Gillmann, Kevin MD, MBBS, FEBOphth, MArch; Meduri, Enrico MD; Niegowski, Laëtitia J. MD; Mermoud, André MD
doi : 10.1097/IJG.0000000000001724
March 2021 - Volume 30 - Issue 3 - p e32-e39
Pseudoexfoliative glaucoma (PEXG) is the most common cause of secondary open-angle glaucoma worldwide. It is more aggressive and often more resistant to conventional treatments than primary open-angle glaucoma, yet there is currently no clear consensus on best management practices. This review explores current literature on PEXG to assess the safety and efficacy of currently available surgical techniques, and discusses clinical considerations on the diagnosis and management of the disease.
Realini, Tony MD, MPH*; Gupta, Preeya K. MD†; Radcliffe, Nathan M. MD‡; Garg, Sumit MD§; Wiley, William F. MD?; Yeu, Elizabeth MD¶; Berdahl, John P. MD#; Kahook, Malik Y. MD**
doi : 10.1097/IJG.0000000000001722
March 2021 - Volume 30 - Issue 3 - p 209-218
A healthy corneal endothelium is required for corneal clarity. Both the glaucoma disease state and its various forms of treatment can have adverse effects on the corneal endothelium. Both the presence of glaucoma and the magnitude of intraocular pressure elevation are related to endothelial cell loss (ECL). Topical medical therapy, laser procedures, and both traditional surgeries—trabeculectomy and tube-shunts—and newer minimally invasive glaucoma surgeries have variable effects on ECL. This review will summarize the reported effects of glaucoma and its treatment on ECL. Concerns for corneal endothelial cell health should be part of the decision-making process when planning glaucoma therapy for lowering intraocular pressure, with added caution in case of planned device implantation in eyes with preexisting ECL and low endothelial cell density at high risk for corneal endothelial decompensation.
Ooms, Ashley BS*; Shaikh, Ibraheem BS*; Patel, Nishant BS*; Kardashian-Sieger, Thomas BS*; Srinivasan, Nivetha BS*; Zhou, Benjamin BS*; Wilson, Logan MS†; Szirth, Bernard PhD*; Khouri, Albert S. MD*
doi : 10.1097/IJG.0000000000001731
March 2021 - Volume 30 - Issue 3 - p e40-e46
Telepresence robots (TR) present the versatility to effectively provide remote educational sessions for patients affected by glaucoma to improve disease knowledge. Given COVID-19’s effect on clinical practice, TR can maintain social distancing when educating patients.
Jain, Nikhil MBBS*; Kaur, Simerdip MRCP†; Kopsachilis, Nikolaos MD, PhD†,‡; Zia, Rashid MRCSEd†,‡
doi : 10.1097/IJG.0000000000001771
March 2021 - Volume 30 - Issue 3 - p 219-222
Designing and demonstrating an experiment that shows the risk of airborne transmission of COVID-19 between patients having visual fields analyzed is low.
Baughman, Brittanie D. BA, MS*; Hansemann, Beth K. BS, COT†; Shah, Manjool M. MD†; Weizer, Jennifer S. MD†
doi : 10.1097/IJG.0000000000001748
March 2021 - Volume 30 - Issue 3 - p 223-226
A drive-through clinic was created to obtain intraocular pressure measurements before a virtual visit with their provider, in order to provide care for patients in the Kellogg Glaucoma Clinic while minimizing risk of COVID-19 transmission.
Davanian, Arash M. DO; Donahue, Sean P. MD, PhD; Mogil, Rachel S. MD; Groth, Sylvia L. MD
doi : 10.1097/IJG.0000000000001746
March 2021 - Volume 30 - Issue 3 - p e47-e49
The coronavirus (COVID-19) pandemic has impacted ophthalmology practices significantly. American Academy of Ophthalmology and Center for Disease Control guidelines suggest mandatory masking of patients and physicians during outpatient visits. We have recently become aware of a mask-induced phenomenon, whereby the intraocular pressure (IOP) as measured by Goldmann applanation tonometry (GAT) is artificially elevated due to mechanical interference from the mask.
