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Endothelial Keratoplasty Update 2020
Price, Marianne O. PhD*; Feng, Matthew T. MD†; Price, Francis W. Jr MD†
doi : 10.1097/ICO.0000000000002565
Cornea: May 2021 - Volume 40 - Issue 5 - p 541-547
Endothelial keratoplasty has revolutionized the treatment of corneal endothelial dysfunction and lowered the threshold for treatment by providing rapid visual rehabilitation and setting a high standard for safety and efficacy. Over time, endothelial keratoplasty techniques have evolved toward the use of thinner tissue to optimize visual outcomes; refinements have facilitated donor tissue preparation, handling, and attachment; and adaptations have expanded utilization in eyes with challenging ocular anatomy. Despite early concerns about graft longevity, emerging 10-year endothelial cell loss and graft survival data have been encouraging. A shortage of human donor corneas restricts utilization in many areas of the world and is driving a search for keratoplasty alternatives. Further work is needed to expand the donor supply, minimize impediments to adoption, optimize graft survival, and improve refractive predictability.
Clinical Profile and Demographic Distribution of Corneal Dystrophies in India: A Study of 4198 Patients
Das, Anthony Vipin FRCS*; Chaurasia, Sunita MS†
doi : 10.1097/ICO.0000000000002450
Cornea: May 2021 - Volume 40 - Issue 5 - p 548-553
To describe the clinical profile and demographic distribution of corneal dystrophy in patients presenting to a multitier ophthalmology hospital network in India.
Conjunctival Melanoma: Outcomes Based on Age at Presentation in 629 Patients at a Single Ocular Oncology Center
Dalvin, Lauren A. MD; Yaghy, Antonio MD; Vaidya, Sarangdev BA; Pacheco, Richard R. BA; Perez, Alejandro L. MD; Lally, Sara E. MD; Shields, Jerry A. MD; Shields, Carol L. MD
doi : 10.1097/ICO.0000000000002449
Cornea: May 2021 - Volume 40 - Issue 5 - p 554-563
To investigate the clinical features and outcomes for conjunctival melanoma based on patient age.
Safety of KPI-121 Ophthalmic Suspension 0.25% in Patients With Dry Eye Disease: A Pooled Analysis of 4 Multicenter, Randomized, Vehicle-Controlled Studies
Korenfeld, Michael MD*; Nichols, Kelly K. OD, MPH, PhD†; Goldberg, Damien MD‡; Evans, David OD§; Sall, Ken MD¶; Foulks, Gary MD?; Coultas, Susan PhD**; Brazzell, Kim PhD**
doi : 10.1097/ICO.0000000000002452
Cornea: May 2021 - Volume 40 - Issue 5 - p 564-570
The safety of KPI-121 0.25%, an ophthalmic nanoparticle suspension of loteprednol etabonate, was evaluated in subjects with dry eye disease (DED) in one phase 2 and three phase 3 randomized trials of similar design.
Ocular Features in a Large Cohort of Indians With Xeroderma Pigmentosum
Nandyala, Sushma MSc*,†; Mohamed, Ashik MBBS, MTech, PhD, MAMS*; Chaurasia, Sunita MBBS, MS‡,§; Kaliki, Swathi MBBS, MS¶; Ramappa, Muralidhar MBBS, MS‡,?; Vemuganti, Geeta K. MBBS, MD†
doi : 10.1097/ICO.0000000000002499
Cornea: May 2021 - Volume 40 - Issue 5 - p 571-577
Xeroderma pigmentosum (XP) is an extreme hypersensitivity to sunlight causing skin freckling and pigmentary changes because of defective DNA repair mechanisms. The purpose of this article is to evaluate the spectrum of ocular and systemic features in XP at a tertiary eye care center in India over 32 years.
