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Associate Editorial Board
doi : 10.1016/S0007-0912(22)00703-6
Volume 130, Issue 2, February 2023, Page ii
Centre for Perioperative Care anaemia guideline: implications for anaesthesia
Tristan Hawkins 1,* , Seema Agarwal 2 and Caroline R. Evans
doi : 10.1016/j.bja.2022.11.009
Volume 130, Issue 2, February 2023, Pages 115-119
Assessment of haemostatic function in paediatric surgical patients: ‘if you prick us, do we not bleed?’
Kenichi Tanaka * and Alberto J. de Armendi
doi : 10.1016/j.bja.2022.11.008
Volume 130, Issue 2, February 2023, Pages 119-121
Physiological relationship between cardiorespiratory fitness and fitness for surgery: a narrative review
Brendon H. Roxburgh 1,2, *, James D. Cotter 2 , Holly A. Campbell 1 , Ulla Reymann 1 , Luke C. Wilson 3 , David Gwynne-Jones 1,4 , Andre M. van Rij 1 and Kate N. Thomas
doi : 10.1016/j.bja.2022.10.039
Volume 130, Issue 2, February 2023, Pages 122-132
Comparison of the effects of sugammadex versus neostigmine for reversal of neuromuscular block on hospital costs of care
Luca J. Wachtendorf 1,2,3,y, Tim M. Tartler 2,3,y, Elena Ahrens 2,3 , Annika S. Witt 1 , Omid Azimaraghi 1 , Philipp Fassbender 1,4 , Aiman Suleiman 2,3,5 , Felix C. Linhardt 1,2,3 , Michael Blank 1,2,3 , Sarah Y. Nabel 2 , Jerry Y. Chao 1 , Pavel Goriacko 6 , Parsa Mirhaji 7,8 , Timothy T. Houle 9 , Maximilian S. Schaefer 2,3,10 and Matthias Eikermann
doi : 10.1016/j.bja.2022.10.015
Volume 130, Issue 2, February 2023, Pages 133-141
Sugammadex reversal of neuromuscular block facilitates recovery of neuromuscular function after surgery, but the drug is expensive. We evaluated the effects of sugammadex on hospital costs of care.
Dexmedetomidine provides type-specific tumour suppression without tumour-enhancing effects in syngeneic murine models
Wanpei Chen 1,2 , Ziwei Qi 2 , Peng Fan2 , Naidong Zhang 2 , Long Qian 2 , Cui Chen 1 , Yuhui Huang 2, * and Sanqing Jin
doi : 10.1016/j.bja.2022.10.036
Volume 130, Issue 2, February 2023, Pages 142-153
Dexmedetomidine is a widely used anaesthetic adjuvant for cancer resection surgeries. However, recent reports suggest that it may promote tumour growth or metastasis, so it is essential to clarify its tumour-related effects.
Sex-specific hypnotic effects of the neuroactive steroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile are mediated by peripheral metabolism into an active hypnotic steroid
Francesca M. Manzella1,2 , Omar H. Cabrera 1 , Davis Wilkey 1 , Brier Fine-Raquet 1 , Jelena Klawitter 1 , Kathiresan Krishnan 3 , Douglas F. Covey 3,4 , Vesna Jevtovic-Todorovic 1,5 and Slobodan M. Todorovic
doi : 10.1016/j.bja.2022.09.025
Volume 130, Issue 2, February 2023, Pages 154-164
The novel synthetic neuroactive steroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile (3β-OH) blocks T-type calcium channels but does not directly modulate neuronal γ-aminobutyric acid type A (GABAA) currents like other anaesthetic neurosteroids. As 3β-OH has sex-specific hypnotic effects in adult rats, we studied the mechanism contributing to sex differences in its effects.
Thromboelastometry-guided treatment algorithm in postpartum haemorrhage: a randomised, controlled pilot trial
Samuli Jokinen 1, *, Anne Kuitunen 2 , Jukka Uotila 3 and Arvi Yli-Hankala
doi : 10.1016/j.bja.2022.10.031
Volume 130, Issue 2, February 2023, Pages 165-174
Postpartum haemorrhage causes significant mortality among parturients. Early transfusion of blood products based on clinical judgement and conventional coagulation testing has been adapted to the treatment of postpartum haemorrhage, but rotational thromboelastometry (ROTEM) may provide clinicians means for a goal-directed therapy to control coagulation.
