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June 2023 Stroke Highlights.
Sur, Nicole B. MD
doi : 10.1161/STROKEAHA.123.043538
Volume 54(6) pgs. 1463-1705,e231-e293 June 2023
Exoskeleton-Assisted Anthropomorphic Movement Training for the Upper Limb After Stroke: The EAMT Randomized Trial.
Chen, Ze-Jian MD ,,*; He, Chang PhD ,,*; Xu, Jiang MD; Zheng, Chan-Juan MD; Wu, Jing MD; Xia, Nan MD; Hua, Qiang MD; Xia, Wen-Guang MD; Xiong, Cai-Hua PhD; Huang, Xiao-Lin MD, PhD
doi : 10.1161/STROKEAHA.122.041480
Robot-assisted arm training is generally delivered in the robot-like manner of planar or mechanical 3-dimensional movements. It remains unclear whether integrating upper extremity (UE) natural coordinated patterns into a robotic exoskeleton can improve outcomes.
Upper Extremity Robotic-Assisted Rehabilitation: Results Not Yet Robust.
Dobkin, Bruce H. MD; Busza, Ania MD, PhD
Infarcts in a New Territory: Insights From the ESCAPE-NA1 Trial.
Singh, Nishita MD; Cimflova, Petra MD; Ospel, Johanna Maria MD; Kashani, Nima MD; Marko, Martha MD; Mayank, Arnuv BSc; Nogueira, Raul G. MD; McTaggart, Ryan A. MD; Demchuk, Andrew M. MD; Poppe, Alexandre Y. MD; Rempel, Jeremy L. MD; Field, Thalia S. MD; Dowlatshahi, Dar MD; van Adel, Brian MD; Swartz, Richard H. MD; Shah, Ruchir MD; Sauvageau, Eric MD; Puetz, Volker MD; Silver, Frank L. MD; Campbell, Bruce MD; Chapot, Rene MD; Tymianski, Michael MD; Goyal, Mayank MD; Almekhlafi, Mohammed A. MD; Hill, Michael D. MD; on behalf of the ESCAPE-NA1 Trial Investigators
doi : 10.1161/STROKEAHA.122.042200
Infarct in a new territory (INT) is a known complication of endovascular stroke therapy. We assessed the incidence of INT, outcomes after INT, and the impact of concurrent treatments with intravenous thrombolysis and nerinetide.
Prevalence and Procedural Risk of Intracranial Atherosclerotic Stenosis Coexisting With Unruptured Intracranial Aneurysm.
Coexistence of intracranial atherosclerotic stenosis (ICAS) and unruptured intracranial aneurysms (UIAs) is increasingly encountered in clinical practice.
doi : 10.1161/STROKEAHA.122.041553
Coexistence of intracranial atherosclerotic stenosis (ICAS) and unruptured intracranial aneurysms (UIAs) is increasingly encountered in clinical practice.
Five-Year Stroke Risk and Its Predictors in Asymptomatic Moyamoya Disease: Asymptomatic Moyamoya Registry (AMORE).