A Retrospective Study of Corneal Endothelial Dystrophy in Dogs (1991–2014)
Leonard, Brian C. DVM, PhD*; Kermanian, Celine S. DVM*; Michalak, Sarah R. BS*; Kass, Philip H. DVM, MPVM, MS, PhD†; Hollingsworth, Steven R. DVM*; Good, Kathryn L. DVM*; Maggs, David J. BVSc*; Thomasy, Sara M. DVM, PhD*,‡
doi : 10.1097/ICO.0000000000002488
Cornea: May 2021 - Volume 40 - Issue 5 - p 578-583
To retrospectively evaluate the clinical data, diagnostic tests, treatments, and outcomes for dogs with corneal endothelial dystrophy (CED) and determine risk factors for CED when compared with a canine reference population.
Dupilumab-Associated Ocular Surface Disease: Clinical Characteristics, Treatment, and Follow-Up
Bohner, Austin BS*; Topham, Christina BS*; Strunck, Jennifer BS†; Haynes, Dylan MD, MCR‡; Brazil, Molly MD‡; Clements, John MD§; Simpson, Eric MD, MCR†; Chamberlain, Winston MD, PhD¶
doi : 10.1097/ICO.0000000000002461
Cornea: May 2021 - Volume 40 - Issue 5 - p 584-589
A consecutive case series of patients with dupilumab-associated ocular surface disease (DAOSD) that describes common ocular symptoms and signs, proposes a symptom disease severity grading system, and describes treatment strategies of DAOSD patients was evaluated.
Keratoplasty Outcomes in Patients With Uveitis
Hennein, Lauren MD*; Lambert, Nathan G. MD†; Chamberlain, Winston MD, PhD†; Hirabayashi, Kristin MD‡; Rose-Nussbaumer, Jennifer MD*,§,¶; Schallhorn, Julie M. MD, MS*,¶
doi : 10.1097/ICO.0000000000002527
Cornea: May 2021 - Volume 40 - Issue 5 - p 590-595
To examine the corneal transplant failure rates and associations with uveitic eye disease.
Indications for Wear, Visual Outcomes, and Complications of Custom Imprint 3D Scanned Scleral Contact Lens Use
Silverman, Joanna I. M. BA*; Huffman, James M. MD*; Zimmerman, M. Bridget PhD†; Ling, Jennifer J. MD*; Greiner, Mark A. MD*
doi : 10.1097/ICO.0000000000002588
Cornea: May 2021 - Volume 40 - Issue 5 - p 596-602
To report indications for wear, visual outcomes, and complications of EyePrintPRO (EPP) scleral contact lens (SCL) use.
Validation of a Novel Confocal Microscopy Imaging Protocol With Assessment of Reproducibility and Comparison of Nerve Metrics in Dry Eye Disease Compared With Controls
Takhar, Jaskirat S. MD*,†; Joye, Ashlin S. DO*,‡; Lopez, Sarah E. OD*,§; Marneris, Athanasios G. DO*,§; Tsui, Edmund MD*,§; Seitzman, Gerami D. MD*,§; Keenan, Jeremy D. MD, MPH*,§; Gonzales, John A. MD*,§
doi : 10.1097/ICO.0000000000002549
Cornea: May 2021 - Volume 40 - Issue 5 - p 603-612
The purposes of this study were to assess the reproducibility of a novel standardized technique for capturing corneal subbasal nerve plexus images with in vivo corneal confocal microscopy and to compare nerve metrics captured with this method in participants with dry eye and control participants.
Deep Anterior Lamellar Keratoplasty After Previous Anterior Lamellar Keratoplasty to Improve the Visual Outcomes
Sarnicola, Caterina MD*,†; Sarnicola, Enrica MD*,†; Cheung, Albert Y. MD‡; Panico, Edoardo§; Panico, Claudio MD*; Sarnicola, Vincenzo MD†
doi : 10.1097/ICO.0000000000002525
Cornea: May 2021 - Volume 40 - Issue 5 - p 613-617
To describe a series of patients who underwent deep anterior lamellar keratoplasty (DALK) after previous anterior lamellar keratoplasty (ALK) to improve their visual outcomes.
Outcomes of Penetrating and Lamellar Corneal Patch Grafts
Sharma, Supriya DNB*; Rathi, Anubha MD*; Murthy, Somasheila I. MD*; Trivedi, Mihika DOpt*; Patel, Chaitali MD*; Mohamed, Ashik MBBS, MTech, PhD, MAMS†; Chaurasia, Sunita MD*
doi : 10.1097/ICO.0000000000002529
Cornea: May 2021 - Volume 40 - Issue 5 - p 618-623
To report the indications, long-term structural and functional outcomes, and prognostic factors for the success of penetrating and lamellar corneal patch grafts.