Factor XIII levels, clot strength, and impact of fibrinogen concentrate in infants undergoing cardiopulmonary bypass: a mechanistic sub-study of the FIBCON trial
Kristina Siemens 1 , Beverley J. Hunt 2 , Kiran Parmar3 , Dan Taylor 4 , Caner Salih 5 and Shane M. Tibby
doi : 10.1016/j.bja.2022.09.022
Volume 130, Issue 2, February 2023, Pages 175-182
Acquired factor XIII (FXIII) deficiency after major surgery can increase postoperative bleeding. We evaluated FXIII contribution to clot strength and the effect of fibrinogen concentrate administration on FXIII activity in infants undergoing cardiac surgery using cardiopulmonary bypass.
Determination of reference ranges for the ClotPro® thromboelastometry device in paediatric patients
Katarina Laukova 1, *, Veronika Petrikova 1 , Lubomira Poloniova 1 , Lucia Babulicova 1 , Ladislava Wsolova 2 and Thorsten Haas
doi : 10.1016/j.bja.2022.09.023
Volume 130, Issue 2, February 2023, Pages 183-190
A new thromboelastometry analyser (ClotPro®) was developed with advanced diagnostics. The reference ranges of ClotPro® in children ages 0–16 yr have not been reported.
Repeated early-life exposure to anaesthesia and surgery causes subsequent anxiety-like behaviour and gut microbiota dysbiosis in juvenile rats
Xue Zhou 1,2,y, Xuanxian Xu 1,y, Dihan Lu 1,y, Keyu Chen 1,y, Yan Wu 1 , Xiaoyu Yang 1 , Wei Xiong 1 , Xi Chen 3 , Liangtian Lan 1 , Wenda Li 4 , Shiqian Shen 2 , Wen He 5, * and Xia Feng
doi : 10.1016/j.bja.2022.06.039
Volume 130, Issue 2, February 2023, Pages 191-201
Early exposure to general anaesthetics for multiple surgeries or procedures might negatively affect brain development. Recent studies indicate the importance of microbiota in the development of stress-related behaviours. We determined whether repeated anaesthesia and surgery in early life cause gut microbiota dysbiosis and anxiety-like behaviours in rats.
Effect of intrathecal NIS-lncRNA antisense oligonucleotides on neuropathic pain caused by nerve trauma, chemotherapy, or diabetes mellitus
Chun-Hsien Wen 1,y,z, Tolga Berkman 1,y, Xiang Li 1,y, Shibin Du 1,y, Gokulapriya Govindarajalu 1 , Haijun Zhang 1 , Alex Bekker 1 , Steve Davidson 2 and Yuan-Xiang Tao
doi : 10.1016/j.bja.2022.09.027
Volume 130, Issue 2, February 2023, Pages 202-216
Blocking increased expression of nerve injury-specific long non-coding RNA (NIS-lncRNA) in injured dorsal root ganglia (DRG) through DRG microinjection of NIS-lncRNA small hairpin interfering RNA or generation of NIS-lncRNA knockdown mice mitigates neuropathic pain.
Assistive artificial intelligence for ultrasound image interpretation in regional anaesthesia: an external validation study
James S. Bowness 1,2, *, David Burckett-St Laurent 3 , Nadia Hernandez 4 , Pearse A. Keane 5,6 , Clara Lobo7 , Steve Margetts 8 , Eleni Moka 9 , Amit Pawa 10,11 , Meg Rosenblatt 12 , Nick Sleep8 , Alasdair Taylor 13 , Glenn Woodworth 14 , Asta Vasalauskaite 8 , J. Alison Noble 15 and Helen Higham
doi : 10.1016/j.bja.2022.06.031
Volume 130, Issue 2, February 2023, Pages 217-225
Ultrasonound is used to identify anatomical structures during regional anaesthesia and to guide needle insertion and injection of local anaesthetic. ScanNav Anatomy Peripheral Nerve Block (Intelligent Ultrasound, Cardiff, UK) is an artificial intelligence-based device that produces a colour overlay on real-time B-mode ultrasound to highlight anatomical structures of interest.
Evaluation of the impact of assistive artificial intelligence on ultrasound scanning for regional anaesthesia
James S. Bowness 1,2, *, Alan J. R. Macfarlane 3,4 , David Burckett-St Laurent 5 , Catherine Harris 2 , Steve Margetts6 , Megan Morecroft 6 , David Phillips 2 , Tom Rees2 , Nick Sleep6 , Asta Vasalauskaite 6 , Simeon West7 , J. Alison Noble8 and Helen Higham
doi : 10.1016/j.bja.2022.07.049
Volume 130, Issue 2, February 2023, Pages 226-233
Ultrasound-guided regional anaesthesia relies on the visualisation of key landmark, target, and safety structures on ultrasound. However, this can be challenging, particularly for inexperienced practitioners.
