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What Should We Expect for Real-World Outcomes of Deep Brain Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy?.
Lundstrom, Brian Nils MD, PhD; Gregg, Nicholas M. MD
doi : 10.1212/WNL.0000000000201455
Volume 100(18) pgs. 845-887,e1852-e1943 May 2, 2023
Bilingualism, Epilepsy, and Connectome Resilience.
Royer, Jessica PsyD; Bernhardt, Boris PhD
Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Drug-Resistant Epilepsy in the MORE Multicenter Patient Registry.
Peltola, Jukka MD, PhD; Colon, Albert J. MD, PhD; Pimentel, Jose MD, PhD; Coenen, Volker A. MD; Gil-Nagel, Antonio MD, PhD; Goncalves Ferreira, Antonio MD, PhD; Lehtimaki, Kai MD, PhD; Ryvlin, Philippe MD, PhD; Taylor, Rod S. MSc, PhD; Ackermans, Linda MD, PhD; Ardesch, Jacqueline MD; Bentes, Carla MD, PhD; Bosak, Magdalena MD; Burneo, Jorge G. MD, MSPH; Chamadoira, Clara MD; Elger, Christian E. MD, PhD, FRCP; Eross, Lorand MD, PhD; Fabo, Daniel MD, PhD; Faulkner, Howard FRCP PhD; Gawlowicz, Jacek MD, PhD; Gharabaghi, Alireza MD; Iacoangeli, Maurizio MD, PhD; Janszky, Jozsef MD, PhD; Jarvenpaa, Soila MD, PhD; Kaufmann, Elisabeth MD; Kho, Kuan H. MD; Kumlien, Eva MD, PhD; Laufs, Helmut MD, PhD; Lettieri, Christian MD; Linhares, Paulo MD; Noachtar, Soheyl MD; Parrent, Andrew MD; Pataraia, Ekaterina MD; Patel, Nikunj K. MD FRCS(SN); Peralta, Ana Rita MD, MSc; Racz, Attila MD, PhD; Campos, Alexandre Rainha MD; Rego, Ricardo MD; Ricciuti, Riccardo A. MD; Rona, Sabine MD, PhD; Rouhl, Rob P.W. MD, PhD; Schulze-Bonhage, Andreas MD, PhD; Schuurman, Rick MD, PhD; Sprengers, Mathieu MD, PhD; Sufianov, Albert MD; Temel, Yasin MD, PhD; Theys, Tom MD, PhD; Van Paesschen, Wim MD, PhD; Van Roost, Dirk MD, PhD; Vaz, Rui MD, PhD; Vonck, Kristl MD, PhD; Wagner, Louis MD; Zwemmer, Jack MD, PhD; Abouihia, Abdallah MStat; Brionne, Thomas C. PhD; Gielen, Frans PhD; Boon, Paul A.J.M. MD, PhD; for The MORE Study Group; for The MORE Study Group; Amorim, Isabel MD; Aull-Watschinger, Susanne; BALAS, Istvan MD, PhD; BONE, Beata M.D., PhD; Brown, Suzan; Cesaroni, Elisabetta MD; Cleeren, Evy PhD; Dec-Cwiek, Malgorzata MD, PhD; Eleopra, Dr. Roberto; Falk, Daniela MD; Franco, Ana MD; Hackelberg, Birte; Hampel, Kevin MD; Hirsch, Dr. Martin; Meyne, Johannes Konrad; KOVACS, Norbert M.D., PhD; Lang, Nicolas; Moddel, Gabriel MD; Moeller, Bettina; Mondani, Dr. Massimo; Nass, Robert D MD; Novak, Klaus MD; Obszanska, Dr. Katarzyna; Orlov, Alexander MD; Pietraszko, Wojciech MD; Scerrati, Massimo MD, PhD; Shapkin, Andrey MD; Skripnikov, Alexander MD; Van Hoylandt, Anais; Viebahn, Bettina MD; Wieszmuellner, Sonja; Zamponi, Nelia MD
doi : 10.1212/WNL.0000000000206887
The efficacy of deep brain stimulation of the anterior nucleus of the thalamus (ANT DBS) in patients with drug-resistant epilepsy (DRE) was demonstrated in the double-blind Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy randomized controlled trial.
Systematic Review of Cost-Effectiveness Analysis for Surgical and Neurostimulation Treatments for Drug-Resistant Epilepsy in Adults.
Ngan Kee, Nicholas BSc, MD *; Foster, Emma MBBS, PhD, FRACP *; Marquina, Clara MSc, PhD; Tan, Andy; Pang, Samantha S.T.; O'Brien, Terence J. MBBS, MD, FRACP; Kwan, Patrick MBBChir, PhD, FRACP; Jackson, Graeme D. MBBS, FRACP, PhD; Chen, Zhibin PhD, CStat +; Ademi, Zanfina MPharm, MPH, PhD +
doi : 10.1212/WNL.0000000000207137
Surgical and neurostimulator treatments are effective for reducing seizure burden in selected individuals living with drug-resistant epilepsy (DRE).