Do Patients With Keratoconus Have Minimal Disease Knowledge?
Baenninger, Philipp B. MD*; Bachmann, Lucas M. MD, PhD†; Ritzmann, Markus MSc‡; Blaser, Frank MD§; Gatzioufas, Zisis MD, PhD¶; Alder, Marco MD?; Handzic, Armin MMed*; Iselin, Katja MD*; Kaufmann, Claude MD*; Thiel, Michael A. MD, PhD*
doi : 10.1097/ICO.0000000000002501
Cornea: May 2021 - Volume 40 - Issue 5 - p 624-627
To assess whether Swiss adult citizens diagnosed with keratoconus have the minimal knowledge that a corneal specialist would expect they should have.
Long-term Results of a Combined Procedure of Cataract Surgery and Descemet Membrane Endothelial Keratoplasty With Stromal Rim
Studeny, Pavel MD, PhD, MHA*; Hlozankova, Katerina MD, FEBO*; Krizova, Deli MD, FEBO*; Netukova, Magdalena MD, PhD*; Veith, Miroslav MD*; Mojzis, Peter MD, PhD, FEBO*; Pi?ero, David P. PhD†
doi : 10.1097/ICO.0000000000002574
Cornea: May 2021 - Volume 40 - Issue 5 - p 628-634
To evaluate the long-term results of combining cataract surgery, intraocular lens (IOL) implantation, and Descemet membrane endothelial keratoplasty with peripheral stromal support (DMEK-S).
Combining In Vivo Corneal Confocal Microscopy With Deep Learning–Based Analysis Reveals Sensory Nerve Fiber Loss in Acute Simian Immunodeficiency Virus Infection
McCarron, Megan E. BS*; Weinberg, Rachel L. BS*; Izzi, Jessica M. DVM*; Queen, Suzanne E. MS*; Tarwater, Patrick M. PhD†; Misra, Stuti L. BOptom, PhD, FAAO‡; Russakoff, Daniel B. PhD§; Oakley, Jonathan D. PhD§; Mankowski, Joseph L. DVM, PhD*
doi : 10.1097/ICO.0000000000002661
Cornea: May 2021 - Volume 40 - Issue 5 - p 635-642
To characterize corneal subbasal nerve plexus features of normal and simian immunodeficiency virus (SIV)-infected macaques by combining in vivo corneal confocal microscopy (IVCM) with automated assessments using deep learning–based methods customized for macaques.
Comparison of Visual and Tomographic Outcomes of Epithelium-On and Epithelium-Off Accelerated Corneal Crosslinking: A Longitudinal Study
Niyazmand, Hamed PhD*; McKelvie, James FRANZCO†; Li, Ye MBBS‡; McLintock, Cameron FRANZCO‡
doi : 10.1097/ICO.0000000000002567
Cornea: May 2021 - Volume 40 - Issue 5 - p 643-647
To compare the visual and tomographic outcomes of epithelium-on and epithelium-off corneal collagen crosslinking (CXL) in an accelerated protocol in eyes with progressive keratoconus.
Treatment of Progressive Scleromalacia Perforans by Tectonic Enhancement With Lyophilized Equine Pericardium
Droutsas, Konstantinos MD; Giachos, Ioannis MD; Katsiampoula, Vasiliki MD; Kourti, Persefoni MD; Kymionis, Georgios MD, PhD; Petrou, Petros MD, PhD
doi : 10.1097/ICO.0000000000002465
Cornea: May 2021 - Volume 40 - Issue 5 - p 648-651
To describe the off-label use of lyophilized equine pericardium for tectonic enhancement of the sclera in a case of progressive scleromalacia perforans.