Kuroda, Satoshi MD; Yamamoto, Shusuke MD; Funaki, Takeshi MD; Fujimura, Miki MD; Kataoka, Hiroharu MD; Hishikawa, Tomohito MD; Takahashi, Jun MD; Endo, Hidenori MD; Nariai, Tadashi MD; Osato, Toshiaki MD; Saito, Nobuhito MD; Sato, Norihiro MD; Hori, Emiko MD; Ito, Yoichi M. PhD; Miyamoto, Susumu MD; the AMORE Study Group; Inaji, Motoki; Morita, Kenichi; Maruyama, Daisuke; Nakagawara, Jyoji; Hashimura, Naoki; Hamano, Eika; Iihara, Koji; Hashimoto, Nobuo; Honjo, Kaori; Nakamura, Hirohiko; Kashiwazaki, Daina; Imai, Hideaki; Miyawaki, Satoru; Hongo, Hiroki; Yoshida, Kazumichi; Kikuchi, Takayuki; Mineharu, Yohei; Isozaki, Makoto; Kikuta, Kenichiro; Araki, Yoshio; Kanamori, Fumiaki; Date, Isao; Ono, Junichi; Machida, Toshio; Mase, Mitsuhito; Katano, Hiroyuki; Yamaguchi, Koji; Kawamata, Takakazu; Tominaga, Teiji; Uchino, Haruto; Tokairin, Kikutaro; Ito, Masaki; Houkin, Kiyohiro; Chida, Kohei; Ogasawara, Kuniaki; Nagata, Izumi; Horie, Nobutaka; Oka, Hidehiro; Kumabe, Toshihiro; Itoh, Yoshiaki; Abe, Takato; Oki, Koichi; Takahashi, Shinichi; Suzuki, Norihiro
doi : 10.1161/STROKEAHA.122.041932
Long-term outcomes are unknown in patients with asymptomatic moyamoya disease. In this report, we aimed to clarify their 5-year risk of stroke and its predictors.
Artificial Intelligence for Clinical Decision Support in Acute Ischemic Stroke: A Systematic Review.
Akay, Ela Marie Z. ,*; Hilbert, Adam MSc ,*; Carlisle, Benjamin G. PhD; Madai, Vince I. MD, PhD; Mutke, Matthias A. MD; Frey, Dietmar MD, JD
doi : 10.1161/STROKEAHA.122.041442
Established randomized trial-based parameters for acute ischemic stroke group patients into generic treatment groups, leading to attempts using various artificial intelligence (AI) methods to directly correlate patient characteristics to outcomes and thereby provide decision support to stroke clinicians.
Artificial Intelligence in Clinical Decisions Support for Stroke: Balancing Opportunity With Caution.
Bravata, Dawn M. MD; Ranta, Anna MD, PhD
Receipt of Mental Health Treatment in People Living With Stroke: Associated Factors and Long-Term Outcomes.
Tjokrowijoto, Priscilla BA; Stolwyk, Renerus J. PhD; Ung, David PhD; Kneebone, Ian PsychD; Kilkenny, Monique F. PhD; Kim, Joosup PhD; Olaiya, Muideen T. PhD; Dalli, Lachlan L. PhD; Cadilhac, Dominique A. PhD; Nelson, Mark R. PhD; Lannin, Natasha A. PhD; Andrew, Nadine E. PhD; on behalf of the PRECISE Investigators
doi : 10.1161/STROKEAHA.122.041355
Untreated poststroke mood problems may influence long-term outcomes. We aimed to investigate factors associated with receiving mental health treatment following stroke and impacts on long-term outcomes.
Mental Health Issues Poststroke: Underrecognized and Undertreated.
Terrill, Alexandra L. PhD
Adolescent Hypertension Is Associated With Stroke in Young Adulthood: A Nationwide Cohort of 1.9 Million Adolescents.
Fishman, Boris MD, MPH; Bardugo, Aya MD, MSc; Zloof, Yair MD; Bendor, Cole D. MD; Libruder, Carmit MSc; Zucker, Inbar MD, MPH, MBA; Lutski, Miri PhD; Ram, Amit RN, MPH; Hershkovitz, Yael MSc; Orr, Omri MD, MPH; Omer, Ma'ayan MD; Furer, Ariel MD, MBA; Goldman, Adam MD, MPH; Yaniv, Gal MD, PhD; Tanne, David MD; Derazne, Estela MSc; Tzur, Dorit MBA; Afek, Arnon MD, MHA; Grossman, Ehud MD; Twig, Gilad MD, MPH, PhD
doi : 10.1161/STROKEAHA.122.042100
Adult hypertension is a well-established risk factor for stroke in young adults (aged <55 years), and the effects are even more deleterious than at an older age.
