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Should We test for IgG Antibodies Against MOG in Both Serum and CSF in Patients With Suspected MOGAD?.
Kim, Ho Jin MD, PhD; Palace, Jacqueline MB, DM
doi : 10.1212/WNL.0000000000206805
Volume 100(11) pgs. 497-545,e1095-e1206 March 14, 2023
Suicidality in Epilepsy: Common With Various Mood and Anxiety Disorders.
Munger Clary, Heidi MD, MPH; Gilliam, Frank MD
Hyperacute Perfusion Imaging Before Pediatric Thrombectomy: One Step Closer.
Stence, Nicholas; Dlamini, Nomazulu MBBS, MRCPCH, MSc (Lon), PhD
Significance of Myelin Oligodendrocyte Glycoprotein Antibodies in CSF: A Retrospective Multicenter Study.
Carta, Sara MD *; Cobo Calvo, Alvaro MD, PhD *; Armangue, Thais MD, PhD; Saiz, Albert MD, PhD; Lechner, Christian MD; Rostasy, Kevin MD; Breu, Markus MD, PhD; Baumann, Matthias MD; Hoftberger, Romana MD, PhD; Ayzenberg, Ilya MD; Schwake, Carolin MD; Sepulveda, Maria MD, PhD; Martinez-Hernandez, Eugenia MD, PhD; Olive-Cirera, Gemma MD; Arrambide, Georgina MD, PhD; Tintore, Mar MD, PhD; Bernard-Valnet, Raphael MD, PhD; Du Pasquier, Renaud MD; Brilot, Fabienne PhD; Ramanathan, Sudarshini MD, PhD; Schanda, Kathrin MSc; Gajofatto, Alberto MD, PhD; Ferrari, Sergio MD; Sechi, Elia MD; Flanagan, Eoin P. MD; Pittock, Sean J. MD; Redenbaugh, Vyanka MD; Reindl, Markus PhD; Marignier, Romain MD, PhD +; Mariotto, Sara MD, PhD +
doi : 10.1212/WNL.0000000000201662
Although the diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is based on serum MOG antibodies (MOG-Abs) positivity, patients with coexisting or restricted MOG-Abs in the CSF have been reported.
Hematopoietic Stem Cell Transplantation in People With Active Secondary Progressive Multiple Sclerosis.
Boffa, Giacomo MD *; Signori, Alessio PhD *; Massacesi, Luca MD; Mariottini, Alice MD, PhD; Sbragia, Elvira MD; Cottone, Salvatore MD; Amato, Maria Pia MD; Gasperini, Claudio MD, PhD; Moiola, Lucia MD, PhD; Meletti, Stefano MD, PhD; Repice, Anna Maria MD; Brescia Morra, Vincenzo MD; Salemi, Giuseppe MD; Patti, Francesco MD; Filippi, Massimo MD; De Luca, Giovanna MD; Lus, Giacomo MD; Zaffaroni, Mauro MD; Sola, Patrizia MD, PhD; Conte, Antonella MD, PhD; Nistri, Riccardo MD; Aguglia, Umberto MD; Granella, Franco; Galgani, Simonetta MD; Caniatti, Luisa Maria MD; Lugaresi, Alessandra MD, PhD; Romano, Silvia MD, PhD; Iaffaldano, Pietro MD; Cocco, Eleonora MD; Saccardi, Riccardo MD; Angelucci, Emanuele MD; Trojano, Maria MD; Mancardi, Giovanni Luigi MD; Sormani, Maria Pia PhD; Inglese, Matilde MD, PhD; on behalf of the Italian BMT-MS Study Group and the Italian MS Register; Capobianco, Marco MD; Zimatore, Giovanni Bosco MD; Frau, Jessica MD; Scarpini, Elio MD; Meucci, Giuseppe MD; Guidetti, Donata MD; Gualandi, Francesca MD; Varaldo, Riccardo MD; Raiola, Anna Maria MD; Innocenti, Chiara MD; Zoli, Valerio MD; Ciceri, Fabio MD; Greco, Raffaella MD; Scim`e, Rosanna MD; De Gobbi, Marco MD; Barilaro, Alessandro MD, PhD
doi : 10.1212/WNL.0000000000206750
Uncontrolled evidence suggests that autologous hematopoietic stem cell transplantation (AHSCT) can be effective in people with active secondary progressive multiple sclerosis (SPMS).
