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Trends in the incidence of kidney replacement therapy: comparisons of ERA, USRDS and Japan registries
Kunihiro Yamagata
doi : 10.1093/ndt/gfac312
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 797–799
Care about the flare: the importance of avoiding lupus nephritis recurrence
Julia Weinmann-Menke, Daniel Kraus
doi : 10.1093/ndt/gfac323
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 800–802
Renal sarcoidosis
Swati Mehta, Andrea Lightle, Marc A Judson
doi : 10.1093/ndt/gfac219
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 803–810
Renal sarcoidosis (RS) is a rare form of sarcoidosis that results in granulomatous inflammation of renal parenchyma. We describe the epidemiology, pathogenesis, clinical features, diagnostic approach, treatment strategies and outcomes of this condition.
Estimating urine volume from the urine creatinine concentration
Yishan Dong, Stephen M Silver, Richard H Sterns
doi : 10.1093/ndt/gfab337
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 811–818
Spot determinations of the urine creatinine concentration are widely used as a substitute for 24-h urine collections. Expressed as the amount excreted per gram of creatinine, urine concentrations in a single-voided sample are often used to estimate 24-h excretion rates of protein, sodium, potassium, calcium, magnesium, urea and uric acid.
Klotho in kidney diseases: a crosstalk between the renin–angiotensin system and endoplasmic reticulum stress
Ajinath Kale, Himanshu Sankrityayan, Hans-Joachim Anders, Anil Bhanudas Gaikwad
doi : 10.1093/ndt/gfab340
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 819–825
Klotho is a transmembrane anti-ageing protein that exists in three forms, i.e. α-Klotho, β-Klotho and γ-Klotho, with distinct organ-specific expression and functions in the body.
The role of PLA2R antibody monitoring: what we know and what we do not know
Pierre Ronco, Emmanuelle Plaisier, Hanna Debiec
doi : 10.1093/ndt/gfab356
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 826–833
For a long time, kidney biopsy was the only diagnostic means for membranous nephropathy (MN) and proteinuria and serum creatinine were the only markers of disease activity.
Overcoming barriers in the design and implementation of clinical trials for acute kidney injury: a report from the 2020 Kidney Disease Clinical Trialists meeting
Daniel Lazzareschi, Ravindra L Mehta, Laura M Dember, Juliane Bernholz, Alparslan Turan, Amit Sharma, Sachin Kheterpal, Chirag R Parikh, Omar Ali, Ivonne H Schulman, Abigail Ryan, Jean Feng, Noah Simon, Romain Pirracchio, Patrick Rossignol, Matthieu Legrand
doi : 10.1093/ndt/gfac003
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 834–844
Acute kidney injury (AKI) is a growing epidemic and is independently associated with increased risk of death, chronic kidney disease (CKD) and cardiovascular events.
Non-steroidal mineralocorticoid receptor antagonists and cardiorenal outcomes in chronic kidney disease
Kevin Bryan Lo, Janani Rangaswami, Muthiah Vaduganathan
doi : 10.1093/ndt/gfac322
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 845–854
The burden of adverse cardiorenal outcomes among patients with the trifecta of diabetes, heart failure (HF) and chronic kidney disease (CKD) remains high.
Towards a tailored prescription of dialysis adequacy: the key role of incremental haemodialysis
Carlo Basile, Francesco Gaetano Casino, Sandip Mitra, EuDial Working Group of the European Renal Association
doi : 10.1093/ndt/gfac281
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 855–857
Roxadustat (FG-4592) protects against ischaemia-induced acute kidney injury via improving CD73 and decreasing AIM2 inflammasome activation
Huan Yang, Yong Wu, Ming Cheng, Ming Zhang, Xiaoyan Qiu, Shaojun Liu, Minmin Zhang
doi : 10.1093/ndt/gfac308
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 858–875
Hypoxia-mediated inflammation plays a crucial role in renal ischaemia–reperfusion (IR)-induced acute kidney injury (AKI) and may influence renal graft survival, with no available pharmacological treatments.
