Transplantation

Bikhet, Mohamed MD1; Iwase, Hayato MD, PhD1; Yamamoto, Takayuki MD, PhD1; Jagdale, Abhijit MD1; Foote, Jeremy B. PhD2; Ezzelarab, Mohamed MD3; Anderson, Douglas J. MD, MS4; Locke, Jayme E. MD, MPH4; Eckhoff, Devin E. MD4; Hara, Hidetaka MD, PhD1; Cooper, David K.C. MD, PhD, FRCS1

doi : 10.1097/TP.0000000000003622

June 2021 - Volume 105 - Issue 6 - p 1143-1155

We discuss what therapeutic regimen might be acceptable/successful in the first clinical trial of genetically engineered pig kidney or heart transplantation. As regimens based on a calcineurin inhibitor or CTLA4-Ig have proved unsuccessful, the regimen we administer to baboons is based on induction therapy with antithymocyte globulin, an anti-CD20 mAb (Rituximab), and cobra venom factor, with maintenance therapy based on blockade of the CD40/CD154 costimulation pathway (with an anti-CD40 mAb), with rapamycin, and a corticosteroid. An anti-inflammatory agent (etanercept) is administered for the first 2 wk, and adjuvant therapy includes prophylaxis against thrombotic complications, anemia, cytomegalovirus, and pneumocystis. Using this regimen, although antibody-mediated rejection certainly can occur, we have documented no definite evidence of an adaptive immune response to the pig xenograft. This regimen could also form the basis for the first clinical trial, except that cobra venom factor will be replaced by a clinically approved agent, for example, a C1-esterase inhibitor. However, none of the agents that block the CD40/CD154 pathway are yet approved for clinical use, and so this hurdle remains to be overcome. The role of anti-inflammatory agents remains unproven. The major difference between this suggested regimen and those used in allotransplantation is the replacement of a calcineurin inhibitor with a costimulation blockade agent, but this does not appear to increase the complications of the regimen.

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Donor Warm Ischemia Time in DCD Liver Transplantation—Working Group Report From the ILTS DCD, Liver Preservation, and Machine Perfusion Consensus Conference

Kalisvaart, Marit MD, PhD1; Croome, Kristopher P. MD, MS2; Hernandez-Alejandro, Roberto MD3; Pirenne, Jacques MD, PhD4; Cortés-Cerisuelo, Miriam MD, PhD5; Mi?ambres, Eduardo MD, PhD6; Abt, Peter L. MD7

doi : 10.1097/TP.0000000000003819

June 2021 - Volume 105 - Issue 6 - p 1156-1164

Donation after circulatory death (DCD) grafts are commonly used in liver transplantation. Attributable to the additional ischemic event during the donor warm ischemia time (DWIT), DCD grafts carry an increased risk for severe ischemia/reperfusion injury and postoperative complications, such as ischemic cholangiopathy. The actual ischemia during DWIT depends on the course of vital parameters after withdrawal of life support and varies widely between donors. The ischemic period (functional DWIT) starts when either Spo2 or blood pressure drop below a certain point and lasts until the start of cold perfusion during organ retrieval. Over the years, multiple definitions and thresholds of functional DWIT duration have been used. The International Liver Transplantation Society organized a Consensus Conference on DCD, Liver Preservation, and Machine Perfusion on January 31, 2020 in Venice, Italy. The aim of this conference was to reach consensus about various aspects of DCD liver transplantation in context of currently available evidence. Here we present the recommendations with regards to the definitions used for DWIT and functional DWIT, the importance of vital parameters after withdrawal of life support, and acceptable thresholds of duration of functional DWIT to proceed with liver transplantation.

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Prediction of Organ Donation After Circulatory Death: In Search of a Better Crystal Ball

Cannon, Robert M. MD1

doi : 10.1097/TP.0000000000003431

June 2021 - Volume 105 - Issue 6 - p 1165-1166

خرید پکیج و مشاهده آنلاین مقاله

Navigating in the Dark, Challenges Assessing the Liver-kidney Safety Net

Roll, Garrett R. MD1; Safa, Kassem MD2; Yeh, Heidi MD3

doi : 10.1097/TP.0000000000003366

June 2021 - Volume 105 - Issue 6 - p 1167-1168

خرید پکیج و مشاهده آنلاین مقاله

What Is Past Is Prologue

Heimbach, Julie K. MD1; Taner, Timucin MD, PhD1

doi : 10.1097/TP.0000000000003379

June 2021 - Volume 105 - Issue 6 - p 1169-1170

خرید پکیج و مشاهده آنلاین مقاله

Donor-derived Cell-free DNA for the Diagnosis of Kidney Transplant Rejection: An Attractive Test With Ambiguous Answers!