Mood and Anxiety Disorders and Suicidality in Patients With Newly Diagnosed Focal Epilepsy: An Analysis of a Complex Comorbidity.
Kanner, Andres M. MD; Saporta, Anita S. MD; Kim, Dong H. MD; Barry, John J. MD; Altalib, Hamada MD; Omotola, Hope MD; Jette, Nathalie MD; O'Brien, Terence J. MD; Nadkarni, Siddhartha MD; Winawer, Melodie R. MD, MS; Sperling, Michael MD; French, Jacqueline A. MD; Abou-Khalil, Bassel MD; Alldredge, Brian PharmD; Bebin, Martina MD; Cascino, Gregory D. MD; Cole, Andrew J. MD; Cook, Mark J. MD; Detyniecki, Kamil MD; Devinsky, Orrin MD; Dlugos, Dennis MD; Faught, Edward MD; Ficker, David MD; Fields, Madeline MD; Gidal, Barry PharmD; Gelfand, Michael MD; Glynn, Simon MD; Halford, Jonathan J. MD; Haut, Sheryl MD; Hegde, Manu MD; Holmes, Manisha G. MD; Kalviainen, Reetta MD; Kang, Joon MD; Klein, Pavel MD; Knowlton, Robert C. MD; Krishnamurthy, Kaarkuzhali MD; Kuzniecky, Ruben MD; Kwan, Patrick MD, PhD; Lowenstein, Daniel H. MD; Marcuse, Lara MD; Meador, Kimford J. MD; Mintzer, Scott MD; Pardoe, Heath R. PhD; Park, Kristen MD; Penovich, Patricia MD; Singh, Rani K. MD; Somerville, Ernest MD; Szabo, Charles A. MD; Szaflarski, Jerzy P. MD, PhD; Lin Thio, K. Liu MD, PhD; Trinka, Eugen MD, MSc, FRCP; Burneo, Jorge G. MD, MSPH; and the Human Epilepsy Project
doi : 10.1212/WNL.0000000000201671
Mood, anxiety disorders, and suicidality are more frequent in people with epilepsy than in the general population. Yet, their prevalence and the types of mood and anxiety disorders associated with suicidality at the time of the epilepsy diagnosis are not established.
Association Between Frailty and Antiseizure Medication Tolerability in Older Adults With Epilepsy.
Vary-O'Neal, Arielle BA, BSc; Miranzadeh, Sareh BSc; Husein, Nafisa MSc; Holroyd-Leduc, Jayna MD, PhD; Sajobi, Tolulope T. PhD; Wiebe, Samuel MD, MSc; Deacon, Charles MD, MSc; Tellez-Zenteno, Jose Francisco MD, MSc; Josephson, Colin Bruce MD, MSc; Keezer, Mark R. MD, PhD
doi : 10.1212/WNL.0000000000201701
Frailty is an important aspect of biological aging, referring to the increased vulnerability of individuals with frailty to physical and psychological stressors. While older adults with epilepsy are an important and distinct clinical group, there are no data on frailty in this population.
Hyperacute Perfusion Imaging Before Pediatric Thrombectomy: Analysis of the Save ChildS Study.
Lee, Sarah MD; Mlynash, Michael MD, BSc; Christensen, Soren PhD; Jiang, Bin MD; Wintermark, Max MD; Strater, Ronald MD; Broocks, Gabriel MD; Grams, Astrid MD, PhD; Nikoubashman, Omid MD; Morotti, Andrea MD; Trenkler, Johannes MD; Mohlenbruch, Markus MD; Fiehler, Jens MD; Wildgruber, Moritz MD, PhD; Kemmling, Andre MD, MHBA; Psychogios, Marios MD; Sporns, Peter B. MD, MHBA
doi : 10.1212/WNL.0000000000201687
Perfusion imaging can identify adult patients with salvageable brain tissue who would benefit from thrombectomy in later time windows. The feasibility of obtaining hyperacute perfusion sequences in pediatric stroke is unknown.
