دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
-
http://medilib.ir
- ﻣﺪﺕ ﺯﻣﺎﻥ : 365 ﺭﻭﺯ
قیمت : 3,800,000 تومان- قیمت ویژه : 1,900,000تومان
Toxicity and Biocompatibility of Liquid Metals (Adv. Healthcare Mater. 3/2023)
Sen Chen, Ruiqi Zhao, Xuyang Sun, Hongzhang Wang, Lei Li, Jing Liu
doi : 10.1002/adhm.202370008
Volume 12, Issue 3
Photosensitive and Conductive Hydrogel Induced Innerved Bone Regeneration for Infected Bone Defect Repair (Adv. Healthcare Mater. 3/2023)
Xirui Jing, Chao Xu, Weijie Su, Qiuyue Ding, Bing Ye, Yanlin Su, Keda Yu, Lian Zeng, Xu Yang, Yanzhen Qu, Kaifang Chen, Tingfang Sun, Zhiqiang Luo, Xiaodong Guo
doi : 10.1002/adhm.202370009
Wearable Hydrogel-Based Epidermal Sensor with Thermal Compatibility and Long Term Stability for Smart Colorimetric Multi-Signals Monitoring (Adv. Healthcare Mater. 3/2023)
Fei Han, Xueyong Xie, Tiansong Wang, Chaoyu Cao, Juju Li, Tianying Sun, Hao Liu, Songmei Geng, Zhao Wei, Jing Li, Feng Xu
doi : 10.1002/adhm.202370012
Self-Assembled Integrative Nutrient Carrier Platform Containing Green Tea Catechin for Short Bowel Syndrome Treatment (Adv. Healthcare Mater. 3/2023)
Zhengming Zhou, Ke Li, Lei Shi, Yunfeng Wang, Yunxiang He, Wen Hu, Junling Guo
doi : 10.1002/adhm.202370013
Toxicity and Biocompatibility of Liquid Metals
Sen Chen, Ruiqi Zhao, Xuyang Sun, Hongzhang Wang, Lei Li, Jing Liu
doi : 10.1002/adhm.202201924
Recently, room-temperature liquid metals have attracted increasing attention from researchers owing to their excellent material properties. Systematic interpretation of the potential toxicity issues involved is essential for a wide range of applications, especially in the biomedical and healthcare fields.
Photosensitive and Conductive Hydrogel Induced Innerved Bone Regeneration for Infected Bone Defect Repair
Xirui Jing, Chao Xu, Weijie Su, Qiuyue Ding, Bing Ye, Yanlin Su, Keda Yu, Lian Zeng, Xu Yang, Yanzhen Qu, Kaifang Chen, Tingfang Sun, Zhiqiang Luo, Xiaodong Guo
doi : 10.1002/adhm.202201349
Repairing infected bone defects is a challenge in the field of orthopedics because of the limited self-healing capacity of bone tissue and the susceptibility of refractory materials to bacterial activity.
Wearable Hydrogel-Based Epidermal Sensor with Thermal Compatibility and Long Term Stability for Smart Colorimetric Multi-Signals Monitoring
Fei Han, Xueyong Xie, Tiansong Wang, Chaoyu Cao, Juju Li, Tianying Sun, Hao Liu, Songmei Geng, Zhao Wei, Jing Li, Feng Xu
doi : 10.1002/adhm.202201730
Hydrogel-based wearable epidermal sensors (HWESs) have attracted widespread attention in health monitoring, especially considering their colorimetric readout capability.
Self-Assembled Integrative Nutrient Carrier Platform Containing Green Tea Catechin for Short Bowel Syndrome Treatment
Zhengming Zhou, Ke Li, Lei Shi, Yunfeng Wang, Yunxiang He, Wen Hu, Junling Guo
doi : 10.1002/adhm.202201933
Extensive resection of the small intestine leads to the development of short bowel syndrome (SBS), which reduces the effective absorptive surface area of the intestine and predisposes patients to emaciation, malnutrition, and other severe symptoms.
Controlled Delivery of Corticosteroids Using Tunable Tough Adhesives
Esther Koh, Benjamin R Freedman, Farshad Ramazani, Johannes Gross, Adam Graham, Andreas Kuttler, Eckhard Weber, David J Mooney
doi : 10.1002/adhm.202201000
Hydrogel-based drug delivery systems typically aim to release drugs locally to tissue in an extended manner. Tissue adhesive alginate-polyacrylamide tough hydrogels are recently demonstrated to serve as an extended-release system for the corticosteroid triamcinolone acetonide.
