Kute, Vivek B. MD, DM, FASN, FRCP1; Patel, Himanshu V. MD, DNB1; Modi, Pranjal R. MS, DNB2; Rizvi, Syed J. MS, MCh2; Engineer, Divyesh P. MD, DM1; Banerjee, Subho MD, DM1; Butala, Bina P. MD3; Gandhi, Shruti MD4; Patel, Ansy H. MBBS5; Mishra, Vineet V. MS6
doi : 10.1097/TP.0000000000003421
Transplantation: May 2021 - Volume 105 - Issue 5 - p 929-932
Paired kidney exchanges provide unique opportunities for blood group or tissue-type incompatible donor/recipient couples and are well established in some regions of the developed world,1-10 less so, however, in emerging countries.11-20 Long chains may optimize the transplant potential, however, require also a significant amount of coordinated efforts by administrators and healthcare providers. The National Kidney Registry5,6 and Alliance for Paired Donations1 in the United States have reported on long kidney exchange chains (2–35 pairs) utilizing real-time software.
Singh, Prince1; Luo, Xunrong2
doi : 10.1097/TP.0000000000003760
Transplantation: May 2021 - Volume 105 - Issue 5 - p 933-934
Cosimi, A. Benedict MD1; Ascher, Nancy L. PhD2; Emond, Jean C. MD3; Kaufman, Dixon B. PhD4; Madsen, Joren C. MD1; Miller, Joshua MD5; Monaco, Anthony P. MD6; Montgomery, Robert A. MD7; Newell, Kenneth A. PhD8; S?nchez-Fueyo, Alberto MD9; Sarwal, Minnie M. PhD2; Scandling, John D. MD10; Strober, Samuel MD11; Todo, Satoru MD12; Weir, Matthew R. MD13; Sachs, David H. MD1
doi : 10.1097/TP.0000000000003532
Transplantation: May 2021 - Volume 105 - Issue 5 - p 935-940
Karpen, Stephen R. PharmD1; Klein, Amanda PharmD1; Alloway, Rita R. PharmD2; Albrecht, Renata MD (retired)3; Belen, Ozlem MD3; Campbell, Michelle PhD3; Kluetz, Paul MD3; Minasian, Lori M. MD4; Mitchell, Sandra A. PhD4; O’Doherty, Inish PhD1; Papadopoulos, Elektra MD3; Sapir-Pichhadze, Ruth MD, PhD5; Spear, Nicole BS1; van Gelder, Teun MD6; Velidedeoglu, Ergun MD3; Page, C. Alex PharmD Candidate7; Everly, Matthew J. PharmD8
doi : 10.1097/TP.0000000000003556
Transplantation: May 2021 - Volume 105 - Issue 5 - p 941-944
Hessheimer, Amelia J. MD, PhD1; Polak, Wojciech MD, PhD2; Antoine, Corinne MD3; Dondero Pozzo, Federica MD4; Maluf, Daniel MD5; Monbaliu, Diethard MD, PhD6; Oniscu, Gabriel MD7
doi : 10.1097/TP.0000000000003729
Transplantation: May 2021 - Volume 105 - Issue 5 - p 945-951
Donation after circulatory death (DCD) donors are an increasingly more common source of livers for transplantation in many parts of the world. Events that occur during DCD liver recovery have a significant impact on the success of subsequent transplantation. This working group of the International Liver Transplantation Society evaluated current evidence as well as combined experience and created this guidance on DCD liver procurement. Best practices for the recovery and transplantation of livers arising through DCD after euthanasia and organ procurement with super-rapid cold preservation and recovery as well as postmortem normothermic regional perfusion are described, as are the use of adjuncts during DCD liver procurement.