Genetically Predicted Sleep Traits and Functional Outcome After Ischemic Stroke: A Mendelian Randomization Study.
Zhang, Zhizhong PhD; Wang, Mengmeng MD; Gill, Dipender MD, PhD; Zhu, Wusheng PhD; Liu, Xinfeng PhD
doi : 10.1212/WNL.0000000000206745
Sleep traits can have implications for ischemic stroke recovery in observational studies. The purpose of our present study was to explore the relationship between genetically predicted sleep traits and poststroke functional outcomes with Mendelian randomization (MR) method.
Advanced Brain Age and Chronic Poststroke Aphasia Severity.
Busby, Natalie PhD; Wilmskoetter, Janina PhD; Gleichgerrcht, Ezequiel MD, PhD; Rorden, Chris PhD; Roth, Rebecca BA; Newman-Norlund, Roger PhD; Hillis, Argye Elizabeth MD, MA; Keller, Simon S. PhD; de Bezenac, Christophe PhD; Kristinsson, Sigfus PhD; Fridriksson, Julius PhD; Bonilha, Leonardo MD, PhD
doi : 10.1212/WNL.0000000000201693
Chronic poststroke language impairment is typically worse in older individuals or those with large stroke lesions. However, there is unexplained variance that likely depends on intact tissue beyond the lesion.
Interim Safety Profile From the Feasibility Study of the BrainGate Neural Interface System.
Rubin, Daniel B. MD, PhD; Ajiboye, A. Bolu PhD; Barefoot, Laurie APRN; Bowker, Marguerite BSN, RN; Cash, Sydney S. MD, PhD; Chen, David MD; Donoghue, John P. PhD; Eskandar, Emad N. MD; Friehs, Gerhard MD; Grant, Carol BSN, RN, CCRN, CCRP; Henderson, Jaimie M. MD; Kirsch, Robert F. PhD; Marujo, Rose RN; Masood, Maryam MS; Mernoff, Stephen T. MD; Miller, Jonathan P. MD; Mukand, Jon A. MD, PhD; Penn, Richard D. MD; Shefner, Jeremy MD, PhD; Shenoy, Krishna V. PhD; Simeral, John D. PhD; Sweet, Jennifer A. MD; Walter, Benjamin L. MD; Williams, Ziv M. MD; Hochberg, Leigh R. MD, PhD
doi : 10.1212/WNL.0000000000201707
Brain-computer interfaces (BCIs) are being developed to restore mobility, communication, and functional independence to people with paralysis. Though supported by decades of preclinical data, the safety of chronically implanted microelectrode array BCIs in humans is unknown.
Mirogabalin for Central Neuropathic Pain After Spinal Cord Injury: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study in Asia.
Ushida, Takahiro MD, PhD; Katayama, Yoichi MD, PhD; Hiasa, Yoichi MD, PhD; Nishihara, Makoto MD, PhD; Tajima, Fumihiro MD, PhD; Katoh, Shinsuke MD, PhD; Tanaka, Hirotaka MD, PhD; Maeda, Takeshi MD, PhD; Furusawa, Kazunari MD, PhD; Richardson, Mary MSc; Kakehi, Yoshihiro MS; Kikumori, Kunika MS; Kuroha, Masanori DVM, PhD
doi : 10.1212/WNL.0000000000201709
Patients with spinal cord injury (SCI) commonly experience central neuropathic pain (CNeP), which is challenging to treat. Mirogabalin is effective for peripheral neuropathic pain, but evidence for CNeP is lacking. Methods: This randomized, double-blind, placebo-controlled, phase 3 study investigated mirogabalin efficacy and safety for the treatment of CNeP in patients with traumatic SCI.
Prevalence of Spinal Muscular Atrophy in the Era of Disease-Modifying Therapies: An Italian Nationwide Survey.