Biodegradable Carbon Dioxide-Derived Non-Viral Gene Vectors for Osteosarcoma Gene Therapy
Meirong Li, Zheng-Ian Lin, Jingyu Yang, Haoqiang Huang, Guan-Lin Liu, Qiqi Liu, Xinmeng Zhang, Ying Zhang, Zhourui Xu, Haoming Lin, Yujuan Chai, Xin Chen, Bao-Tsan Ko, Jia Liu, Chih-Kuang Chen, Chengbin Yang
doi : 10.1002/adhm.202201306
Osteosarcoma often occurs in children and adolescents with high invasiveness and high mortality. Polo-like kinase 1 (PLK1) overexpressed in most tumors promotes cancer cell proliferation and transformation.
Versatile Red Blood Cells for Triple-Negative Breast Cancer Treatment via Stepwise Photoactivations
Yuanyuan Cheng, Qian Chen, Zhanyin Qian, Tianhe Shan, Liya Bai, Xiaoyu Jiang, Chunyu Li, Yinsong Wang
doi : 10.1002/adhm.202201690
Phototherapies have many advantages for triple-negative breast cancer (TNBC) treatment. However, their effects are often limited by short blood circulation time, poor tumor selectivity and weak penetration of phototherapeutic agents, and tumor hypoxia.
Superwetting Injectable Hydrogel with Ultrastrong and Fast Tissue Adhesion for Minimally Invasive Hemostasis
Congying Wei, Weili Shi, Chuangqi Zhao, Shuai Yang, Jiajia Zheng, JinPan Zhong, Tianyi Zhao, Simin Kong, Xi Gong, Mingjie Liu
doi : 10.1002/adhm.202201799
Injectable hydrogels have recently emerged as alternatives to sutures for various clinical indications. However, existing injectable hydrogels are unsuitable for hemostasis in minimally invasive surgery because of their weak interfacial adhesion and complex/prolonged processing.
Invasion and Secondary Site Colonization as a Function of In Vitro Primary Tumor Matrix Stiffness: Breast to Bone Metastasis
Lekha Shah, Ayşe Latif, Kaye J. Williams, Elena Mancuso, Annalisa Tirella
doi : 10.1002/adhm.202201898
Increased breast tissue stiffness is correlated with breast cancer risk and invasive cancer progression. However, its role in promoting bone metastasis, a major cause of mortality, is not yet understood.
Swelling-Mediated Mechanical Stimulation Regulates Differentiation of Adipose-Derived Mesenchymal Stem Cells for Intervertebral Disc Repair Using Injectable UCST Microgels
Xianpeng Huang, Di Chen, Chengzhen Liang, Kesi Shi, Xiaopeng Zhou, Yuang Zhang, Yi Li, Jiangjie Chen, Kaishun Xia, Jiawei Shu, Biao Yang, Jingkai Wang, Haibin Xu, Chao Yu, Feng Cheng, Shaoke Wang, Yongxiang Zhang, Chenggui Wang, Liwei Ying, Hao Li, Meiling Han, Fangcai Li, Yiqing Tao, Qian Zhao, Qixin Chen
doi : 10.1002/adhm.202201925
Mechanical stimulation is an effective approach for controlling stem cell differentiation in tissue engineering. However, its realization in in vivo tissue repair remains challenging since this type of stimulation can hardly be applied to injectable seeding systems.
Graphene Oxide Nanoscale Platform Enhances the Anti-Cancer Properties of Bortezomib in Glioblastoma Models
Paul S. Sharp, Maria Stylianou, Luis M. Arellano, Juliana C. Neves, Alfredo M. Gravagnuolo, Abbie Dodd, Katharine Barr, Neus Lozano, Thomas Kisby, Kostas Kostarelos
doi : 10.1002/adhm.202201968
Graphene-based 2D nanomaterials possess unique physicochemical characteristics which can be utilized in various biomedical applications, including the transport and presentation of chemotherapeutic agents. In glioblastoma multiforme (GBM), intratumorally administered thin graphene oxide (GO) nanosheets demonstrate a widespread distribution throughout the tumor volume without impact on tumor growth, nor spread into normal brain tissue.
