immune response[low single comma quotation mark] stable levels of maintenance immunosupression are required. However[low single comma quotation mark] the need for lifelong immunosuppression poses the risk of severe side effects, such as increased risk of infection, metabolic complications, and malignancies.
Beyond Adaptive Alloreactivity: Contribution of Innate B Cells to Allograft Inflammation and Rejection.
Sayin, Ismail PhD 1; Chong, Anita S. PhD 1
doi : 10.1097/TP.0000000000004377
AB Innate B cells are a heterogeneous group of cells that function in maintaining homeostatic levels of circulating natural antibodies and being the first line of defense against infections.
Diagnostic and Therapeutic Implications of Ex Vivo Lung Perfusion in Lung Transplantation: Potential Benefits and Inherent Limitations.
Yu, Jing MD 1; Zhang, Nan MD 1; Zhang, Zhiyuan BMc 1; Li, Yuping PhD 2; Gao, Jiameng BMc 1; Chen, Chang PhD 2; Wen, Zongmei PhD 1
doi : 10.1097/TP.0000000000004414
AB Ex vivo lung perfusion (EVLP), a technique in which isolated lungs are continually ventilated and perfused at normothermic temperature, is emerging as a promising platform to optimize donor lung quality and increase the lung graft pool.
A Prevascularized Sinus Tract on the Liver Surface for Islet Transplantation.
Li, Feng MD 1; Lv, Yi MD 1; Li, Xiaohang MD 1; Yang, Zhaoming MD 1,2; Guo, Tingwei MD 1; Zhang, Jialin MD, PhD 1
doi : 10.1097/TP.0000000000004236
The lack of a suitable transplantation site has become a bottleneck restricting the development of islet transplantation. Methods. In this study, for the first time, a prevascularized sinus tract (PST) for islet transplantation was constructed in a mouse model by temporarily embedding a 4x silk thread between the liver surface and the attached decellularized human amniotic membrane.
CCAAT/Enhancer-binding Protein Homologous Protein Promotes ROS-mediated Liver Ischemia and Reperfusion Injury by Inhibiting Mitophagy in Hepatocytes.
Zhou, Shun MD 1; Rao, Zhuqing MD 2; Xia, Yongxiang MD 1; Wang, Qi MD 1,3; Liu, Zheng MD 1; Wang, Ping MD 1; Cheng, Feng MD 1; Zhou, Haoming MD 1
doi : 10.1097/TP.0000000000004244
Liver ischemia and reperfusion (IR) injury represent a major risk factor in both partial hepatectomy and liver transplantation. CCAAT/enhancer-binding protein homologous protein (CHOP) is a key regulator of cell death, its precise molecular basis in regulating hepatocyte death during liver IR has not been delineated.
Lymph Node Fibroblastic Reticular Cells Attenuate Immune Responses Through Induction of Tolerogenic Macrophages at Early Stage of Transplantation.
Liu, Beichen PhD 1,2; Liu, Huihui PhD 1; Liu, Siwei PhD 1; Qin, Chenchen PhD 1; He, Xiaoya PhD 1; Song, Zhengyang PhD 1; Dong, Yujun MD, PhD 1; Ren, Hanyun MD, PhD 1
doi : 10.1097/TP.0000000000004245
Fibroblastic reticular cells (FRCs) are a type of stromal cells located in the T zone in secondary lymphoid organs. Previous studies showed that FRCs possess the potential to promote myeloid differentiation.
Clamping of the Aortic Arch Vessels During Normothermic Regional Perfusion Does Not Negatively Affect Donor Cardiac Function in Donation After Circulatory Death.
Moeslund, Niels MD 1,2; Zhang, Zhang Long MD 3; Dalsgaard, Frederik Flyvholm MS 1,2; Glenting, Sif Bay MD 2; Ilkjaer, Lars Bo MD 4; Ryhammer, Pia MD 5; Palmfeldt, Johan PhD 6; Pedersen, Michael PhD 2; Erasmus, Michiel MD, PhD 3; Eiskjaer, Hans MD, DMSc 1
doi : 10.1097/TP.0000000000004298
The hemodynamic effects of aortic arch vessel (AAV) clamping during normothermic regional perfusion (NRP) in donation after circulatory death is unknown. We investigated effects of AAV clamping during NRP compared with no clamping in a porcine model.
Outcomes of Sorafenib for Recurrent Hepatocellular Carcinoma After Liver Transplantation in the Era of Combined and Sequential Treatments.
