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French Recommendations for a National Competency Framework of Therapeutic Patient Education in Solid Organ Transplantation.
Monchaud, Caroline PharmD, PhD 1,2; Villeneuve, Claire PhD 2,3; Belaiche, Stephanie PharmD, PhD 4,5; Charbit, Marina MD, PhD 6; Colosio, Charlotte MD 7; Houssel, Pauline MD 8; Meurette, Aurelie MD 9; Nubret, Karine MD 10; Tissot, Adrien MD 11; Albouy, Marion MD 12,13,14; Esposito, Laure MD 15
doi : 10.1097/TP.0000000000004354
Volume 107(3) pgs. 549-791,e74-e87 March 2023
Transforming Genes to Protect Against Liver Disease: Will siRNA-based Therapeutics Reduce the Need for Liver Transplantation?.
Waller, Karen M.J. MBBS, PhD 1; Bowen, David G. MBBS, PhD, FRACP 1; Strasser, Simone I. MBBS, MD, FRACP, FAASLD 1
Meeting Report: The Fifth International Samuel Strober Workshop on Clinical Immune Tolerance.
Sykes, Megan MD 1; Chandran, Sindhu MD 2; Kawai, Tatsuo MD, PhD 3; Levitsky, Josh MD 4; Mapara, Markus MD, PhD 1; Mathew, James PhD 5; Thomson, Angus PhD, DSc 6; Yamada, Kazuhiko MD, PhD 1
Utility of OPO Procurement Surgeons in Reducing Discards of Marginal Liver Allografts.
Boyan, William P. MD 1; Guarrera, James V. MD, FACS 1
Leveraging Big Data for Small Patients: Identifying Maternal and Neonatal Risk Factors for Pediatric Organ Transplant.
Jackson, Kyle R. MD, PhD 1
When the Deceased Donor Has Sustained Blunt Trauma to the Liver: What Happens Next?.
Verran, Deborah J. MBChB, FRACS 1
The Supply Side of Coagulation: Fibrinogen and Bleeding in Liver Disease and Transplantation.
Wagener, Gebhard MD 1
Large Population-based Study Exposes Higher Incidence and Mortality in Emergency Surgical Conditions in Transplant Recipients.
Steines, Louisa MD, BSc 1; Wirtz, Tobias MD 1
Klotho in Kidney Transplantation: A New and Important Target?.
Lim, Kenneth MD, PhD, MPhil, FASN 1; Chen, Neal MD, PhD 1; Hato, Takashi MD 1
Unanswered Questions on the Management of Nocardia Infections in Transplant Recipients.
Clemente, Wanessa Trindade MD, PhD 1,2
Infection, Rejection, and the Connection.
Higdon, Lauren E. PhD 1; Tan, Jane C. MD, PhD 1; Maltzman, Jonathan S. MD, PhD 1,2
An Overview of Solid Organ Transplantation in Patients With Sickle Cell Disease.
Sharpe, Claire C. MBBS, PhD 1,2; Suddle, Abid MBBS, MD 3; Stuart-Smith, Sara MBBS, MD 4
doi : 10.1097/TP.0000000000004305
AB Sickle cell disease is a common genetic disorder affecting >300 000 people across the world. The vast majority of patients cared for in high-resource settings live well into adulthood, but many develop a high burden of disease complications.
Can We Use Eplets (or Molecular) Mismatch Load Analysis to Improve Organ Allocation? The Hope and the Hype.
Tambur, Anat R. DMD, PhD 1; Das, Rajdeep MD, PhD 1
The Value of Klotho in Kidney Transplantation.
Donate-Correa, Javier PhD 1,2,3; Matos-Perdomo, Emiliano MSc 1,4; Gonzalez-Luis, Ainhoa MSc 1,3,4; Martin-Olivera, Alberto MSc 1,3,4; Ortiz, Alberto PhD 5,6; Mora-Fernandez, Carmen MD 1,2,6; Navarro-Gonzalez, Juan F. PhD 1,2,3,6
doi : 10.1097/TP.0000000000004331
AB Kidney transplant recipients have better survival rates and improved quality of life than long-term dialysis patients. However, delayed graft function, immunosuppressive therapy nephrotoxicity, and rejection episodes may compromise graft and patient survival.
Real-time Lung Weight Measurement During Cellular Ex Vivo Lung Perfusion: An Early Predictor of Transplant Suitability.