Violet Phosphorus Nanosheet: A Biocompatible and Stable Platform for Stimuli-Responsive Multimodal Cancer Phototherapy
Chen Zhao, Xiao Han, Shanshan Wang, ZhenYi Pan, Xiaoying Tang, Zhenqi Jiang
doi : 10.1002/adhm.202201995
As a functional 2D material, black phosphorus (BP) has garnered wide attention from many researchers in recent years. BP has a wide NIR absorption window and is a promising candidate for cancer phototherapy including photothermal therapy (PTT) and photodynamic therapy (PDT).
Stress Relaxation-Induced Colon Tumor Multicellular Spheroid Culture Based on Biomimetic Hydrogel for Nanoenzyme Ferroptosis Sensitization Evaluation
Yi Zhang, Liyi Peng, Ke Hu, Ning Gu
doi : 10.1002/adhm.202202009
Ferroptosis has recently become a research hotspot, and the induction of tumor cell ferroptosis has emerged as a powerful method for tumor therapy. However, the efficiency of tumor cell ferroptosis induction remains unmet for clinical use, which may be attributed to the large discrepancies between in vitro and in vivo models.
Boosting Doxorubicin-Induced Mitochondria Apoptosis for the Monodrug-Mediated Combination of Chemotherapy and Chemodynamic Therapy
Tao Liu, Cheng-Feng Xiong, Lin-Jun Zhang, Guan-Hua Jiao, Hui Shi, Jun Feng, Xian-Zheng Zhang
doi : 10.1002/adhm.202202045
Doxorubicin (Dox)-mediated generation of reactive oxygen radicals (ROS) for mitochondrial apoptosis is identified as a new cytotoxic mechanism in addition to the well-established one via nuclear DNA replication interference. However, this mechanism contributes far less than the latter to Dox therapy.
Lipid Nanoparticle Delivery of Chemically Modified NGFR100W mRNA Alleviates Peripheral Neuropathy
Xiang Yu, Zheng Yang, Yu Zhang, Jia Xia, Jiahui Zhang, Qi Han, Hang Yu, Chengbiao Wu, Yingjie Xu, Wei Xu, Wen Yang
doi : 10.1002/adhm.202202127
Messenger RNA (mRNA) carries genetic instructions to the cell machinery for the transient production of antigens or therapeutic proteins and shows enormous potential in vaccine development, cancer immunotherapy, protein replacement therapy, and genome engineering.
Highly Efficient Photodynamic Therapy with Mitochondria-Targeting Aggregation-Induced Emission Photosensitizer for Retinoblastoma (Adv. Healthcare Mater. 3/2023)
Lingbo Zhou, Luojia Chen, Sijie Chen, Zeyuan Pu, Meijia Gu, Yin Shen
doi : 10.1002/adhm.202370011
Highly Efficient Photodynamic Therapy with Mitochondria-Targeting Aggregation-Induced Emission Photosensitizer for Retinoblastoma
Lingbo Zhou, Luojia Chen, Sijie Chen, Zeyuan Pu, Meijia Gu, Yin Shen
doi : 10.1002/adhm.202202219
Retinoblastoma (RB) is an aggressive eye cancer in infancy and childhood, lethal by metastasis if left untreated. Currently, the survival rate and the chance of saving vision depend on the severity of the disease.
Toxicity and Biocompatibility of Liquid Metals (Adv. Healthcare Mater. 3/2023)
Sen Chen, Ruiqi Zhao, Xuyang Sun, Hongzhang Wang, Lei Li, Jing Liu
doi : 10.1002/adhm.202370008
Volume 12, Issue 3
Photosensitive and Conductive Hydrogel Induced Innerved Bone Regeneration for Infected Bone Defect Repair (Adv. Healthcare Mater. 3/2023)
Xirui Jing, Chao Xu, Weijie Su, Qiuyue Ding, Bing Ye, Yanlin Su, Keda Yu, Lian Zeng, Xu Yang, Yanzhen Qu, Kaifang Chen, Tingfang Sun, Zhiqiang Luo, Xiaodong Guo
doi : 10.1002/adhm.202370009
Wearable Hydrogel-Based Epidermal Sensor with Thermal Compatibility and Long Term Stability for Smart Colorimetric Multi-Signals Monitoring (Adv. Healthcare Mater. 3/2023)
Fei Han, Xueyong Xie, Tiansong Wang, Chaoyu Cao, Juju Li, Tianying Sun, Hao Liu, Songmei Geng, Zhao Wei, Jing Li, Feng Xu
doi : 10.1002/adhm.202370012
Self-Assembled Integrative Nutrient Carrier Platform Containing Green Tea Catechin for Short Bowel Syndrome Treatment (Adv. Healthcare Mater. 3/2023)
Zhengming Zhou, Ke Li, Lei Shi, Yunfeng Wang, Yunxiang He, Wen Hu, Junling Guo
doi : 10.1002/adhm.202370013
Toxicity and Biocompatibility of Liquid Metals
Sen Chen, Ruiqi Zhao, Xuyang Sun, Hongzhang Wang, Lei Li, Jing Liu
doi : 10.1002/adhm.202201924
Recently, room-temperature liquid metals have attracted increasing attention from researchers owing to their excellent material properties. Systematic interpretation of the potential toxicity issues involved is essential for a wide range of applications, especially in the biomedical and healthcare fields.