Tovoli, Francesco MD 1,2; Pallotta, Dante Pio MD 2; Sansone, Vito MD 1; Iavarone, Massimo PhD, MD 3; De Giorgio, Massimo PhD, MD 4; Ielasi, Luca MD 1; Di Costanzo, Giovan Giuseppe MD 5; Giuffrida, Paolo MD 4,6; Sacco, Rodolfo PhD, MD 7,8; Pressiani, Tiziana MD 9; Di Donato, Maria Francesca MD 3; Trevisani, Franco PhD, MD 2,10; Fagiuoli, Stefano MD 4,11; Piscaglia, Fabio PhD, MD 1,2; Granito, Alessandro MD 1,2
doi : 10.1097/TP.0000000000004271
Sorafenib and other tyrosine kinase inhibitors are the current standard of care for hepatocellular carcinoma (HCC) recurring after liver transplantation (LT).
Impact of Older Donor Age on Recipient and Graft Survival After LDLT: The US Experience.
Kanneganti, Mounika MD 1; Olthoff, Kim M. MD 2; Bittermann, Therese MD, MSCE 3,4
doi : 10.1097/TP.0000000000004289
The impact of selecting older donors for living donor liver transplantation (LDLT) in the United States is incompletely studied, particularly in light of the recent expansion of LDLT nationally.
Urgent Liver Transplantation for Acute Liver Failure in Pregnant Women: The Optimum Timing for Delivery.
Ichai, Philippe MD 1,2,3; Bouchghoul, Hanane MD 4; Laurent-Bellue, Astrid MD 5; Sacleux, Sophie-Caroline MD 1,3; Boudon, Marc MD 1,2,3; Cherqui, Daniel MD, PhD 2,3,6; Tortajada, Pauline MD 6; Braun, Marius MD 7; Lemaitre, Elise MD 1; Pittau, Gabriella MD 2,3,6; Ordan, Marie-Amelie MD 1,3; Levi, Sharon MD 1; Azoulay, Daniel MD, PhD 2,3,6; Fernandez, Herve MD, PhD 4; Guettier, Catherine MD, PhD 2,3,5; Samuel, Didier MD, PhD 1,2,3; Saliba, Faouzi MD 1,2,3
doi : 10.1097/TP.0000000000004290
The occurrence of acute liver failure (ALF) in pregnant women due to an etiology unrelated to pregnancy (pregALF) that leads to liver transplantation (LT) has rarely been reported.
Does Exercise Training Improve Physical Fitness and Health in Adult Liver Transplant Recipients? A Systematic Review and Meta-analysis.
De Smet, Stefan PT, PhD 1,2,3; O'Donoghue, Katriona BSc 4; Lormans, Maud MD 3; Monbaliu, Diethard MD, PhD 3,5; Pengel, Liset PhD 6
doi : 10.1097/TP.0000000000004313
The impaired physical fitness of end-stage liver disease patients often persists after liver transplantation (LT) and compromises posttransplant recovery. This systematic review and meta-analysis evaluated evidence supporting the potential of exercise training to improve physical fitness and health-related quality of life (HRQOL) after LT.
PASC in Solid Organ Transplant Recipients With Self-reported SARS-CoV-2 Infection.
Alasfar, Sami MD 1; Chiang, Teresa Po-Yu MD, MPH 2; Snyder, Andrew J. BS 3; Ou, Michael T. BS 2; Boyarsky, Brian J. MD, PhD 2; Abedon, Aura T. BS 2; Alejo, Jennifer L. MD 2; Cook, Sydney BS 4; Cochran, Willa CRNP 1; Brigham, Emily MD 5,6; Parker, Ann M. MD, PhD 1; Garonzik-Wang, Jacqueline MD, PhD 7; Massie, Allan B. PhD 8; Brennan, Daniel C. MD 1; Vannorsdall, Tracy PhD 9; Segev, Dorry L. MD, PhD 8; Avery, Robin K. MD 1
doi : 10.1097/TP.0000000000004340
Postacute sequelae of SARS-CoV-2 infection (PASC) is an increasingly recognized phenomenon and manifested by long-lasting cognitive, mental, and physical symptoms beyond the acute infection period.
Humoral Response to the Fourth BNT162b2 Vaccination and Link Between the Fourth Dose, Omicron Infection, and Disease Severity in Renal Transplant Recipients.
