دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Short-Term Adverse Outcomes After Mifepristone–Misoprostol Versus Procedural Induced Abortion
Ning Liu, PhD  and Joel G. Ray, MD, MSc
doi : 10.7326/M22-2568
February 2023Volume 176, Issue 2
Prior studies comparing first-trimester pharmaceutical induced abortion (IA) with procedural IA were prone to selection bias, were underpowered to assess serious adverse events (SAEs), and did not account for confounding by indication. Starting in 2017, mifepristone–misoprostol was dispensed at no cost in outpatient pharmacies across Ontario, Canada.
High- Versus Low-Dose Exercise Therapy for Knee Osteoarthritis
Tom Arild Torstensen, MSc, RPT ,  Håvard Østerås, MSc, RPT ,  Riccardo LoMartire, PhD, RPT ,  Georg Mørtvedt Rugelbak, MSc, RPT ,  Wilhelmus Johannes Andreas Grooten, PhD, RPT ,  and Björn Olov Äng, PhD, RPT
doi : 10.7326/M22-2348
The benefits of exercise in patients with knee osteoarthritis are well documented, but the optimal exercise dose remains unknown.
Hydroxychloroquine Dose and Risk for Incident Retinopathy
Ronald B. Melles, MD* , April M. Jorge, MD* , Michael F. Marmor, MD , Baijun Zhou, MHS , Carol Conell, PhD , Jingbo Niu, MD, ScD , Natalie McCormick, PhD , Yuqing Zhang, ScDâ€
doi : 10.7326/M22-2453
Hydroxychloroquine is recommended for all patients with systemic lupus erythematosus and is often used for other inflammatory conditions, but a critical long-term adverse effect is vision-threatening retinopathy.
Epstein–Barr Viral Load Monitoring Strategy and the Risk for Posttransplant Lymphoproliferative Disease in Adult Liver Transplantation
Bastian N. Ruijter, MD ,  Ron Wolterbeek, MD, MSc ,  Mitchell Hew, MD ,  Marjolein van Reeven, MD ,  Danny van der Helm, MSc, PhD ,  Jeroen Dubbeld, MD ,  Maarten E. Tushuizen, MD, PhD ,  Herold Metselaar, MD, PhD ,  Ann C.T.M. Vossen, MD, PhD ,  and Bart van Hoek, MD, PhD
doi : 10.7326/M22-0364
Primary infection with or reactivation of Epstein–Barr virus (EBV) can occur after liver transplant (LT) and can lead to posttransplant lymphoproliferative disease (PTLD).
Effectiveness and Safety of Treatments to Prevent Fractures in People With Low Bone Mass or Primary Osteoporosis: A Living Systematic Review and Network Meta-analysis for the American College of Physicians
Chelsea Ayers, MPH , Devan Kansagara, MD, MCR , Brittany Lazur, MPH , Rongwei Fu, PhD , Amy Kwon, MD , and Curtis Harrod, PhD, MPH
doi : 10.7326/M22-0684
The prevalence of osteoporosis is increasing in the United States.
Nonpharmacologic and Pharmacologic Treatments of Adult Patients With Major Depressive Disorder: A Systematic Review and Network Meta-analysis for a Clinical Guideline by the American College of Physicians
Gerald Gartlehner, MD, MPH , Andreea Dobrescu, MD, PhD , Andrea Chapman, MA, BSc , Ana Toromanova , Robert Emprechtinger, MSc , Emma Persad, MD , Lisa Affengruber, MSc , Christoph Pieh, MD , Irma Klerings , and Gernot Wagner, MD
doi : 10.7326/M22-1845
Primary care patients and clinicians may prefer alternative options to second-generation antidepressants for major depressive disorder (MDD).
Cost-Effectiveness of First- and Second-Step Treatment Strategies for Major Depressive Disorder
Andreea Dobrescu, MD, PhD , Andrea Chapman, MA, BSc , Lisa Affengruber, MSc , Emma Persad, MD , Ana Toromanova , Gernot Wagner, MD , Irma Klerings , Robert Emprechtinger, MSc , and Gerald Gartlehner, MD, MPH
doi : 10.7326/M22-1872
Major depressive disorder (MDD) is the most prevalent, disabling form of depression, with a high economic effect.
Values and Preferences of Patients With Depressive Disorders Regarding Pharmacologic and Nonpharmacologic Treatments
Lisa Affengruber, MSc , Gernot Wagner, MD , Andreea Dobrescu, MD, PhD , Ana Toromanova , Andrea Chapman, MA, BSc , Emma Persad, MD , Irma Klerings , and Gerald Gartlehner, MD, MPH
doi : 10.7326/M22-1900
Developers of clinical practice guidelines need to take patient values and preferences into consideration when weighing benefits and harms of treatment options for depressive disorder.