Krawitz, Brian D. MD*; Sirinek, Portia MD†; Doobin, David MD*; Nanda, Tavish MD*; Ghiassi, Maryam MD*; Horowitz, Jason D. MD*; Liebmann, Jeffrey M. MD*; De Moraes, Carlos G. MD, PhD, MPH*
doi : 10.1097/IJG.0000000000001763
March 2021 - Volume 30 - Issue 3 - p e50-e53
To report a case of bilateral acute angle-closure glaucoma associated with hyponatremia in the setting of chlorthalidone use and SARS-CoV-2 infection, and to demonstrate the challenges of managing this patient given her infectious status.
Reilly, Matthew A. PhD*,†; Roberts, Cynthia J. PhD*,†
doi : 10.1097/IJG.0000000000001753
March 2021 - Volume 30 - Issue 3 - p e54
Tang, Yuan MS*; Chen, Yanyan MS*,†; Li, Chunchun MS†; Qu, Jia OD, PhD†
doi : 10.1097/IJG.0000000000001752
March 2021 - Volume 30 - Issue 3 - p e54-e55
Holl?, G?bor MD, PhD, DSc
doi : 10.1097/IJG.0000000000001750
March 2021 - Volume 30 - Issue 3 - p e105
Gür Güng?r, Sirel MD; Sarigül Sezen?z, Almila MD, FEBO; ?ztürk, Caner MD; G?kg?z, Gül?ah MD; Akman, Ahmet MD
doi : 10.1097/IJG.0000000000001751
March 2021 - Volume 30 - Issue 3 - p e105-e106
Kumari, Nitu DNB; Sarma, Prafulla MS; Tayab, Shahinur MS; Sangma, Chengchira A. DO; Chirania, Palak DNB
doi : 10.1097/IJG.0000000000001666
March 2021 - Volume 30 - Issue 3 - p e106
Brescia, Lorenza MD; Agnifili, Luca MD, PhD; Mastropasqua, Leonardo MD, FEBOphth
doi : 10.1097/IJG.0000000000001665
March 2021 - Volume 30 - Issue 3 - p e106-e107
Grzybowski, Andrzej MD, PhD, MBA*,†; Kanclerz, Piotr MD, PhD‡
doi : 10.1097/IJG.0000000000001708
March 2021 - Volume 30 - Issue 3 - p e123
Eichenbaum, David A. MD; Liebmann, Jeffrey M. MD; Barton, Keith MD; Weinreb, Robert N. MD; Gupta, Preeya K. MD; McCabe, Cathleen M. MD; Wolfe, Jeremy D. MD; Ahmed, Iqbal MD; Sheybani, Arsham MD; Craven, E. Randy MD
doi : 10.1097/IJG.0000000000001707
March 2021 - Volume 30 - Issue 3 - p e123-e124
Geoffrion, Dominique BSc*,†; Harissi-Dagher, Mona MD, FRCSC†
doi : 10.1097/IJG.0000000000001772
March 2021 - Volume 30 - Issue 3 - p e124-e125
Quercia, Andressa Z.F.; Silva, Luzia D. MD; de Oliveira, Filipe; Teixeira, Sergio H. MD; de Sousa, Luciene B. MD; de Oliveira, Lauro A. MD
doi : 10.1097/IJG.0000000000001773
March 2021 - Volume 30 - Issue 3 - p e125
Kumari, Priti MS; Dubey, Suneeta MS
doi : 10.1097/IJG.0000000000001778
March 2021 - Volume 30 - Issue 3 - p e126
Belamkar, Aditya V.*; Mansukhani, Sasha A. MBBS, MS*; Savica, Rodolfo MD, PhD†; Spiegel, Matthew R. MS‡; Hodge, David O. MS‡; Sit, Arthur J. SM, MD*
doi : 10.1097/IJG.0000000000001774
March 2021 - Volume 30 - Issue 3 - p 227-234
In this population-based study of 509 open-angle glaucoma (OAG) patients over a 36-year period, we identified a decreased rate of developing dementia compared with the rate in the general population.
