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Cool Crosslinking: Riboflavin at 4[degrees]C for Pain Management After Crosslinking for Keratoconus Patients, A Randomized Clinical Trial.
Toro-Giraldo, Laura MD *; Morales Flores, Norma MD *; Santana-Cruz, Omar OD +; Ramirez-Miranda, Arturo MD, Msc *; Navas, Alejandro MD, Msc *; Olivo-Payne, Andrew MD *; Lichtinger, Alejandro MD *; Jimenez-Corona, Aida PhD ++; Graue-Hernandez, Enrique O. MD, Msc *
doi : 10.1097/ICO.0000000000002484
Volume 40(1), January 2021, p 1-4
Purpose: To explore corneal cooling as a method of pain management in corneal-accelerated collagen cross-linking.
Tolerance to Light of Patients Suffering From Infectious Keratitis.
Courrier, Emilie PhD *; Lambert, Victor +; Renault, Didier *; Garcin, Thibaud MD, PhD *,+; Moine, Baptiste PhD ++; Herbepin, Pascal *; Thuret, Gilles MD, PhD *,+,[S]; Gain, Philippe MD, PhD *,+
doi : 10.1097/ICO.0000000000002516
Volume 40(1), January 2021, p 5-11
Purpose: With very photophobic patients, the advantages of red or near infrared light to develop new ophthalmology imaging devices seem obvious: no or little glare, possibility of long signal integration, no phototoxicity, and lesser autofluorescence of ocular tissues. Nevertheless, in this range, the shortest possible wavelength facilitates signal detection. The aim of this study was, thus, to determine the maximal irradiance tolerated with 6 wavelengths: 2 red, 2 far red, and 1 near infrared lights to determine the shortest wavelength well tolerated by patients, in comparison with the standard cobalt blue light of ophthalmology slitlamp.
Comparison of 1-Year Outcomes Between Small Incision Lenticule Extraction With Prophylactic Cross-Linking and Femtosecond Laser-Assisted In Situ Keratomileusis With Prophylactic Cross-Linking.
Liu, Chunlei MD, PhD *; Wang, Zheng MD, PhD +; Wu, De MD ++; Luo, Tian MD [S]; Su, Yun MD *; Mo, Junbai MD *; Fang, Xuejun MD, PhD [P]
doi : 10.1097/ICO.0000000000002547
Volume 40(1), January 2021, p 12-18
Purpose: To compare small incision lenticule extraction with prophylactic cross-linking (SMILE Xtra) and femtosecond laser-assisted in situ keratomileusis with prophylactic cross-linking (FS-LASIK Xtra) in their safety, efficacy, predictability, and stability.
Patient Reported Outcomes in Microbial Keratitis.
Tuohy, Megan M. MD *; Niziol, Leslie M. MS *; I. Mian, Shazhad MD *; Ballouz, Dena BS *; Bosch, David BA +; Woodward, Maria A. MD, MSc +,++
doi : 10.1097/ICO.0000000000002362
Volume 40(1), January 2021, p 19-25
Purpose: The aim of this investigation was to study the patient-reported outcomes of patients with microbial keratitis (MK) using the 9-item National Eye Institute-Visual Function Questionnaire (NEI VFQ-9).
Long-term Results of Intraocular Pressure Elevation and Post-DMEK Glaucoma After Descemet Membrane Endothelial Keratoplasty.
Maier, Anna-Karina B. MD; Pilger, Daniel MD; Gundlach, Enken MD; Winterhalter, Sibylle MD; Torun, Necip MD
doi : 10.1097/ICO.0000000000002363
Volume 40(1), January 2021, p 26-32
Purpose: Intraocular pressure (IOP) elevation occurs regularly after Descemet membrane endothelial keratoplasty (DMEK). This study evaluated the long-term incidence of IOP elevation and post-DMEK glaucoma after DMEK.
Use of Corneas From Septic Donors for Descemet Membrane Endothelial Keratoplasty.
Vasiliauskaite, Indre MSc *,+; de Jong, Maloeke *,++; Quilendrino, Ruth MD *,+,++; van der Wees, Jacqueline PhD *,++; Oellerich, Silke PhD *; Melles, Gerrit R. J. MD, PhD *,+,++
doi : 10.1097/ICO.0000000000002443
Volume 40(1), January 2021, p 33-38
Purpose: To evaluate the suitability of corneas from septic donors for transplantation by analyzing the discard rate in the eye bank and the clinical outcome of Descemet membrane endothelial keratoplasty (DMEK) using organ-cultured corneal grafts from septic versus nonseptic donors.
Impact of Scleral Contact Lens Use on the Rate of Corneal Transplantation for Keratoconus.
Ling, Jennifer J. MD *; Mian, Shahzad I. MD *; Stein, Joshua D. MD, MSc *,+,++; Rahman, Moshiur PhD *; Poliskey, Joel BSc [S]; Woodward, Maria A. MD, MSc *,+
doi : 10.1097/ICO.0000000000002388
Volume 40(1), January 2021, p 39-42
Purpose: To evaluate the association of scleral contact lens (SCL) use on the risk for keratoplasty for people with keratoconus.