Photosensitive and Conductive Hydrogel Induced Innerved Bone Regeneration for Infected Bone Defect Repair
Xirui Jing, Chao Xu, Weijie Su, Qiuyue Ding, Bing Ye, Yanlin Su, Keda Yu, Lian Zeng, Xu Yang, Yanzhen Qu, Kaifang Chen, Tingfang Sun, Zhiqiang Luo, Xiaodong Guo
doi : 10.1002/adhm.202201349
Repairing infected bone defects is a challenge in the field of orthopedics because of the limited self-healing capacity of bone tissue and the susceptibility of refractory materials to bacterial activity.
Wearable Hydrogel-Based Epidermal Sensor with Thermal Compatibility and Long Term Stability for Smart Colorimetric Multi-Signals Monitoring
Fei Han, Xueyong Xie, Tiansong Wang, Chaoyu Cao, Juju Li, Tianying Sun, Hao Liu, Songmei Geng, Zhao Wei, Jing Li, Feng Xu
doi : 10.1002/adhm.202201730
Hydrogel-based wearable epidermal sensors (HWESs) have attracted widespread attention in health monitoring, especially considering their colorimetric readout capability.
Self-Assembled Integrative Nutrient Carrier Platform Containing Green Tea Catechin for Short Bowel Syndrome Treatment
Zhengming Zhou, Ke Li, Lei Shi, Yunfeng Wang, Yunxiang He, Wen Hu, Junling Guo
doi : 10.1002/adhm.202201933
Extensive resection of the small intestine leads to the development of short bowel syndrome (SBS), which reduces the effective absorptive surface area of the intestine and predisposes patients to emaciation, malnutrition, and other severe symptoms.
Controlled Delivery of Corticosteroids Using Tunable Tough Adhesives
Esther Koh, Benjamin R Freedman, Farshad Ramazani, Johannes Gross, Adam Graham, Andreas Kuttler, Eckhard Weber, David J Mooney
doi : 10.1002/adhm.202201000
Hydrogel-based drug delivery systems typically aim to release drugs locally to tissue in an extended manner. Tissue adhesive alginate-polyacrylamide tough hydrogels are recently demonstrated to serve as an extended-release system for the corticosteroid triamcinolone acetonide.
Biodegradable Carbon Dioxide-Derived Non-Viral Gene Vectors for Osteosarcoma Gene Therapy
Meirong Li, Zheng-Ian Lin, Jingyu Yang, Haoqiang Huang, Guan-Lin Liu, Qiqi Liu, Xinmeng Zhang, Ying Zhang, Zhourui Xu, Haoming Lin, Yujuan Chai, Xin Chen, Bao-Tsan Ko, Jia Liu, Chih-Kuang Chen, Chengbin Yang
doi : 10.1002/adhm.202201306
Osteosarcoma often occurs in children and adolescents with high invasiveness and high mortality. Polo-like kinase 1 (PLK1) overexpressed in most tumors promotes cancer cell proliferation and transformation.
Versatile Red Blood Cells for Triple-Negative Breast Cancer Treatment via Stepwise Photoactivations
Yuanyuan Cheng, Qian Chen, Zhanyin Qian, Tianhe Shan, Liya Bai, Xiaoyu Jiang, Chunyu Li, Yinsong Wang
doi : 10.1002/adhm.202201690
Phototherapies have many advantages for triple-negative breast cancer (TNBC) treatment. However, their effects are often limited by short blood circulation time, poor tumor selectivity and weak penetration of phototherapeutic agents, and tumor hypoxia.