Smith, Michael A. MD1
doi : 10.1097/TP.0000000000003482
Transplantation: May 2021 - Volume 105 - Issue 5 - p 952
Simpson, Mary Ann PhD1
doi : 10.1097/TP.0000000000003341
Transplantation: May 2021 - Volume 105 - Issue 5 - p 953-954
Askar, Medhat MD, PhD1; Hanna, Rabi MD2
doi : 10.1097/TP.0000000000003343
Transplantation: May 2021 - Volume 105 - Issue 5 - p 955-957
Testa, Giuliano MD, MBA1; Johannesson, Liza MD, PhD1
doi : 10.1097/TP.0000000000003347
Transplantation: May 2021 - Volume 105 - Issue 5 - p 958-959
James, Laura J. MPH1,2; Wong, Germaine PhD1,2,3; Tong, Allison PhD1,2; Craig, Jonathan C. PhD4; Howard, Kirsten PhD1; Howell, Martin PhD1,2
doi : 10.1097/TP.0000000000003500
Transplantation: May 2021 - Volume 105 - Issue 5 - p 960-967
Providing care for transplant recipients is challenging given the need to maintain optimal graft function and survival while managing the debilitating side effects and complications associated with immunosuppression including infection, cancer, new-onset diabetes mellitus, and cardiovascular disease. Given the complexity of treatment options and the uncertainty about long-term benefits and harms of treatment, understanding patient preferences and values are key to ensuring that clinical decisions take into consideration patient priorities to support shared decision making and self-management. Choice experiments are increasingly used to quantify patient and community preferences, including in the field of transplantation. Discrete choice experiments (DCEs) are a well-established, validated methodology used to elicit preferences for decision making in health and other settings. In transplantation, for example, DCEs have been used to elicit patient preferences for outcomes following kidney transplantation, to identify community preferences factors for organ allocation and in establishing core outcomes. This article provides an overview of the concepts and methods used in the design of DCEs and how patients’ preferences can be applied in shared decision making in transplantation.
Marinelli, Tina M. MBBS1; Kumar, Deepali MD1
doi : 10.1097/TP.0000000000003486
Transplantation: May 2021 - Volume 105 - Issue 5 - p 968-978
Influenza infection poses significant risk for solid organ transplant recipients who often experience more severe infection with increased rates of complications, including those relating to the allograft. Although symptoms of influenza experienced by transplant recipients are similar to that of the general population, fever is not a ubiquitous symptom and lymphopenia is common. Annual inactivated influenza vaccine is recommended for all transplant recipients. Newer strategies such as using a higher dose vaccine or multiple doses in the same season appear to provide greater immunogenicity. Neuraminidase inhibitors are the mainstay of treatment and chemoprophylaxis although resistance may occur in the transplant setting. Influenza therapeutics are advancing, including the recent licensure of baloxavir; however, many remain to be evaluated in transplant recipients and are not yet in routine clinical use. Further population-based studies spanning multiple influenza seasons are needed to enhance our understanding of influenza epidemiology in solid organ transplant recipients. Specific assessment of newer influenza therapeutics in transplant recipients and refinement of prevention strategies are vital to reducing morbidity and mortality.
Prasad, Nikhil K. MB ChB1; Pasrija, Chetan MD1; Talaie, Tara MD1; Krupnick, Alexander S. MD1; Zhao, Yunge PhD1; Lau, Christine L. MD1
doi : 10.1097/TP.0000000000003483
Transplantation: May 2021 - Volume 105 - Issue 5 - p 979-985
There is a severe shortage in the availability of donor organs for lung transplantation. Novel strategies are needed to optimize usage of available organs to address the growing global needs. Ex vivo lung perfusion has emerged as a powerful tool for the assessment, rehabilitation, and optimization of donor lungs before transplantation. In this review, we discuss the history of ex vivo lung perfusion, current evidence on its use for standard and extended criteria donors, and consider the exciting future opportunities that this technology provides for lung transplantation.
Tchouta, Lise N. MD, MS1,2; Alghanem, Fares BS2,3; Rojas-Pena, Alvaro MD2; Bartlett, Robert H. MD2
doi : 10.1097/TP.0000000000003475
Transplantation: May 2021 - Volume 105 - Issue 5 - p 986-998
For 2 centuries, researchers have studied ex vivo perfusion intending to preserve the physiologic function of isolated organs. If it were indeed possible to maintain ex vivo organ viability for days, transplantation could become an elective operation with clinicians methodically surveilling and reconditioning allografts before surgery. To this day, experimental reports of successfully prolonged (?24 hours) organ perfusion are rare and have not translated into clinical practice. To identify the crucial factors necessary for successful perfusion, this review summarizes the history of prolonged normothermic ex vivo organ perfusion. By examining successful techniques and protocols used, this review outlines the essential elements of successful perfusion, limitations of current perfusion systems, and areas where further research in preservation science is required.
Orizondo, Ryan A. PhD1–3; Omecinski, Katelin S. BS1,3; May, Alexandra G. PhD1,4; Dhamotharan, Vishaal MS1,3; Frankowski, Brian J. AS1; Burgreen, Greg W. PhD5; Ye, Sang-Ho PhD1,6; Kocyildirim, Ergin MD1,7; Sanchez, Pablo G. MD, PhD8; D’Cunha, Jonathan MD, PhD9; Wagner, William R. PhD1,3,4,6; Federspiel, William J. PhD1,3,4,10,11
doi : 10.1097/TP.0000000000003481
Transplantation: May 2021 - Volume 105 - Issue 5 - p 999-1007
A wearable artificial lung could improve lung transplantation outcomes by easing implementation of physical rehabilitation during long-term pretransplant respiratory support. The Modular Extracorporeal Lung Assist System (ModELAS) is a compact pumping artificial lung currently under development. This study evaluated the long-term in vivo performance of the ModELAS during venovenous support in awake sheep. Feedback from early trials and computational fluid dynamic analysis guided device design optimization along the way.
