دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Investing in National HIV PrEP Preparedness
Jeremiah Johnson, M.P.H., Amy Killelea, J.D., and Kenyon Farrow
doi : 10.1056/NEJMp2216100
Vol. 388 No. 9
Health Care Reform and Equity for Undocumented Immigrants — When Crisis Meets Opportunity
Patricia Mae G. Santos, M.D., Kanan Shah, M.D., Francesca M. Gany, M.D., and Fumiko Chino, M.D.
doi : 10.1056/NEJMp2213751
The Injury Equity Framework — Establishing a Unified Approach for Addressing Inequities
Sadiqa Kendi, M.D., M.P.H., and Michelle L. Macy, M.D.
doi : 10.1056/NEJMp2212378
Aligning Quality Measures across CMS — The Universal Foundation
Douglas B. Jacobs, M.D., M.P.H., Michelle Schreiber, M.D., Meena Seshamani, M.D., Ph.D., Daniel Tsai, B.A., Elizabeth Fowler, Ph.D., J.D., and Lee A. Fleisher, M.D.
doi : 10.1056/NEJMp2215539
Hard to Swallow
Debra Malina, Ph.D., Mridula Nadamuni, M.D., Lisa Rosenbaum, M.D., Caren Solomon, M.D., M.P.H., and Timothy Vining
doi : 10.1056/NEJMp2301652
Hydrochlorothiazide and Prevention of Kidney-Stone Recurrence
Nasser A. Dhayat, M.D., Olivier Bonny, M.D., Ph.D., Beat Roth, M.D., Andreas Christe, M.D., Alexander Ritter, M.D., Nilufar Mohebbi, M.D., Nicolas Faller, M.D., Ph.D., Lisa Pellegrini, M.D., Giulia Bedino, M.D., Reto M. Venzin, M.D., Philipp Grosse, M.D., Carina Hüsler, M.D., Irene Koneth, M.D., Christian Bucher, M.D., Rosaria Del Giorno, M.D., Luca Gabutti, M.D., Michael Mayr, M.D., Urs Odermatt, M.D., Florian Buchkremer, M.D., Thomas Ernandez, M.D., Catherine Stoermann-Chopard, M.D., Daniel Teta, M.D., Bruno Vogt, M.D., Marie Roumet, Ph.D., Luca Tamò, Ph.D., Grazia M. Cereghetti, Ph.D., Sven Trelle, M.D., and Daniel G. Fuster, M.D.
doi : 10.1056/NEJMoa2209275
Nephrolithiasis is one of the most common conditions affecting the kidney and is characterized by a high risk of recurrence. Thiazide diuretic agents are widely used for prevention of the recurrence of kidney stones, but data regarding the efficacy of such agents as compared with placebo are limited. Furthermore, dose–response data are also limited.
Intravenous Doxycycline, Azithromycin, or Both for Severe Scrub Typhus
George M. Varghese, M.D., Divya Dayanand, M.P.H., Karthik Gunasekaran, M.D., Debasree Kundu, Ph.D., Mukta Wyawahare, M.D., Navneet Sharma, M.D., Dhruva Chaudhry, D.M., Sanjay K. Mahajan, M.D., Kavitha Saravu, M.D., Blessed W. Aruldhas, M.D., Binu S. Mathew, M.D., Roshini G. Nair, M.P.H.,
doi : 10.1056/NEJMoa2208449
The appropriate antibiotic treatment for severe scrub typhus, a neglected but widespread reemerging zoonotic infection, is unclear.
Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients
Nicholas C. Allen, M.P.H., Andrew J. Martin, Ph.D., Victoria A. Snaidr, F.R.A.C.G.P., Renee Eggins, M.Biostat., Alvin H. Chong, F.A.C.D., Pablo Fernandéz-Peñas, Ph.D., Douglas Gin, F.A.C.D., Shireen Sidhu, F.R.C.P., F.A.C.D., Vanessa L. Paddon, F.A.C.D., Leith A. Banney, F.A.C.D., Adrian Lim, F.A.C.D., Edward Upjohn, F.A.C.D., Helmut Schaider, F.A.C.D., Aparna D. Ganhewa, M.S., Jennifer Nguyen, M.P.H., Catriona A. McKenzie, F.R.C.P.A., Saurabh Prakash, F.R.C.P.A., Catriona McLean, F.R.C.P.A., Alistair Lochhead, F.R.C.P.A., Jan Ibbetson, F.R.C.P.A., Andrew Dettrick, F.R.C.P.A., Anthony Landgren, F.R.C.P.A., Katherine J. Allnutt, M.B., B.S., Clare Allison, M.B., Ch.B., Rachael B. Davenport, M.B., B.S., Blake P. Mumford, M.B., B.S., Brittany Wong, M.B., B.S., Brendan Stagg, M.B., B.S., Alexander Tedman, M.B., B.S., Hannah Gribbin, M.D., Harrison A. Edwards, M.Clin.Epi., Nicholas De Rosa, M.Sci.(Med.), Thomas Stewart, M.Med., Brent J. Doolan, M.B., B.S., Yonatan Kok, M.D., Kate Simpson, M.B., B.S., Zhi M. Low, M.B., B.S., Tom Kovitwanichkanont, M.P.H., Richard A. Scolyer, M.D., Haryana M. Dhillon, Ph.D., Janette L. Vardy, Ph.D., Steven J. Chadban, Ph.D., David G. Bowen, Ph.D., Andrew C. Chen, Ph.D., and Diona L. Damian, Ph.D.
