Nlandu, Yannick Mayamba MD1; Makulo, Jean-Robert Rissassy MD, PhD1; Nkondi, Clarysse Nsenga MD1; Engole, Yannick Mompango MD1; Sumaili, Ernest Kiswaya MD, PhD1; Nseka, Nazaire Mangani MD, PhD1
doi : 10.1097/TP.0000000000003425
Transplantation: April 2021 - Volume 105 - Issue 4 - p 677-678
McCallion, Oliver MRCS1; Issa, Fadi DPhil, FRCS1
doi : 10.1097/TP.0000000000003699
Transplantation: April 2021 - Volume 105 - Issue 4 - p 679-680
Dixon, Wesley BS1; Feng, Sandy PhD1; Gardner, James PhD1
doi : 10.1097/TP.0000000000003538
Transplantation: April 2021 - Volume 105 - Issue 4 - p 681-682
doi : 10.1097/TP.0000000000003561
Transplantation: April 2021 - Volume 105 - Issue 4 - p 683-685
Bonifazi, Francesca MD1; Sica, Simona MS2,3; Angeletti, Alessia MD4; Marktel, Sarah MD5; Prete, Arcangelo MD, PhD6; Iori, Anna Paola MD, PhD7; Olivari, Diletta MD4; Rossetti, Giulia MD4; Bertaina, Alice MD, PhD8; Botti, Stefano BsC9; Busca, Alessandro MD10; Carella, Angelo Michele MD11; Cerretti, Raffaella MD, PhD12; Gargiulo, Gianpaolo Msc13; Grassi, Anna MD14; Gualandi, Francesca MD15; Irrera, Giuseppe MD16; Milone, Giuseppe MD17; Risitano, Antonio Maria MD, PhD18; Santarone, Stella MD19; Vassallo, Elena MD20; Zecca, Marco MD21; Ciceri, Fabio MD22,23; Pomponio, Giovanni MD24
doi : 10.1097/TP.0000000000003569
Transplantation: April 2021 - Volume 105 - Issue 4 - p 686-694
Variation in clinical practice affects veno-occlusive disease management, mainly in patients who undergo allogeneic hematopoietic stem cell transplantation. Disputes about diagnostic criteria, treatment, and prophylaxis, due to the lack of high-quality data, are at the base of this variability. With the aim of limiting inconsistency in clinical care, thus improving both patient outcomes and data collection reliability, the Italian Society of Stem cell transplant (Gruppo Italiano Trapianto Midollo Osseo e Terapia Cellulare) launched a collaborative effort to formulate recommendations based on integration of available evidence and expert’s consensus. A systematic method, according to US National Institute of Health guidelines and Italian National System for Guidelines, was used. Twenty-nine recommendations were approved with a strong (20) or weak (9) level of agreement, while 26 were rejected. In particular, the panel pointed out the need to achieve an early diagnosis, encouraging the adoption of European Society for Blood and Marrow Transplantation criteria and the prompt use of ultrasonography. Moreover, our experts strongly recommended in favor of prophylactic use of ursodeoxycholic acid. As soon as a veno-occlusive disease diagnosis is established, treatment with defibrotide should be started for at least 21 days. A number of areas of uncertainty, particularly concerning risk stratification and use of diagnostic tools such as elastography has been identified and discussed.