Parker, Maura H. PhD1; Stone, Diane BSc1; Abrams, Kraig BSc1; Johnson, Melissa BSc1; Granot, Noa MD1; Storb, Rainer MD1,2
doi : 10.1097/TP.0000000000003489
Transplantation: May 2021 - Volume 105 - Issue 5 - p 1008-1016
Chronic graft-versus-host disease (GVHD) is a significant cause of morbidity and mortality in transplant patients. We have previously shown that 3 doses of an anti-inducible costimulator (ICOS) mAb transiently ameliorated symptoms and extended survival of dogs affected by chronic GVHD over that of control dogs. The purpose of this study was to specifically correlate changes in T-cell populations in the peripheral blood with anti-ICOS treatment and chronic GVHD progression and regression to reach a better understanding of the mechanism of the disease and prioritize future studies.
Han, Yuqiu MM1; Wu, Li MM1; Ling, Qi MD2; Wu, Pin MD3; Zhang, Chenzhi MD2; Jia, Longfei MB4; Weng, Honglei MD5; Wang, Baohong MD1,6
doi : 10.1097/TP.0000000000003494
Transplantation: May 2021 - Volume 105 - Issue 5 - p 1017-1029
Long-time use of pharmacological immunosuppressive agents frequently leads to metabolic disorders. Most studies have focused on islet toxicity leading to posttransplantation diabetes mellitus. In contrast, the link between intestinal dysbiosis and immunosuppressive drug-induced metabolic disorders remains unclear.
Gilbo, Nicholas MD1,2; Fieuws, Steffen PhD3; Meurisse, Nicolas MD4; Nevens, Frederik PhD5; van der Merwe, Schalk PhD5; Laleman, Wim PhD5; Verslype, Chris PhD5; Cassiman, David PhD5; van Malenstein, Hannah PhD5; Roskams, Tania PhD6; Sainz-Barriga, Mauricio PhD1,2; Pirenne, Jacques PhD1,2; Jochmans, Ina PhD1,2,*; Monbaliu, Diethard PhD1,2,*
doi : 10.1097/TP.0000000000003335
Transplantation: May 2021 - Volume 105 - Issue 5 - p 1030-1038
Donor hepatectomy and liver implantation time reduce long-term graft and patient survival after liver transplantation. It is not known whether these surgical times influence early outcomes after liver transplantation.
Krause, Sandra MA1; Pritlove, Cheryl PhD2; Abbey, Susan MD1,2; Jung, Judy MHSc2
doi : 10.1097/TP.0000000000003333
Transplantation: May 2021 - Volume 105 - Issue 5 - p 1039-1043
Scarring can greatly impact quality of life for individuals (ie, causing depression posttraumatic stress disorder and body image issues). Those who wish to be anonymous live liver donors are warned of the potential negative psychological impacts associated with the large scar left from liver donation surgery. Given the unique degree of autonomy that these patients have over their surgery, we explore whether a sample of 26 anonymous live liver donors experience a unique relationship with their scar.
Troisi, Roberto I. MSc, MD, PhD, FEBS1,2,3; Elsheikh, Yasser MD1; Alnemary, Yasir MD1; Zidan, Ahmed MD1; Sturdevant, Mark MD1; Alabbad, Saleh MD1; Algoufi, Talal MD1; Shagrani, Mohammed MD1,3; Broering, Dieter C. MD, PhD, FEBS, FACS1,3
doi : 10.1097/TP.0000000000003332
Transplantation: May 2021 - Volume 105 - Issue 5 - p 1044-1051
There is a growing interest in left lateral sectionectomy for donor hepatectomy. No data are available concerning the safety of the robotic (ROB) approach.
Kaur, Navpreet MD1,2; Emamaullee, Juliet MD, PhD1,2; Lian, Tiffany BS2; Lo, Mary MS3; Ender, Philip PhD4; Kahn, Jeffrey MD2,5; Sher, Linda MD1,2
doi : 10.1097/TP.0000000000003404
Transplantation: May 2021 - Volume 105 - Issue 5 - p 1052-1060
Body mass index (BMI) limits for liver transplant (LT) candidacy are controversial. In this study, we evaluate waitlist and post-LT outcomes, and prognostic factors and examine regional patterns of LT waitlist registration in patients with BMI ?40 versus BMI 18–39.