Yang, Zhiyong MD, PhD*; Mansouri, Kaweh MD†,‡; Moghimi, Sasan MD*; Weinreb, Robert N. MD*
doi : 10.1097/IJG.0000000000001727
March 2021 - Volume 30 - Issue 3 - p e56-e60
The aim was to determine whether 24-hour recording of intraocular pressure (IOP)-related ocular dimensional changes with a contact lens sensor (CLS, Triggerfish) is associated with the rate of visual field (VF) progression in primary open-angle glaucoma (POAG) patients.
Rao, Harsha L. MD, PhD*,†; Srinivasan, Thanemozhi MS‡; Pradhan, Zia S. FRCOphth‡; Sreenivasaiah, Shruthi DNB‡; Rao, Dhanaraj A.S. MS‡; Puttaiah, Narendra K. DNB*; Devi, Sathi DNB‡; Moghimi, Sasan MD§; Mansouri, Kaweh MD?,¶; Webers, Carroll A.B. MD, PhD†; Weinreb, Robert N. MD
doi : 10.1097/IJG.0000000000001745
March 2021 - Volume 30 - Issue 3 - p e61-e67
Lower whole enface disc (coefficient: 0.02, P=0.03) and macular vessel densities (coefficient: 0.04, P=0.02) on optical coherence tomography angiography (OCTA) were significantly associated with faster rate of mean deviation (MD) decline.
Chakravarti, Tutul MD*,†,‡; Moghimi, Sasan MD*; De Moraes, Carlos Gustavo MD, PhD, MPH§; Weinreb, Robert N. MD*
doi : 10.1097/IJG.0000000000001747
March 2021 - Volume 30 - Issue 3 - p e68-e75
This study demonstrates the substantial association between visual field (VF) defect within the central-most 4 points in 24-2 VF and the VF defect exhibited by 10-2 test pattern relative to the initial defect in 24-2 VF.
Ballae Ganeshrao, Shonraj PhD*,†,‡; Jaleel, Amina MSc†; Madicharla, Srija BS§; Kavya Sri, Vanga BS§; Zakir, Juwariah BS§; Garudadri, Chandra S. FRCS*; Senthil, Sirisha FRCS*
doi : 10.1097/IJG.0000000000001757
March 2021 - Volume 30 - Issue 3 - p e76-e82
Saccadic eye movements were compared between high-tension glaucoma (HTG), normal-tension glaucoma (NTG), and primary angle-closure glaucoma (PACG). Saccades were differently affected between the subtypes of primary glaucoma.
Barayev, Edward MD, MHA*,†; Geffen, Noa MD*,†; Nahum, Yoav MD*,†; Gershoni, Assaf MD*,†
doi : 10.1097/IJG.0000000000001728
March 2021 - Volume 30 - Issue 3 - p e83-e89
Brand glaucoma medication prices vastly increased in the United States over the past 7 years, despite a reduction in eye-care providers’ tendency to prescribe brand medications over generics.
Okonya, Ochije BS*; Lai, Elaine BS*,†; Ottwell, Ryan BS*; Khattab, Mostafa BS*; Arthur, Wade BS*; Khaimi, Mahmoud A. MD‡; Wright, Drew N. MLS§; Hartwell, Micah PhD*,?; Vassar, Matt PhD*
doi : 10.1097/IJG.0000000000001735
March 2021 - Volume 30 - Issue 3 - p 235-241
Spin—the misrepresentation of the study’s actual findings—carries the ability to distort a reader’s perception of a treatments’ full benefits and risks. Recent studies have suggested that spin is common in abstracts of randomized controlled trials and systematic reviews focused on treatments for a variety of medical disorders. Therefore, our primary objective was to evaluate the prevalence of spin in the abstracts of systematic reviews and meta-analyses related to glaucoma treatments. We further assessed whether specific study characteristics were associated with spin, including the methodological quality of a study.
