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DAMPening Mortality in COVID-19
Nordin M.J. Hanssen, Bart Spaetgens, Prabhakara R. Nagareddy, Andrew J. Murphy
doi : 10.1161/CIRCULATIONAHA.120.053025
Circulation. 2021 | Volume 143, Issue 10: 971–973
Gestational Diabetes History and Glucose Tolerance After Pregnancy Associated With Coronary Artery Calcium in Women During Midlife
Erica P. Gunderson, Baiyang Sun, Janet M. Catov, Mercedes Carnethon, Cora E. Lewis, Norrina B. Allen, Stephen Sidney, Melissa Wellons, Jamal S. Rana, Lifang Hou, John Jeffrey Carr
doi : 10.1161/CIRCULATIONAHA.120.047320
Circulation. 2021 | Volume 143, Issue 10: 974–987
Gestational diabetes (GD) leads to earlier onset and heightened risk of type 2 diabetes, a strong risk factor for cardiovascular disease (CVD). However, it is unclear whether attaining normoglycemia can ameliorate the excess CVD risk associated with GD history. This study sought to evaluate GD history and glucose tolerance after pregnancy associated with coronary artery calcification (CAC) in women, a manifestation of atherosclerotic CVD and a predictor of CVD clinical events.
Cardiovascular Consequences of Gestational Diabetes
Jennifer B. Green
doi : 10.1161/CIRCULATIONAHA.120.052995
Circulation. 2021 | Volume 143, Issue 10: 988–990
Variation in the Proportion of Adults in Need of Blood Pressure–Lowering Medications by Hypertension Care Guideline in Low- and Middle-Income Countries
Nikkil Sudharsanan, Michaela Theilmann, Tabea K. Kirschbaum, Jennifer Manne-Goehler, Sina Azadnajafabad, Pascal Bovet, Simiao Chen, Albertino Damasceno, Jan-Walter De Neve, Maria Dorobantu, Cara Ebert, Farshad Farzadfar, Gladwell Gathecha, Mongal Singh Gurung, Kosar Jamshidi, Jutta M.A. J?rgensen, Demetre Labadarios, Julia Lemp, Nuno Lunet, Joseph K. Mwangi, Sahar Saeedi Moghaddam, Silver K. Bahendeka, Zhaxybay Zhumadilov, Till B?rnighausen, Sebastian Vollmer, Rifat Atun, Justine I. Davies, Pascal Geldsetzer
doi : 10.1161/CIRCULATIONAHA.120.051620
Circulation. 2021 | Volume 143, Issue 10: 991–1001
Current hypertension guidelines vary substantially in their definition of who should be offered blood pressure–lowering medications. Understanding the effect of guideline choice on the proportion of adults who require treatment is crucial for planning and scaling up hypertension care in low- and middle-income countries.
Emulating Randomized Clinical Trials With Nonrandomized Real-World Evidence Studies
Jessica M. Franklin, Elisabetta Patorno, Rishi J. Desai, Robert J. Glynn, David Martin, Kenneth Quinto, Ajinkya Pawar, Lily G. Bessette, Hemin Lee, Elizabeth M. Garry, Nileesa Gautam, Sebastian Schneeweiss
doi : 10.1161/CIRCULATIONAHA.120.051718
Circulation. 2021 | Volume 143, Issue 10: 1002–1013
Regulators are evaluating the use of noninterventional real-world evidence (RWE) studies to assess the effectiveness of medical products. The RCT DUPLICATE initiative (Randomized, Controlled Trials Duplicated Using Prospective Longitudinal Insurance Claims: Applying Techniques of Epidemiology) uses a structured process to design RWE studies emulating randomized, controlled trials (RCTs) and compare results. We report findings of the first 10 trial emulations, evaluating cardiovascular outcomes of antidiabetic or antiplatelet medications.