Hessheimer, Amelia J. MD, PhD1,2; Kalisvaart, Marit MD, PhD2,3
doi : 10.1097/TP.0000000000003631
Transplantation: April 2021 - Volume 105 - Issue 4 - p 695-696
Valujskikh, Anna PhD1
doi : 10.1097/TP.0000000000003468
Transplantation: April 2021 - Volume 105 - Issue 4 - p 697-698
Edwards, Audrene S. MS1; Kaplan, Bruce MD2; Jie, Tun MD3
doi : 10.1097/TP.0000000000003316
Transplantation: April 2021 - Volume 105 - Issue 4 - p 699-703
Park, Sook Hyeon MD1,2; Mazumder, Nikhilesh R.1,3; Mehrotra, Sanjay1,4,5; Ho, Bing MD, MPH1,2; Kaplan, Bruce MD6; Ladner, Daniela P. MD, MPH1,7
doi : 10.1097/TP.0000000000003304
Transplantation: April 2021 - Volume 105 - Issue 4 - p 704-708
Agopian, Vatche G. MD1
doi : 10.1097/TP.0000000000003311
Transplantation: April 2021 - Volume 105 - Issue 4 - p 709-710
Kumar, Nicolas BSc1,*; Hussain, Nasir MD, MSc1,*; Kumar, Julia BSc1; Essandoh, Michael K. MD, FASE1; Bhatt, Amar M. MD1; Awad, Hamdy MD1; Perez, William J. MD1; Whitson, Bryan A. MD, PhD2; Ganapathi, Asvin M. MD2; Mokadam, Nahush A. MD2; Gorelik, Leonid MD1; Turner, Katja MD1; Iyer, Manoj H. MD1
doi : 10.1097/TP.0000000000003407
Transplantation: April 2021 - Volume 105 - Issue 4 - p 711-722
Pulmonary artery obstruction is an uncommon but significant complication after lung transplantation. Although numerous reports have documented its occurrence, the hemodynamic parameters associated with its presentation and diagnostic considerations remain ill-defined. This systematic review summarizes evidence in the literature surrounding pulmonary artery obstruction after lung transplantation surgery.
Connor, Katie L. MRCS1,2,3; O’Sullivan, Eoin D. MBBS3; Marson, Lorna P. MD2,3; Wigmore, Stephen J. MD2,3; Harrison, Ewen M. PhD4
doi : 10.1097/TP.0000000000003424
Transplantation: April 2021 - Volume 105 - Issue 4 - p 723-735
Pulmonary artery obstruction is an uncommon but significant complication after lung transplantation. Although numerous reports have documented its occurrence, the hemodynamic parameters associated with its presentation and diagnostic considerations remain ill-defined. This systematic review summarizes evidence in the literature surrounding pulmonary artery obstruction after lung transplantation surgery.
Imburgia, Teresa M. MPH1,2; Shew, Marcia L. MD, MPH1; Gravitt, Patti E. PhD, MS3; Katzenellenbogen, Rachel A. MD1
doi : 10.1097/TP.0000000000003444
Transplantation: April 2021 - Volume 105 - Issue 4 - p 736-742
Ivanics, Tommy MD1; Abreu, Phillipe MD, MSc1; De Martin, Eleonora MD, PhD2; Sapisochin, Gonzalo MD, PhD, MSc1
doi : 10.1097/TP.0000000000003454
Transplantation: April 2021 - Volume 105 - Issue 4 - p 743-756
Deng, Jin PhD1; Wang, Xin2; Zhou, Qin2; Xia, Yue2; Xiong, Chongxiang PhD2; Shao, Xiaofei2; Zou, Hequn PhD2
doi : 10.1097/TP.0000000000003446
Transplantation: April 2021 - Volume 105 - Issue 4 - p 757-767
Chronic renal allograft dysfunction (CRAD) is a major condition that impedes the long-term survival of renal allografts. However, the mechanism of CRAD is obscure, and the effective strategies for controlling the progression of CRAD are lacking. The present study used a CRAD rat model to assess the effect of glycogen synthase kinase 3? (GSK-3?) inhibition on the development of CRAD.
Major, Triin PhD1,2; Ball, Alexandra L. MRCP, PhD1,2; Stone, John P. PhD1,2,3; Edge, Rebecca J. PhD1,2; Lopez-Castejon, Gloria PhD3; Sj?berg, Trygve PhD4; Andreasson, Anders FRCS, PhD5; Brough, David PhD6; Steen, Stig MD, PhD4; Fisher, Andrew J. MRCP, PhD5,7; Fildes, James E. PhD, FRSB1,2,3
doi : 10.1097/TP.0000000000003463
Transplantation: April 2021 - Volume 105 - Issue 4 - p 768-774
Ex vivo lung perfusion (EVLP) is used to evaluate and recondition extended criteria donor lungs for transplantation. Interleukin-1? (IL-1?) has been identified as a prognostic indicator of nonrecovery during EVLP. This may be an effect of inflammasome activation or cellular necrosis following donation and graft preservation. Delineating the mechanism of IL-1? release is required.