Pharmacologic Treatment of Primary Osteoporosis or Low Bone Mass to Prevent Fractures in Adults: A Living Clinical Guideline From the American College of Physicians
Amir Qaseem, MD, PhD, MHA , Lauri A. Hicks, DO , Itziar Etxeandia-Ikobaltzeta, PharmD , Tatyana Shamliyan, MD, MS , and Thomas G. Cooney, MD , for the Clinical Guidelines Committee of the American College of Physicians* , J. Thomas Cross Jr., MD, MPH , Nick Fitterman, MD , Jennifer S. Lin, MD, MCR , Michael Maroto, JD, MBA , Adam J. Obley, MD , Jeffrey A. Tice, MD , Janice E. Tufte
doi : 10.7326/M22-1034
This guideline updates the 2017 American College of Physicians (ACP) recommendations on pharmacologic treatment of primary osteoporosis or low bone mass to prevent fractures in adults.
Nonpharmacologic and Pharmacologic Treatments of Adults in the Acute Phase of Major Depressive Disorder: A Living Clinical Guideline From the American College of Physicians
Amir Qaseem, MD, PhD, MHA , Douglas K. Owens, MD, MS , Itziar Etxeandia-Ikobaltzeta, PharmD, PhD , Janice Tufte , J. Thomas Cross Jr., MD, MPH , and Timothy J. Wilt, MD, MPH , for the Clinical Guidelines Committee of the American College of Physicians*†, Carolyn J. Crandall, MD, MS , Ethan Balk, MD , Thomas G. Cooney, MD , Nick Fitterman, MD , Lauri A. Hicks, DO , Jennifer S. Lin, MD, MCR , Michael Maroto, JD, MBA , Adam J. Obley, MD , Jeffrey A. Tice, MD , Jennifer Yost, RN, PhD
doi : 10.7326/M22-2056
The purpose of this guideline from the American College of Physicians (ACP) is to present updated clinical recommendations on nonpharmacologic and pharmacologic interventions as initial and second-line treatments during the acute phase of a major depressive disorder (MDD) episode, based on the best available evidence on the comparative benefits and harms, consideration of patient values and preferences, and cost.
How Would You Resuscitate This Patient With Septic Shock?
Zahir Kanjee, MD, MPH , Katherine Berg, MD , Taison D. Bell, MD, MBA , and Eileen E. Reynolds, MD
doi : 10.7326/M22-3385
Sepsis is a potentially life-threatening systemic dysregulatory response to infection, and septic shock occurs when sepsis leads to systemic vasodilation and subsequent tissue hypoperfusion.
Colinet–Caplan Syndrome: History of an Outbreak of Autoimmune Disease in Scouring Powder Workers
Steven Ronsmans, MD, PhD  and Paul D. Blanc, MD, MSPH
doi : 10.7326/M22-2630
The first modern description linking rheumatoid arthritis to occupational dust exposure is generally attributed to the British physician Anthony Caplan. In 1953, Caplan reported on a “peculiar� nodular pattern on chest radiographs of Welsh coal miners with rheumatoid arthritis that differed from the typical coal workers' pneumoconiosis.
The Dark Side of Rapid Reviews: A Retreat From Systematic Approaches and the Need for Clear Expectations and Reporting
Zachary Munn, PhD ,  Danielle Pollock, PhD ,  Timothy Hugh Barker, PhD ,  Jennifer Stone, PhD ,  Cindy Stern, PhD ,  Edoardo Aromataris, PhD ,  Alan Pearson, PhD ,  Sharon Straus, MD, MSc ,  Hanan Khalil, PhD ,  Reem A. Mustafa, MD, MPH, PhD ,  Andrea C. Tricco, PhD ,  and Holger J. Schünemann, MD, PhD
doi : 10.7326/M22-2603
EMTALA After Dobbs: Emergency Reproductive Health Care in the Balance
Eli Y. Adashi, MD, MS and I. Glenn Cohen, JD
doi : 10.7326/M22-3222
What Follows From State-Mandated Pregnancy?