Effectiveness of oral versus intravenous tranexamic acid in primary total hip and knee arthroplasty: a randomised, non-inferiority trial
Christopher J. DeFrancesco1 , Julia F. Reichel 2 , Ejiro Gbaje 2 , Marko Popovic 2 , Carrie Freeman 2 , Marisa Wong 2 , Danya DeMeo 2 , Jiabin Liu 2,3 , Alejandro Gonzalez Della Valle 1 , Amar Ranawat 1 , Michael Cross 4 , Peter K. Sculco 1 , Stephen Haskins 2,3 , David Kim 2,3 , Daniel Maalouf 2,3 , Meghan Kirksey 2,3 , Kethy Jules-Elysee 2,3 , Ellen M. Soffin 2,3 , Kanupriya Kumar2,3 , Jonathan Beathe 2,3 , Mark Figgie 1 , Allan Inglis Jr. 1 , Sean Garvin 2,3 , Michael Alexiades 1 , Kathryn DelPizzo2,3 , Linda A. Russell 5 , Alexandra Sideris 2 , Jawad Saleh 6 , Haoyan Zhong 2 and Stavros G. Memtsoudis
doi : 10.1016/j.bja.2022.11.003
Volume 130, Issue 2, February 2023, Pages 234-241
Tranexamic acid (TXA) reduces rates of blood transfusion for total hip arthroplasty (THA) and total knee arthroplasty (TKA). Although the use of oral TXA rather than intravenous (i.v.) TXA might improve safety and reduce cost, it is not clear whether oral administration is as effective.
Correspondence in the British Journal of Anaesthesia from 2018–21: article types, authorship, and COVID-19
Sara Tan 1,2 and Kate Leslie
doi : 10.1016/j.bja.2022.10.042
Volume 130, Issue 2, February 2023, Pages e181-e183
Intralipid® improves left ventricular function in rats with lipopolysaccharide-induced endotoxaemia by a Src-STAT3-mediated mechanism
Somanshu Banerjee 1 , Michael Zargari1 , Lejla Medzikovic1 , Hanzi Russino 1 , Matthew Mikhael 1 , Natalie Koons2 , Tristan Grogan3 , Siamak Rahman1 , Mansoureh Eghbali1 and Soban Umar
doi : 10.1016/j.bja.2022.10.019
Volume 130, Issue 2, February 2023, Pages e183-e187
Use of videolaryngoscopy as the first option for all tracheal intubations: not so fast. Response to Br J Anaesth 2023; 130: e12–e13
Audrey De Jong 1,2 , Yvan Pouzeratte 1 , Thomas Sfara1 and Samir Jaber
doi : 10.1016/j.bja.2022.10.020
Volume 130, Issue 2, February 2023, Pages e187-e189
Postoperative anaemia and patient-centred outcomes after major abdominal surgery: pathophysiology versus statistics. Comment on Br J Anaesth 2022; 129: 346–54
Henrik Kehlet
doi : 10.1016/j.bja.2022.10.022
Volume 130, Issue 2, February 2023, Pages e189-e190
Development and validation of a multivariable prediction model for the early prediction of chronic postsurgical pain. Response to Br J Anaesth 2022; 129: e155
Marjelle E. C. van Driel, Frank J. P. M. Huygen and Mienke Rijsdijk
doi : 10.1016/j.bja.2022.10.032
Volume 130, Issue 2, February 2023, Pages e190-e191
A survey of mentoring patterns, practices, and attitudes of active medical school-affiliated anaesthesiologists in the USA
Abimbola O. Faloye 1,* , Allison J. Bechtel2 , David W. Boorman 1 and Emily Methangkool 3
doi : 10.1016/j.bja.2022.10.033
Volume 130, Issue 2, February 2023, Pages e191-e193
Fluids, vasopressors, and acute kidney injury after major abdominal surgery. Comment on Br J Anaesth 2022; 129: 317–26
Jean-Luc Fellahi 1,2,* , Remi Schweizer1 , Martin Ruste1,2 and Matthias Jacquet-Lagreze
doi : 10.1016/j.bja.2022.10.037
Volume 130, Issue 2, February 2023, Pages e193-e194
Tranexamic acid for safer surgery: does the evidence support preventative use? Response to Br J Anaesth 2023; 130: e23–e24
The UK Royal Colleges Tranexamic Acid in Surgery Implementation Group, Michael P. W. Grocott 1,2 , Mike Murphy3,4 , Ian Roberts 5,* , Rob Sayers 6,7 and Cheng-Hock Toh
doi : 10.1016/j.bja.2022.11.010
Volume 130, Issue 2, February 2023, Pages e195-e196
Postdural puncture headache and cerebral venous thrombosis in obstetric anaesthesia
Stephanie Poteau, Alina Genis and Sangeeta Kumaraswami
doi : 10.1016/j.bja.2022.11.011
Volume 130, Issue 2, February 2023, Pages e196-e198
A retrospective review of therapies in patients with right ventricular dysfunction on mechanical circulatory support
Andriana Harris and Grainne Gallagher
doi : 10.1016/j.bja.2022.10.024