Ricardo-da-Silva, Fernanda Yamamoto MsC1; Armstrong, Roberto Jr1; Vidal-dos-Santos, Marina1; Correia, Cristiano de Jesus PhD1; Coutinho e Silva, Raphael dos Santos1; da Anunciaç?o, Lucas Ferreira1; Moreira, Luiz Felipe Pinho MD, PhD1; Leuvenink, Hendrik Gerrit Derk PhD2; Breithaupt-Faloppa, Ana Cristina PhD1
doi : 10.1097/TP.0000000000003467
Transplantation: April 2021 - Volume 105 - Issue 4 - p 775-784
Brain death (BD) affects the viability of lungs for transplantation. A correlation exists between high-lung inflammation after BD and the decrease in female sex hormones, especially estradiol. Therefore, we investigated the effects of 17?-estradiol (E2) treatment on the lungs of female brain dead rats.
Hsu, Yu-Chen PhD1; Yu, I-Shing PhD2; Tsai, Yu-Fei3; Wu, Yao-Ming MD4; Chen, You-Tzung PhD5,6; Sheu, Jin-Chuan MD, PhD1,7; Lin, Shu-Wha PhD3,8
doi : 10.1097/TP.0000000000003461
Transplantation: April 2021 - Volume 105 - Issue 4 - p 785-795
Hepatocyte transplantation has been extensively investigated as an alternative to orthotopic liver transplantation. However, its application in routine clinical practice has been restricted because of low initial engraftment and subsequent repopulation.
Martins, Paulo N. MD, PhD1; Rizzari, Michael D. MD2; Ghinolfi, Davide MD, PhD3; Jochmans, Ina MD, PhD4,5; Attia, Magdy MD6; Jalan, Rajiv MD, PhD7; Friend, Peter J. MD8; ILTS Special Interest Group “DCD, Preservation and Machine Perfusion”
doi : 10.1097/TP.0000000000003573
Transplantation: April 2021 - Volume 105 - Issue 4 - p 796-815
Recent trials in liver machine perfusion (MP) have revealed unique challenges beyond those seen in most clinical studies. Correct trial design and interpretation of data are essential to avoid drawing conclusions that may compromise patient safety and increase costs.
Cullaro, Giuseppe MD1; Verna, Elizabeth C. MD, MS2; Emond, Jean C. MD3; Orandi, Babak J. MD, PhD, MSc4; Mohan, Sumit MD, MPH5; Lai, Jennifer C. MD, MBA1
doi : 10.1097/TP.0000000000003310
Transplantation: April 2021 - Volume 105 - Issue 4 - p 816-823
With the implementation of the “Safety Net,” we aimed to determine the impact of simultaneous liver-kidney transplantation (SLKT), as compared to kidney transplant after liver transplant (KALT), on kidney allograft failure (KF).
Braun, Hillary J. MD1; Dodge, Jennifer L. MPH1; Grab, Joshua D. MS1; Schwab, Marisa E. MD1; Liu, Iris H. BA1; Glencer, Alexa C. MD1; Stock, Peter G. MD, PhD1; Hirose, Ryutaro MD1; Roberts, John P. MD1; Ascher, Nancy L. MD, PhD1
doi : 10.1097/TP.0000000000003318
Transplantation: April 2021 - Volume 105 - Issue 4 - p 824-831
Share 35 was a policy implemented in 2013 to increase regional sharing of deceased donor livers to patients with model for end-stage liver disease???35 to decrease waitlist mortality for the sickest patients awaiting liver transplantation (LT). The purpose of this study was to determine whether live donor liver transplantation (LDLT) volume was impacted by the shift in allocation of deceased donor livers to patients with higher model for end-stage liver disease scores.