Role of IgE-Fc?R1 in Pathological Cardiac Remodeling and Dysfunction
Hongmei Zhao, Hongqin Yang, Chi Geng, Yang Chen, Junling Pang, Ting Shu, Meijun Zhao, Yaqin Tang, Zhiwei Li, Baicun Li, Cuiliu Hou, Xiaomin Song, Aoxue Wu, Xiaoxiao Guo, Si Chen, Bin Liu, Chen Yan, Jing Wang
doi : 10.1161/CIRCULATIONAHA.120.047852
Circulation. 2021 | Volume 143, Issue 10: 1014–1030
Immunoglobulin E (IgE) belongs to a class of immunoglobulins involved in immune response to specific allergens. However, the roles of IgE and IgE receptor (Fc?R1) in pathological cardiac remodeling and heart failure are unknown.
Microthrombi as a Major Cause of Cardiac Injury in COVID-19
Dario Pellegrini, Rika Kawakami, Giulio Guagliumi, Atsushi Sakamoto, Kenji Kawai, Andrea Gianatti, Ahmed Nasr, Robert Kutys, Liang Guo, Anne Cornelissen, Lara Faggi, Masayuki Mori, Yu Sato, Irene Pescetelli, Matteo Brivio, Maria Romero, Renu Virmani, Aloke V. Finn
doi : 10.1161/CIRCULATIONAHA.120.051828
Circulation. 2021 | Volume 143, Issue 10: 1031–1042
Cardiac injury is common in patients who are hospitalized with coronavirus disease 2019 (COVID-19) and portends poorer prognosis. However, the mechanism and the type of myocardial damage associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain uncertain.
Transcatheter Aortic Valve Replacement in Bicuspid Aortic Valve Stenosis
Flavien Vincent, Julien Ternacle, Tom Denimal, Mylène Shen, Bjorn Redfors, Cédric Delhaye, Matheus Simonato, Nicolas Debry, Basile Verdier, Bahira Shahim, Thibault Pamart, Hugues Spillemaeker, Guillaume Schurtz, François Pontana, Vinod H. Thourani, Philippe Pibarot, Eric Van Belle
doi : 10.1161/CIRCULATIONAHA.120.048048
Circulation. 2021 | Volume 143, Issue 10: 1043–1061
After 15 years of successive randomized, controlled trials, indications for transcatheter aortic valve replacement (TAVR) are rapidly expanding. In the coming years, this procedure could become the first line treatment for patients with a symptomatic severe aortic stenosis and a tricuspid aortic valve anatomy. However, randomized, controlled trials have excluded bicuspid aortic valve (BAV), which is the most frequent congenital heart disease occurring in 1% to 2% of the total population and representing at least 25% of patients 80 years of age or older referred for aortic valve replacement. The use of a less invasive transcatheter therapy in this elderly population became rapidly attractive, and approximately 10% of patients currently undergoing TAVR have a BAV. The U.S. Food and Drug Administration and the “European Conformity” have approved TAVR for low-risk patients regardless of the aortic valve anatomy whereas international guidelines recommend surgical replacement in BAV populations. Given this progressive expansion of TAVR toward younger and lower-risk patients, heart teams are encountering BAV patients more frequently, while the ability of this therapy to treat such a challenging anatomy remains uncertain. This review will address the singularity of BAV anatomy and associated technical challenges for the TAVR procedure. We will examine and summarize available clinical evidence and highlight critical knowledge gaps regarding TAVR utilization in BAV patients. We will provide a comprehensive overview of the role of computed tomography scans in the diagnosis, and classification of BAV and TAVR procedure planning. Overall, we will offer an integrated framework for understanding the current role of TAVR in the treatment of bicuspid aortic stenosis and for guiding physicians in clinical decision-making.