Higher Hospital Frailty Risk Score Is Associated With Increased Risk of Stroke: Observational and Genetic Analyses.
Renedo, Daniela MD ,,*; Acosta, Julian N. MD ,*; Koo, Andrew B. MD; Rivier, Cyprien MD, MS; Sujijantarat, Nanthiya MD; de Havenon, Adam MD, MSCI; Sharma, Richa MD, MPH; Gill, Thomas M. MD; Sheth, Kevin N. MD; Falcone, Guido J. MD, ScD, MPH ,+; Matouk, Charles C. MD ,+
doi : 10.1161/STROKEAHA.122.041891
Frailty is a prevalent state associated with several aging-related traits and conditions. The relationship between frailty and stroke remains understudied.
Location-Specific Hematoma Volume Cutoff and Clinical Outcomes in Intracerebral Hemorrhage.
Teo, Kay-Cheong MBBS, FHKAM; Fong, Sze-Man MBBS; Leung, William C.Y. MBBS; Leung, Ian Y.H. MBBS, FHKAM; Wong, Yuen-Kwun PhD; Choi, Olivia M.Y. MPsych; Yam, Ka-Keung MBBS, FHKAM; Lo, Rachel C.N. BSc; Cheung, Raymond T.F. MD, PhD; Ho, Shu-Leong MD; Tsang, Anderson C.O. MS; Leung, Gilberto K.K. MS, PhD; Chan, Koon-Ho MD, PhD ,,,*; Lau, Kui-Kai DPhil ,,,*
doi : 10.1161/STROKEAHA.122.041246
Major intracerebral hemorrhage (ICH) trials have largely been unable to demonstrate therapeutic benefit in improving functional outcomes.
Hematoma Tolerance: Location Matters.
Dowlatshahi, Dar MD, PhD; Jamal, Mobin MD, MSc; Raposo, Nicolas MD, PhD
Reversibility of Diffusion-Weighted Imaging Lesions in Patients With Ischemic Stroke in the WAKE-UP Trial.
Scheldeman, Lauranne MD, PhD; Wouters, Anke MD, PhD; Bertels, Jeroen PhD; Dupont, Patrick PhD; Cheng, Bastian MD; Ebinger, Martin MD; Endres, Matthias MD; Fiebach, Jochen B. MD; Gerloff, Christian MD; Muir, Keith W. MD; Nighoghossian, Norbert MD; Pedraza, Salvador MD, PhD; Simonsen, Claus Z. MD, PhD; Thijs, Vincent MD, PhD; Thomalla, Gotz MD; Lemmens, Robin MD, PhD
doi : 10.1161/STROKEAHA.122.041505
Reversibility of the diffusion-weighted imaging (DWI) lesion means that not all of the DWI lesion represents permanently injured tissue.
Effect of Imaging Selection Paradigms on Endovascular Thrombectomy Outcomes in Patients With Acute Ischemic Stroke.
Miao, Jian MS ,,*; Sang, Hongfei MD ,*; Li, Fengli MD ,*; Saver, Jeffrey L. MD; Lei, Bo MD; Li, Jinglun MD; Nogueira, Raul Gomes MD; Song, Bo MS; Liu, Shudong MS; Nguyen, Thanh N. MD; Jin, Zhenglong MD; Zeng, Hongliang MS; Wen, Changming MS; Yuan, Guangxiong MS; Kong, Weilin MD; Luo, Weidong MS; Liu, Shuai MS; Xie, Dongjing MS; Huang, Jiacheng MD; Liu, Chang MD; Yang, Jie MS; Hu, Jinrong MS; Song, Jiaxing MS; Yue, Chengsong MS; Li, Linyu MS; Tian, Yan MS; Zhang, Xiao MS; Feng, Dan MS; Gao, Yani MS; Fu, Huiying MS; Zi, Wenjie MD; Yang, Qingwu MD; Qiu, Zhongming MD; Wang, Shaojun MD
doi : 10.1161/STROKEAHA.122.042203
The effect of imaging selection paradigms on endovascular thrombectomy outcomes in patients with acute ischemic stroke with large vessel occlusion remains uncertain.