Puttarajappa, Chethan M. MD, MS1; Mehta, Rajil B. MD1; Hariharan, Sundaram MD1

doi : 10.1097/TP.0000000000003696

June 2021 - Volume 105 - Issue 6 - p 1171-1172

خرید پکیج و مشاهده آنلاین مقاله

Bracing for the Next Wave on the Long Haul: Lung Transplantation for Post–COVID-19 Respiratory Failure

Vos, Robin MD, PhD1,2; Ceulemans, Laurens J. MD, PhD2,3

doi : 10.1097/TP.0000000000003707

June 2021 - Volume 105 - Issue 6 - p 1173-1175

خرید پکیج و مشاهده آنلاین مقاله

The Problem of Subclinical Antibody-mediated Rejection in Kidney Transplantation

Filippone, Edward John MD1; Farber, John L. MD2

doi : 10.1097/TP.0000000000003543

June 2021 - Volume 105 - Issue 6 - p 1176-1187

Defined as histologic evidence of rejection on a protocol biopsy in the absence of kidney dysfunction, subclinical rejection has garnered attention since the 1990s. The major focus of much of this research, however, has been subclinical T cell–mediated rejection (TCMR). Herein, we review the literature on subclinical antibody-mediated rejection (AMR), which may occur with either preexisting donor-specific antibodies (DSA) or upon the development of de novo DSA (dnDSA). In both situations, subsequent kidney function and graft survival are compromised. Thus, we recommend protocol biopsy routinely within the first year with preexisting DSA and at the initial detection of dnDSA. In those with positive biopsies, baseline immunosuppression should be maximized, any associated TCMR treated, and adherence stressed, but it remains uncertain if antibody-reduction treatment should be initiated. Less invasive testing of blood for donor DNA or gene profiling may have a role in follow-up of those with negative initial biopsies. If a protocol biopsy is positive in the absence of detectable HLA-DSA, it also remains to be determined whether non-HLA-DSA should be screened for either in particular or on a genome-wide basis and how these patients should be treated. Randomized controlled trials are clearly needed.

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Peripheral Vascular Disease and Kidney Transplant Outcomes: Rethinking an Important Ongoing Complication

Hern?ndez, Domingo MD, PhD1; V?zquez, Teresa MD1; Armas-Padr?n, Ana Mar?a MD2; Alonso-Titos, Juana MD1; Casas, Cristina MD1; Gutiérrez, Elena MD1; Jironda, Cristina MD1; Cabello, Mercedes MD, PhD1; L?pez, Ver?nica MD, PhD1

doi : 10.1097/TP.0000000000003518

June 2021 - Volume 105 - Issue 6 - p 1188-1202

Peripheral vascular disease (PVD) is highly prevalent in patients on the waiting list for kidney transplantation (KT) and after transplantation and is associated with impaired transplant outcomes. Multiple traditional and nontraditional risk factors, as well as uremia- and transplant-related factors, affect 2 processes that can coexist, atherosclerosis and arteriosclerosis, leading to PVD. Some pathogenic mechanisms, such as inflammation-related endothelial dysfunction, mineral metabolism disorders, lipid alterations, or diabetic status, may contribute to the development and progression of PVD. Early detection of PVD before and after KT, better understanding of the mechanisms of vascular damage, and application of suitable therapeutic approaches could all minimize the impact of PVD on transplant outcomes. This review focuses on the following issues: (1) definition, epidemiological data, diagnosis, risk factors, and pathogenic mechanisms in KT candidates and recipients; (2) adverse clinical consequences and outcomes; and (3) classical and new therapeutic approaches.