Outcomes of Ipsilateral Simple Limbal Epithelial Transplantation, Tenonectomy, Mitomycin and Amniotic Membrane Transplantation for Treatment of Recurrent Pterygium.
Trinh, Tanya FRANZCO, MBBS *; Mimouni, Michael MD *; Mednick, Zale FRCSC, MD *; Einan-Lifshitz, Adi MD +; Cohen, Eyal MD +; Santaella, Gisella MD *; Sorkin, Nir MD *,++; Slomovic, Allan FRCSC, MD *
doi : 10.1097/ICO.0000000000002336
Volume 40(1), January 2021, p 43-47
Purpose: To report on the outcomes of recurrent pterygium treated by ipsilateral simple limbal epithelial transplantation (SLET), mitomycin, tenonectomy, and amniotic membrane transplantation.
Preclinical Studies of a Novel Microfabricated Device to Treat Corneal Epithelial Disease.
Chaum, Edward MD, PhD
doi : 10.1097/ICO.0000000000002444
Volume 40(1), January 2021, p 48-53
Purpose: Anterior stromal puncture is an inexpensive technique for treating recurrent corneal erosions but is often ineffective and cannot be used in the optical axis because of scarring. These studies tested a novel microfabricated imprinting instrument to assess its potential efficacy for the treatment of corneal epithelial disease in the optical axis.
Clinical Outcomes of Allogeneic Ocular Surface Stem Cell Transplantation in Pediatric Patients.
Cheung, Albert Y. MD *,+; Sarnicola, Enrica MD *,++; Eslani, Medi MD *; Wright, Elizabeth LPN *; Goebel, Jens MD [S]; Hooper, David K. MD [P]; Govil, Amit MD [P]; Kurji, Khaliq H. MD *; Holland, Edward J. MD *
doi : 10.1097/ICO.0000000000002379
Volume 40(1), January 2021, p 54-60
Purpose: To describe the outcomes of allograft ocular surface stem cell transplantation (OSST) and the complication profile of systemic immunosuppression (SI) in pediatric patients with limbal stem cell deficiency.
Diagnostic Value of Corneal Epithelial and Stromal Thickness Distribution Profiles in Forme Fruste Keratoconus and Subclinical Keratoconus.
Toprak, Ibrahim MD, FEBO, FICO *,+; Vega, Alfredo MD, PhD *,++,[S]; Alio del Barrio, Jorge L. MD, PhD, FEBOS-CR *,++,[S]; Espla, Elias ++; Cavas, Francisco PhD [P]; Alio, Jorge L. MD, PhD, FEBO *,++,[S]
doi : 10.1097/ICO.0000000000002435
Volume 40(1), January 2021, p 61-72
Purpose: To assess the diagnostic values of corneal epithelial and stromal thickness distribution characteristics in forme fruste keratoconus (FFKC) and subclinical keratoconus (KC).
Corneal Endothelial Morphology and Thickness Alterations in Patients With Severe Obstructive Sleep Apnea-Hypopnea Syndrome.
Chalkiadaki, Evangelia MD *; Andreanos, Konstantinos MD, PhD +; Florou, Chrysoula MD +; Droutsas, Konstantinos MD, PhD +; Maniou, Chrysoula MD ++; Amfilochiou, Anastasia MD, PhD ++; Georgalas, Ilias MD, PhD +; Papaconstantinou, Dimitrios MD, PhD +; Koutsandrea, Chrysanthi MD, PhD +
doi : 10.1097/ICO.0000000000002373
Volume 40(1), January 2021, p 73-77
Purpose: To investigate central endothelial cell density (ECD), morphology, and central corneal thickness (CCT) in patients newly diagnosed with severe obstructive sleep apnea-hypopnea syndrome (OSAHS) and to determine the correlation between these parameters and OSAHS severity.
Topography-Guided Photorefractive Keratectomy for Postkeratoplasty Astigmatism: Long-Term Outcomes.
Bizrah, Mukhtar MBBS, FRCOphth, FRCSC, FEBO *; Lin, David T. C. MD, FRCSC +; Babili, Abdulaa BSc ++; Wirth, Magdalena Anna MD *; Arba-Mosquera, Samuel MSc, PhD [S]; Holland, Simon P. MD, FRCSC, FRCS *,+
doi : 10.1097/ICO.0000000000002403
Volume 40(1), January 2021, p 78-87
Purpose: To evaluate the long-term efficacy and safety of topography-guided photorefractive keratectomy (TG-PRK) for postkeratoplasty refractive error correction.
Association of Collagen Gene (COL4A3) rs55703767 Variant With Response to Riboflavin/Ultraviolet A-Induced Collagen Cross-Linking in Female Patients With Keratoconus.