Hod, Tammy MD 1,2,3; Ben-David, Aharon MD 1,2,3; Mor, Eytan MD 1,2; Olmer, Liraz MSc 4; Halperin, Rebecca RN, BA 5; Indenbaum, Victoria PhD 2,6; Beckerman, Pazit MD 2,3; Doolman, Ram PhD 2,7; Asraf, Keren PhD 2,7; Atari, Nofar PhD 6; Benjamini, Ohad MD 2,8; Lustig, Yaniv PhD 2,6; Grossman, Ehud MD 2,9; Mandelboim, Michal PhD 2,6; Rahav, Galia MD, PhD 2,5
doi : 10.1097/TP.0000000000004383
The effectiveness of the fourth BNT162b2 vaccination in reducing the rate and severity of coronavirus disease 2019 (COVID-19) caused by the Omicron variant in renal transplant recipients (RTRs) is unknown.
Humoral and Cellular Response of Transplant Recipients to a Third Dose of mRNA SARS-CoV-2 Vaccine: A Systematic Review and Meta-analysis.
Bailey, Adrian J.M. BSc 1,2; Maganti, Harinad B. PhD 2,3; Cheng, Wei PhD 4; Shorr, Risa MLIS 5; Arianne Buchan, C. MD, FRCPC 1,6; Allan, David S. MD, FRCPC 1,2,3,7
doi : 10.1097/TP.0000000000004386
High rates of nonresponse to 2 doses of mRNA severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine have been reported in transplant recipients.
Real-world Evidence of COVID-19 Vaccines Effectiveness in Solid-organ Transplant Recipient Population in Colombia: A Study Nested in the Esperanza Cohort.
Pinto-Alvarez, Mariana MPH 1; Fernandez-Nino, Julian A. PhD 2,3; Arregoces-Castillo, Leonardo DrPH 1; Rojas-Botero, Maylen L. PhD 4; Palacios, Andres F. MSc 1; Galvis-Pedraza, Maryory MSc 1; Ruiz-Gomez, Fernando DrPH 5
doi : 10.1097/TP.0000000000004411
Solid-organ transplant recipients (SOTRs) have a higher risk of coronavirus disease 2019 (COVID-19) complications and death and a less powerful and lasting response to vaccines and to natural infection.
Splenic Vessels as a Rescue for Pediatric Kidney Retransplantation in Children With Iliac-caval Agenesis or Thrombosis.
Tandoi, Francesco MD, PhD, FEBS 1,*; Peruzzi, Licia MD, PhD 2,*; Lonardi, Pietro MD 2; Cussa, Davide MD 1; Catalano, Silvia MD 1; Verri, Aldo MD 3; Merlo, Maurizio MD 3; Sedigh, Omidreza MD 4; Gerocarni Nappo, Simona MD 5; Melloni, Claudia MD 3; Patrono, Damiano MD, PhD, FEBS 1; Gianoglio, Bruno MD 2; Romagnoli, Renato MD, FEBS 1
doi : 10.1097/TP.0000000000004255
Unavailability of the iliac-caval system due to thrombosis or aberrant anatomy may preclude kidney transplantation (KT) in small infants, exposing them to the complications of long-term dialysis.
Seeking Standardized Definitions for HLA-incompatible Kidney Transplants: A Systematic Review.
Jatana, Sukhdeep S. MD 1; Zhao, Hedi MD 1; Bow, Laurine M. PhD 2; Cozzi, Emanuele MD, PhD 3,4; Batal, Ibrahim MD 5; Horak, Tillie 6; Amar-Zifkin, Alexandre MLIS 7; Schinstock, Carrie MD 8; Askar, Medhat MD, PhD 9,10; Dadhania, Darshana M. MD, MS 11; Cooper, Matthew MD 12; Naesens, Maarten MD, PhD 13; Kraus, Edward S. MD 6; Sapir-Pichhadze, Ruth MD, PhD, FRCPC 1,14; on behalf of the Banff Antibody-Mediated Injury Working Group
doi : 10.1097/TP.0000000000004262
There is no standard definition for "HLA incompatible" transplants. For the first time, we systematically assessed how HLA incompatibility was defined in contemporary peer-reviewed publications and its prognostic implication to transplant outcomes.
Clinical Outcomes and Risk Factors for Carbapenem-resistant Enterobacterales Bloodstream Infection in Solid Organ Transplant Recipients.