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Donor-derived Cell-free DNA in Solid-organ Transplant Diagnostics: Indications, Limitations, and Future Directions

Kataria, Ashish MD1; Kumar, Dhiren MD2; Gupta, Gaurav MD2,3

doi : 10.1097/TP.0000000000003651

June 2021 - Volume 105 - Issue 6 - p 1203-1211

The last few years have seen an explosion in clinical research focusing on the use of donor-derived cell-free DNA (dd-cfDNA) in solid-organ transplants (SOT). Although most of the literature published so far focuses on kidney transplants, there are several recent as well as ongoing research studies on heart, lung, pancreas, and liver transplants. Though initially studied as a noninvasive means of identifying subclinical or acute rejection in SOT, it is rapidly becoming clear that instead of being a specific marker for allograft rejection, dd-cfDNA is more appropriately described as a marker of severe injury, although the most common cause of this injury is allograft rejection. Multiple studies in kidney transplants have shown that although sensitivity for the diagnosis of antibody-mediated rejection is excellent, it is less so for T-cell–mediated rejection. It is possible that combining dd-cfDNA with other novel urine- or blood-based biomarkers may increase the sensitivity for the diagnosis of rejection. Irrespective of the cause, though, elevated dd-cfDNA seems to portend adverse allograft prognosis and formation of de novo donor-specific antibody. Although current data do not lend themselves to a clear conclusion, ongoing studies may reveal the utility of serial surveillance for the management of SOT as following levels of dd-cfDNA over time may provide windows of opportunity to intervene early and before irreversible allograft injury. Finally, cost-effectiveness studies will be needed to guide the ideal incorporation of dd-cfDNA into routine clinical practice.

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Overexpression of the MSK1 Kinase in Patients With Chronic Lung Allograft Dysfunction and Its Confirmed Role in a Murine Model

Nemska, Simona PhD1,2; Daubeuf, François PhD1,3; Obrecht, Adeline BSc3; Israel-Biet, Dominique MD, PhD4; Stern, Marc MD, PhD5; Kessler, Romain MD, PhD6; Roux, Antoine MD, PhD5; Tavakoli, Reza MD, PhD2; Villa, Pascal PhD3; Tissot, Adrien MD7,8; Danger, Richard PhD7,9; Reber, Laurent PhD1; Durand, Eugénie BSc7; Foureau, Aurore MSc7,8; Brouard, Sophie DVM, PhD7,9; Magnan, Antoine MD8; Frossard, Nelly PhD1; the COLT consortium

doi : 10.1097/TP.0000000000003606

June 2021 - Volume 105 - Issue 6 - p 1212-1224

Chronic lung allograft dysfunction (CLAD) and its obstructive form, the obliterative bronchiolitis (OB), are the main long-term complications related to high mortality rate postlung transplantation. CLAD treatment lacks a significant success in survival. Here, we investigated a new strategy through inhibition of the proinflammatory mitogen- and stress-activated kinase 1 (MSK1) kinase.

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Integrative Analysis of Prognostic Biomarkers for Acute Rejection in Kidney Transplant Recipients

Cao, Yue BSc1; Alexander, Stephen I. MD2; Chapman, Jeremy R. MD3; Craig, Jonathan C. PhD4; Wong, Germaine PhD2,3,5,*; Yang, Jean Y.H. PhD1,6,*

doi : 10.1097/TP.0000000000003516

June 2021 - Volume 105 - Issue 6 - p 1225-1237

Noninvasive biomarkers may predict adverse events such as acute rejection after kidney transplantation and may be preferable to existing methods because of superior accuracy and convenience. It is uncertain how these biomarkers, often derived from a single study, perform across different cohorts of recipients.

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Unraveling the Crucial Roles of FoxP3+ Regulatory T Cells in Vascularized Composite Allograft Tolerance Induction and Maintenance

Anggelia, Madonna Rica PhD1; Cheng, Hui-Yun PhD1; Chuang, Wen-Yu MD2; Hsieh, Yun-Huan MD1; Wang, Aline Yen Ling PhD1; Lin, Chih-Hung MD1,3; Wei, Fu-Chan MD1; Brandacher, Gerald MD4; Lin, Cheng-Hung MD1

doi : 10.1097/TP.0000000000003509

June 2021 - Volume 105 - Issue 6 - p 1238-1249

The role of regulatory T cells (Treg) in tolerance induction of vascularized composite allotransplantation (VCA) remains unclear. This study was designed to examine characteristics of Treg after VCA and their capacity to rescue allografts from rejection.