Bouchet-Delbos, Laurence MSc1; Even, Amandine PhD1; Varey, Emilie MSc1; Saïagh, Soraya PhD2; Bercegeay, Sylvain PhD2; Braudeau, Cécile PhD1,3; Dréno, Brigitte MD, PhD2; Blancho, Gilles MD, PhD1; Josien, Régis MD, PhD1,3; Cuturi, Maria-Cristina MD1,4; Moreau, Aurélie PhD1,4
doi : 10.1097/TP.0000000000003315
Transplantation: April 2021 - Volume 105 - Issue 4 - p 832-841
Kidney transplantation is the therapeutic of choice for patients with kidney failure. While immunosuppressive drugs can control graft rejection, their use is associated with increased infections and cancer, and they do not effectively control chronic graft rejection. Cell therapy is an attractive strategy to minimize the use of pharmacological drugs.
Kute, Vivek B. MD, DM, FASN, FRCP1; Godara, Suraj MD, DM2; Guleria, Sandeep MS, DNB, FRCS, FRCP3; Ray, Deepak S. MD, DM4; Aziz, Feroz MD, DM5; Hegde, Umapati MD, DNB6; Sharma, Ashish MS, MCh7; Nayak, K.S. MD, DNB, FASN, FRCP8; Siddini, Vishwanath MNAMS, DNB9; Sarkar, Piyali MBBS, MRCP(UK)10; Thukral, Sharmila MD, DNB5; Mondal, Rabi Ranjan Sow MD, DNB, MRCP5; Goswami, Jitendra MD, DM11; Patel, Himanshu V. MD, DNB, FRCP1; Abraham M., Abi MD, DM, DNB, FASN, FRCP12; Pathak, Vivek MD, DNB13; Anandh, Urmila MD, DM, DNB, FASN, FRCP14; Jha, Pranaw Kumar MD, DNB15; Bavikar, Suhas MD, DNB16; Bonu, Ravi Shankar MD, DM, FRCP, FASN17; Gulati, Sanjeev MD, DM, DNB, FRCPC(Canada)18; B.T., Anil Kumar MD, DNB19; Yadav, Dinesh Kumar MD, DM15
doi : 10.1097/TP.0000000000003609
Transplantation: April 2021 - Volume 105 - Issue 4 - p 842-850
There is lack of data on feasibility and safety of kidney transplants from living donors who recovered from COVID-19.
Kute, Vivek B. MD1; Bhalla, Anil K. MD2; Guleria, Sandeep MS3; Ray, Deepak S. MD4; Bahadur, Madan M. MD5; Shingare, Ashay MD5; Hegde, Umapati MD6; Gang, Sishir MD6; Raju, Sreebhushan MD7; Patel, Himanshu V. MD1; Jain, Siddharth MD8; Godara, Suraj MD9; Modi, Pranjal MS10; Gumber, Manoj MD11; Engineer, Divyesh P. MD1; Dalal, Sonal MD12; Darji, Prakash MD13; Balwani, Manish MD14; Patel, Ansy H. MBBS15; Mishra, Vineet V. MS16
doi : 10.1097/TP.0000000000003593
Transplantation: April 2021 - Volume 105 - Issue 4 - p 851-860
There is a scarcity of data on the consequences of coronavirus disease-19 (COVID-19) infections in kidney transplant recipients (KTRs) from emerging countries.
Benvenuto, Luke MD1; Snyder, Mark E. MD2; Aversa, Meghan MD1; Patel, Shreena BA1; Costa, Joseph DHSc, PA-C3; Shah, Lori MD1; Robbins, Hilary MD1; D’Ovidio, Frank MD, PhD3; Sonett, Joshua MD3; Stanifer, Bryan P. MD, MPH3; Lemaitre, Philippe MD, PhD3; Arcasoy, Selim MD1; Anderson, Michaela R. MD, MS1
doi : 10.1097/TP.0000000000003600
Transplantation: April 2021 - Volume 105 - Issue 4 - p 861-866
Regional variation in lung transplantation practices due to local coronavirus disease 2019 (COVID-19) prevalence may cause geographic disparities in access to lung transplantation.