Kosaka, Ryo PhD 1; Sakota, Daisuke PhD 1; Sakanoue, Ichiro MD 2,3; Niikawa, Hiromichi MD, PhD 4; Ohuchi, Katsuhiro PhD 5; Arai, Hirokuni MD, PhD 6; McCurry, Kenneth R. MD 2,3,7; Okamoto, Toshihiro MD, PhD 2,3,7
doi : 10.1097/TP.0000000000004380
Increased extravascular lung water during ex vivo lung perfusion (EVLP) is associated with ischemia reperfusion injury and poor pulmonary function. A non-invasive technique for evaluating extravascular lung water during EVLP is desired to assess the transplant suitability of lungs.
Prolonged Controlled Oxygenated Rewarming Improves Immediate Tubular Function and Energetic Recovery of Porcine Kidneys During Normothermic Machine Perfusion.
Ogurlu, Baran BSc 1; Pamplona, Carolina C. MSc 1; Van Tricht, Isa M. 1; Hamelink, Tim L. BSc 1; Lantinga, Veerle A. BSc 1; Leuvenink, Henri G.D. PhD 1; Moers, Cyril MD, PhD 1; Pool, Merel B.F. MD, PhD 1
doi : 10.1097/TP.0000000000004427
Normothermic machine perfusion (NMP) is typically performed after a period of hypothermic preservation, which exposes the kidney to an abrupt increase in temperature and intravascular pressure.
No Stone Left Unturned: Utilization of an Organ Procurement Organization Donor Surgeon at Procurement Reduces Discards of Marginal Liver Allografts.
Shubin, Andrew D. MD, PhD 1; MacConmara, Malcolm P. MB, Bch 2; Patel, Madhukar S. MD 1; Wang, Benjamin K. BS 1; Feizpour, Cyrus A. MD 1; Reese, Jeffrey MD 3; Niles, Patricia A. BS 3; Shah, Jigesh A. MD 1; Desai, Dev M. MD, PhD 1; De Gregorio, Lucia MD 1; Hanish, Steven I. MD 1; Vagefi, Parsia A. MD 1; Hwang, Christine S. MD 1
doi : 10.1097/TP.0000000000004367
The recent trend of organ procurement organizations (OPOs) employing independent surgeons for organ procurement has been developed with the goal of improving the supply of suitable organs for transplantation.
Impact of Recipient Age at Liver Transplant on Long-term Outcomes.
Niazi, Shehzad K. MD, FRCPC 1,2; Brennan, Emily MPH 2,3; Spaulding, Aaron PhD 2,3; Crook, Julia PhD 4; Borkar, Shalmali MPH 2,3; Keaveny, Andrew MD, FRCPI 5; Vasquez, Adriana MD 1; Gentry, Melanie T. MD 6; Schneekloth, Terry MD 7; Taner, C. Burcin MD 5
doi : 10.1097/TP.0000000000004426
The age of a liver transplant (LT) candidate is one of many variables used in the transplant selection process. Most research about the age at transplant has used prespecified age ranges or categories in assessing associations with transplant outcomes.
Liver Transplantation Using Allografts With Recent Liver Blunt Trauma: A Nationwide Audit From the French CRISTAL Biomedicine Agency Registry.
Seckler, Florian MD 1; Turco, Celia MD 1,2; Mohkam, Kayvan MD, PhD 3; Addeo, Pietro MD, PhD 4; Robin, Fabien MD 5; Cauchy, Francois MD, PhD 6; Maulat, Charlotte MD 7; Brustia, Raffaele MD, PhD 8; Paquette, Brice MD 1; Faitot, Francois MD, PhD 4; Weil Verhoeven, Delphine MD, PhD 9; Minello, Anne MD, PhD 10; Lakkis, Zaher MD, PhD 1; Di Martino, Vincent MD, PhD 9; Latournerie, Marianne MD, PhD 10; Chiche, Laurence MD, PhD 11; El Amrani, Mehdi MD, PhD 12; Bucur, Petru MD, PhD 13; Navarro, Francis MD, PhD 14; Chopinet, Sophie MD 15; Chirica, Mircea MD, PhD 16; Gagniere, Johan MD, PhD 17; Iannelli, Antonio MD, PhD 18; Cheisson, Gaelle MD 19; Chardot, Christophe MD, PhD 20; Sommacale, Daniele MD, PhD 8; Muscari, Fabrice MD, PhD 7; Dondero, Federica MD 6; Sulpice, Laurent MD, PhD 5; Bachellier, Philippe MD, PhD 4; Scatton, Olivier MD, PhD 2; Mabrut, Jean Yves MD, PhD 3; Heyd, Bruno MD, PhD 1; Doussot, Alexandre MD, PhD 1
doi : 10.1097/TP.0000000000004434
In the current setting of organ shortage, brain-dead liver donors with recent liver trauma (RLT) represent a potential pool of donors. Yet, data on feasibility and safety of liver transplantation (LT) using grafts with RLT are lacking.