Jake Earl, PhD and Caitlin J. Cain, MD
doi : 10.7326/M22-2879
Lessons From the Front Line of Fighting Gender Inequity
Luci K. Leykum, MD, MBA, MSc
doi : 10.7326/M22-3213
Chess Lessons: Harnessing Collective Human Intelligence and Imitation Learning to Support Clinical Decisions
Gary E. Weissman, MD, MSHP ,  Lyle H. Ungar, PhD ,  and Scott D. Halpern, MD, PhD
doi : 10.7326/M22-2998
The War on Reproductive Health Care in the United States
Carol J. Hogue, PhD, MPH
doi : 10.7326/M22-3634
The American College of Physicians Living Guideline on Depression: A Step Forward, but Gaps Remain
Miriam Shuchman, MD and Elia Abi-Jaoude, MSc, MD, PhD
doi : 10.7326/M22-3701
Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19
Teluguakula Narasaraju, PhD , Amita Krishnappa, MD , Marko Radic, PhD , Vincent T.K. Chow, MD, PhD
doi : 10.7326/L22-0455
Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19
Eleftherios Mylonakis, MD, PhD , Christina Barkauskas, MD , Garyfallia Poulakou, MD, PhD , Barnaby E. Young, MD, PhD
doi : 10.7326/L22-0456
Tea Consumption and All-Cause and Cause-Specific Mortality in the UK Biobank
Yasutaka Nishiyama, MD  and Tatsuya Fujikawa, MD, PhD
doi : 10.7326/L22-0477
Tea Consumption and All-Cause and Cause-Specific Mortality in the UK Biobank
Maki Inoue-Choi, PhD , Yesenia Ramirez, MPH , Neal D. Freedman, PhD , Erikka Loftfield, PhD
doi : 10.7326/L22-0478
Correction: In the Clinic: Monoclonal Gammopathy of Undetermined Significance
doi : 10.7326/L22-0509
Correction: Total Ankle Replacement Versus Arthrodesis for End-Stage Ankle Osteoarthritis
doi : 10.7326/L22-0523
Chagas Disease
Natasha S. Hochberg, MD, MPH , Susan P. Montgomery, DVM, MPH
doi : 10.7326/AITC202302210
Chagas disease, which is caused by infection with the parasite Trypanosoma cruzi, is a leading neglected tropical disease in the United States. An estimated 240 000 to 350 000 persons in the United States are infected, primarily immigrants from Mexico, Central America, and South America, where the disease is endemic.
In basilar-artery occlusion stroke, thrombectomy improved functional outcome at 90 d but increased ICH
Bruce Lo, MD, MBA
doi : 10.7326/J22-0119
In basilar-artery occlusion stroke, thrombectomy improved functional outcomes without increasing ICH
Bruce Lo, MD, MBA
doi : 10.7326/J22-0120
In hypertension, evening vs. morning dosing of antihypertensive drugs did not differ for major CV outcomes at 5.2 y
KoKo Aung, MD, MPH , Thwe Htay, MD
doi : 10.7326/J22-0116
In high-risk outpatients with COVID-19, neither colchicine nor aspirin reduced disease progression or death at 45 d
Joel M. Schectman, MD, MPH
doi : 10.7326/J22-0118
In adults, a single colonoscopy screening invitation vs. no invitation reduced CRC incidence at 10 y
Thomas F. Imperiale, MD , David F. Ransohoff, MD
doi : 10.7326/J22-0112
In adults, sigmoidoscopy screening invitation reduced CRC incidence and related mortality at 15 y
Thomas F. Imperiale, MD , David F. Ransohoff, MD
doi : 10.7326/J22-0113
In nonalcoholic fatty liver disease, a diet of freshwater fish vs. freshwater fish plus red meat reduced liver fat
Sandeep Mukherjee, MD
doi : 10.7326/J22-0117
In complicated UTI or pyelonephritis, cefepime–enmetazobactam increased success vs. piperacillin–tazobactam at 14 d
Dennis G. Maki, MD
doi : 10.7326/J22-0114
In adults with active dermatomyositis, IV immune globulin improved treatment response at 16 wk vs. placebo
Ami Schattner, MD
doi : 10.7326/J22-0111
In adults aged ≥65 y with head injuries, use of warfarin, but not DOACs, was associated with delayed ICH
Shan W. Liu, MD, SD , Christopher R. Carpenter, MD, MSc
doi : 10.7326/J22-0115
Annals Graphic Medicine - Banking Blood
Michael J. Green, MD, MS , Molly Osborne, MD, PhD , Kimberly R. Myers, PhD, MA , and Zoe S. Schein, MA
doi : 10.7326/G22-0029
Annals Graphic Medicine - Dr. Mom: Assorted Clinical Pearls From 2022
Grace E. Farris, MD
doi : 10.7326/G22-0081
Annals for Hospitalists Inpatient Notes - How to Treat Poor Sleep in the Hospital
Katrina L. Piggott, MD, MSc and Christine Soong, MD, MSc
doi : 10.7326/M23-0001
Summary for Patients: Short-Term Adverse Outcomes After Mifepristone–Misoprostol Versus Procedural Induced Abortion
doi : 10.7326/P22-0026
Summary for Patients: High-Dose Versus Low-Dose Exercise Therapy for Knee Osteoarthritis
doi : 10.7326/P22-0029
Summary for Patients: Hydroxychloroquine Dose and Risk for Incident Retinopathy
doi : 10.7326/P22-0028
Summary for Patients: Pharmacologic Treatment of Primary Osteoporosis or Low Bone Mass to Prevent Fractures in Adults
doi : 10.7326/P22-0025
Summary for Patients: Nonpharmacologic and Pharmacologic Treatments of Adults in the Acute Phase of Major Depression
doi : 10.7326/P22-0027