Characterization and Prediction of Short-term Outcomes in Memory After Temporal Lobe Resection in Children With Epilepsy.
Kaur, Navkiranjot MD, MS; Nowacki, Amy S. PhD; Lachhwani, Deepak K. MD; Berl, Madison M. PhD; Hamberger, Marla J. PhD; Klaas, Patricia PhD; Bingaman, William MD; Busch, Robyn M. PhD
doi : 10.1212/WNL.0000000000207143
The aim of this study was to characterize short-term outcomes in episodic memory, as assessed by the Children's Memory Scale (CMS), after temporal lobe resection in children with epilepsy using empirical methods for assessing cognitive change (i.e., reliable change indices [RCI] and standardized regression-based change scores [SRB]) and develop and internally validate clinically applicable models to predict postoperative memory decline.
Bilingualism and Structural Network Organization in Temporal Lobe Epilepsy: Resilience in Neurologic Disease.
Stasenko, Alena PhD *; Kaestner, Erik PhD *; Arienzo, Donatello PhD; Schadler, Adam MA; Reyes, Anny MS; Shih, Jerry J. MD; Helm, Jonathan L. PhD; Polczynska, Monika PhD, DLitt; McDonald, Carrie R. PhD
doi : 10.1212/WNL.0000000000207087
There is growing evidence that bilingualism can induce neuroplasticity and modulate neural efficiency, resulting in greater resistance to neurologic disease.
Safety and Efficacy of Tenecteplase and Alteplase in Patients With Tandem Lesion Stroke: A Post Hoc Analysis of the EXTEND-IA TNK Trials.
Yogendrakumar, Vignan MD, MSc; Churilov, Leonid PhD; Mitchell, Peter J. MMed; Kleinig, Timothy J. PhD; Yassi, Nawaf MD, PhD; Thijs, Vincent PhD; Wu, Teddy MD, PhD; Shah, Darshan MBBS; Bailey, Peter MD; Dewey, Helen M. PhD; Choi, Philip M.C. MBChB; Ma, Alice MBBS; Wijeratne, Tissa MD; Garcia-Esperon, Carlos PhD; Cloud, Geoffrey MBBS; Chandra, Ronil V. MD; Cordato, Dennis J. PhD; Yan, Bernard DMedSc; Sharma, Gagan MCA; Desmond, Patricia M. MD, PhD; Parsons, Mark W. PhD; Donnan, Geoffrey A. MD; Davis, Stephen M. MD; Campbell, Bruce C.V. MBBS, PhD; for the EXTEND-IA TNK Investigators; for the EXTEND-IA TNK Investigators; Dowling, Richard MBBS; Bush, Steven MBBS; Scroop, Rebecca MBBS; Simpson, Marion MBBS; Brooks, Mark MBBS; Asadi, Hamed MBBS; Ang, Timothy MBBS; Miteff, Ferdinand MBBS; Levi, Christopher MBBS; Rodrigues, Edrich MBBS; Zhao, Henry PhD; Ng, Felix PhD; Alemseged, Fana PhD; Salvaris, Patrick MBBS; Rice, Henry MBBS; de Villiers, Laetitia MBBS; Brown, Helen MBBS; Redmond, Kendal MBBS; Leggett, David MBBS; Fink, John MD; Collecutt, Wayne MBBS; Kraemer, Thomas MD; Muller, Claire MBBS; Coulthard, Alan MBBS; Mitchell, Ken MBBS; Clouston, John MBBS; Mahady, Kate MBBS; Field, Deborah MBBS; O'Brien, Bill MBBS; Clissold, Benjamin MBBS; Clissold, Anna MBBS; Bolitho, Leslie MBBS; Bonavia, Luke MBBS; Bhattacharya, Arup MBBS; Wright, Alistair MBBS; Mamun, Abul MBBS; O'Rourke, Fintan MBBS; Worthington, John MBBS; Wong, Andrew PhD; Ma, Henry PhD; Phan, Thanh PhD; Chong, Winston MBBS; Slater, Lee-Anne MBBS; Krause, Martin MD; Harrington, Timothy MBBS; Faulder, Kenneth MBBS; Steinfort, Brendan MBBS; Bladin, Christopher PhD
doi : 10.1212/WNL.0000000000207138
The safety and efficacy of tenecteplase (TNK) in patients with tandem lesion (TL) stroke is unknown. We performed a comparative analysis of TNK and alteplase in patients with TLs.
Characteristics and Clinical Implication of White Matter Lesions in Patients With Adult Moyamoya Disease.
Yang, Wookjin MD; Jung, Keun-Hwa MD, PhD; Kang, Dong-Wan MD; Lee, Eung-Joon MD; Jeong, Han-Yeong MD; Chung, Matthew MD; Kim, Youngjoon MD; Ha, Jiyeon MD; Kim, Jeong-Min MD, PhD; Lee, Seung-Hoon MD, PhD
doi : 10.1212/WNL.0000000000207130
White matter hyperintensities (WMHs) are reportedly increased in moyamoya disease (MMD); however, their clinical importance is not well-established owing to their pathophysiologic heterogeneity by distribution.