DCD Hepatitis C Virus-positive Donor Livers Can Achieve Favorable Outcomes With Liver Transplantation and Are Underutilized.
Myers, Bryan MD 1; Bekki, Yuki MD, PhD 2; Kozato, Akio MD 2; Crismale, James F. MD 2; Schiano, Thomas D. MD 2; Florman, Sander MD 2
doi : 10.1097/TP.0000000000004401
Hepatitis C virus (HCV)-positive donors (antibody-positive [Ab+] or nucleic acid test positive [NAT+] donors) have been underutilized. The aim of this study was to evaluate the utilization of livers from HCV-positive with donation after circulatory death (DCD) and to assess outcomes in recipients of these grafts.
Is Liver Transplant Justified at Any MELD Score?.
Oden-Brunson, Hannah BA 1; McDonald, Malcolm F. BS 2; Godfrey, Elizabeth MD 3; Keeling, Stephanie S. BSA 1; Cholankeril, George MD 4,5; Kanwal, Fasiha MD 5; O'Mahony, Christine MD 4; Goss, John MD 4; Rana, Abbas MD 4
doi : 10.1097/TP.0000000000004345
Assessing the survival benefit of transplantation in patients with end-stage liver disease is critical in guiding the decision-making process for liver allocation.
Preoperative Fibrinogen Level and Bleeding in Liver Transplantation for End-stage Liver Disease: A Cohort Study.
Carrier, Francois Martin MD, MSc 1,2,3,4; Deshetres, Annie MD 5; Ferreira Guerra, Steve MSc 6; Rioux-Masse, Benjamin MD 7,8; Zaouter, Cedrick MD, MSc 1,4; Lee, Nick Med Stud 5; Amzallag, Eva MSc 3; Joosten, Alexandre MD, PhD 9; Massicotte, Luc MD 1,4; Chasse, Michael MD, PhD 2,3,8
doi : 10.1097/TP.0000000000004333
Liver transplantation is a high-risk surgery associated with important perioperative bleeding and transfusion needs. Uncertainties remain on the association between preoperative fibrinogen level and bleeding in this population.
Normothermic Regional Perfusion in Pediatric Controlled Donation After Circulatory Death Can Lead to Optimal Organ Utilization and Posttransplant Outcomes.
Minambres, Eduardo MD, PhD 1,2; Estebanez, Belen MD 3; Ballesteros, Maria Angeles MD, PhD 1; Coll, Elisabeth MD, PhD 4; Flores-Cabeza, Eva Mercedes MD 3; Mosteiro, Fernando MD 5; Lara, Ramon MD 6; Dominguez-Gil, Beatriz MD, PhD 4
doi : 10.1097/TP.0000000000004326
The benefits of normothermic regional perfusion (NRP) in posttransplant outcomes after controlled donation after the determination of death by circulatory criteria (cDCD) has been shown in different international adult experiences.
Antibody-mediated Rejection Without Detectable Donor-specific Antibody Releases Donor-derived Cell-free DNA: Results From the Trifecta Study.
Halloran, Philip F. MD, PhD 1,2,3; Reeve, Jeff PhD 1; Madill-Thomsen, Katelynn S. PhD 3; Demko, Zachary PhD 4; Prewett, Adam MBA 4; Gauthier, Philippe MD 4; Billings, Paul MD, PhD 4; Lawrence, Christopher MD 5; Lowe, Dave PhD 5; Hidalgo, Luis G. PhD 6; the Trifecta Investigators
doi : 10.1097/TP.0000000000004324
Trifecta (ClinicalTrials.gov #NCT04239703) is a prospective trial defining relationships between donor-derived cell-free DNA (dd-cfDNA), donor-specific antibody (DSA), and molecular findings in kidney transplant biopsies.