Minqiang, Liu MD1; Xiaoshan, Li PhD2; Bo, Xu BD3; Guilong, Wang PhD3; Zhengfeng, Gu MD3; Dong, Wei PhD2; Jingyu, Chen PhD2; Qiang, Wu PhD1; Chunxiao, Hu BD3
doi : 10.1097/TP.0000000000003290
Transplantation: April 2021 - Volume 105 - Issue 4 - p 867-875
Extracorporeal membrane oxygenation (ECMO) is widely used for cardiopulmonary assistance during lung transplantation (LTx). However, the optimal timing for ECMO removal remains controversial. This study aimed to evaluate the risk factors and early prognosis of delayed withdrawal ECMO after LTx.
Mansour, Sherry G. DO, MS1,2; Liu, Caroline MHS3; Jia, Yaqi MPH3; Reese, Peter P. MD, MSCE4,5,6; Hall, Isaac E. MD, MS7; El-Achkar, Tarek M. MD8; LaFavers, Kaice A. PhD8; Obeid, Wassim PhD3; Rosenberg, Avi Z. MD, PhD9; Daneshpajouhnejad, Parnaz MD9; Doshi, Mona D. MD10; Akalin, Enver MD11; Bromberg, Jonathan S. MD, PhD12,13; Harhay, Meera N. MD, MSCE14,15,16; Mohan, Sumit MD, MPH17,18; Muthukumar, Thangamani MD19,20; Schr?ppel, Bernd MD21; Singh, Pooja MD22; El-Khoury, Joe M.1; Weng, Francis L. MD, MSCE23; Thiessen-Philbrook, Heather R. Mmath3; Parikh, Chirag R. MD, PhD3
doi : 10.1097/TP.0000000000003299
Transplantation: April 2021 - Volume 105 - Issue 4 - p 876-885
Deceased-donor kidneys experience extensive injury, activating adaptive and maladaptive pathways therefore impacting graft function. We evaluated urinary donor uromodulin (UMOD) and osteopontin (OPN) in recipient graft outcomes.
Lia, Daniel MD1; Singer, Pamela MD1; Nair, Vinay DO1; Yang, Jingyan MSc, PhD1; Teperman, Lewis MD1; Grodstein, Elliot MD1
doi : 10.1097/TP.0000000000003317
Transplantation: April 2021 - Volume 105 - Issue 4 - p 886-890
Deceased donor kidneys with acute kidney injury (AKI) and donation after circulatory death (DCD) kidneys are viable sources of organs. The outcomes of renal transplantation from DCD donors with AKI are not known.
Khandelwal, Pooja MD1; Yeh, Rosa F. PharmD2; Yu, Louie BS2; Lane, Adam PhD1,3; Dandoy, Christopher E. MD1,3; El-Bietar, Javier MD1,3; Davies, Stella M. MBBS1,3; Grimley, Michael S. MD1,3
doi : 10.1097/TP.0000000000003327
Transplantation: April 2021 - Volume 105 - Issue 4 - p 891-896
We hypothesized that the addition of 4 doses of abatacept to our standard acute graft-versus-host disease (GVHD) prophylaxis would reduce the incidence of day?+100 severe acute GVHD in children with transfusion-dependent beta-thalassemia major undergoing a myeloablative allogeneic hematopoietic stem cell transplant (HSCT), without impacting engraftment.