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Combination of a CD26 Inhibitor, G-CSF, and Short-term Immunosuppressants Modulates Allotransplant Survival and Immunoregulation in a Rodent Hindlimb Allotransplant Model

Chen, Chien-Chang MD1,2; Chen, Rong-Fu PhD1; Wang, Yu-Chi MD1; Li, Yun-Ting MS1; Chuang, Jiin-Haur MD3; Kuo, Yur-Ren PhD1,4,5,6

doi : 10.1097/TP.0000000000003504

June 2021 - Volume 105 - Issue 6 - p 1250-1260

Recent studies have demonstrated that inhibition of CD26 potentiates stromal cell–derived factor-1? (SDF-1?), promotes tissue regeneration, and suppresses the rejection of organ transplants. This study investigated whether the combination of a CD26 inhibitor (CD26i) with granulocyte colony-stimulating factor (G-CSF) and short-term immunosuppressants modulates vascularized composite tissue allotransplant survival in a rodent orthotopic hindlimb allotransplant model.

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Early Outcomes With the Liver-kidney Safety Net

Cannon, Robert M. MD1; Goldberg, David S. MD2; Eckhoff, Devin E. MD1; Anderson, Douglas J. MD1; Orandi, Babak J. MD1; Locke, Jayme E. MD1

doi : 10.1097/TP.0000000000003365

June 2021 - Volume 105 - Issue 6 - p 1261-1272

A safety net policy was implemented in August 2017 giving liver transplant alone (LTA) recipients with significant renal dysfunction posttransplant priority for subsequent kidney transplantation (KT). This study was undertaken to evaluate early outcomes under this policy.

خرید پکیج و مشاهده آنلاین مقاله

Timing for Introduction of Total Laparoscopic Living Donor Right Hepatectomy; Initial Experience Based on the Data of Laparoscopic Major Hepatectomy

Lee, Boram MD1; Choi, YoungRok MD1; Lee, Woohyung MD2; Park, Youngmi MA3; Kim, Kil Hwan MD1; Hyun, In Gun MD1; Han, Sun Jong MD1; Cho, Jai Young MD, PhD1; Yoon, Yoo-Seok MD, PhD1; Han, Ho-Seong MD, PhD1

doi : 10.1097/TP.0000000000003344

June 2021 - Volume 105 - Issue 6 - p 1273-1279

This study evaluated the timing of safe introduction of total laparoscopic donor right hepatectomy (TLDRH) based on outcomes of laparoscopic major hepatectomy (LMH).

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Clinical Impact of Antecedent Bariatric Surgery on Liver Transplant Outcomes: A Retrospective Matched Case-control Study

Serrano, Oscar K. MD, MBA1; Peterson, Kent J. MD1; Vock, David M. PhD2; Berglund, Danielle BS1; Kandaswamy, Raja MBBS1; Lake, John R. MD3; Pruett, Timothy L. MD1; Chinnakotla, Srinath MBBS1

doi : 10.1097/TP.0000000000003378

June 2021 - Volume 105 - Issue 6 - p 1280-1284

Bariatric surgery (BS) may be associated with significant malabsorption and nutritional deficiencies.

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Liver Transplantation of HCV-viremic Donors Into HCV-negative Recipients in the United States: Increasing Frequency With Profound Geographic Variation

Cotter, Thomas G. MB BCh1; Aronsohn, Andrew MD1; Reddy, K. Gautham MD1; Charlton, Michael MD1

doi : 10.1097/TP.0000000000003382

June 2021 - Volume 105 - Issue 6 - p 1285-1290

Direct-acting antiviral therapy made possible the novel practice of utilizing hepatitis C virus (HCV)-viremic (HCV RNA-positive) donors into HCV-negative recipients in the United States. Although initial reports of outcomes have been satisfactory, higher-quality longer-term outcomes remain to be elucidated.

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Parietal Peritoneum as a Novel Substitute for Middle Hepatic Vein Reconstruction During Living Donor Liver Transplantation

Hong, Suk Kyun MD1; Yi, Nam-Joon MD, PhD1; Cho, Jae-Hyung MD1; Lee, Jeong-Moo MD1; Hong, Kwangpyo MD1; Han, Eui Soo MD1; Lee, Kwang-Woong MD, PhD1; Suh, Kyung-Suk MD, PhD1

doi : 10.1097/TP.0000000000003349

June 2021 - Volume 105 - Issue 6 - p 1291-1296

Although autologous, cryopreserved, or artificial vascular grafts can be used as interpositional vascular substitutes for middle hepatic vein (MHV) reconstruction during living donor liver transplantation (LDLT), they are not always available, are limited in size and length, and are associated with risks of infection. This study aimed to evaluate the parietal peritoneum as a novel substitute for MHV reconstruction during LDLT.