Coratti, Giorgia PhD; Ricci, Martina MD; Capasso, Anna MD; D'amico, Adele PhD; Sansone, Valeria PhD; Bruno, Claudio PhD; Messina, Sonia PhD; Ricci, Federica PhD; Mongini, Tiziana PhD; Coccia, Michela PhD; Siciliano, Gabriele PhD; Pegoraro, Elena PhD; Turri, Mara MD; Filosto, Massimiliano PhD; Comi, Giacomo MD; Masson, Riccardo MD; Maggi, Lorenzo MD; Bruno, Irene PhD; D'Angelo, Maria Grazia PhD; Trabacca, Antonio MD; Vacchiano, Veria MD; Donati, Maria MD; Simone, Isabella MD; Ruggiero, Lucia PhD; Varone, Antonio MD; Verriello, Lorenzo MD; Berardinelli, Angela MD; Agosto, Caterina MD; Pini, Antonella PhD; Maioli, Maria Antonietta PhD; Passamano, Luigia PhD; Brighina, Filippo MD; Carboni, Nicola MD; Garibaldi, Matteo PhD; Zuccarino, Riccardo MD, PhD; Gagliardi, Delio MD; Siliquini, Sabrina MD; Previtali, Stefano MD, PhD; Taruscio, Domenica MD; Boccia, Stefania PhD; Pera, Maria Carmela PhD; Pane, Marika PhD; Mercuri, Eugenio MD; on behalf of ITASMAC working group
doi : 10.1212/WNL.0000000000201654
Spinal muscular atrophy (SMA) is a neurodegenerative disorder caused by mutations in the SMN1 gene. The aim of this study was to assess the prevalence of SMA and treatment prescription in Italy. Methods: An online survey was distributed to 36 centers identified by the Italian government as referral centers for SMA.
Clinical Reasoning: A 60-Year-Old Man With Asymmetric Weakness and Persistent Fever.
Zheng, Yang MD, PhD; Xiang, Jing-Jing MD; Zhang, Xiao-Fang MD, PhD; Zhang, Shuo MS; Ding, Mei-Ping MD; Huang, Jiao MD
doi : 10.1212/WNL.0000000000201697
AB Peripheral neuropathies, especially those with atypical features, remain a diagnostic challenge. In this case, a 60-year-old patient presented with acute-onset weakness starting in the right hand then sequentially involving the left leg, left hand, and right leg over 5 days.
Right Brain: The Purple Scarf and the Cortical Ribbon.
Fu, Katherine MD; Acosta, Lealani Mae MD, MPH
doi : 10.1212/WNL.0000000000201698
AB A patient with probable Creutzfeldt Jakob disease (CJD) who was previously a high-functioning financial analyst remains fiercely independent despite her family's concerns about her safety.
Teaching Video NeuroImage: Wernekink Commissure Syndrome.
Nakamura, Takashi MD; Ueno, Tatsuya MD; Haga, Rie MD; Arai, Akira MD; Baba, Masayuki MD; Tomiyama, Masahiko MD, PhD
Editors' Note: Association of Amount of Weight Lost After Bariatric Surgery With Intracranial Pressure in Women With Idiopathic Intracranial Hypertension.
Siegler, James E. MD; Galetta, Steven MD
Reader Response: Association of Amount of Weight Lost After Bariatric Surgery With Intracranial Pressure in Women With Idiopathic Intracranial Hypertension.
Ramsamy, Shelby; Singhal, Sumeet; Patel, Rupa; Gruener, Anna M.
Author Response: Association of Amount of Weight Lost After Bariatric Surgery With Intracranial Pressure in Women With Idiopathic Intracranial Hypertension.
Mollan, Susan P.; Sinclair, Alex J.
Reader Response: Association of Amount of Weight Lost After Bariatric Surgery With Intracranial Pressure in Women With Idiopathic Intracranial Hypertension.
Brenner, Steven R.
Author Response: Association of Amount of Weight Lost After Bariatric Surgery With Intracranial Pressure in Women With Idiopathic Intracranial Hypertension.
Mollan, Susan P.; Sinclair, Alex J.
Clinically Relevant Changes for Cognitive Outcomes in Preclinical and Prodromal Cognitive Stages: Implications for Clinical Alzheimer Trials.
Juvenile Myoclonic Epilepsy 25 Years After Seizure Onset: A Population-Based Study.