Volume 130, Issue 2, February 2023, Pages e199-e200
Reporting excellence at Oxford Heart Centre
Elizabeth Russell 1, Rhiannon Furr2 , Craig New 3 and Alison Shefler
doi : 10.1016/j.bja.2022.10.025
Volume 130, Issue 2, February 2023, Page e200
Fibrinogen concentrate (Fibryga®) use in cardiac surgery: a single-centre retrospective analysis of coagulation correction and blood product administration
Matthew Baker and Dale Watson
doi : 10.1016/j.bja.2022.10.026
Volume 130, Issue 2, February 2023, Pages e200-e201
Intraoperative opioid strategy in adult cardiac surgery: a service evaluation of two alternative techniques
Pierre Vila, Paul Balfour, Olivia Kent and Madhusudan Puchakayala
doi : 10.1016/j.bja.2022.10.027
Volume 130, Issue 2, February 2023, Page e201
Evolving practice of perioperative pain management for cardiac surgery – patient-controlled analgesia, parasternal blocks, and beyond: a narrative experience from a regional centre
Shilpa Shankar, Laura Wilson, Grant Harris, David Mayhew and Anurodh Bhawnani
doi : 10.1016/j.bja.2022.10.028
Volume 130, Issue 2, February 2023, Pages e201-e202
Review of postoperative extubation in cardiac surgery patients
Alison Evans and Seena Thommachan
doi : 10.1016/j.bja.2022.10.029
Volume 130, Issue 2, February 2023, Pages e202-e203
Melatonin and sleep parameters in patients with chronic pain: first results from the double-blind randomised controlled trial of exogenous administration of melatonin in chronic pain (DREAM-CP) trial
Helen F. Galley 1, Uzunma Onyeakazi 1 , Malachy O. Columb 2 , Rosalind Adam 1 and Saravanakumar Kanakarajan
doi : 10.1016/j.bja.2022.10.007
Volume 130, Issue 2, February 2023, Page e204
Incidence and risk factors of postoperative cardiac complications: an international prospective cohort study
Sivesh K. Kamarajah, on behalf of the STARSurg & EuroSurg Collaborative
doi : 10.1016/j.bja.2022.10.008
Volume 130, Issue 2, February 2023, Pages e204-e205
Two-dimensional modelling of tracheostomy Above Cuff Vocalisation using computational fluid dynamics
A. Michael 1 , Rashid Jamshidi 1 , L. Tumi2 , M. Brown2, Brendan A. McGrath 2 and Rasool Erfani
doi : 10.1016/j.bja.2022.10.009
Volume 130, Issue 2, February 2023, Pages e205-e206
Long-term healthcare use after postoperative complications: a prospective analysis of linked primary and secondary care routine data
Alexander J. Fowler, Adam Brayne, Rupert M. Pearse and John R. Prowle
doi : 10.1016/j.bja.2022.10.010
Volume 130, Issue 2, February 2023, Page e206
Feasibility of right ventricular free wall longitudinal strain assessment of contractile reserve in patients undergoing lung resection
James McErlane, Adam Glass, Alvin Soosay, Philip McCall and Ben Shelley
doi : 10.1016/j.bja.2022.10.011
Volume 130, Issue 2, February 2023, Pages e206-e207
Investigating candidate modifier loci in malignant hyperthermia susceptibility using CRISPR/Cas gene editing
Rohan Paranjpe, Christine Diggle, Vikas Kaura, Marie-Anne Shaw and Phil Hopkins
doi : 10.1016/j.bja.2022.10.012
Volume 130, Issue 2, February 2023, Pages e207-e208
Managing Long COVID Syndrome, T. Vasu, TFM Publishing Limited (2022), p. 300, Price £25.00. ISBN 9781913755201
Aneeta Bhatia, James Chen and Jiapeng Huang
doi : 10.1016/j.bja.2022.10.043
Volume 130, Issue 2, February 2023, Pages 242-243
Presumption of insensibility during general anaesthesia
Andrew E. Hudson
doi : 10.1016/j.bja.2022.09.010
Volume 130, Issue 2, February 2023, Pages e209-e212
Microfluidics-assisted blood–brain barrier device: a powerful tool to study perioperative neurocognitive disorder
Zhongcong Xie
doi : 10.1016/j.bja.2022.08.024
Volume 130, Issue 2, February 2023, Pages e212-e214
Linking and unlinking the paediatric brain: age-invariant neural correlates of general anaesthesia
Michael P. Puglia II 1,2,* and George A. Mashour
doi : 10.1016/j.bja.2022.06.015
Volume 130, Issue 2, February 2023, Pages e215-e216