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Retransplantation After Living Donor Liver Transplantation: Data from the Adult to Adult Living Donor Liver Transplantation Study

Braun, Hillary J. MD1; Grab, Joshua D. MS1; Dodge, Jennifer L. MPH1; Syed, Shareef M. MD1; Roll, Garrett R. MD1; Schwab, Marisa P. MD1; Liu, Iris H. BA1; Glencer, Alexa C. MD1; Freise, Chris E. MD1; Roberts, John P. MD1; Ascher, Nancy L. MD, PhD1

doi : 10.1097/TP.0000000000003361

June 2021 - Volume 105 - Issue 6 - p 1297-1302

The use of living donor liver transplantation (LDLT) for primary liver transplantation (LT) may quell concerns about allocating deceased donor organs if the need for retransplantation (re-LT) arises because the primary LT did not draw from the limited organ pool. However, outcomes of re-LT after LDLT are poorly studied. The purpose of this study was to analyze the Adult to Adult Living Donor Liver Transplantation Study (A2ALL) data to report outcomes of re-LT after LDLT, with a focus on long-term survival after re-LT.

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Diagnostic Accuracy of Donor-derived Cell-free DNA in Renal-allograft Rejection: A Meta-analysis

Xiao, Hanyu MD1; Gao, Fang MD2; Pang, Qidan MD3; Xia, Qiuxiang MD, PhD1; Zeng, Xianpeng MD, PhD1; Peng, Jingtao MD, PhD1; Fan, Lei MD, PhD4; Liu, Jiali MD1; Wang, Zhendi MD, PhD1; Li, Heng MD, PhD1

doi : 10.1097/TP.0000000000003443

June 2021 - Volume 105 - Issue 6 - p 1303-1310

Donor-derived cell-free DNA (dd-cfDNA) is a potential noninvasive molecular marker of graft rejection after kidney transplant, whose diagnostic accuracy remains controversial.

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External Validation of the DCD-N Score and a Linear Prediction Model to Identify Potential Candidates for Organ Donation After Circulatory Death: A Nationwide Multicenter Cohort Study

Nijhoff, Maaike F. BSc1; Pol, Robert A. MD, PhD1; Volbeda, Meint MD, PhD2; Kotsopoulos, Angela M.M. MD, PhD3; Sonneveld, Johan P.C. MD, PhD4; Otterspoor, Luuk MD, PhD5; Abdo, Wilson F. MD, PhD6; Silderhuis, Vera M. MD, PhD7; El Moumni, Mostafa MD, PhD1; Moers, Cyril MD, PhD1

doi : 10.1097/TP.0000000000003430

June 2021 - Volume 105 - Issue 6 - p 1311-1316

Donation after circulatory death (DCD) is a procedure in which after planned withdrawal of life-sustaining treatment (WLST), the dying process is monitored. A DCD procedure can only be continued if the potential organ donor dies shortly after WLST. This study performed an external validation of 2 existing prediction models to identify potentially DCD candidates, using one of the largest cohorts.

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The Introduction of cPRA and Its Impact on Access to Deceased Donor Kidney Transplantation for Highly Sensitized Patients in Australia

Sypek, Matthew P. MBBS1,2,3,4; Kausman, Joshua Y. PhD3,5,6; Watson, Narelle MSc7; Wyburn, Kate PhD8; Holt, Stephen G. PhD1,2; Hughes, Peter PhD1,2; Clayton, Philip A. PhD4,9,10

doi : 10.1097/TP.0000000000003410

June 2021 - Volume 105 - Issue 6 - p 1317-1325

In March 2016, Australia’s deceased donor kidney allocation program introduced calculated panel reactive antibody (cPRA) based on antibody exclusions using multiplex assays to define sensitization for waitlisted candidates. We aimed to assess the impact of this change and review access to transplantation for highly sensitized patients under the current allocation rules.

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Loss to Follow-up in Adolescent and Young Adult Renal Transplant Recipients

Melanson, Taylor A. PhD1; Mersha, Karie MD2; Patzer, Rachel E. PhD, MPH1; George, Roshan P. MD3

doi : 10.1097/TP.0000000000003445

June 2021 - Volume 105 - Issue 6 - p 1326-1336

Patients’ loss to follow-up (LFU) has significant impacts on outcomes and is a barrier to improving care, especially in adolescent and young adult (AYA) renal transplant recipients. There is limited information regarding the relationship between transfer of care from pediatric to adult transplant centers, age, and LFU among AYA renal transplant recipients.