Cadmium, active smoking and renal function deterioration in patients with type 2 diabetes
Milou M Oosterwijk, Ilse J M Hagedoorn, Ronald G H J Maatman, Stephan J L Bakker, Gerjan Navis, Gozewijn D Laverman
doi : 10.1093/ndt/gfac270
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 876–883
Cadmium is an established nephrotoxin, present in cigarette smoke. We investigated the hazards of cadmium concentration and smoking status on renal function deterioration.
The influence of repeated flares in response to therapy and prognosis in lupus nephritis
Abril A Perez-Arias, SofÃa E Márquez-Macedo, Oscar R Pena-Vizcarra, MarÃa Fernanda Zavala-Miranda, Juanita Romero-DÃaz, Luis E Morales-Buenrostro, Juan M MejÃa-Vilet
doi : 10.1093/ndt/gfac304
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 884–893
Repeated renal flares in lupus nephritis (LN) have been associated with worse long-term kidney function. This study aimed to assess the impact of repeated LN flares in response to therapy, kidney and patient prognosis.
Design of the COmbinatioN effect of FInerenone anD EmpaglifloziN in participants with chronic kidney disease and type 2 diabetes using a UACR Endpoint study (CONFIDENCE)
Jennifer B Green, Amy K Mottl, George Bakris, Hiddo J L Heerspink, Johannes F E Mann, Janet B McGill, Masaomi Nangaku, Peter Rossing, Charlie Scott, Alain Gay, Rajiv Agarwal
doi : 10.1093/ndt/gfac198
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 894–903
Despite available interventions, people with type 2 diabetes (T2D) remain at risk of chronic kidney disease (CKD).
Prospective associations of health literacy with clinical outcomes in adults with CKD: findings from the CRIC study
Mayra L Estrella, Paula Allen-Meares, Ana C Ricardo, Michael J Fischer, Elisa J Gordon, Eunice Carmona-Powell, James Sondheimer, Jing Chen, Edward Horwitz, Xue Wang, Jesse Y Hsu, James P Lash, Claudia Lora, the CRIC Study Investigators
doi : 10.1093/ndt/gfac201
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 904–912
Limited health literacy is associated with significant morbidity and mortality in the general population but the relation of health literacy with long-term clinical outcomes among adults with chronic kidney disease (CKD) is less clear.
Retrospective study of 59 cases of cancer-associated thrombotic microangiopathy: presentation and treatment characteristics
Antoine Decaestecker, Aghilès Hamroun, François Provot, Eric Rondeau, Stanislas Faguer, Marion Sallee, Dimitri Titeca-Beauport, Jean Michel Rebibou, Alexandra Forestier, Raymond Azar, Clément Deltombe, Alain Wynckel, Steven Grange, Veronique Fremeaux Bacchi, Claire Cartery
doi : 10.1093/ndt/gfac213
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 913–921
Cancer-associated thrombotic microangiopathy (TMA) is a rare disease, with a poor prognosis. The classical treatment is urgent chemotherapy. Few data are available on the efficacy of plasma exchange (PE) and eculizumab in these patients.
Patient views regarding cannabis use in chronic kidney disease and kidney failure: a survey study
David Collister, Gwen Herrington, Lucy Delgado, Reid Whitlock, Karthik Tennankore, Navdeep Tangri, Remi Goupil, Annie-Claire Nadeau-Fredette, Sara N Davison, Ron Wald, Michael Walsh
doi : 10.1093/ndt/gfac226
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 922–931
Cannabis is frequently used recreationally and medicinally, including for symptom management in patients with kidney disease.
CKD-MBD biomarkers and CKD progression: an analysis by the joint model
Graziella D'Arrigo, Francesca Mallamaci, Patrizia Pizzini, Daniela Leonardis, Giovanni Tripepi, Carmine Zoccali
doi : 10.1093/ndt/gfac212
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 932–938
Biomarkers of chronic kidney disease–mineral and bone disorder (CKD-MBD) have been implicated in CKD progression in follow-up studies focusing on single measurements of individual biomarkers made at baseline only.
Sequential rituximab therapy sustains remission of nephrotic syndrome but carries high risk of adverse effects
Aditi Sinha, Georgie Mathew, Arushi Arushi, Srinivasavaradan Govindarajan, Kshetrimayum Ghanapriya, Neetu Grewal, Khushboo Rai, Megha Brijwal, Sree Laya Kalluru, Prachi Tewari, Angeli Misra, Priyanka Khandelwal, Pankaj Hari, Arvind Bagga
doi : 10.1093/ndt/gfac228
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 939–949
Sequential rituximab (RTX) administration has emerged as an important strategy to sustain remission of disease in patients with difficult-to-treat nephrotic syndrome.