Association of Maternal and Neonatal Birth Outcomes With Subsequent Pediatric Transplants.
Cote-Corriveau, Gabriel MD, FRCPC 1,2; Luu, Thuy Mai MD, FRCPC 3; Bilodeau-Bertrand, Marianne MSc 2; Auger, Nathalie MD, FRCPC 1,2,4,5
doi : 10.1097/TP.0000000000004318
We identified maternal and neonatal birth characteristics that were associated with organ or tissue transplants during childhood. Methods. We designed a retrospective cohort study of the population of children born between 2006 and 2019 in Quebec, Canada.
Immunosuppression in Uterus Transplantation: Experience From the Dallas Uterus Transplant Study.
Wilson, Nicole K. PharmD, MSc 1; Schulz, Philipp MD 2; Wall, Anji MD, PhD 2; Parrott, Megan MD 2; Testa, Giuliano MD, MBA 2; Johannesson, Liza MD, PhD 2,3; Sam, Teena PharmD, BCCP 1
doi : 10.1097/TP.0000000000004437
Uterus transplantation is a temporary transplant allowing women with absolute uterine factor infertility to experience pregnancy and childbirth. The degree of immunosuppression (IS) required to prevent rejection while minimizing toxicity to the recipient and fetus remains an area of investigation.
Change in First-year Intravascular Ultrasound Results Predicts Adverse Events in Heart Transplant Recipients: Implications for Clinical Trial Endpoints.
Seguchi, Osamu MD, PhD 1,2; Azarbal, Babak MD 1; Mirocha, James MS 3; Youn, Jong-Chan MD, PhD 1,4; Passano, Elizabeth BA 1; Patel, Jignesh MD, PhD 1; Kobashigawa, Jon MD 1
doi : 10.1097/TP.0000000000004395
Heart transplantation (HTx) is an established therapeutic option for patients with advanced heart failure who are refractory to conventional guideline-directed treatments.
Absolute Lymphocyte Count as a Marker for Cytomegalovirus Infection After Heart Transplantation.
Schoeberl, Armin-Kai MD 1; Zuckermann, Andreas MD 1; Kaider, Alexandra MSc 2; Aliabadi-Zuckermann, Arezu MD 1; Uyanik-Uenal, Keziban MD 1; Laufer, Guenther MD 1; Goekler, Johannes MD 1
doi : 10.1097/TP.0000000000004360
Previous studies indicate an association between reduced absolute lymphocyte count (ALC) and cytomegalovirus (CMV) infection after solid organ transplantation and have therefore highlighted the potential of ALC as a simple tool to predict CMV infection in transplant patients.
Incidence and Mortality of Emergency General Surgery Conditions Among Solid Organ Transplant Recipients in Ontario, Canada: A Population-based Analysis.
Gomez, David MD, PhD 1,2,3,4,5; Acuna, Sergio A. MD, PhD 1; Joseph Kim, S. MD, PhD, MHS, MBA 2,5,6; Nantais, Jordan MD 4; Santiago, Robin 7; Calzavara, Andrew MSc 2; Saskin, Refik MSc 2; Baxter, Nancy N. MD, PhD 1,2,4,5,8
doi : 10.1097/TP.0000000000004299
AB Background. Emergency general surgery (EGS) conditions and their outcomes are perceived to be disproportionately high among solid organ transplant recipients (SOTRs). However, this has not been adequately investigated at a population level. We characterized the incidence and mortality of EGS conditions among SOTRs compared with nontransplant patients.
Isavuconazole for the Treatment of Invasive Mold Disease in Solid Organ Transplant Recipients: A Multicenter Study on Efficacy and Safety in Real-life Clinical Practice.