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Decline in Club Cell Secretory Proteins, Exosomes Induction and Immune Responses to Lung Self-antigens, K?1 Tubulin and Collagen V, Leading to Chronic Rejection After Human Lung Transplantation

Itabashi, Yoshihiro MD1,*; Ravichandran, Ranjithkumar PhD1,*; Bansal, Sandhya PhD1; Bharat, Ankit MD2; Hachem, Ramsey MD3; Bremner, Ross MD, PhD1; Smith, Michael MD1; Mohanakumar, T. PhD1

doi : 10.1097/TP.0000000000003428

June 2021 - Volume 105 - Issue 6 - p 1337-1346

Chronic lung allograft dysfunction (CLAD), is a major hurdle for long-term lung allograft survival after lung transplant and roughly 50% of lung transplant recipients (LTxRs) develop CLAD within 5 years. The mechanisms of CLAD development remain unknown. Donor-specific immune responses to HLA and lung self-antigens (SAgs) are vital to the pathogenesis of CLAD. Reduction in Club cell secretory protein (CCSP) has been reported in bronchoalveolar lavage (BAL) fluid samples from LTxRs with bronchiolitis obliterans syndrome (BOS). CCSP levels in BAL fluid and development of antibodies to lung SAgs in plasma were determined by ELISA. Cytokines in BAL fluid were analyzed by 30-plex Luminex panel. Exosomes from BAL fluid or plasma were analyzed for SAgs, natural killer (NK) cells markers, and cytotoxic molecules.

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Myocardial Vascular Function Assessed by Dynamic Oxygenation-sensitive Cardiac Magnetic Resonance Imaging Long-term Following Cardiac Transplantation

Iannino, Nadia MD, MSc1; Fischer, Kady PhD1,2,3; Friedrich, Matthias MD1,3; Hafyane, Tarik MSc1; Mongeon, Francois-Pierre MD1,4; White, Michel MD1,4

doi : 10.1097/TP.0000000000003419

June 2021 - Volume 105 - Issue 6 - p 1347-1355

Coronary vascular function is related to adverse outcomes following cardiac transplantation (CTx) in patients with or without cardiac allograft vasculopathy (CAV). The noninvasive assessment of the myocardial vascular response using oxygenation-sensitive cardiac magnetic resonance (OS-CMR has not been investigated in stable long-term CTx recipients).

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Living Kidney Donors’ Financial Expenses and Mental Health

Barnieh, Lianne PhD1; Arnold, Jennifer B.1; Boudville, Neil MD2,3; Cuerden, Meaghan S. MSc1; Dew, Mary Amanda PhD4; Dipchand, Christine MD5; Feldman, Liane S MD6; Gill, John S. MD7; Karpinski, Martin MD8; Klarenbach, Scott MD9; Knoll, Greg MD10; Lok, Charmaine MD11; Miller, Matt MD12; Monroy, Mauricio MD13; Nguan, Chris MD7; Prasad, G.V. Ramesh MD14; Sontrop, Jessica M. PhD15; Storsley, Leroy MD8; Garg, Amit X. MD15,16,17; for the Donor Nephrectomy Outcomes Research (DONOR) Network

doi : 10.1097/TP.0000000000003401

June 2021 - Volume 105 - Issue 6 - p 1356-1364

Living kidney donors incur donation-related expenses, but how these expenses impact postdonation mental health is unknown.

خرید پکیج و مشاهده آنلاین مقاله

Outcomes of COVID-19 in Solid Organ Transplant Recipients: A Propensity-matched Analysis of a Large Research Network

Hadi, Yousaf B. MD1; Naqvi, Syeda F.Z. MD2; Kupec, Justin T. MD1; Sofka, Sarah MD3; Sarwari, Arif MD3

doi : 10.1097/TP.0000000000003670

June 2021 - Volume 105 - Issue 6 - p 1365-1371

Organ transplant recipients comprise an immunocompromised and vulnerable cohort. Outcomes of coronavirus disease 2019 (COVID-19) in solid organ transplant (SOT) recipients remain understudied.