Variation in Carotid Artery Stenosis Measurements Among Facilities Seeking Carotid Stenting Facility Accreditation.
Jareczek, Francis J. MD, PhD; Farrell, Mary Beth EdD; Lehman, Erik B. MS; Sila, Cathy MD; Terry, John B. MD; Sacks, David MD; Kalapos, Paul MD; Simon, Scott D. MD; Cockroft, Kevin M. MD, MSc
doi : 10.1161/STROKEAHA.122.041397
Based on the inclusion criteria of clinical trials, the degree of cervical carotid artery stenosis is often used as an indication for stent placement in the setting of extracranial carotid atherosclerotic disease.
Interobserver Agreement on Intracranial Hemorrhage on Magnetic Resonance Imaging in Patients With Ischemic Stroke.
van der Ende, Nadinda A.M. MD; Luijten, Sven P.R. MD; Kluijtmans, Leo MD; Postma, Alida A. MD, PhD; Cornelissen, Sandra A. MD, PhD; van Hattem, Antonius M.G. MD; Lycklama a Nijeholt, Geert J. MD, PhD; Bokkers, Reinoud P.H. MD, PhD; Thomassen, Lars MD, PhD; Waje-Andreassen, Ulrike MD, PhD; Logallo, Nicola MD, PhD; Bracard, Serge MD, PhD; Gory, Benjamin MD, PhD; Roozenbeek, Bob MD, PhD; Dippel, Diederik W.J. MD, PhD; van der Lugt, Aad MD, PhD
doi : 10.1161/STROKEAHA.122.042145
The Heidelberg Bleeding Classification, developed for computed tomography, is also frequently used to classify intracranial hemorrhage (ICH) on magnetic resonance imaging.
Rbpj Deficiency Disrupts Vascular Remodeling via Abnormal Apelin and Cdc42 (Cell Division Cycle 42) Activity in Brain Arteriovenous Malformation.
Adhicary, Subhodip PhD; Fanelli, Kayleigh MA; Nakisli, Sera BS; Ward, Brittney BS; Pearce, Isaac DO; Nielsen, Corinne M. PhD
doi : 10.1161/STROKEAHA.122.041853
Brain arteriovenous malformations (bAVM) are characterized by enlarged blood vessels, which direct blood through arteriovenous shunts, bypassing the artery-capillary-vein network and disrupting blood flow. Clinically, bAVM treatments are invasive and not routinely applicable.
R-spondin 3/LGR4 (Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 4) Axis Is a Novel Inflammatory and Neurite Outgrowth Signaling System in the Ischemic Brain in Mice.
Shimamura, Munehisa MD, PhD; Hayashi, Hiroki PhD; Ju, Nan MD, PhD; Yoshida, Shota MD, PhD; Baba, Satoshi MD; Sasaki, Tsutomu MD, PhD; Mochizuki, Hideki MD, PhD; Morishita, Ryuichi MD, PhD; Nakagami, Hironori MD, PhD
doi : 10.1161/STROKEAHA.122.041970
Although stimulation of Wnt/[beta]-catenin signaling is an important strategy to treat ischemic stroke, its signaling pathway has not been fully clarified yet
Epidermal Growth Factor Receptor Mediates Neuronal Apoptosis After Subarachnoid Hemorrhage in Mice.
Nakano, Fumi MD, PhD; Kanamaru, Hideki MD, PhD; Kawakita, Fumihiro MD, PhD; Liu, Lei MD, PhD; Nakatsuka, Yoshinari MD, PhD; Nishikawa, Hirofumi MD, PhD; Okada, Takeshi MD, PhD; Suzuki, Hidenori MD, PhD
doi : 10.1161/STROKEAHA.122.041977
Early brain injury including neuronal apoptosis is a main contributor to neurological deterioration after subarachnoid hemorrhage (SAH).