Superwetting Injectable Hydrogel with Ultrastrong and Fast Tissue Adhesion for Minimally Invasive Hemostasis
Congying Wei, Weili Shi, Chuangqi Zhao, Shuai Yang, Jiajia Zheng, JinPan Zhong, Tianyi Zhao, Simin Kong, Xi Gong, Mingjie Liu
doi : 10.1002/adhm.202201799
Injectable hydrogels have recently emerged as alternatives to sutures for various clinical indications. However, existing injectable hydrogels are unsuitable for hemostasis in minimally invasive surgery because of their weak interfacial adhesion and complex/prolonged processing.
Invasion and Secondary Site Colonization as a Function of In Vitro Primary Tumor Matrix Stiffness: Breast to Bone Metastasis
Lekha Shah, Ayşe Latif, Kaye J. Williams, Elena Mancuso, Annalisa Tirella
doi : 10.1002/adhm.202201898
Increased breast tissue stiffness is correlated with breast cancer risk and invasive cancer progression. However, its role in promoting bone metastasis, a major cause of mortality, is not yet understood.
Swelling-Mediated Mechanical Stimulation Regulates Differentiation of Adipose-Derived Mesenchymal Stem Cells for Intervertebral Disc Repair Using Injectable UCST Microgels
Xianpeng Huang, Di Chen, Chengzhen Liang, Kesi Shi, Xiaopeng Zhou, Yuang Zhang, Yi Li, Jiangjie Chen, Kaishun Xia, Jiawei Shu, Biao Yang, Jingkai Wang, Haibin Xu, Chao Yu, Feng Cheng, Shaoke Wang, Yongxiang Zhang, Chenggui Wang, Liwei Ying, Hao Li, Meiling Han, Fangcai Li, Yiqing Tao, Qian Zhao, Qixin Chen
doi : 10.1002/adhm.202201925
Mechanical stimulation is an effective approach for controlling stem cell differentiation in tissue engineering. However, its realization in in vivo tissue repair remains challenging since this type of stimulation can hardly be applied to injectable seeding systems.
Graphene Oxide Nanoscale Platform Enhances the Anti-Cancer Properties of Bortezomib in Glioblastoma Models
Paul S. Sharp, Maria Stylianou, Luis M. Arellano, Juliana C. Neves, Alfredo M. Gravagnuolo, Abbie Dodd, Katharine Barr, Neus Lozano, Thomas Kisby, Kostas Kostarelos
doi : 10.1002/adhm.202201968
Graphene-based 2D nanomaterials possess unique physicochemical characteristics which can be utilized in various biomedical applications, including the transport and presentation of chemotherapeutic agents. In glioblastoma multiforme (GBM), intratumorally administered thin graphene oxide (GO) nanosheets demonstrate a widespread distribution throughout the tumor volume without impact on tumor growth, nor spread into normal brain tissue.
Violet Phosphorus Nanosheet: A Biocompatible and Stable Platform for Stimuli-Responsive Multimodal Cancer Phototherapy
Chen Zhao, Xiao Han, Shanshan Wang, ZhenYi Pan, Xiaoying Tang, Zhenqi Jiang
doi : 10.1002/adhm.202201995
As a functional 2D material, black phosphorus (BP) has garnered wide attention from many researchers in recent years. BP has a wide NIR absorption window and is a promising candidate for cancer phototherapy including photothermal therapy (PTT) and photodynamic therapy (PDT).
Stress Relaxation-Induced Colon Tumor Multicellular Spheroid Culture Based on Biomimetic Hydrogel for Nanoenzyme Ferroptosis Sensitization Evaluation
Yi Zhang, Liyi Peng, Ke Hu, Ning Gu
doi : 10.1002/adhm.202202009
Ferroptosis has recently become a research hotspot, and the induction of tumor cell ferroptosis has emerged as a powerful method for tumor therapy. However, the efficiency of tumor cell ferroptosis induction remains unmet for clinical use, which may be attributed to the large discrepancies between in vitro and in vivo models.
Boosting Doxorubicin-Induced Mitochondria Apoptosis for the Monodrug-Mediated Combination of Chemotherapy and Chemodynamic Therapy
Tao Liu, Cheng-Feng Xiong, Lin-Jun Zhang, Guan-Hua Jiao, Hui Shi, Jun Feng, Xian-Zheng Zhang
doi : 10.1002/adhm.202202045
Doxorubicin (Dox)-mediated generation of reactive oxygen radicals (ROS) for mitochondrial apoptosis is identified as a new cytotoxic mechanism in addition to the well-established one via nuclear DNA replication interference. However, this mechanism contributes far less than the latter to Dox therapy.