Anesi, Judith A. MD, MSCE 1,2,3; Lautenbach, Ebbing MD, MPH, MSCE 1,2,3; Thom, Kerri A. MD, MS 4; Tamma, Pranita D. MD, MHS 5; Blumberg, Emily A. MD 1; Alby, Kevin PhD 6; Bilker, Warren B. PhD 2,3; Werzen, Alissa MD 7; Ammazzalorso, Alyssa MD 8; Tolomeo, Pam MPH 2; Omorogbe, Jacqueline BA 2; Pineles, Lisa MA 4; Han, Jennifer H. MD, MSCE 1,2,3
doi : 10.1097/TP.0000000000004265
The clinical outcomes associated with, and risk factors for, carbapenem-resistant Enterobacterales (CRE) bloodstream infections (BSIs) in solid organ transplant (SOT) recipients remain ill-defined.
Prediction of Renal Function in Living Kidney Donors and Recipients of Living Donor Kidneys Using Quantitative Histology.
Buus, Niels Henrik MD, PhD 1,2,*; Nielsen, Cecilie Molgaard MD 1,3,*; Skov, Karin MD, PhD 1; Ibsen, Lotte MD 4; Krag, Soren MD, PhD 5; Nyengaard, Jens Randel MD, DMSc 2,3
doi : 10.1097/TP.0000000000004266
Living kidney donors (LKDs) are at increased risk of chronic kidney disease, whereas transplant recipients experience progressive reduction of graft function.
An Assessment of the Value of Donor-derived Cell-free DNA Surveillance in Patients With Preserved Kidney Allograft Function.
Huang, Edmund MD 1; Haas, Mark MD, PhD 2; Gillespie, Matt PharmD 1; Sethi, Supreet MD 1; Peng, Alice MD 1; Najjar, Reiad MD 1; Vo, Ashley PharmD 1; Jordan, Stanley C. MD 1
doi : 10.1097/TP.0000000000004267
Donor-derived cell-free DNA (dd-cfDNA) is a biomarker validated to detect rejection when measured to assess kidney allograft dysfunction. However, it remains unclear whether routine surveillance with dd-cfDNA provides additional information over standard monitoring of kidney allografts with creatinine and donor-specific antibodies (DSAs), particularly among those with little suspicion of rejection or injury.
Can the Area Under the Curve/Trough Level Ratio Be Used to Optimize Tacrolimus Individual Dose Adjustment?.
Woillard, Jean-Baptiste PharmD, PhD 1,2; Monchaud, Caroline PharmD, PhD 1,2; Saint-Marcoux, Franck PharmD, PhD 1,2; Labriffe, Marc MD 1,2; Marquet, Pierre MD, PhD 1,2
doi : 10.1097/TP.0000000000004405
The aim of this work was to evaluate, in a large data set of renal transplant recipients, the intraindividual variability of the area under the curve (AUC)/predose concentration (C0) ratio in comparison with that of AUC, C0, AUC/dose, and C0/dose.
RE: Imlifidase-generated Single-cleaved IgG: Implications for Transplantation.
de Weerd, Annelies E. MD, PhD 1; Reinders, Marlies E.J. MD, PhD 1; van de Wetering, Jacqueline MD, PhD 1; Roelen, Dave L. MSc, PhD 2
Laparoscopic Sleeve Gastrectomy for Obesity After Combined Liver-intestinal Transplantation: A Case Report.
Clarysse, Mathias MD 1,2,3; Van Aelst, Pieter MD 4; Vanuytsel, Tim MD, PhD 3,5; Monbaliu, Diethard MD, PhD 1,2,3; Ceulemans, Laurens J. MD, PhD 3,6; Mertens, Ann MD, PhD 7; Vangoitsenhoven, Roman MD, PhD 7; Van der Schueren, Bart MD, PhD 7; Lannoo, Matthias MD, PhD 4,7; Pirenne, Jacques MD, PhD 1,2,3; Deleus, Ellen MD 4,7
Psoriasis Flare in a Liver Transplant Patient: A Case Report of a Successful Treatment With Apremilast.
Rosi, Elia MD 1; Fastame, Maria Thais MD 1; Di Cesare, Antonella MD 1; Prignano, Francesca MD, PhD 1
Single-center Experience on Nonlung Solid Organ Transplantation From SARS-CoV-2-positive Donors.
Covarrubias, Karina MD 1; Brubaker, Aleah L. MD, PhD 1; Mekeel, Kristin MD 1; Pretorius, Victor MD 2; Shah, Mita MD 3; Adler, Eric MD 4; Ajmera, Veeral MD 5; Schnickel, Gabriel T. MD 1; Aslam, Saima MD, MS 6
Antibody-mediated Rejection Without Detectable Donor-specific Antibody Releases Donor-derived Cell-free DNA: Results From the Trifecta Study: Erratum.
Four Decades of Clinical Liver Transplantation Research: Results of a Comprehensive Bibliometric Analysis: Erratum.