Misfolded [alpha]-Synuclein Assessment in the Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorder.
Iranzo, Alex MD, PhD *; Mammana, Angela PhD; Munoz-Lopetegi, Amaia MD; Dellavalle, Sofia MSc; Maya, Gerard MD, PhD; Rossi, Marcello PhD; Serradell, Monica BSc; Baiardi, Simone MD, PhD; Arqueros, Aurora MSc; Quadalti, Corinne PhD; Perissinotti, Andres MD, PhD; Ruggeri, Edoardo MSc; Cano, Joan Santamaria MD PhD; Gaig, Carles MD, PhD; Parchi, Piero MD, PhD *
doi : 10.1212/WNL.0000000000207147
Real-time quaking-induced conversion (RT-QuIC) assay detects misfolded [alpha]-synuclein (AS) in the skin and CSF of patients with the synucleinopathies Parkinson disease and dementia with Lewy bodies.
NIH Music-Based Intervention Toolkit: Music-Based Interventions for Brain Disorders of Aging.
Edwards, Emmeline PhD *; St Hillaire-Clarke, Coryse PhD *; Frankowski, David W. PhD; Finkelstein, Robert PhD; Cheever, Thomas PhD; Chen, Wen G. PhD; Onken, Lisa PhD; Poremba, Amy PhD; Riddle, Robert PhD; Schloesser, Dana PhD; Burgdorf, Caitlin E. PhD; Wells, Nena; Fleming, Renee; Collins, Francis S. MD, PhD
doi : 10.1212/WNL.0000000000206797
AB Music-based interventions (MBIs) show promise for managing symptoms of various brain disorders. To fully realize the potential of MBIs and dispel the outdated misconception that MBIs are rooted in soft science, the NIH is promoting rigorously designed, well-powered MBI clinical trials.
Clinical Reasoning: A 25-Year-Old Woman With Eye Swelling and Headache.
Hehir, Aoife MB, BCh, BAO; Gilmore, Ruth MB, BCh, BAO; Power, Sarah MB, BCh, BAO; Monaghan, Thomas MB, BCh, BAO *; McGrath, Emer R. MB, PhD *
doi : 10.1212/WNL.0000000000206836
AB Cerebral venous sinus thrombosis (CVST) is uncommon. Risk factors include inherited and acquired factors. Rapid diagnosis and treatment is essential and can help prevent complications, which can include seizures and visual disturbance.
Teaching NeuroImage: Intracranial Solitary Fibrous Tumor With Liver Metastasis.
Webb, Mason James MD, PhD; Campian, Jian L. MD, PhD; Sener, Ugur MD
Editors' Note: Teaching NeuroImage: Atypical Unilateral Cortical Ribboning in Anti-NMDA Receptor Encephalitis.
Ganesh, Aravind MD, DPhil, FRCPC; Galetta, Steven MD
Reader Response: Teaching NeuroImage: Atypical Unilateral Cortical Ribboning in Anti-NMDA Receptor Encephalitis.
Budhram, Adrian; Mirian, Ario; Sharma, Manas
Reader Response: Teaching NeuroImage: Atypical Unilateral Cortical Ribboning in Anti-NMDA Receptor Encephalitis.
Scheel, Michael; Pruss, Harald; Finke, Carsten
Evaluating the Association Between Genetically Proxied Neurodevelopmental Language Phenotypes and the Risk of Primary Progressive Aphasia.
Nassan, Malik MD; Piras, Ignazio S. PhD; Rogalski, Emily PhD; Geula, Changiz PhD; Mesulam, M. Marsel MD; Huentelman, Matt PhD
doi : 10.1212/WNL.0000000000207136
Primary progressive aphasia (PPA) is a neurodegenerative syndrome of progressive language decline. PPA has 3 main subtypes: logopenic, semantic, and agrammatic.
Association of Mitochondrial DNA Copy Number With Brain MRI Markers and Cognitive Function: A Meta-analysis of Community-Based Cohorts.
Zhang, Yuankai MA; Liu, Xue MPH; Wiggins, Kerri L. MS; Kurniansyah, Nuzulul MS; Guo, Xiuqing PhD; Rodrigue, Amanda L. PhD; Zhao, Wei PhD; Yanek, Lisa R. MPH; Ratliff, Scott M. MS; Pitsillides, Achilleas PhD; Aguirre Patino, Juan Sebastian BS; Sofer, Tamar PhD; Arking, Dan E. PhD; Austin, Thomas R. PhD; Beiser, Alexa S. PhD; Blangero, John PhD; Boerwinkle, Eric PhD; Bressler, Jan PhD; Curran, Joanne E. PhD; Hou, Lifang MD, PhD; Hughes, Timothy M. PhD; Kardia, Sharon L.R. PhD; Launer, Lenore J. PhD; Levy,
doi : 10.1212/WNL.0000000000207157
Previous studies suggest that lower mitochondrial DNA (mtDNA) copy number (CN) is associated with neurodegenerative diseases.