Menahem, Benjamin MD, PhD1,2; Dejardin, Olivier PhD2,3; Alves, Arnaud MD, PhD1,2; Launay, Ludivine PhD2; Lubrano, Jean MD, PhD1,2; Duvoux, Christophe MD, PhD4; Laurent, Alexis MD, PhD5,6; Launoy, and Guy MD, PhD2; French Liver Transplantation Group*
doi : 10.1097/TP.0000000000003340
Transplantation: May 2021 - Volume 105 - Issue 5 - p 1061-1068
To investigate the value of European deprivation index (EDI) and hepatocellular carcinoma (HCC) characteristics and their relationships with outcome after liver transplantation (LT).
Wiegley, Nasim MD1; Walavalkar, Vighnesh MD2; Aujla, Harleen MD1; Chen, Ling-Xin MD, MS1; Huang, Yihung MD1; Lee, Brian K. MD3; Jen, Kuang-Yu MD, PhD4
doi : 10.1097/TP.0000000000003363
Transplantation: May 2021 - Volume 105 - Issue 5 - p 1069-1076
The vast majority of polyomavirus nephropathy (PVN) is due to BK virus, but rare cases result from JC virus reactivation. To date, only a handful of biopsy-proven JC-PVN cases have been reported. Here, we describe the clinical and pathologic findings in 7 patients with biopsy-proven JC-PVN.
Fronek, Jiri MD, PhD1,2,3,4; Janousek, Libor MD, PhD1,3; Kristek, Jakub MD1,4; Chlupac, Jaroslav MD, PhD1,2,4; Pluta, Marek MD, PhD5; Novotny, Robert MD, PhD1; Maluskova, Jana MD6; Olausson, Michael MD, PhD7
doi : 10.1097/TP.0000000000003346
Transplantation: May 2021 - Volume 105 - Issue 5 - p 1077-1081
Nulliparous uterine grafts have never been used in uterus transplantation (UTx), possibly due to presumed infertility. Our objective was to verify the feasibility of nulliparous uterine graft transplantation.
Morozova, Gala MScR1; Martindale, Amanda B. PhD1; Richards, Hugh MSc1; Stirling, John RGN2; McIntyre, Cecelia RGN2; Currie, Ian S. PhD2,3
doi : 10.1097/TP.0000000000003385
Transplantation: May 2021 - Volume 105 - Issue 5 - p 1082-1089
The National Organ Retrieval Service (NORS) 2015 review recommended a single scrub practitioner provide support simultaneously to abdominal and cardiothoracic teams in UK multiorgan retrieval. Previously, this model had been used only by the combined abdominal and cardiac team in Scotland. This study reports the impact on performance as part of the Vanguard project, which utilized the single scrub practitioner role with 5 NORS teams, to determine applicability United Kingdom wide.
Okamura, Hiroshi MD, PhD1; Nakamae, Mika MD, PhD1; Koh, Shiro MD, PhD1; Nanno, Satoru MD, PhD1; Nakashima, Yasuhiro MD, PhD1; Koh, Hideo MD, PhD1; Nakane, Takahiko MD, PhD1; Hirose, Asao MD, PhD1; Hino, Masayuki MD, PhD1; Nakamae, Hirohisa MD, PhD1
doi : 10.1097/TP.0000000000003357
Transplantation: May 2021 - Volume 105 - Issue 5 - p 1090-1096
Allogeneic hematopoietic cell transplantation (allo-HCT) is a curative treatment option for malignant hematological disorders. Transplant clinicians estimate patient-specific prognosis empirically in clinical practice based on previous studies on similar patients. However, this approach does not provide objective data. The present study primarily aimed to develop a tool capable of providing accurate personalized prognosis prediction after allo-HCT in an objective manner.
Park, Sung-Soo MD1; Min, Gi June MD1; Park, Silvia MD, PhD1; Lee, Sung-Eun MD, PhD1; Yoon, Jae-Ho MD, PhD1; Shin, Seung Hwan MD, PhD2; Cho, Byung-Sik MD, PhD1; Eom, Ki-Seong MD, PhD1; Kim, Yoo-Jin MD, PhD1; Lee, Seok MD, PhD1; Min, Chang-Ki MD, PhD1; Kim, Hee-Je MD, PhD1; Cho, Seok-Goo MD, PhD1; Lee, Jong Wook MD, PhD1
doi : 10.1097/TP.0000000000003342
Transplantation: May 2021 - Volume 105 - Issue 5 - p 1097-1105
Regarding patients with severe aplastic anemia (SAA) who fail immunosuppressive therapy and lack an HLA-matched sibling donor (MSD), the best alternative donor including unrelated (URD) and haploidentical (HAPLO) donors for allogeneic stem cell transplantation (SCT) remains to be established.