Connected consciousness after tracheal intubation in young adults: an international multicentre cohort study
Richard Lennertz 1 , Kane O. Pryor2 , Aeyal Raz3 , Maggie Parker 1 , Vincent Bonhomme 4 , Peter Schuller 5 , Gerhard Schneider 6 , Matt Moore 7 , Mark Coburn 8 , James C. Root 2,9 , Jacqueline M. Emerson2 , Alexandra L. Hohmann 2 , Haya Azaria 3 , Neta Golomb 3 , Aline Defresne 4 , Javier Montupil 4 , Stefanie Pilge 6 , David P. Obert 6 , Hanna van Waart 7 , Marta Seretny 7 , Rolf Rossaint10 , Ana Kowark 10 , Alexander Blair 1 , Bryan Krause 1 , Alex Proekt 11 , Max Kelz 11 , Jamie Sleigh 12 , Amy Gaskell 12 and Robert D. Sanders
doi : 10.1016/j.bja.2022.04.010
Volume 130, Issue 2, February 2023, Pages e217-e224
Connected consciousness, assessed by response to command, occurs in at least 5% of general anaesthetic procedures and perhaps more often in young people. Our primary objective was to establish the incidence of connected consciousness after tracheal intubation in young people aged 18–40 yr.
Quantitative analysis of early-stage EEG reactivity predicts awakening and recovery of consciousness in patients with severe brain injury
Eleonore Bouchereau 1,2, *, Angela Marchi 3 , Bertrand Hermann 4,5,6,y, Estelle Pruvost-Robieux 2,6,7,y, Eleonore Guinard 2,6,7 , Camille Legouy 1 , Caroline Schimpf 1 , Aurelien Mazeraud 1,6 , Jean-Claude Baron 2,6,8,9 , Celine Ramdani 10 , Martine Gavaret 2,6,7,9,z, Tarek Sharshar 1,2,6,9,z and Guillaume Turc
doi : 10.1016/j.bja.2022.09.005
Volume 130, Issue 2, February 2023, Pages e225-e232
Decisions of withdrawal of life-sustaining therapy for patients with severe brain injury are often based on prognostic evaluations such as analysis of electroencephalography (EEG) reactivity (EEG-R). However, EEG-R usually relies on visual assessment, which requires neurophysiological expertise and is prone to inter-rater variability.
The posterior dominant rhythm: an electroencephalographic biomarker for cognitive recovery after general anaesthesia
Alyssa K. Labonte 1,2,y, MohammadMehdi Kafashan 1,3,y, Emma R. Huels 1,4 , Stefanie Blain-Moraes 5 , Mathias Basner 6 , Max B. Kelz 7 , George A. Mashour 4 , Michael S. Avidan 1,3,8,9 , Ben Julian A. Palanca 1,2,3,9,10, *, and the ReCCognition Study Group
doi : 10.1016/j.bja.2022.01.019
Volume 130, Issue 2, February 2023, Pages e233-e242
The posterior dominant rhythm (PDR) was the first oscillatory pattern noted in the EEG. Evoked by wakeful eyelid closure, these oscillations dissipate over seconds during loss of arousal.
Processed electroencephalography-guided general anaesthesia to reduce postoperative delirium: a systematic review and meta-analysis
Matthew Sumner 1 , Carolyn Deng1 , Lis Evered 2,3,4 , Chris Frampton 5 , Kate Leslie4,6,7 , Timothy Short 1,8 and Doug Campbell
doi : 10.1016/j.bja.2022.01.006
Volume 130, Issue 2, February 2023, Pages e243-e253
Postoperative delirium (POD) is the most common serious postoperative complication in older adults. It has uncertain aetiology, limited preventative strategies, and poor long-term outcomes. This updated systematic review and meta-analysis aimed to estimate the effect of processed electroencephalography (pEEG)-guided general anaesthesia during surgery on POD incidence.
Perioperative risk factors associated with increased incidence of postoperative delirium: systematic review, meta-analysis, and Grading of Recommendations Assessment, Development, and Evaluation system report of clinical literature
Lior Mevorach 1, *, Ali Forookhi 1 , Alessio Farcomeni 2 , Stefano Romagnoli 3 and Federico Bilotta
doi : 10.1016/j.bja.2022.05.032
Volume 130, Issue 2, February 2023, Pages e254-e262
Systematic reviews to date have neglected to exclusively include studies using a validated diagnostic scale for postoperative delirium and monitoring patients for more than 24 h. Evidence on current risk factors is evolving with significantly heterogeneous study designs, inconsistent reporting of results, and a lack of adjustment for bias.