Bioresorbable Poly (L-Lactic Acid) Flow Diverter Versus Cobalt-Chromium Flow Diverter: In Vitro and In Vivo Analysis.
Sasaki, Natsuhi MD; Ishii, Akira MD, PhD; Yagi, Shinichi PhD; Nishi, Hidehisa MD, PhD; Akiyama, Ryo MD; Okawa, Masakazu MD, PhD; Abekura, Yu MD, PhD; Tsuji, Hirofumi MD; Sakurai, Shinichi PhD; Miyamoto, Susumu MD, PhD
doi : 10.1161/STROKEAHA.122.042043
Permanent metallic flow diverter (FD) implantation for treatment of intracranial aneurysms requires antiplatelet therapy for an unclear duration and restricts postprocedural endovascular access
Spatial Proteomics Analysis of Soft and Stiff Regions in Human Acute Arterial Thrombus.
Mai, Hongcheng MD ,,,,*; Zhang, Tianyuan MD ,,*; Zhang, Tao MD, PhD ,*; Lu, Aijun MD; Wu, Zhengdong MD; Yang, Bing MD; He, Niu MSc; Liu, Xiaoyan MD, PhD; Tsang, Chi Kwan PhD; Xu, Anding MD, PhD; Lu, Dan MD, PhD
doi : 10.1161/STROKEAHA.123.042486
The soft regions of a thrombus tend to be more susceptible to r-tPA (recombinant tissue-type plasminogen activator)-mediated thrombolysis and are more easily removed by mechanical thrombectomy than the stiff counterpart.
Sympathetic Nervous Hyperactivity Impairs Microcirculation Leading to Early Brain Injury After Subarachnoid Hemorrhage.
Demura, Munehiro MD; Ishii, Hiroshi MD, PhD; Takarada-Iemata, Mika PhD; Kamide, Tomoya MD, PhD; Yoshikawa, Akifumi MD, PhD; Nakada, Mitsutoshi MD, PhD; Hori, Osamu MD, PhD
doi : 10.1161/STROKEAHA.123.042799
Although early brain injury (EBI) is recognized as a critical step following subarachnoid hemorrhage (SAH), its pathophysiology and underlying mechanisms remain poorly understood.
Clinical Outcomes of Anticoagulated Patients With Atrial Fibrillation After Falls or Head Injury: Insights From RE-LY.
Caldeira, Daniel MD, PhD; Alves da Silva, Pedro MD; Pinto, Fausto J. MD, PhD
doi : 10.1161/STROKEAHA.122.041628
Falls are always a concern regarding the balance of risk/benefit in patients with atrial fibrillation treated with anticoagulants. In this analysis, we aimed to evaluate the outcomes of patients that had a fall/head injury reported in the RE-LY clinical trial (Randomized Evaluation of Long-Term Anticoagulation Therapy) and to explore the safety of dabigatran (a nonvitamin K antagonist oral anticoagulant).
Effect of an Educational Intervention for Primary Stroke Risk Reduction in Ghana and Nigeria: Pilot Randomized Controlled Trial.
Sarfo, Fred Stephen MD, PhD; Akinyemi, Joshua Odunayo PhD; Obiako, Reginald PhD; Nichols, Michelle PhD; Fakunle, Adekunle Gregory PhD; Adusei, Nathaniel BA; Ampofo, Michael BA; Arulogun, Oyedunni PhD; Jenkins, Carolyn PhD; Akpa, Onoja M. PhD; Aribisala, Benjamin PhD; Abdulrasaq, Saheed BSc; Akinyemi, Rufus MD, PhD; Ovbiagele, Bruce MD; Owolabi, Mayowa O. MD, DrM
doi : 10.1161/STROKEAHA.123.042618
Using tailored mobile health interventions to improve global vascular risk awareness and control is yet to be investigated for primary stroke prevention in Africa.