Quantifying the benefits of remission duration in focal and segmental glomerulosclerosis
Arenn Jauhal, Heather N Reich, Michelle Hladunewich, Moumita Barua, Bettina E Hansen, David Naimark, Stéphan Troyanov, Daniel C Cattran, The Toronto Glomerulonephritis Registry group
doi : 10.1093/ndt/gfac238
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 950–960
Although the clinical benefit of obtaining a remission in proteinuria in nephrotic patients with focal segmental glomerulosclerosis (FSGS) is recognized, the long-term value of maintaining it and the impact of relapses on outcome are not well described.
Efficacy and safety of methylprednisolone pulse followed by oral prednisone vs. oral prednisone alone in sarcoidosis tubulointerstitial nephritis: a randomized, open-label, controlled clinical trial
Matthieu Mahevas, Vincent Audard, Alexandra Rousseau, Alexandre Cez, Dominique Guerrot, David Verhelst, Michel Delahousse, Catherine Hanrotel, Evangeline Pillebout, Eric Daugas, Evguenia Krastinova, Dominique Valeyre, Jean-Jacques Boffa, for the GSF French Sarcoidosis Group
doi : 10.1093/ndt/gfac227
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 961–968
We determine the benefit of pulsed methylprednisolone for improving kidney function in patients with sarcoidosis tubulointerstitial nephritis.
Humoral response after the fourth dose of the SARS-CoV-2 vaccine in the CKD spectrum: a prespecified analysis of the SENCOVAC study
Borja Quiroga, MarÃa José Soler, Alberto Ortiz, Carlos Jesús Jarava Mantecón, Virginia Olinda Gomes Pérez, Antoni Bordils, José Lacueva, Antonio José Marin Franco, Pablo Delgado Conde, Patricia Muñoz Ramos, Carmen Calderón González, Juan Manuel Cazorla López, Jinny Sanchez-Rodriguez, Ana Sánchez Horrillo, Tania Raquel Monzón Vázquez, Alba Leyva, José Rojas, Ron T Gansevoort, Patricia de Sequera, SENCOVAC collaborative network
doi : 10.1093/ndt/gfac307
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 969–981
There is scarce evidence on the fourth dose of severe acute respiratory syndrome coronavirus 2 vaccines in chronic kidney disease (CKD) patients. We evaluated the humoral response and effectivity of the fourth dose in the CKD spectrum: non-dialysis CKD (ND-CKD), haemodialysis (HD), peritoneal dialysis (PD) and kidney transplant (KT) recipients.
Modified-release nicotinamide for the treatment of hyperphosphataemia in haemodialysis patients: 52-week efficacy and safety results of the phase 3 randomized controlled NOPHOS trial
Markus Ketteler, Andrzej Wiecek, Alexander R Rosenkranz, Claudia Ose, Jan Rekowski, Horst Lorenz, Burkhard Hellmann, Michael Karus, Michaela Ruhmann, Richard Ammer
doi : 10.1093/ndt/gfac206
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 982–991
We previously reported that modified-release nicotinamide (NAMR) was superior to placebo in reducing serum phosphate concentrations over 12 weeks in a large cohort of haemodialysis patients with hyperphosphataemia. Here we report outcomes after 52 weeks of treatment.
Hippocampal subfield morphology in regular hemodialysis patients
Hui Juan Chen, Jie Qiu, Yonghui Qi, Lili Fu, Qingqing Fu, Wenyuan Wu, Ganmian Dai, Feng Chen
doi : 10.1093/ndt/gfac263
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 992–1001
Hippocampal alterations have been implicated in the pathophysiology of cognitive impairment in hemodialysis patients. The hippocampus consists of several distinct subfields, and the molecular mechanisms underlying cognition might be associated with specific hippocampal subfield volume changes.