Sotomayor, Camilo G. MD1,2; te Velde-Keyzer, Charlotte A. MD, PhD1; Diepstra, Arjan MD, PhD3; van Londen, Marco MD, PhD1; Pol, Robert A. MD, PhD4; Post, Adrian BSc1; Gans, Rijk O.B. MD, PhD5; Nolte, Ilja M. PhD6; Slart, Riemer H.J.A. MD, PhD7; de Borst, Martin H. MD, PhD1; Berger, Stefan P. MD, PhD1; Rodrigo, Ram?n MSc8; Navis, Gerjan J. MD, PhD1; de Boer, Rudolf A. MD, PhD9; Bakker, Stephan J.L. MD, PhD1
doi : 10.1097/TP.0000000000003359
Transplantation: May 2021 - Volume 105 - Issue 5 - p 1106-1115
Galectin-3 may play a causal role in kidney inflammation and fibrosis, which may also be involved in the development of kidney graft failure. With novel galectin-3-targeted pharmacological therapies increasingly coming available, we aimed to investigate whether galectin-3 is associated with risk of late graft failure in kidney transplant recipients (KTR).
Ward, Stephanie BA1; Boger, Matthew MS2; Fleishman, Aaron MPH1; Shenkel, Jessica MA1; Calvo, Amanda BS1; Pomahac, Bohdan MD3,4; Zwolak, Robert MD5,6; Krishnan, Namrata MD7,8; Rodrigue, James R. PhD1,4
doi : 10.1097/TP.0000000000003376
Transplantation: May 2021 - Volume 105 - Issue 5 - p 1116-1124
There are 20 million living US armed forces veterans; however, the organ donation attitudes of veterans have not been examined.
Deshmukh, Tejas MClinTRes1,2; Emerson, Peter MBBS1; Anderson, Patricia MN (Research)3; Kizana, Eddy PhD1,2,4; O’Connell, Philip J. PhD5,6; Holmes-Walker, D. Jane PhD2,7; Chong, James J.H. PhD1,2,4
doi : 10.1097/TP.0000000000003377
Transplantation: May 2021 - Volume 105 - Issue 5 - p 1125-1129
Cardiac autonomic neuropathy (CAN) is a significant cause of morbidity and mortality for people with type 1 (T1D) and type 2 (T2D) diabetes. Heart rate variability (HRV) has been shown to be a marker of CAN with 24-hour Holter monitoring being a robust modality to assess HRV.
Boyarsky, Brian J. MD1; Ou, Michael T. BA1; Werbel, William A. MD2; Avery, Robin K. MD2; Clarke, William A. PhD3; Tobian, Aaron A.R. MD, PhD3; Massie, Allan B. PhD1; Segev, Dorry L. MD, PhD1; Garonzik Wang, Jacqueline M. MD, PhD1
doi : 10.1097/TP.0000000000003637
Transplantation: May 2021 - Volume 105 - Issue 5 - p e52-e53
Seet, Christopher MBBS1; Dabare, Dilan MBChB, MRCS1; Forbes, Suzanne MBChB1; Khurram, Muhammad PhD, FRCS1; Mohamed, Ismail H. MD, FRCS1
doi : 10.1097/TP.0000000000003652
Transplantation: May 2021 - Volume 105 - Issue 5 - p e54-e55
Boyarsky, Brian J. MD1; Ou, Michael T. BS1; Greenberg, Ross S. BA1; Teles, Aura T. BS1; Werbel, William A. MD2; Avery, Robin K. MD2; Massie, Allan B. PhD1; Segev, Dorry L. MD, PhD1; Garonzik-Wang, Jacqueline M. MD, PhD1
doi : 10.1097/TP.0000000000003654
Transplantation: May 2021 - Volume 105 - Issue 5 - p e56-e57
Saner, Fuat H. MD1; Bezinover, Dmitri2; Blasi, Annabel3; Lisman, Ton4; Weiss, Emmanuel5
doi : 10.1097/TP.0000000000003656
Transplantation: May 2021 - Volume 105 - Issue 5 - p e58-e59
Nguyen-Buckley, Christine MD1; Gao, Wei MD2; Agopian, Vatche MD3; Wray, Christopher MD1; Steadman, Randolph H. MD4; Xia, Victor W. MD1
doi : 10.1097/TP.0000000000003657
Transplantation: May 2021 - Volume 105 - Issue 5 - p e60
آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