Transuterine Ultrasound-Guided Fetal Embolization of Vein of Galen Malformation, Eliminating Postnatal Pathophysiology.
Orbach, Darren B. MD, PhD; Wilkins-Haug, Louise E. MD, PhD; Benson, Carol B. MD; Tworetzky, Wayne MB, ChB; Rangwala, Shivani D. MD; Guseh, Stephanie H. MD; Gately, Nicole K. RN; Stout, Jeffrey N. PhD; Mizrahi-Arnaud, Arielle MD; See, Alfred P. MD
Prevalence and Predictors of Multivessel Occlusions at Baseline Imaging in ESCAPE-NA1 Trial.
Singh, Nishita MD; Cimflova, Petra MD; Ospel, Johanna Maria MD; Kashani, Nima MD; Marko, Martha MD; Mayank, Arnuv MD; Hill, Michael D. MD; on behalf of the ESCAPE-NA1 Trial Investigators
Carotid Computed Tomography Crescent Sign.
Zedde, Marialuisa MD; Napoli, Manuela MD, PhD; Moratti, Claudio MD; Pascarella, Rosario MD
Ischemic Stroke Secondary to Middle Cerebral Artery Branch Occlusion From a Thrombosed Saccular Aneurysm.
Marzoughi, Sina MD; Hennawy, Mirna MD; Al Hashash, Hessah MD; Zhou, Lily W. MD
Advances in Stroke: Quality Improvement.
Bravata, Dawn M. MD; Purvis, Tara MSci; Ding, Qinglan Pricilla PhD; Waddell, Kimberly J. PhD; Kilkenny, Monique F. PhD
Role of the Meningeal Lymphatics in Stroke.
Perla, Maharajni BSA; Caretti, Viola MD, PhD; Moro, Maria A. PhD; McCullough, Louise D. MD, PhD
Direct Transfer to the Neuroangiography Suite for Patients With Stroke.
Desai, Shashvat M. MD; Psychogios, Marios MD; Khatri, Pooja MD; Jovin, Tudor G. MD; Jadhav, Ashutosh P. MD, PhD
doi : 10.1161/STROKEAHA.122.033447
AB The therapeutic focus in acute ischemic stroke over the last 2.5 decades has been to balance the benefits of rapid reperfusion therapy with the risks of treatment-related complications. Both intravenous thrombolytics and endovascular thrombectomy are proven to substantially improve outcomes in a time-dependent manner.
Composition, Treatment, and Outcomes by Radiologically Defined Thrombus Characteristics in Acute Ischemic Stroke.
Das, Saurav MD; Goldstein, Eric D. MD; de Havenon, Adam MD; Abbasi, Mehdi MD; Nguyen, Thanh N. MD; Aguiar de Sousa, Diana MD; Yaghi, Shadi MD
doi : 10.1161/STROKEAHA.122.038563
AB Occlusive and nonocclusive cervicocephalic thrombi can be encountered during neurovascular imaging in patients with acute ischemic stroke. Radiographic and morphological characteristics on basic and advanced imaging modalities can be important clues towards determination of pathomechanism and the choice of acute and subacute treatment modalities.
Large Vessel Occlusion Stroke due to Intracranial Atherosclerotic Disease: Identification, Medical and Interventional Treatment, and Outcomes.
de Havenon, Adam MD, MS; Zaidat, Osama O. MD; Amin-Hanjani, Sepideh MD; Nguyen, Thanh N. MD; Bangad, Aaron BA; Abbasi, Mehdi MD; Anadani, Mohammad MD; Almallouhi, Eyad MD; Chatterjee, Rano MD; Mazighi, Mikael MD, PhD; Mistry, Eva A. MBBS, MSCI; Yaghi, Shadi MD; Derdeyn, Colin P. MD; Hong, Keun-Sik MD; Kvernland, Alexandra MD; Leslie-Mazwi, Thabele M. MD; Al Kasab, Sami MD
doi : 10.1161/STROKEAHA.122.040008
AB Large vessel occlusion stroke due to underlying intracranial atherosclerotic disease (ICAD-LVO) is prevalent in 10 to 30% of LVOs depending on patient factors such as vascular risk factors, race and ethnicity, and age.