A Tale of 2 Blocks
Ajay Pillai, Kenneth A. Ellenbogen, Santosh K. Padala
doi : 10.1161/CIRCULATIONAHA.120.052981
Circulation. 2021 | Volume 143, Issue 10: 1062–1065
Short-Chain Enoyl-CoA Hydratase Mediates Histone Crotonylation and Contributes to Cardiac Homeostasis
Xiaoqiang Tang, Xiao-Feng Chen, Xin Sun, Peng Xu, Xiang Zhao, Ying Tong, Xiao-Man Wang, Ke Yang, Yu-Tong Zhu, De-Long Hao, Zhu-Qin Zhang, De-Pei Liu, Hou-Zao Chen
doi : 10.1161/CIRCULATIONAHA.120.049438
Circulation. 2021 | Volume 143, Issue 10: 1066–1069
Letter by Loomba et al Regarding Article, “Acute Heart Failure in Multisystem Inflammatory Syndrome in Children in the Context of Global SARS-CoV-2 Pandemic”
Rohit S. Loomba, Enrique G. Villarreal, Saul Flores
doi : 10.1161/CIRCULATIONAHA.120.048968
Circulation. 2021 | Volume 143, Issue 10: e755–e756
Letter by Cardenas Suri and Jimomila Bening Regarding Article, “Acute Heart Failure in Multisystem Inflammatory Syndrome in Children in the Context of Global SARS-CoV-2 Pandemic”
Hisyovi Cardenas Suri, David Jimomila Bening
doi : 10.1161/CIRCULATIONAHA.120.049139
Circulation. 2021 | Volume 143, Issue 10: e757–e758
Letter by Navarro Castellanos and Dahdah Regarding Article, “Acute Heart Failure in Multisystem Inflammatory Syndrome in Children in the Context of Global SARS-CoV-2 Pandemic”
I?aki Navarro Castellanos, Nagib Dahdah
doi : 10.1161/CIRCULATIONAHA.120.049239
Circulation. 2021 | Volume 143, Issue 10: e759–e760
Letter by Ren et al Regarding Article, “Acute Heart Failure in Multisystem Inflammatory Syndrome in Children in the Context of Global SARS-CoV-2 Pandemic”
Chuanli Ren, Manning Qian, Chongxu Han
doi : 10.1161/CIRCULATIONAHA.120.051555
Circulation. 2021 | Volume 143, Issue 10: e761–e762
Psychological Health, Well-Being, and the Mind-Heart-Body Connection: A Scientific Statement From the American Heart Association
Glenn N. Levine, Beth E. Cohen, Yvonne Commodore-Mensah, Julie Fleury, Jeff C. Huffman, Umair Khalid, Darwin R. Labarthe, Helen Lavretsky, Erin D. Michos, Erica S. Spatz, Laura D. Kubzansky and On behalf of the American Heart Association Council on Clinical Cardiology; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular and Stroke Nursing; and Council on Lifestyle and Cardiometabolic Health
doi : 10.1161/CIR.0000000000000947
Circulation. 2021 | Volume 143, Issue 10: e763–e783
As clinicians delivering health care, we are very good at treating disease but often not as good at treating the person. The focus of our attention has been on the specific physical condition rather than the patient as a whole. Less attention has been given to psychological health and how that can contribute to physical health and disease. However, there is now an increasing appreciation of how psychological health can contribute not only in a negative way to cardiovascular disease (CVD) but also in a positive way to better cardiovascular health and reduced cardiovascular risk. This American Heart Association scientific statement was commissioned to evaluate, synthesize, and summarize for the health care community knowledge to date on the relationship between psychological health and cardiovascular health and disease and to suggest simple steps to screen for, and ultimately improve, the psychological health of patients with and at risk for CVD. Based on current study data, the following statements can be made: There are good data showing clear associations between psychological health and CVD and risk; there is increasing evidence that psychological health may be causally linked to biological processes and behaviors that contribute to and cause CVD; the preponderance of data suggest that interventions to improve psychological health can have a beneficial impact on cardiovascular health; simple screening measures can be used by health care providers for patients with or at risk for CVD to assess psychological health status; and consideration of psychological health is advisable in the evaluation and management of patients with or at risk for CVD.
Correction to: 2020 ACC/AHA Guideline on the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines
doi : 10.1161/CIR.0000000000000966
Circulation. 2021 | Volume 143, Issue 10: e784
Correction to: Hck/Fgr Kinase Deficiency Reduces Plaque Growth and Stability by Blunting Monocyte Recruitment and Intraplaque Motility
doi : 10.1161/CIR.0000000000000965
Circulation. 2021 | Volume 143, Issue 10: e785