Lipid Nanoparticle Delivery of Chemically Modified NGFR100W mRNA Alleviates Peripheral Neuropathy
Xiang Yu, Zheng Yang, Yu Zhang, Jia Xia, Jiahui Zhang, Qi Han, Hang Yu, Chengbiao Wu, Yingjie Xu, Wei Xu, Wen Yang
doi : 10.1002/adhm.202202127
Messenger RNA (mRNA) carries genetic instructions to the cell machinery for the transient production of antigens or therapeutic proteins and shows enormous potential in vaccine development, cancer immunotherapy, protein replacement therapy, and genome engineering.
Highly Efficient Photodynamic Therapy with Mitochondria-Targeting Aggregation-Induced Emission Photosensitizer for Retinoblastoma (Adv. Healthcare Mater. 3/2023)
Lingbo Zhou, Luojia Chen, Sijie Chen, Zeyuan Pu, Meijia Gu, Yin Shen
doi : 10.1002/adhm.202370011
Highly Efficient Photodynamic Therapy with Mitochondria-Targeting Aggregation-Induced Emission Photosensitizer for Retinoblastoma
Lingbo Zhou, Luojia Chen, Sijie Chen, Zeyuan Pu, Meijia Gu, Yin Shen
doi : 10.1002/adhm.202202219
Retinoblastoma (RB) is an aggressive eye cancer in infancy and childhood, lethal by metastasis if left untreated. Currently, the survival rate and the chance of saving vision depend on the severity of the disease.
Toxicity and Biocompatibility of Liquid Metals (Adv. Healthcare Mater. 3/2023)
Sen Chen, Ruiqi Zhao, Xuyang Sun, Hongzhang Wang, Lei Li, Jing Liu
doi : 10.1002/adhm.202370008
Volume 12, Issue 3
Photosensitive and Conductive Hydrogel Induced Innerved Bone Regeneration for Infected Bone Defect Repair (Adv. Healthcare Mater. 3/2023)
Xirui Jing, Chao Xu, Weijie Su, Qiuyue Ding, Bing Ye, Yanlin Su, Keda Yu, Lian Zeng, Xu Yang, Yanzhen Qu, Kaifang Chen, Tingfang Sun, Zhiqiang Luo, Xiaodong Guo
doi : 10.1002/adhm.202370009
Wearable Hydrogel-Based Epidermal Sensor with Thermal Compatibility and Long Term Stability for Smart Colorimetric Multi-Signals Monitoring (Adv. Healthcare Mater. 3/2023)
Fei Han, Xueyong Xie, Tiansong Wang, Chaoyu Cao, Juju Li, Tianying Sun, Hao Liu, Songmei Geng, Zhao Wei, Jing Li, Feng Xu
doi : 10.1002/adhm.202370012
Self-Assembled Integrative Nutrient Carrier Platform Containing Green Tea Catechin for Short Bowel Syndrome Treatment (Adv. Healthcare Mater. 3/2023)
Zhengming Zhou, Ke Li, Lei Shi, Yunfeng Wang, Yunxiang He, Wen Hu, Junling Guo
doi : 10.1002/adhm.202370013
Toxicity and Biocompatibility of Liquid Metals
Sen Chen, Ruiqi Zhao, Xuyang Sun, Hongzhang Wang, Lei Li, Jing Liu
doi : 10.1002/adhm.202201924
Recently, room-temperature liquid metals have attracted increasing attention from researchers owing to their excellent material properties. Systematic interpretation of the potential toxicity issues involved is essential for a wide range of applications, especially in the biomedical and healthcare fields.
Photosensitive and Conductive Hydrogel Induced Innerved Bone Regeneration for Infected Bone Defect Repair
Xirui Jing, Chao Xu, Weijie Su, Qiuyue Ding, Bing Ye, Yanlin Su, Keda Yu, Lian Zeng, Xu Yang, Yanzhen Qu, Kaifang Chen, Tingfang Sun, Zhiqiang Luo, Xiaodong Guo
doi : 10.1002/adhm.202201349
Repairing infected bone defects is a challenge in the field of orthopedics because of the limited self-healing capacity of bone tissue and the susceptibility of refractory materials to bacterial activity.