Canovai, Emilio MD1,2,3; Ceulemans, Laurens J. MD, PhD1,2; Peers, Guido MSc4; De Pourcq, Lutgart RN5; Pijpops, Marleen RN6; Hoffman, Ilse MD, PhD2,6; De Hertogh, Gert MD, PhD2,7; Hiele, Martin MD, PhD2,8; Jochmans, Ina MD, PhD1,2,3; Monbaliu, Diethard MD, PhD1,2,3; Vanuytsel, Tim MD, PhD2,8; Pirenne, Jacques MD, PhD1,2,3
doi : 10.1097/TP.0000000000003328
Transplantation: April 2021 - Volume 105 - Issue 4 - p 897-904
Intestinal transplantation (ITx) is the most expensive abdominal organ transplant. Detailed studies about exact costs and cost-effectiveness compared to home parenteral nutrition (HPN) therapy in chronic intestinal failure are lacking. The aim is to provide an in-depth analysis of ITx costs and evaluate cost-effectiveness compared to HPN.
Owen, Ruth V. MBBS1; Thompson, Emily R. MBBS1; Tingle, Samuel J. MBBS1; Ibrahim, Ibrahim K. MBBS1; Manas, Derek M. PhD2; White, Steve A. PhD2; Wilson, Colin H. PhD1,2
doi : 10.1097/TP.0000000000003334
Transplantation: April 2021 - Volume 105 - Issue 4 - p 905-915
In many transplant centers, a recipient body mass index (BMI) >30?kg/m2 would be considered a contraindication for pancreas transplantation. This study aims to investigate the impact of recipient BMI on graft outcomes after pancreas transplantation.
Glander, Petra PhD1; Waiser, Johannes MD1; Hambach, Pia1; Bachmann, Friederike MD1; Budde, Klemens MD1; Eckardt, Kai-Uwe MD1; Friedersdorff, Frank MD2; Gaedeke, Jens MD1; Kron, Susanne MD1; Lorkowski, Christine1; Mai, Marco1; Neumayer, Hans-H. MD1; Peters, Robert2; Rudolph, Birgit MD3; Schmidt, Danilo4; Wu, Kaiyin3; Liefeldt, Lutz MD1
doi : 10.1097/TP.0000000000003336
Transplantation: April 2021 - Volume 105 - Issue 4 - p 916-927
Mycophenolic acid (MPA) is a standard immunosuppressant in organ transplantation. A simple monitoring biomarker for MPA treatment has not been established so far. Here, we describe inosine 5?-monophosphate dehydrogenase (IMPDH) monitoring in erythrocytes and its application to kidney allograft recipients.
Ikegami, Toru MD1; Furukawa, Kenei1; Haruki, Koichiro1; Onda, Shinji1; Gocho, Takeshi1
doi : 10.1097/TP.0000000000003583
Transplantation: April 2021 - Volume 105 - Issue 4 - p e43
Kusakabe, Jiro MD, PhD1; Yagi, Shintaro MD, PhD1; Uemoto, Shinji MD, PhD1
doi : 10.1097/TP.0000000000003584
Transplantation: April 2021 - Volume 105 - Issue 4 - p e44-e45
Devresse, Arnaud MD1,2; Godefroid, Nathalie MD2,3; Anthonissen, Blaise MD1; Labriola, Laura MD1,2; de Magnée, Catherine PhD2,4; Reding, Raymond PhD2,4; Sokal, Etienne PhD2,5; Stephenne, Xavier PhD2,5; Gillion, Valentine MD1,2; Kanaan, Nada MD1,2
doi : 10.1097/TP.0000000000003597
Transplantation: April 2021 - Volume 105 - Issue 4 - p e46-e47
Mazzeo, Anna Teresa MD1; Gupta, Deepak MS, MCH, PhD2
doi : 10.1097/TP.0000000000003625
Transplantation: April 2021 - Volume 105 - Issue 4 - p e48-e49
Buscemi, Vincenzo MD1; De Carlis, Riccardo MD1; Lauterio, Andrea MD1; Camozzi, Mario Livio MD2; De Carlis, Luciano MD1,3
doi : 10.1097/TP.0000000000003626
Transplantation: April 2021 - Volume 105 - Issue 4 - p e50-e51
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