Serum phosphate as an independent factor associated with cholesterol metabolism in patients undergoing hemodialysis: a cross-sectional analysis of the DREAM cohort
Yujiro Okute, Tetsuo Shoji, Naoko Shimomura, Yoshihiro Tsujimoto, Yuki Nagata, Hideki Uedono, Shinya Nakatani, Tomoaki Morioka, Katsuhito Mori, Shinya Fukumoto, Yasuo Imanishi, Masanori Emoto
doi : 10.1093/ndt/gfac222
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 1002–1008
Hyperphosphatemia is a risk factor for cardiovascular outcomes in patients with chronic kidney disease. In an experimental model, hyperphosphatemia promoted atherosclerosis by activating sterol regulatory element-binding protein 2, which controls cholesterol homeostasis.
Factors associated with dropout from an intradialytic exercise program among patients undergoing maintenance hemodialysis
Tomoya Yamaguchi, Hiroki Yabe, Kenichi Kono, Yoshifumi Moriyama, Tetsuya Yamada
doi : 10.1093/ndt/gfac264
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 1009–1016
Continuation of an intradialytic exercise program is necessary to improve and maintain physical function in patients undergoing hemodialysis. Factors associated with dropout must be identified to ensure program continuation.
Development and validation of a diagnostic nomogram for sarcopenia in Chinese hemodialysis patients
Danshu Xie, Qin Zhu, Jianxin Lu, Chun Hu, Jianying Niu, Chen Yu, Junli Zhao, Liming Zhang, Hualin Qi, Suhua Zhang, Qi Guo, Feng Ding, Wei Ding
doi : 10.1093/ndt/gfac260
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 1017–1026
Sarcopenia is a clinical condition that is common in patients with chronic kidney disease (CKD), especially in those on dialysis. However, the relatively complicated diagnostic procedure limits its use in clinical situations.
Increasing numbers and improved overall survival of patients on kidney replacement therapy over the last decade in Europe: an ERA Registry study
Jilske A Huijben, Anneke Kramer, Julia Kerschbaum, Johan de Meester, Frederic Collart, Olga LucÃa RodrÃguez Arévalo, Jaakko Helve, Mathilde Lassalle, Runolfur Palsson, Marc ten Dam, Anna Casula, Shona Methven, Alberto Ortiz, Pietro Manuel Ferraro, MÃ¥rten Segelmark, Pablo Ucio Mingo, Mustafa Arici, Anna Varberg Reisæter, Maria Stendahl, Vianda S Stel, Kitty J Jager
doi : 10.1093/ndt/gfac165
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 1027–1040
The aim of this study was to describe the trends in the incidence, prevalence and survival of patients on kidney replacement therapy (KRT) for end-stage kidney disease (ESKD) across Europe from 2008 to 2017.
Plasma endotrophin, reflecting tissue fibrosis, is associated with graft failure and mortality in KTRs: results from two prospective cohort studies
Daan Kremer, Firas F Alkaff, Adrian Post, Tim J Knobbe, Martin Tepel, Olivier Thaunat, Stefan P Berger, Jacob van den Born, Federica Genovese, Morten A Karsdal, Daniel G K Rasmussen, Stephan J L Bakker
doi : 10.1093/ndt/gfac332
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 1041–1052
Fibrosis is a suggested cause of graft failure and mortality among kidney transplant recipients (KTRs). Accumulating evidence suggests that collagen type VI is tightly linked to fibrosis and may be a marker of systemic fibrosis and ageing.
Comparison of clinicopathological features between patients with and without hypocomplementemia in IgG4-related kidney disease
Takako Saeki, Tasuku Nagasawa, Yoshifumi Ubara, Yoshinori Taniguchi, Motoko Yanagita, Shinichi Nishi, Michio Nagata, Yutaka Yamaguchi, Takao Saito, Hitoshi Nakashima, Mitsuhiro Kawano
doi : 10.1093/ndt/gfac317
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 1053–1056
Exome data reanalysis solved case in undetermined nephropathy with detection of TULP3-truncating variant
Thomas Robert, Benjamin Savenkoff, Tristan Legris, Laure Raymond, Julia Torrents, Stéphane Burtey, Marine Dancer
doi : 10.1093/ndt/gfac319
Nephrology Dialysis Transplantation, Volume 38, Issue 4, April 2023, Pages 1057–1060