Contribution of intraoperative electroencephalogram suppression to frailty-associated postoperative delirium: mediation analysis of a prospective surgical cohort
Pan-pan Fang1,y, Zi-xiang Shang 1,y, Jian Xu 1 , Jun Hu 2 , Si-chen Zhang 3 , Yin-guang Fan3 , Yao Lu 1, *, Xue-Sheng Liu 1, * and Mervyn Maze
doi : 10.1016/j.bja.2022.11.002
Volume 130, Issue 2, February 2023, Pages e263-e271
Frailty is a risk factor for postoperative delirium (POD), and has led to preoperative interventions that have reduced, but not eliminated, the risk. We hypothesised that EEG suppression, another risk factor for POD, mediates some of the frailty risk for POD.
Effect of acute pain on the association between preoperative cognitive impairment and postoperative delirium: a secondary analysis of three trials
Jia-Hui Ma 1,y, Ya-Fei Liu 1,y, Hong Hong 1,y, Chun-Jing Li 1 , Fan Cui 1 , Dong-Liang Mu 1, * and Dong-Xin Wang
doi : 10.1016/j.bja.2022.06.033
Volume 130, Issue 2, February 2023, Pages e272-e280
The association between preoperative cognitive impairment, postoperative pain, and postoperative delirium in older patients after noncardiac surgery is not known.
Functional brain network and trail making test changes following major surgery and postoperative delirium: a prospective, multicentre, observational cohort study
Fienke L. Ditzel 1,y, *, Simone J. T. van Montfort 1,y, Lisette M. Vernooij 1,2 , Ilse M. J. Kant 1 , Ellen Aarts 1,3 , Claudia D. Spies 4 , Jeroen Hendrikse 5 , Arjen J. C. Slooter1,6 , Edwin van Dellen 1,7 on behalf of the Biomarker Development for Postoperative Cognitive Impairment in the Elderly Consortium
doi : 10.1016/j.bja.2022.07.054
Volume 130, Issue 2, February 2023, Pages e281-e288
Delirium is a frequent complication after surgery in older adults and is associated with an increased risk of long-term cognitive impairment and dementia. Disturbances in functional brain networks were previously reported during delirium.
Sevoflurane dose and postoperative delirium: a prospective cohort analysis
Jennifer Taylor 1,2 , Thomas Payne 1,2 , Cameron Casey 3 , David Kunkel 3 , Maggie Parker 3 , Cameron Rivera 3 , Henrik Zetterberg 4,5,6,7,8 , Kaj Blennow 4 , Robert A. Pearce 3 , Richard C. Lennertz 3 , Tim McCulloch 1,2 , Amy Gaskell 9 and Robert D. Sanders
doi : 10.1016/j.bja.2022.08.022
Volume 130, Issue 2, February 2023, Pages e289-e297
Recent trials are conflicting as to whether titration of anaesthetic dose using electroencephalography monitoring reduces postoperative delirium. Titration to anaesthetic dose itself might yield clearer conclusions. We analysed our observational cohort to clarify both dose ranges for trials of anaesthetic dose and biological plausibility of anaesthetic dose influencing delirium.
Dose-dependent relationship between intra-procedural hypoxaemia or hypocapnia and postoperative delirium in older patients
Elena Ahrens1,2 , Tim M. Tartler 1,2 , Aiman Suleiman 1,2,3 , Luca J. Wachtendorf 1,2,4 , Haobo Ma 1 , Guanqing Chen 1,2 , Samir M. Kendale 1 , Peter Kienbaum5 , Balachundhar Subramaniam 1,6 , Soeren Wagner 1,7,8 and Maximilian S. Schaefer
doi : 10.1016/j.bja.2022.08.032
Volume 130, Issue 2, February 2023, Pages e298-e306
Previous studies indicated an association between impaired cerebral perfusion and post-procedural neurological disorders. We investigated whether intra-procedural hypoxaemia or hypocapnia are associated with delirium after surgery.
Dexmedetomidine administration during brain tumour resection for prevention of postoperative delirium: a randomised trial
Shu Li 1,y, Ruowen Li 1,y, Muhan Li 1 , Qianyu Cui 1 , Xingyue Zhang 1 , Tingting Ma 1 , Dexiang Wang1 , Min Zeng1 , Hao Li 2 , Zhaoshi Bao3 , Yuming Peng 1, * and Daniel I. Sessler
doi : 10.1016/j.bja.2022.10.041
Volume 130, Issue 2, February 2023, Pages e307-e316
Delirium is common, especially after neurosurgery. Dexmedetomidine might reduce delirium by improving postoperative analgesia and sleep quality. We tested the primary hypothesis that dexmedetomidine administration during intracerebral tumour resection reduces the incidence of postoperative delirium.