Wearable Hydrogel-Based Epidermal Sensor with Thermal Compatibility and Long Term Stability for Smart Colorimetric Multi-Signals Monitoring
Fei Han, Xueyong Xie, Tiansong Wang, Chaoyu Cao, Juju Li, Tianying Sun, Hao Liu, Songmei Geng, Zhao Wei, Jing Li, Feng Xu
doi : 10.1002/adhm.202201730
Hydrogel-based wearable epidermal sensors (HWESs) have attracted widespread attention in health monitoring, especially considering their colorimetric readout capability.
Self-Assembled Integrative Nutrient Carrier Platform Containing Green Tea Catechin for Short Bowel Syndrome Treatment
Zhengming Zhou, Ke Li, Lei Shi, Yunfeng Wang, Yunxiang He, Wen Hu, Junling Guo
doi : 10.1002/adhm.202201933
Extensive resection of the small intestine leads to the development of short bowel syndrome (SBS), which reduces the effective absorptive surface area of the intestine and predisposes patients to emaciation, malnutrition, and other severe symptoms.
Controlled Delivery of Corticosteroids Using Tunable Tough Adhesives
Esther Koh, Benjamin R Freedman, Farshad Ramazani, Johannes Gross, Adam Graham, Andreas Kuttler, Eckhard Weber, David J Mooney
doi : 10.1002/adhm.202201000
Hydrogel-based drug delivery systems typically aim to release drugs locally to tissue in an extended manner. Tissue adhesive alginate-polyacrylamide tough hydrogels are recently demonstrated to serve as an extended-release system for the corticosteroid triamcinolone acetonide.
Biodegradable Carbon Dioxide-Derived Non-Viral Gene Vectors for Osteosarcoma Gene Therapy
Meirong Li, Zheng-Ian Lin, Jingyu Yang, Haoqiang Huang, Guan-Lin Liu, Qiqi Liu, Xinmeng Zhang, Ying Zhang, Zhourui Xu, Haoming Lin, Yujuan Chai, Xin Chen, Bao-Tsan Ko, Jia Liu, Chih-Kuang Chen, Chengbin Yang
doi : 10.1002/adhm.202201306
Osteosarcoma often occurs in children and adolescents with high invasiveness and high mortality. Polo-like kinase 1 (PLK1) overexpressed in most tumors promotes cancer cell proliferation and transformation.
Versatile Red Blood Cells for Triple-Negative Breast Cancer Treatment via Stepwise Photoactivations
Yuanyuan Cheng, Qian Chen, Zhanyin Qian, Tianhe Shan, Liya Bai, Xiaoyu Jiang, Chunyu Li, Yinsong Wang
doi : 10.1002/adhm.202201690
Phototherapies have many advantages for triple-negative breast cancer (TNBC) treatment. However, their effects are often limited by short blood circulation time, poor tumor selectivity and weak penetration of phototherapeutic agents, and tumor hypoxia.
Superwetting Injectable Hydrogel with Ultrastrong and Fast Tissue Adhesion for Minimally Invasive Hemostasis
Congying Wei, Weili Shi, Chuangqi Zhao, Shuai Yang, Jiajia Zheng, JinPan Zhong, Tianyi Zhao, Simin Kong, Xi Gong, Mingjie Liu
doi : 10.1002/adhm.202201799
Injectable hydrogels have recently emerged as alternatives to sutures for various clinical indications. However, existing injectable hydrogels are unsuitable for hemostasis in minimally invasive surgery because of their weak interfacial adhesion and complex/prolonged processing.
Invasion and Secondary Site Colonization as a Function of In Vitro Primary Tumor Matrix Stiffness: Breast to Bone Metastasis
Lekha Shah, Ayşe Latif, Kaye J. Williams, Elena Mancuso, Annalisa Tirella
doi : 10.1002/adhm.202201898
Increased breast tissue stiffness is correlated with breast cancer risk and invasive cancer progression. However, its role in promoting bone metastasis, a major cause of mortality, is not yet understood.
Swelling-Mediated Mechanical Stimulation Regulates Differentiation of Adipose-Derived Mesenchymal Stem Cells for Intervertebral Disc Repair Using Injectable UCST Microgels
Xianpeng Huang, Di Chen, Chengzhen Liang, Kesi Shi, Xiaopeng Zhou, Yuang Zhang, Yi Li, Jiangjie Chen, Kaishun Xia, Jiawei Shu, Biao Yang, Jingkai Wang, Haibin Xu, Chao Yu, Feng Cheng, Shaoke Wang, Yongxiang Zhang, Chenggui Wang, Liwei Ying, Hao Li, Meiling Han, Fangcai Li, Yiqing Tao, Qian Zhao, Qixin Chen
doi : 10.1002/adhm.202201925
Mechanical stimulation is an effective approach for controlling stem cell differentiation in tissue engineering. However, its realization in in vivo tissue repair remains challenging since this type of stimulation can hardly be applied to injectable seeding systems.
