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Associate Editorial Board
doi : 10.1016/S0007-0912(23)00149-6
Volume 130, Issue 5, May 2023, Page ii
Erector spinae plane block: the ultimate ‘plan A’ block?
Amit Pawa 1,2 , Christopher King 1 , Christopher Thang 3,4,5 and Leigh White
doi : 10.1016/j.bja.2023.01.012
Volume 130, Issue 5, May 2023, Pages 497-502
Ethical considerations for theatre teams in organ donation after circulatory determination of death
Christine Lennon 1 , Dan Harvey 2,3 and Peter A. Goldstein
doi : 10.1016/j.bja.2023.01.018
Volume 130, Issue 5, May 2023, Pages 502-507
Spin and fragility in anaesthesia studies: when sirens sing into anaesthetists' ears
Marcelo Gama de Abreu 1,2,3,4,* , Marcus J. Schultz 5,6,7 and Ary Serpa Neto
doi : 10.1016/j.bja.2023.02.021
Volume 130, Issue 5, May 2023, Pages 507-510
Ephedrine to treat intraoperative hypotension in infants: what is the target?
Jurgen C. de Graaff 1,* and Peter Frykholm
doi : 10.1016/j.bja.2023.02.007
Volume 130, Issue 5, May 2023, Pages 510-515
Diagnosing nociplastic pain in cancer survivors: a major step forward
Emmanuel Verspyck 1 and Nadine Attal
doi : 10.1016/j.bja.2023.02.006
Volume 130, Issue 5, May 2023, Pages 515-518
Norepinephrine versus phenylephrine for treating hypotension during general anaesthesia in adult patients undergoing major noncardiac surgery: a multicentre, open-label, cluster-randomised, crossover, feasibility, and pilot trial
Matthieu Legrand 1,2, * , Rishi Kothari 1,3 , Nicholas Fong 1,4 , Nandini Palaniappa 1 , David Boldt 5 , Lee-Lynn Chen 1 , Philip Kurien 1 , Eilon Gabel 5 , Jillene Sturgess-DaPrato 1 , Michael O. Harhay 6 , Romain Pirracchio 1 , Michael P. Bokoch1 , and for the VEGA-1 trial investigators
doi : 10.1016/j.bja.2023.02.004
Volume 130, Issue 5, May 2023, Pages 519-527
Intraoperative hypotension is associated with postoperative complications. The use of vasopressors is often required to correct hypotension but the best vasopressor is unknown.
Spin and fragility in randomised controlled trials in the anaesthesia literature: a systematic review
Achille Demarquette 1, * , Tristan Perrault 1 , Thomas Alapetite 1 , Madjid Bouizegarene 1 , Romain Bronnert 1 , Ga€el Foure 1 , Charline Masson 1 , Vivian Nicolas 1 , Sigismond Lasocki 1 and Maxime Leger
doi : 10.1016/j.bja.2023.01.001
Volume 130, Issue 5, May 2023, Pages 528-535
Given variable frequency of misleading reports and the potential for spin (a way of describing results that can mislead readers) to influence interpretation of randomised controlled trials (RCTs), we have undertaken a spin reassessment. We evaluated the quality of recent literature in anaesthesia journals by assessing the presence of spin and calculating the fragility index.
Five commercial ‘depth of anaesthesia’ monitors provide discordant clinical recommendations in response to identical emergence-like EEG signals
Darren Hight 1, *, Matthias Kreuzer 2 , Gesar Ugen 1 , Peter Schuller 3 , Frank Stu ̈ ber 1 , Jamie Sleigh 4 and Heiko A. Kaiser
doi : 10.1016/j.bja.2022.12.026
Volume 130, Issue 5, May 2023, Pages 536-545
‘Depth of anaesthesia’ monitors claim to measure hypnotic depth during general anaesthesia from the EEG, and clinicians could reasonably expect agreement between monitors if presented with the same EEG signal. We took 52 EEG signals showing intraoperative patterns of diminished anaesthesia, similar to those that occur during emergence (after surgery) and subjected them to analysis by five commercially available monitors.