Case Series of Urrets-Zavalia Syndrome After Descemet Membrane Endothelial Keratoplasty
Bhullar, Paramjit K. MD; Venkateswaran, Nandini MD; Kim, Terry MD
doi : 10.1097/ICO.0000000000002514
Cornea: May 2021 - Volume 40 - Issue 5 - p 652-655
To present a case series of Urrets-Zavalia syndrome (UZS) that developed after Descemet membrane endothelial keratoplasty (DMEK).
Nivolumab-Induced Ulcerative Keratitis—A Case Report
Losonczy, Gergely MD, PhD*; Gijs, Marlies PhD†; Nuijts, Rudy M.M.A. MD, PhD†
doi : 10.1097/ICO.0000000000002460
Cornea: May 2021 - Volume 40 - Issue 5 - p 656-658
To describe a case of nivolumab-induced ulcerative keratitis rapidly recovering on topical steroid treatment and to determine changes in cytokine levels in the tear fluid caused by nivolumab.
Compression Sutures to Treat Acute Hydrops in a Case of Bilateral Post-Laser In Situ Keratomileusis Ectasia
Bevara, Akhil DNB; Vaddavalli, Pravin K. MD
doi : 10.1097/ICO.0000000000002654
Cornea: May 2021 - Volume 40 - Issue 5 - p 659-661
This a case report of acute hydrops with interface fluid syndrome in a patient with post-laser in situ keratomileusis (LASIK) ectasia treated with compression sutures. A patient with post-LASIK ectasia presented with acute hydrops and fluid accumulation in the LASIK flap–stromal interface sequentially in both eyes. Full thickness compression sutures were applied to appose the edges of the Descemet tear, and this resulted in a rapid resolution of stromal edema and interface fluid. The patient had best distance visual acuities of 20/40 and 20/60 at the last follow-up in the right and left eyes, respectively. Hydrops along with fluid in the interface needed early intervention to prevent complications such as epithelial ingrowth and interface haze. Compression sutures were useful in this case to help bridge the gap between the margins of Descemet tear, hastening the resolution of stromal edema and interface fluid.
Ochrobactrum anthropi Keratitis in a Boston Type 1 Keratoprosthesis Recipient
Ma, Kevin K. MD; Tone, Stephan Ong MDCM, PhD, FRCSC; Chodosh, James MD, MPH; Saeed, Hajirah N. MD, MPH
doi : 10.1097/ICO.0000000000002571
Cornea: May 2021 - Volume 40 - Issue 5 - p 662-663
To report a case of Ochrobactrum anthropi keratitis in an eye with a Boston type 1 keratoprosthesis.
In Vivo Confocal Microscopy Findings in Bowman Layer Transplantation
Garc?a de Oteyza, Gonzalo MD, FEBO*; Vazquez-Romo, Kristian Alfonso MD†; Hern?ndez-Quintela, Everardo MD, MSc, FACS†; de Wit Carter, Guillermo MD, FACS†; Garc?a-Albisua, Ana Mercedes MD†
doi : 10.1097/ICO.0000000000002561
Cornea: May 2021 - Volume 40 - Issue 5 - p 664-668
To report the in vivo confocal microscopy (IVCM) findings of a case who underwent femtosecond laser-assisted Bowman layer transplantation (BLT).
Techniques, Outcomes, and Complications of Preloaded, Trifolded Descemet Membrane Endothelial Keratoplasty Using the DMEK EndoGlide
Ighani, Mehrnaz*,†; Dzhaber, Daliya MD*; Jain, Shivani PhD, MSc*; De Rojas, Joaquin O. MD*; Eghrari, Allen O. MD, MPH*
doi : 10.1097/ICO.0000000000002648
Cornea: May 2021 - Volume 40 - Issue 5 - p 669-674
To describe 2 insertion techniques, outcomes, and complications of preloaded, trifolded Descemet membrane endothelial keratoplasty (DMEK) cases using the DMEK EndoGlide inserter.
Rabies Antigen Detection in Postmortem Cornea
Arora, Ritu MD*; Goel, Ruchi MS*; Singhai, Monil MD†; Gupta, Naveen MD†; Saxena, Sonal MD‡
doi : 10.1097/ICO.0000000000002663
Cornea: May 2021 - Volume 40 - Issue 5 - p e10-e11