Depth of anaesthesia and mortality after cardiac or noncardiac surgery: a systematic review and meta-analysis of randomised controlled trials
Thomas Payne 1,2, *, Hannah Braithwaite 2 , Tim McCulloch 2 , Michael Paleologos 2 , Charlotte Johnstone 2 , Jordan Wehrman 1 , Jennifer Taylor 1 , John Loadsman 1,2 , Andy Y. Wang2,3 and Robert D. Sanders
doi : 10.1016/j.bja.2022.08.034
Volume 130, Issue 2, February 2023, Pages e317-e329
Recent randomised controlled trials have failed to show a benefit in mortality by using processed electroencephalography (pEEG) to guide lighter anaesthesia. We performed a meta-analysis of mortality data from randomised trials of pEEG monitoring to assess the evidence of any protective effect of pEEG-guided light anaesthesia compared with deep anaesthesia in adults aged ≥18 yr.
Effects of remifentanil on brain responses to noxious stimuli during deep propofol sedation
Jesus Pujol 1,2, *, Gerard Martı �nez-Vilavella 1 , Lluı �s Gallart3,4 , Laura Blanco-Hinojo 1,2 , Susana Pacreu 3 , Vincent Bonhomme 5,6 , Joan Deus1,7 , Vı �ctor Perez-Sola 2,8 , Pedro L. Gambu � s 9 and Juan Fernandez-Candil
doi : 10.1016/j.bja.2022.06.038
Volume 130, Issue 2, February 2023, Pages e330-e338
The safety of anaesthesia has improved as a result of better control of anaesthetic depth. However, conventional monitoring does not inform on the nature of nociceptive processes during unconsciousness.
Electroencephalogram-based prediction and detection of responsiveness to noxious stimulation in critical care patients: a retrospective single-centre analysis
Viktor Bublitz 1,3, *, Carlo Jurth 1 , Matthias Kreuzer 2 , Gregor Lichtner 1,3 and Falk von Dincklage
doi : 10.1016/j.bja.2022.09.031
Volume 130, Issue 2, February 2023, Pages e339-e350
Monitoring of pain and nociception in critical care patients unable to self-report pain remains a challenge, as clinical signs are neither sensitive nor specific. Available technical approaches are limited by various constraints.
Cognitive deficits after general anaesthesia in animal models: a scoping review
Ling Yi Guo 1 , Lilia Kaustov 2,3 , Connor T. A. Brenna 3,4 , Vikas Patel 4 , Cheng Zhang 2,3 , Stephen Choi 2,3 , Stephen Halpern 2 , Dian-Shi Wang1,3 and Beverley A. Orser
doi : 10.1016/j.bja.2022.10.004
Volume 130, Issue 2, February 2023, Pages e351-e360
It remains controversial whether general anaesthetic drugs contribute to perioperative neurocognitive disorders in adult patients. Preclinical studies have generated conflicting results, likely because of differing animal models, study protocols, and measured outcomes.
Perioperative ischaemic brain injury and plasma neurofilament light: a secondary analysis of two prospective cohort studies
Jennifer Taylor 1,2 , Laura Eisenmenger 3 , Heidi Lindroth 4 , James Booth 2 , Rosaleena Mohanty 3,5 , Veena Nair 3 , Margaret Parker 6 , David Kunkel 6 , Cameron Rivera 6 , Cameron Casey 6 , Henrik Zetterberg 7,8,9,10,11 , Kaj Blennow 7 , Marko Mrkobrada 12 , Philip J. Devereaux 13,14,15 , Robert A. Pearce 6 , Richard Lennertz 6 , Vivek Prabhakaran 3 and Robert D. Sanders
doi : 10.1016/j.bja.2022.10.018
Volume 130, Issue 2, February 2023, Pages e361-e369
Ischaemic brain infarction can occur without acute neurological symptoms (covert strokes) or with symptoms (overt strokes), both associated with poor health outcomes.