Graphene Oxide Nanoscale Platform Enhances the Anti-Cancer Properties of Bortezomib in Glioblastoma Models
Paul S. Sharp, Maria Stylianou, Luis M. Arellano, Juliana C. Neves, Alfredo M. Gravagnuolo, Abbie Dodd, Katharine Barr, Neus Lozano, Thomas Kisby, Kostas Kostarelos
doi : 10.1002/adhm.202201968
Graphene-based 2D nanomaterials possess unique physicochemical characteristics which can be utilized in various biomedical applications, including the transport and presentation of chemotherapeutic agents. In glioblastoma multiforme (GBM), intratumorally administered thin graphene oxide (GO) nanosheets demonstrate a widespread distribution throughout the tumor volume without impact on tumor growth, nor spread into normal brain tissue.
Violet Phosphorus Nanosheet: A Biocompatible and Stable Platform for Stimuli-Responsive Multimodal Cancer Phototherapy
Chen Zhao, Xiao Han, Shanshan Wang, ZhenYi Pan, Xiaoying Tang, Zhenqi Jiang
doi : 10.1002/adhm.202201995
As a functional 2D material, black phosphorus (BP) has garnered wide attention from many researchers in recent years. BP has a wide NIR absorption window and is a promising candidate for cancer phototherapy including photothermal therapy (PTT) and photodynamic therapy (PDT).
Stress Relaxation-Induced Colon Tumor Multicellular Spheroid Culture Based on Biomimetic Hydrogel for Nanoenzyme Ferroptosis Sensitization Evaluation
Yi Zhang, Liyi Peng, Ke Hu, Ning Gu
doi : 10.1002/adhm.202202009
Ferroptosis has recently become a research hotspot, and the induction of tumor cell ferroptosis has emerged as a powerful method for tumor therapy. However, the efficiency of tumor cell ferroptosis induction remains unmet for clinical use, which may be attributed to the large discrepancies between in vitro and in vivo models.
Boosting Doxorubicin-Induced Mitochondria Apoptosis for the Monodrug-Mediated Combination of Chemotherapy and Chemodynamic Therapy
Tao Liu, Cheng-Feng Xiong, Lin-Jun Zhang, Guan-Hua Jiao, Hui Shi, Jun Feng, Xian-Zheng Zhang
doi : 10.1002/adhm.202202045
Doxorubicin (Dox)-mediated generation of reactive oxygen radicals (ROS) for mitochondrial apoptosis is identified as a new cytotoxic mechanism in addition to the well-established one via nuclear DNA replication interference. However, this mechanism contributes far less than the latter to Dox therapy.
Lipid Nanoparticle Delivery of Chemically Modified NGFR100W mRNA Alleviates Peripheral Neuropathy
Xiang Yu, Zheng Yang, Yu Zhang, Jia Xia, Jiahui Zhang, Qi Han, Hang Yu, Chengbiao Wu, Yingjie Xu, Wei Xu, Wen Yang
doi : 10.1002/adhm.202202127
Messenger RNA (mRNA) carries genetic instructions to the cell machinery for the transient production of antigens or therapeutic proteins and shows enormous potential in vaccine development, cancer immunotherapy, protein replacement therapy, and genome engineering.
Highly Efficient Photodynamic Therapy with Mitochondria-Targeting Aggregation-Induced Emission Photosensitizer for Retinoblastoma (Adv. Healthcare Mater. 3/2023)
Lingbo Zhou, Luojia Chen, Sijie Chen, Zeyuan Pu, Meijia Gu, Yin Shen
doi : 10.1002/adhm.202370011
Highly Efficient Photodynamic Therapy with Mitochondria-Targeting Aggregation-Induced Emission Photosensitizer for Retinoblastoma
Lingbo Zhou, Luojia Chen, Sijie Chen, Zeyuan Pu, Meijia Gu, Yin Shen
doi : 10.1002/adhm.202202219
Retinoblastoma (RB) is an aggressive eye cancer in infancy and childhood, lethal by metastasis if left untreated. Currently, the survival rate and the chance of saving vision depend on the severity of the disease.