doi : 10.1056/NEJMoa2203086
Immunosuppressed organ-transplant recipients have an increased incidence of, and mortality from, skin cancer. Nicotinamide (vitamin B3) enhances the repair of ultraviolet (UV) radiation–induced DNA damage, reduces the cutaneous immunosuppressive effects of UV radiation, and reduces the incidence of keratinocyte cancers (including squamous-cell and basal-cell carcinomas) and actinic keratoses among high-risk immunocompetent patients.
Neoadjuvant–Adjuvant or Adjuvant-Only Pembrolizumab in Advanced Melanoma
Sapna P. Patel, M.D., Megan Othus, Ph.D., Yuanbin Chen, M.D., Ph.D., G. Paul Wright, Jr., M.D., Kathleen J. Yost, M.D., John R. Hyngstrom, M.D., Siwen Hu-Lieskovan, M.D., Ph.D., Christopher D. Lao, M.D., M.P.H., Leslie A. Fecher, M.D., Thach-Giao Truong, M.D., Jennifer L. Eisenstein, M.D., Sunandana Chandra, M.D.,
doi : 10.1056/NEJMoa2211437
Whether pembrolizumab given both before surgery (neoadjuvant therapy) and after surgery (adjuvant therapy), as compared with pembrolizumab given as adjuvant therapy alone, would increase event-free survival among patients with resectable stage III or IV melanoma is unknown.
Cancer Screening after the Adoption of Paid-Sick-Leave Mandates
Kevin Callison, Ph.D., Michael F. Pesko, Ph.D., Serena Phillips, Dr.P.H., and Julie A. Sosa, M.D.
doi : 10.1056/NEJMsa2209197
By the end of 2022, nearly 20 million workers in the United States have gained paid-sick-leave coverage from mandates that require employers to provide benefits to qualified workers, including paid time off for the use of preventive services.
Encapsulating Peritoneal Sclerosis
Xiaojing Tang, M.D., and Lijun Sun, M.D.
doi : 10.1056/NEJMicm2206513
Pseudoxanthoma Elasticum–like Syndrome
Manish Kumar, M.B., B.S., M.D., and Abdul R. Saifudeen, M.B., B.S., M.D.
doi : 10.1056/NEJMicm2024743
A Rocky Resurgence
John W. Ostrominski, M.D., Thomas E. Clancy, M.D., Lynn Bry, M.D., Ph.D., Bruce D. Levy, M.D., and Joseph Loscalzo, M.D., Ph.D.
doi : 10.1056/NEJMcps2107002
Do Thiazides Reduce the Risk of Kidney-Stone Recurrence?
R. Todd Alexander, M.D., Ph.D.
doi : 10.1056/NEJMe2300120
Progress in Treating a Neglected Tropical Disease
David H. Walker, M.D., and Lucas S. Blanton, M.D.
doi : 10.1056/NEJMe2300113
Skin-Cancer Chemoprevention in Transplant Recipients
David M. Miller, M.D., Ph.D., and Kevin S. Emerick, M.D.
doi : 10.1056/NEJMe2214930
Audio Interview: The Path Forward for Covid-19 Therapeutics
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2302292
Health Care in U.S. Correctional Facilities — A Limited and Threatened Constitutional Right
Marcella Alsan, M.D., Ph.D., M.P.H., Crystal S. Yang, J.D., Ph.D., James R. Jolin, Lucy Tu, and Josiah D. Rich, M.D., M.P.H.