Prospective analysis of plasma amyloid beta and postoperative delirium in the Interventions for Postoperative Delirium: Biomarker-3 study
Thomas Payne 1,2 , Jennifer Taylor 1,2 , Cameron Casey 3 , David Kunkel 3 , Maggie Parker 3 , Kaj Blennow4,5 , Henrik Zetterberg 4,5,6,7,8 , Robert A. Pearce 3 , Richard C. Lennertz 3 and Robert D. Sanders
doi : 10.1016/j.bja.2023.01.020
Volume 130, Issue 5, May 2023, Pages 546-556
The effect of postoperative delirium on the amyloid cascade of Alzheimer's dementia is poorly understood. Using early postoperative plasma biomarkers, we explored whether surgery and delirium are associated with changes in amyloid pathways.
Breathe–squeeze: pharmacodynamics of a stimulus-free behavioural paradigm to track conscious states during sedation☆☆
Christian S. Guay 1,2, *, Darren Hight 3 , Gaurang Gupta 4 , MohammadMehdi Kafashan 4 , Anhthi H. Luong 5 , Michael S. Avidan 4,6 , Emery N. Brown 1,2 and Ben Julian A. Palanca
doi : 10.1016/j.bja.2023.01.021
Volume 130, Issue 5, May 2023, Pages 557-566
Conscious states are typically inferred through responses to auditory tasks and noxious stimulation. We report the use of a stimulus-free behavioural paradigm to track state transitions in responsiveness during dexmedetomidine sedation.
‘It was a great brain, and I miss it’: lay perspectives on postoperative cognitive dysfunction
Laura Li 1 , Daniel Dohan 2 , Alexander K. Smith 3 and Elizabeth L. Whitlock
doi : 10.1016/j.bja.2023.02.003
Volume 130, Issue 5, May 2023, Pages 567-572
Postoperative cognitive dysfunction (POCD) is a concern after anaesthesia and surgery, but preoperative discussion of neurocognitive risks with older patients rarely occurs.
Selective activation of cholinergic neurotransmission from the medial septal nucleus to hippocampal pyramidal neurones improves sepsis-induced cognitive deficits in mice
Lu Yin 1,y, Jinming Zhang 2,y , Hongwei Ma 1,y, Xinxin Zhang 1 , Zhongmin Fan1 , Yongheng Yang 1 , Mengyun Li 1 , Jing Han 2, * and Xijing Zhang
doi : 10.1016/j.bja.2023.01.019
Volume 130, Issue 5, May 2023, Pages 573-584
Sepsis-associated encephalopathy is characterised by cognitive dysfunction, and might be mediated by deficits in neurotransmission. Reduced cholinergic neurotransmission in the hippocampus impairs memory function.
Age-dependent changes in arterial blood pressure in neonates during the first week of life: reference values and development of a model
Arjan C. van Zadelhoff1,2 , Jarinda A. Poppe 2 , Sten Willemsen 3,4 , Katya Mauff 3 , Willem van Weteringen 5 , Tom G. Goos 2,6 , Irwin K. M. Reiss 2 , Marijn J. Vermeulen 2 and Jurgen C. de Graaff
doi : 10.1016/j.bja.2023.01.024
Volume 130, Issue 5, May 2023, Pages 585-594
Electroencephalographic delta and alpha oscillations reveal phase-amplitude coupling in paediatric patients undergoing sevoflurane-based general anaesthesia
Luai Zakaria 1,2,3,4 , Adela Desowska 2,3 , Charles B. Berde 2,3,y and Laura Cornelissen
doi : 10.1016/j.bja.2023.01.025
Volume 130, Issue 5, May 2023, Pages 595-602
Sevoflurane-induced anaesthesia generates frontal alpha oscillations as early as 6 months of age, whereas strong delta oscillations are present at birth. In adults, delta oscillations and alpha oscillations are coupled: the phase of delta waves modulates the amplitude of alpha oscillations in a phenomenon known as phase-amplitude coupling.
Effective dose of ephedrine for treatment of hypotension after induction of general anaesthesia in neonates and infants less than 6 months of age: a multicentre randomised, controlled, open label, dose escalation trial
Anne-Sara Szostek1 , Clarisse Saunier 2 , Mad-Helenie Elsensohn 3 , Pierre Boucher 1 , Fanette Merquiol4 , Adeline Gerst 5 , Aurelie Portefaix 2,3 , Dominique Chassard 6, * and Mathilde De Queiroz Siqueira
doi : 10.1016/j.bja.2022.12.006
Volume 130, Issue 5, May 2023, Pages 603-610
The recommended dose of ephedrine in adults (0.1 mg kg−1) frequently fails to treat hypotension after induction of general anaesthesia in neonates and infants less than 6 months of age. The aim of this study was to determine the optimal dose of ephedrine in this population for the treatment of hypotension after induction of general anaesthesia with sevoflurane.