Protective effects of omega-3 fatty acids in a blood–brain barrier-on-chip model and on postoperative delirium-like behaviour in mice
Ting Yang1, * ,y, Ravikanth Velagapudi2,y, Cuicui Kong2,y, Unghyeon Ko3 , Vardhman Kumar4 , Paris Brown4 , Nathan O. Franklin5 , Xiaobei Zhang2 , Ana I. Caceres2 , Hyunjung Min6 , Anthony J. Filiano6,7 , Ramona M. Rodriguiz5 , William C. Wetsel5,8,9 , Shyni Varghese3,4,10 and Niccolo Terrando
doi : 10.1016/j.bja.2022.05.025
Volume 130, Issue 2, February 2023, Pages e370-e380
Peripheral surgical trauma can trigger neuroinflammation and ensuing neurological complications, such as delirium. The mechanisms whereby surgery contributes to postoperative neuroinflammation remain unclear and without effective therapies.
Emerging functional connectivity patterns during sevoflurane anaesthesia in the developing human brain
Adela Desowska*, Charles B. Berdey and Laura Cornelissen
doi : 10.1016/j.bja.2022.05.033
Volume 130, Issue 2, February 2023, Pages e381-e390
Role of midbrain dopaminergic neurones in post-anaesthetic cognitive recovery in rats
Kathleen Vincent 1,2 , Angel Cho1 , Olivia Moody 1,2 , Risako Kato 1,2 , Edlyn Zhang 1,2 and Ken Solt
doi : 10.1016/j.bja.2022.07.022
Volume 130, Issue 2, February 2023, Page e391
Acute dexmedetomidine-induced changes in measures of white matter microstructure and connectivity
Oskari Kantonen 1,2 , Timo Roine2,3 , Jaakko Langsj€o1 , Kimmo Kaskinoro 2 , Roosa Kallionp€a€a
doi : 10.1016/j.bja.2022.07.023
Volume 130, Issue 2, February 2023, Page e392
Pharmacodynamics of a stimulus-free behavioural paradigm to track conscious states during sedation with dexmedetomidine
Christian S. Guay1 , Darren Hight2 and Ben J. Palanca 1
doi : 10.1016/j.bja.2022.07.024
Volume 130, Issue 2, February 2023, Pages e393-e394
Thalamic activity is a neural correlate of connected consciousness
Oskari Kantonen 1,2 , Lauri Laaksonen 1,2 , Michael Alkire 3 , Annalotta Scheinin 1,2 , Jaakko La ̊ ngsj€o 1 , Roosa E. Kallionp€a€a 1,2 , Kaike Kaisti 1 , Linda Radek 1 , Jarkko Johansson 1 , Timo Laitio 2 , Anu Maksimow 2 , Joonas Scheinin 2 , Mikko Nyman2 , Mika Scheinin 1,2 , Olof Solin1 , Tero Vahlberg 1 , Antti Revonsuo 1,4 , Katja Valli 1,2,4 and Harry Scheinin
doi : 10.1016/j.bja.2022.07.025
Volume 130, Issue 2, February 2023, Pages e394-e395
Quantifying the changing epidemiology of delirium in England 1998–2021: a health economics evaluation
Matthew Luney and Martyn Ezra
doi : 10.1016/j.bja.2022.07.026
Volume 130, Issue 2, February 2023, Pages e395-e396
Progress towards MAC-amnesia
Talmage D. Egan, Ken B. Johnson, Alper Sen, Nathan L. Pace, Kane O. Pryor, Odmara L. Barreto-Chang and David MacLeod, for the OLIVER Study Group*
doi : 10.1016/j.bja.2022.07.027
Volume 130, Issue 2, February 2023, Page e396
Subjective experiences are similar during anaesthetic-induced unresponsiveness and non-rapid eye movement sleep
Linda Radek1 , Roosa E. Kallionp€a€a1,2 , Annalotta Scheinin 1,2 , Jaakko La ̊ ngsj€o 1 , Kaike Kaisti 1 , Oskari Kantonen 1 , Jarno Korhonen1 , Tero Vahlberg 1 , Antti Revonsuo 1,3 , Harry Scheinin 1,2 and Katja Valli
doi : 10.1016/j.bja.2022.07.028
Volume 130, Issue 2, February 2023, Pages e397-e398
Protection versus damage by anaesthetics: a matter of biological context and genetic background
Misha Perouansky, Dena Johnson-Schlitz and David A. Wassarman
doi : 10.1016/j.bja.2022.07.029
Volume 130, Issue 2, February 2023, Pages e398-e399
The posterior dominant rhythm: an electroencephalographic surrogate for cognitive recovery after general anaesthesia
Alyssa K. Labonte1,y, Mohammad Mehdi Kafashan1,y, Emma R. Huels2 , Stefanie Blain-Moraes3 , Mathias Basner4 , Max B. Kelz4 , George A. Mashour2 , Michael S. Avidan1 and Ben Julian A. Palanca1 , ReCCognition Study Group
doi : 10.1016/j.bja.2022.07.030
Volume 130, Issue 2, February 2023, Pages e399-e400