doi : 10.1056/NEJMms2211252
Neutralization of BA.4–BA.5, BA.4.6, BA.2.75.2, BQ.1.1, and XBB.1 with Bivalent Vaccine
doi : 10.1056/NEJMc2214916
Investing in National HIV PrEP Preparedness
Jeremiah Johnson, M.P.H., Amy Killelea, J.D., and Kenyon Farrow
doi : 10.1056/NEJMp2216100
Vol. 388 No. 9
Health Care Reform and Equity for Undocumented Immigrants — When Crisis Meets Opportunity
Patricia Mae G. Santos, M.D., Kanan Shah, M.D., Francesca M. Gany, M.D., and Fumiko Chino, M.D.
doi : 10.1056/NEJMp2213751
The Injury Equity Framework — Establishing a Unified Approach for Addressing Inequities
Sadiqa Kendi, M.D., M.P.H., and Michelle L. Macy, M.D.
doi : 10.1056/NEJMp2212378
Aligning Quality Measures across CMS — The Universal Foundation
Douglas B. Jacobs, M.D., M.P.H., Michelle Schreiber, M.D., Meena Seshamani, M.D., Ph.D., Daniel Tsai, B.A., Elizabeth Fowler, Ph.D., J.D., and Lee A. Fleisher, M.D.
doi : 10.1056/NEJMp2215539
Hard to Swallow
Debra Malina, Ph.D., Mridula Nadamuni, M.D., Lisa Rosenbaum, M.D., Caren Solomon, M.D., M.P.H., and Timothy Vining
doi : 10.1056/NEJMp2301652
Hydrochlorothiazide and Prevention of Kidney-Stone Recurrence
Nasser A. Dhayat, M.D., Olivier Bonny, M.D., Ph.D., Beat Roth, M.D., Andreas Christe, M.D., Alexander Ritter, M.D., Nilufar Mohebbi, M.D., Nicolas Faller, M.D., Ph.D., Lisa Pellegrini, M.D., Giulia Bedino, M.D., Reto M. Venzin, M.D., Philipp Grosse, M.D., Carina Hüsler, M.D., Irene Koneth, M.D., Christian Bucher, M.D., Rosaria Del Giorno, M.D., Luca Gabutti, M.D., Michael Mayr, M.D., Urs Odermatt, M.D., Florian Buchkremer, M.D., Thomas Ernandez, M.D., Catherine Stoermann-Chopard, M.D., Daniel Teta, M.D., Bruno Vogt, M.D., Marie Roumet, Ph.D., Luca Tamò, Ph.D., Grazia M. Cereghetti, Ph.D., Sven Trelle, M.D., and Daniel G. Fuster, M.D.
doi : 10.1056/NEJMoa2209275
Nephrolithiasis is one of the most common conditions affecting the kidney and is characterized by a high risk of recurrence. Thiazide diuretic agents are widely used for prevention of the recurrence of kidney stones, but data regarding the efficacy of such agents as compared with placebo are limited. Furthermore, dose–response data are also limited.
Intravenous Doxycycline, Azithromycin, or Both for Severe Scrub Typhus
George M. Varghese, M.D., Divya Dayanand, M.P.H., Karthik Gunasekaran, M.D., Debasree Kundu, Ph.D., Mukta Wyawahare, M.D., Navneet Sharma, M.D., Dhruva Chaudhry, D.M., Sanjay K. Mahajan, M.D., Kavitha Saravu, M.D., Blessed W. Aruldhas, M.D., Binu S. Mathew, M.D., Roshini G. Nair, M.P.H.,
doi : 10.1056/NEJMoa2208449
The appropriate antibiotic treatment for severe scrub typhus, a neglected but widespread reemerging zoonotic infection, is unclear.
Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients
Nicholas C. Allen, M.P.H., Andrew J. Martin, Ph.D., Victoria A. Snaidr, F.R.A.C.G.P., Renee Eggins, M.Biostat., Alvin H. Chong, F.A.C.D., Pablo Fernandéz-Peñas, Ph.D., Douglas Gin, F.A.C.D., Shireen Sidhu, F.R.C.P., F.A.C.D., Vanessa L. Paddon, F.A.C.D., Leith A. Banney, F.A.C.D., Adrian Lim, F.A.C.D., Edward Upjohn, F.A.C.D., Helmut Schaider, F.A.C.D., Aparna D. Ganhewa, M.S., Jennifer Nguyen, M.P.H., Catriona A. McKenzie, F.R.C.P.A., Saurabh Prakash, F.R.C.P.A., Catriona McLean, F.R.C.P.A., Alistair Lochhead, F.R.C.P.A., Jan Ibbetson, F.R.C.P.A., Andrew Dettrick, F.R.C.P.A., Anthony Landgren, F.R.C.P.A., Katherine J. Allnutt, M.B., B.S., Clare Allison, M.B., Ch.B., Rachael B. Davenport, M.B., B.S., Blake P. Mumford, M.B., B.S., Brittany Wong, M.B., B.S., Brendan Stagg, M.B., B.S., Alexander Tedman, M.B., B.S., Hannah Gribbin, M.D., Harrison A. Edwards, M.Clin.Epi., Nicholas De Rosa, M.Sci.(Med.), Thomas Stewart, M.Med., Brent J. Doolan, M.B., B.S., Yonatan Kok, M.D., Kate Simpson, M.B., B.S., Zhi M. Low, M.B., B.S., Tom Kovitwanichkanont, M.P.H., Richard A. Scolyer, M.D., Haryana M. Dhillon, Ph.D., Janette L. Vardy, Ph.D., Steven J. Chadban, Ph.D., David G. Bowen, Ph.D., Andrew C. Chen, Ph.D., and Diona L. Damian, Ph.D.