خرید پکیج و مشاهده آنلاین مقاله

SARS-CoV-2-specific Cell-mediated Immunity in Kidney Transplant Recipients Recovered From COVID-19

Fern?ndez-Ruiz, Mario MD, PhD1; Olea, Beatriz MD2; Giménez, Estela MD, PhD2; Laguna-Goya, Roc?o MD, PhD3; Trujillo, Hernando MD4; Caravaca-Font?n, Fernando MD, PhD4; Gutiérrez, Eduardo MD, PhD4; L?pez-Medrano, Francisco MD, PhD1,5; Remigia, Mar?a José MD, PhD6; Almendro-Vazquez, Patricia BSc3; Polanco, Natalia MD, PhD4; Gonz?lez, Esther MD, PhD4; Ruiz-Merlo, Tamara BSN1; Parra, Patricia CLS1; San Juan, Rafael MD, PhD1,5; Andrés, Amado MD, PhD4; Navarro, David MD, PhD2,7; Aguado, José Mar?a MD, PhD1,5

doi : 10.1097/TP.0000000000003672

June 2021 - Volume 105 - Issue 6 - p 1372-1380

The magnitude and kinetics of severe acute respiratory syndrome coronavirus 2–specific cell-mediated immunity (SARS-CoV-2-CMI) in kidney transplant (KT) recipients remain largely unknown.

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Lung Transplantation for Severe Post–coronavirus Disease 2019 Respiratory Failure

Hawkins, Robert B. MD1; Mehaffey, J. Hunter MD1; Charles, Eric J. MD, PhD1; Mannem, Hannah C. MD2; Roeser, Mark MD1

doi : 10.1097/TP.0000000000003706

June 2021 - Volume 105 - Issue 6 - p 1381-1387

The coronavirus disease 2019 (COVID-19) pandemic has resulted in >72 million cases and 1.6 million deaths. End-stage lung disease from COVID-19 is a new and growing entity that may benefit from lung transplant; however, there are limited data on the patient selection, perioperative management, and expected outcomes of transplantation for this indication.

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Reducing the Safety Limit for Remnant Liver Volume in Living Donor Hepatectomy—Are We Pushing the Envelope Off the Edge?

Reddy, Mettu Srinivas FRCS, PhD1; Rela, Mohamed MS, FRCS2

doi : 10.1097/TP.0000000000003689

June 2021 - Volume 105 - Issue 6 - p e61

خرید پکیج و مشاهده آنلاین مقاله

Reply to “Reducing the Safety Limit for Remnant Liver Volume in Living Donor Hepatectomy: Are We Pushing the Envelope Off the Edge?”

Gorgen, Andre MD1,2; Sapisochin, Gonzalo MD, PhD1,2

doi : 10.1097/TP.0000000000003690

June 2021 - Volume 105 - Issue 6 - p e62

خرید پکیج و مشاهده آنلاین مقاله

Hepatobiliary Scintigraphy to Increase the Safety in Right Lobe Living Donor Liver Transplantation: Not Just a Matter of Age and Remnant Volume

Serenari, Matteo MD1; Ravaioli, Matteo MD, PhD1,2; Cescon, Matteo MD, PhD1,2

doi : 10.1097/TP.0000000000003658

June 2021 - Volume 105 - Issue 6 - p e63

خرید پکیج و مشاهده آنلاین مقاله

Re: Hepatobiliary Scintigraphy to Increase the Safety in Right Lobe Living Donor Liver Transplantation: Not Just a Matter of Age and Remnant Volume

Gorgen, Andre MD1,2; Sapisochin, Gonzalo MD, PhD1,2

doi : 10.1097/TP.0000000000003659

June 2021 - Volume 105 - Issue 6 - p e64

خرید پکیج و مشاهده آنلاین مقاله

Successful Treatment of Suspected Donor-derived Human Herpesvirus-8 Infection in a Liver Transplant Patient With Coronavirus Disease-19

Peri, Anna Maria MD1; Magro, Bianca MD2; van den Bogaart, Lorena MD1,3; dalla Pria, Alessia MD1,4; Giuffrida, Paolo MD5; Gianatti, Andrea MD6; Fabretti, Fabrizio MD7; Maria Barbui, Anna MD8; Tebaldi, Alessandra MD1; Rizzi, Marco MD1; Fagiuoli, and Stefano2

doi : 10.1097/TP.0000000000003684

June 2021 - Volume 105 - Issue 6 - p e65-e67

خرید پکیج و مشاهده آنلاین مقاله