Interventions for Perceptual Disorders in Stroke: A Systematic Review.
Hazelton, Christine PhD; Thomson, Katie PhD; Todhunter-Brown, Alex PhD; Campbell, Pauline PhD; Chung, Charlie S.Y. PhD; Dorris, Liam DClinPsy; Gillespie, David C. PhD; Hunter, Susan M. PhD; McGill, Kris PhD; Nicolson, Donald J. PhD; Williams, Linda J. PhD; Brady, Marian C. PhD
Stroke Literature Synopses (Preclinical).
Hurst, David A. BS; Sohrabji, Farida PhD
Social Media in Stroke Career Development.
McAree, Michael DO; Sharashidze, Vera MD
Varicella Zoster Vasculopathy Exacerbated by Tofacitinib in a Patient With Ulcerative Colitis.
Lyman, Kyle A. MD, PhD; Sreekrishnan, Anirudh MD, MHS; Thatikunta, Prateek MD; McConnell, Ryan MD; Lansberg, Maarten G. MD, PhD; Mijalski Sells, Christina M. MD, MPH
The Neurovasculome: Key Roles in Brain Health and Cognitive Impairment: A Scientific Statement From the American Heart Association/American Stroke Association.
Iadecola, Costantino MD, Chair; Smith, Eric E. MD, FAHA, Vice Chair; Anrather, Josef VMD; Gu, Chenghua PhD; Mishra, Anusha PhD; Misra, Sanjay MD, FAHA; Perez-Pinzon, Miguel A. PhD, FAHA; Shih, Andy Y. PhD; Sorond, Farzaneh A. MD; van Veluw, Susanne J. PhD; Wellington, Cheryl L. PhD; on behalf of the American Heart Association Stroke Council Council on Arteriosclerosis Thrombosis and Vascular Biology Council on Cardiovascular Radiology and Intervention Council on Hypertension Council on Lifestyle and Cardiometabolic Health
doi : 10.1161/STR.0000000000000431
Preservation of brain health has emerged as a leading public health priority for the aging world population. Advances in neurovascular biology have revealed an intricate relationship among brain cells, meninges, and the hematic and lymphatic vasculature (the neurovasculome) that is highly relevant to the maintenance of cognitive function.
Cognitive Impairment After Ischemic and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association/American Stroke Association.
El Husseini, Nada MD, MHSc, FAHA, Chair; Katzan, Irene L. MD, MS, FAHA, Vice Chair; Rost, Natalia S. MD, MPH, FAHA; Blake, Margaret Lehman PhD, CCC-SLP; Byun, Eeeseung RN, PhD; Pendlebury, Sarah T. FRCP, DPhil; Aparicio, Hugo J. MD, MPH; Marquine, Maria J. PhD; Gottesman, Rebecca F. MD, PhD, FAHA; Smith, Eric E. MD, MPH, FAHA; on behalf of the American Heart Association Stroke Council; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; Council on Hypertension; and Council on Lifestyle and Cardiometabolic Health
doi : 10.1161/STR.0000000000000430
Cognitive impairment is a common consequence of stroke and has direct implications for poststroke functioning and quality of life, including the ability to maintain a job, live independently, sustain interpersonal relationships, and drive a vehicle.
Correction to: "Recurrent Ischemic Stroke and Cardiovascular Outcomes in Patients With Atrial Fibrillation With Ischemic Stroke Despite Direct Oral Anticoagulants".