Towards precision pain medicine for pain after cancer: the Cancer Pain Phenotyping Network multidisciplinary international guidelines for pain phenotyping using nociplastic pain criteria
Jo Nijs 1,2,4, *, Astrid Lahousse 1,2,3,14 , Cesar Fernandez-de-las-Pe~nas 12 , Pascal Madeleine 17 , Christel Fontaine 5 , Tomohiko Nishigami 19 , Christine Desmedt9 , Marian Vanhoeij 7,8 , Kenza Mostaqim 1 , Antonio I. Cuesta-Vargas 11 , Eleni Kapreli 16 , Paraskevi Bilika 16 , Andrea Polli 1,3,10 , Laurence Leysen1 , €Omer Elma 1 , Eva Roose 1,14,15 , Emma Rheel 1,13 , Sevilay Tu ̈ mkaya Yılmaz 1 , Liesbet De Baets1 , Eva Huysmans 1,2,3 , Ali Turk18 and _Ismail Sarac ̧ oglu
doi : 10.1016/j.bja.2022.12.013
Volume 130, Issue 5, May 2023, Pages 611-621
Impact of fatigue on anaesthesia providers: a scoping review
Annelies Scholliers 1, * ,y, Stef Cornelis1,y, Maurizio Tosi 1 , Tine Opsomer 1 , David Shaproski 1 , Caroline Vanlersberghe1 , Domien Vanhonacker 1 , Jan Poelaert 1 , Lisa Goudman 2,3,4,5,6 and Maarten Moens
doi : 10.1016/j.bja.2022.12.011
Volume 130, Issue 5, May 2023, Pages 622-635
Recently, fatigue has received more attention as a workplace hazard. This scoping review focuses on fatigue in anaesthesia providers. We explore the prevalence of fatigue in anaesthesia providers, and we examine how fatigue impacts their performance.
Success rate of prehospital emergency front-of-neck access (FONA): a systematic review and meta-analysis
Sarah Morton 1,2, * , Pascale Avery 3 , Justin Kua 4 and Matt O’Meara
doi : 10.1016/j.bja.2023.01.022
Volume 130, Issue 5, May 2023, Pages 636-644
Front-of-neck access (FONA) is an emergency procedure used as a last resort to achieve a patent airway in the prehospital environment. In this systematic review with meta-analysis, we aimed to evaluate the number and success rate of FONA procedures in the prehospital setting, including changes since 2017, when a surgical technique was outlined as the first-line prehospital method.
Plasma HMGB1 levels in postoperative delirium
David Kunkel 1 , Margaret Parker 1 , Robert A. Pearce1 , Robert D. Sanders2,3 and Richard C. Lennertz
doi : 10.1016/j.bja.2023.02.002
Volume 130, Issue 5, May 2023, Pages e449-e451
William Brooke O’Shaughnessy, an Irishman who introduced anaesthesia to India and brought eastern medicine to Britain
Natalie R. Lenggenhager-Krakoski 1,* , Pradipta Bhakta2 , Mohanchandra Mandal3 , Dominic Harmon4 and Brian O’Brien
doi : 10.1016/j.bja.2023.02.008
Volume 130, Issue 5, May 2023, Pages e451-e453
Corrigendum to “Use of transversus abdominus block for alveolar bone graft analgesia in children� (Br J Anaesth 2021; 127: e123–e125)
Richard J. Berwick 1,2,3, *, Charlotte Berwick 1 , Joanne Haidon 1 and Jennie Craske
doi : 10.1016/j.bja.2023.02.005
Volume 130, Issue 5, May 2023, Page 645
Corrigendum to ‘Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study’ (Br J Anaesth 2021; 127: 917-928)
Jeffrey N. Browndyke 1,2,3,4, *, Mary C. Wright 5 , Rosa Yang 6 , Ayesha Syed5,7 , John Park 5,6 , Ashley Hall 5 , Katherine Martucci 4,5 , Michael J. Devinney 5 , Leslie Shaw 8 , Teresa Waligorska 8 , Eugene W. Moretti 5 , Heather E. Whitson 9,10 , Harvey J. Cohen 9,10 , Joseph P. Mathew 5 , Miles Berger 2,4,5,6,9, *, and The MADCO-PC Investigators
doi : 10.1016/j.bja.2023.02.009
Volume 130, Issue 5, May 2023, Page 646