doi : 10.1056/NEJMoa2203086
Immunosuppressed organ-transplant recipients have an increased incidence of, and mortality from, skin cancer. Nicotinamide (vitamin B3) enhances the repair of ultraviolet (UV) radiation–induced DNA damage, reduces the cutaneous immunosuppressive effects of UV radiation, and reduces the incidence of keratinocyte cancers (including squamous-cell and basal-cell carcinomas) and actinic keratoses among high-risk immunocompetent patients.
Neoadjuvant–Adjuvant or Adjuvant-Only Pembrolizumab in Advanced Melanoma
Sapna P. Patel, M.D., Megan Othus, Ph.D., Yuanbin Chen, M.D., Ph.D., G. Paul Wright, Jr., M.D., Kathleen J. Yost, M.D., John R. Hyngstrom, M.D., Siwen Hu-Lieskovan, M.D., Ph.D., Christopher D. Lao, M.D., M.P.H., Leslie A. Fecher, M.D., Thach-Giao Truong, M.D., Jennifer L. Eisenstein, M.D., Sunandana Chandra, M.D.,
doi : 10.1056/NEJMoa2211437
Whether pembrolizumab given both before surgery (neoadjuvant therapy) and after surgery (adjuvant therapy), as compared with pembrolizumab given as adjuvant therapy alone, would increase event-free survival among patients with resectable stage III or IV melanoma is unknown.
Cancer Screening after the Adoption of Paid-Sick-Leave Mandates
Kevin Callison, Ph.D., Michael F. Pesko, Ph.D., Serena Phillips, Dr.P.H., and Julie A. Sosa, M.D.
doi : 10.1056/NEJMsa2209197
By the end of 2022, nearly 20 million workers in the United States have gained paid-sick-leave coverage from mandates that require employers to provide benefits to qualified workers, including paid time off for the use of preventive services.
Encapsulating Peritoneal Sclerosis
Xiaojing Tang, M.D., and Lijun Sun, M.D.
doi : 10.1056/NEJMicm2206513
Pseudoxanthoma Elasticum–like Syndrome
Manish Kumar, M.B., B.S., M.D., and Abdul R. Saifudeen, M.B., B.S., M.D.
doi : 10.1056/NEJMicm2024743
A Rocky Resurgence
John W. Ostrominski, M.D., Thomas E. Clancy, M.D., Lynn Bry, M.D., Ph.D., Bruce D. Levy, M.D., and Joseph Loscalzo, M.D., Ph.D.
doi : 10.1056/NEJMcps2107002
Do Thiazides Reduce the Risk of Kidney-Stone Recurrence?
R. Todd Alexander, M.D., Ph.D.
doi : 10.1056/NEJMe2300120
Progress in Treating a Neglected Tropical Disease
David H. Walker, M.D., and Lucas S. Blanton, M.D.
doi : 10.1056/NEJMe2300113
Skin-Cancer Chemoprevention in Transplant Recipients
David M. Miller, M.D., Ph.D., and Kevin S. Emerick, M.D.
doi : 10.1056/NEJMe2214930
Audio Interview: The Path Forward for Covid-19 Therapeutics
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2302292
Health Care in U.S. Correctional Facilities — A Limited and Threatened Constitutional Right
Marcella Alsan, M.D., Ph.D., M.P.H., Crystal S. Yang, J.D., Ph.D., James R. Jolin, Lucy Tu, and Josiah D. Rich, M.D., M.P.H.
doi : 10.1056/NEJMms2211252
Neutralization of BA.4–BA.5, BA.4.6, BA.2.75.2, BQ.1.1, and XBB.1 with Bivalent Vaccine
doi : 10.1056/NEJMc2214916
Aren’t You the Valet? Tales of Black American Surgeons
Orlando Kirton, M.D., M.B.A., and Selwyn O. Rogers, Jr., M.D., M.P.H.
doi : 10.1056/NEJMpv2301016