Patel, Anik R. PhD*; Schwartz, Gail F. MD†; Campbell, Joanna H. PhD*; Chen, Chi-Chang PhD‡; McGuiness, Catherine B. MSc‡; Multani, Jasjit K. MPH‡; Shih, Vanessa PharmD*; Smith, Oluwatosin U. MD
doi : 10.1097/IJG.0000000000001730
March 2021 - Volume 30 - Issue 3 - p 242-250
Incremental addition of intraocular pressure–lowering topical drops is associated with shorter-lasting benefit and higher health-related costs with each additional agent, suggesting a need for new treatment options to improve disease control and reduce treatment burden.
Gamiochipi-Arjona, Jorge E. MD*; Azses-Halabe, Yael MD*; Tolosa-Tort, Paulina MD, PhD*; Lazcano-G?mez, Gabriel MD*; Gonzalez-Salinas, Roberto MD, PhD†; Turati-Acosta, Mauricio MD*; Garc?a-Huerta, Magdalena MD*; Jiménez-Rom?n, Jes?s MD*
doi : 10.1097/IJG.0000000000001739
March 2021 - Volume 30 - Issue 3 - p 251-256
The prevalence of depression in Mexican patients with glaucoma is higher than that reported in the general population. Depression prevalence and severity are directly associated with glaucoma severity and lower adherence to medical treatment.
Idriss, Baimba R. MMed, MBChB*,†; Tran, Tu M. MD, MSc‡; Atwine, Daniel PhD, MMed*,§; Chang, Robert T. MD?; Myung, David MD, PhD?,¶; Onyango, John MMed*
doi : 10.1097/IJG.0000000000001779
March 2021 - Volume 30 - Issue 3 - p e90-e98
Using optical coherence tomography (OCT) measurements as a reference standard for vertical cup-to-disc ratio (vCDR), a smartphone-based ophthalmic camera has a sensitivity of 67.7% and specificity of 96.7% to detect a vCDR>0.5.
Marco, Sheila A. MBChB, MMED, FEACO*,†; Amin, Samreen BEIT‡; Virani, Aleena BScH§; Rudnisky, Christopher J. MD, MPH, FRCSC‡; Ishani, Sarah MHA?; Kiage, Dan MD, MBChB, MMed, FEACO¶; Damji, Karim F. MD, FRCSC, MBA‡
doi : 10.1097/IJG.0000000000001742
March 2021 - Volume 30 - Issue 3 - p e99-e104
A teleglaucoma (TG) case-finding model was used in Kenya. Of the patients, 3.46% had definite glaucoma and 4.12% were glaucoma suspects. Most cases were of moderate to advanced stage and referred for further assessment.
Lim, Edward J.Y. MBBS*; Cecilia, Aquino M. MD, MMED (Ophth)†; Lim, Dawn K.A. MBBS, MRCP (UK), MMed (Int.Med), MMed (Ophth), FAMS†; Sng, Chelvin C.A. FRCSEd†; Loon, Seng Chee MBBS (S’pore), MMed (Ophth), FRCSEd, FAMS†; Lun, Katherine W.X. MBBS, MMed (Ophth)†; Chew, Paul T.K. MBBS, MMed (Ophth), FRCSEd, FRCOphth, FAMS†; Koh, Victor T.C. MBBS, MMed (Ophth), MRCSEd, FAMS*,†
doi : 10.1097/IJG.0000000000001729
March 2021 - Volume 30 - Issue 3 - p 257-265
Micropulse transscleral cyclophotocoagulation (MPTCP) is only moderately effective in lowering intraocular pressure (IOP) and is useful as an adjunct procedure to other glaucoma surgeries. There was a small risk of loss of vision, prolonged hypotony, and phthisis bulbi.