Fernandez-Ruiz, Mario MD, PhD 1,2,3; Bodro, Marta MD, PhD 3,4; Gutierrez Martin, Isabel MD 5; Rodriguez-Alvarez, Regino MD, PhD 6; Ruiz-Ruigomez, Maria MD, PhD 1; Sabe, Nuria MD, PhD 3,7,8; Lopez-Vinau, Teresa MD 3,9; Valerio, Maricela MD, PhD 2,10,11; Illaro, Aitziber PharmD 12; Fortun, Jesus MD, PhD 3,13,14; Salto-Alejandre, Sonsoles MD 3,15; Cordero, Elisa MD, PhD 3,15; Farinas, Maria del Carmen MD, PhD 3,16,17; Munoz, Patricia MD, PhD 2,10,11; Vidal, Elisa MD, PhD 3,9,18; Carratala, Jordi MD, PhD 3,7,8; Goikoetxea, Josune MD, PhD 6; Ramos-Martinez, Antonio MD, PhD 19,20; Moreno, Asuncion MD, PhD 3,4; Aguado, Jose Maria MD, PhD 1,2,3; SOTIS Study Group
doi : 10.1097/TP.0000000000004312
Isavuconazole has theoretical advantages over other mold-active triazoles for the treatment of invasive aspergillosis and mucormycosis after solid organ transplantation (SOT). The available clinical experience, nevertheless, is scarce.
C-peptide Targets and Patient-centered Outcomes of Relevance to Cellular Transplantation for Diabetes.
Verhoeff, Kevin MD 1; Marfil-Garza, Braulio A. MD 1,2,3; Dajani, Khaled MBChB 1; Bigam, David L. MD, MSc 1; Anderson, Blaire MD 1; Kin, Tatsuya MD, PhD 1,4; Lam, Anna MD 4,5,6; O'Gorman, Doug 4; Senior, Peter A. MD, PhD 4,5,6; Shapiro, A. M. James MD, PhD 1,4,6
doi : 10.1097/TP.0000000000004328
C-peptide levels are a key measure of beta-cell mass following islet transplantation, but threshold values required to achieve clinically relevant patient-centered outcomes are not yet established.
Outcomes of Nocardiosis and Treatment of Disseminated Infection in Solid Organ Transplant Recipients.
Yetmar, Zachary A. MD 1; Challener, Douglas W. MD, MS 1; Seville, Maria Teresa MD 2; Bosch, Wendelyn MD 3; Beam, Elena MD 1
Anti-CD38 Monoclonal Antibodies Interfere With Isoagglutinin Detection.
Del Bello, Arnaud MD, PhD 1,2; Kamar, Nassim MD, PhD 1,2,3; Cointault, Olivier MD 1; Vieu, Guillaume PharmD 4; Gauthier, Katia MD 4
Comment on: "The Supply Side of Coagulation: Fibrinogen and Bleeding in Liver Disease and Transplantation." The Known, the Unknown, the Possibly Known, and the Impossible.
Carrier, Francois Martin MD, MSc 1,2,3,4; Zaouter, Cedrick MD, MSc 1,2
RE: Time-dependent Bias Existing in Their Statistical Analysis Must Be Properly Controlled/Avoided Before Drawing Any Conclusions.
Gaynor, Jeffrey J. PhD 1; Tabbara, Marina M. MD 1; Ciancio, Gaetano MD 1
RE: The Efficacy and Safety of SGLT2 Inhibitor in Kidney Transplant Recipients With Diabetes.
Lim, Jeong-Hoon MD, PhD 1; Cho, Jang-Hee MD, PhD 1
Changes in Donor and Recipient Demographic Characteristics Over Time Explain the Increasing Prevalence of the High-risk Cytomegalovirus Donor-positive/Recipient-negative Serostatus in Solid Organ Transplant Recipients.
Mossad, Sherif Beniameen MD 1
Letter Regarding: Women Leadership in Liver Transplantation-Results of an International Survey.
Choubey, Apurva S. BS 1; Choubey, Ankur P. MD, MPH 2; Ortiz, Alejandro Chiodo BS 3; Ortiz, Jorge MD 3
In Response: Women Leadership in Liver Transplantation.
Pai, Sher-Lu MD 1; Selzner, Nazia MD 2
Immunogenicity, Safety, and Clinical Effectiveness After 2 Doses of BNT162b2 Vaccine Among Pediatric Kidney Transplant Recipients Versus Healthy Volunteers: A Prospective Nonrandomized Study.
Medina-Pestana, Jose PhD 1; Martins, Suelen Bianca Stopa MD 1; Custodio, Luciana de Fatima Porini MD 1; Rissoni, Renata Aparecida Pimentel MSc 2; Dreige, Yasmim Cardoso MSc 1; Nakamura, Monica Rika MSc 1; Amorim, Laysla Verhalen Pouzo undergraduate student 1; Chow, Charles Yea Zen MD 1; Tedesco-Silva, Helio PhD 1; Cristelli, Marina Pontello PhD 1