Salimi, Ali MD, MSc*,†; Watt, Harrison BSc‡; Harasymowycz, Paul MD†
doi : 10.1097/IJG.0000000000001716
March 2021 - Volume 30 - Issue 3 - p 266-275
This longitudinal case series provides valuable long-term data on the safety and efficacy of iStent inject with concomitant cataract surgery. Patients experienced significant and durable reductions in both intraocular pressure (IOP) and medication burden through 3 years postoperative.
Le, Patrick H. BS*; Nguyen, Michelle BS*; Humphrey, Kris-Ann MD†; Klifto, Meredith R. MD†
doi : 10.1097/IJG.0000000000001732
March 2021 - Volume 30 - Issue 3 - p 276-280
Ahmed and Baerveldt implants succeed in 90.7% of cases for lowering intraocular pressure (IOP) <21?mm?Hg at 1 year when used for the treatment of juvenile open-angle glaucoma.
Batlle, Juan F. MD; Corona, Adalgisa MD; Albuquerque, Rachel MD
doi : 10.1097/IJG.0000000000001734
March 2021 - Volume 30 - Issue 3 - p 281-286
The MicroShunt was implanted in 23 patients with primary open-angle glaucoma (POAG) in a feasibility study. Reductions in intraocular pressure (IOP) and medications were sustained for up to 5 years with no long-term sight-threatening adverse events (AEs).
Purtskhvanidze, Konstantine MD*; Saeger, Mark MD*; Frimpong-Boateng, Adjoa MD*,†; Rüfer, Florian MD*,‡; Roider, Johann MD*; N?lle, Bernhard MD*
doi : 10.1097/IJG.0000000000001741
March 2021 - Volume 30 - Issue 3 - p e108-e113
In eyes with intractable glaucoma, drainage devices provide long-term control of intraocular pressure also after penetrating keratoplasty (PK). There is a high incidence of corneal graft failure.
Aktas, Zeynep MD, FEBO, FGS*; Ucgul, Ahmet Y. MD†; Ozdek, Sengul MD, FEBO*; Boluk, Ceyda E. MD*
doi : 10.1097/IJG.0000000000001738
March 2021 - Volume 30 - Issue 3 - p e114-e118
The present study demonstrates that surgical success rates of gonioscopy-assisted transluminal trabeculotomy (GATT) with a target intraocular pressure (IOP)?21?mm?Hg are 93.3% (for qualified success) and 26.7% (for complete success) in vitrectomized patients exhibiting secondary open-angle glaucoma (SOAG) after silicone oil (SO) removal, for an average follow-up of 37.5 months.
Denny, Matthew R. MD*; Chu, Fred B. MD*,†; Cheung, Albert Y. MD‡; Holland, Edward J. MD*
doi : 10.1097/IJG.0000000000001723
March 2021 - Volume 30 - Issue 3 - p e119-e122
Rates of ocular surface failure and glaucoma reoperation were similar between cyclophotocoagulation (CPC) and glaucoma drainage devices (GDDs). CPC is a safe option in the management of secondary glaucoma after ocular surface stem cell transplantation (OSST).
Gershoni, Assaf MD*,†; Glovinsky, Yoseph MD†,‡; Rotenberg, Michael MD§; Barayev, Edward MD, MHA*,†; Segal, Ori MD†,?; Geffen, Noa MD*
doi : 10.1097/IJG.0000000000001720
March 2021 - Volume 30 - Issue 3 - p e127-e133
We present a novel stentless filtration system used to create a permanent sclerocorneal drainage channel that reduces intraocular pressure (IOP) without the need to create a conjunctival incision or a scleral flap.
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