Abdelghany, Ahmed A. MD *; Toraih, Eman A. MD, PhD +,++; Abdelaziz, Eman Z. MD, PhD [S]; El-Sherbeeny, Nagla A. MD, PhD [S]; Fawzy, Manal S. MD, PhD [P],||
doi : 10.1097/ICO.0000000000002489
Volume 40(1), January 2021, p 88-98
Purpose: To investigate for the first time the association of collagen COL4A3 (rs55703767), COL5A1 (rs7044529), and COL4A4 (rs2229813) variants with response to corneal collagen cross-linking (CXL) with riboflavin and ultraviolet A in patients with keratoconus (KC).
Ex Vivo Safety and Efficacy of Paired Peripheral Incisions in Descemet's Membrane Endothelial Keratoplasty Grafts to Facilitate Unscrolling.
de la Presa, Martin MD *; Bedard, Peter MS *,+; Justin, Jeff J. BS +; Hansen, Mark S. MD *,++; Hou, Joshua H. MD *,+
doi : 10.1097/ICO.0000000000002447
Volume 40(1), January 2021, p 99-106
Purpose: To evaluate the ex vivo safety and efficacy of using paired peripheral incisions to achieve a triple scroll conformation that facilitates unscrolling in Descemet membrane endothelial keratoplasty (DMEK).
Short- and Long-Term Stability of Plasma Rich in Growth Factors Eye Drops.
Anitua, Eduardo MD, DDS *,+; de la Fuente, Maria MSc *,+; Muruzabal, Francisco PhD *,+; Merayo-Lloves, Jesus MD, PhD ++,[S]
doi : 10.1097/ICO.0000000000002519
Volume 40(1), January 2021, p 107-112
Purpose: To analyze whether plasma rich in growth factors (PRGFs) eye drops preserve their activity and biological properties after storage for 9 and 12 months at -20[degrees]C, and at 4[degrees]C, and at room temperature (RT) for 3 and 7 days in comparison to fresh samples (t0).
Visian Implantable Collamer Lens Behavior in Descemet Membrane Endothelial Keratoplasty Surgery.
Alio del Barrio, Jorge L. MD, PhD, FEBOS-CR *,+; D'Oria, Francesco MD *,++; Alio, Jorge L. MD, PhD, FEBO *,+
doi : 10.1097/ICO.0000000000002405
Volume 40(1), January 2021, p 113-115
Abstract: Endothelial damage is one of the leading causes for anterior chamber phakic intraocular lens (AC-pIOL) explantation. In young patients, where the pIOL is explanted alone without lensectomy, an important anisometropia is left, unless an exchange with a posterior chamber (PC) pIOL is performed. However, in the event of corneal decompensation, there is no published evidence about the potential influence of a collamer-based PC-pIOL [implantable collamer lens (ICL)] on endothelial keratoplasty surgery. We report a case of severe endothelial damage after AC-pIOL implantation managed by the exchange of the AC-pIOL by an ICL, followed by Descemet membrane endothelial keratoplasty. Collamer-based PC-pIOLs seem to not affect Descemet membrane endothelial keratoplasty outcomes. ICL did not show any transparency loss. These results cannot be extrapolated to other non-collamer-based PC-pIOLs. Further studies with larger samples are necessary to confirm these outcomes.
Case Series: Novel Utilization of Rho-Kinase Inhibitor for the Treatment of Corneal Edema.
Davies, Emma MD
doi : 10.1097/ICO.0000000000002421
Volume 40(1), January 2021, p 116-120
Purpose: To describe 3 cases of corneal clearance after the use of topical rho-kinase inhibitor, netarsudil, in the setting of endothelial cell dysfunction in comparison to one case without corneal clearance after the use of netarsudil.
Improper Use of the Germicidal Range Ultraviolet Lamp for Household Disinfection Leading to Phototoxicity in COVID-19 Suspects.
Leung, Kai Ching Peter MRCSEd; Ko, Tak Chuen Simon FRCS
doi : 10.1097/ICO.0000000000002397
Volume 40(1), January 2021, p 121-122
Purpose: To report the germicidal range ultraviolet (UV) irradiation-induced phototoxicity because of unprotected exposure to the UV lamps for presumed household disinfection of SARS-CoV-2 in a domestic setting.
Acute Corneal Endothelial Graft Rejection With Coinciding COVID-19 Infection.
Jin, Sierra X. MD; Juthani, Viral V. MD
doi : 10.1097/ICO.0000000000002556
Volume 40(1), January 2021, p 123-124
Purpose: To report a case of acute corneal endothelial graft rejection with the concurrent onset of coronavirus disease 2019 (COVID-19) symptoms.
Tuck In Femtosecond Laser Assisted Anterior Lamellar Keratoplasty (T-FALK) for the Management of Superficial Anterior Corneal Scars-A Modified Technique.
Sharma, Vijay K. MS *; Sati, Alok MS *; Kaushik, Jaya MS +; Kumar, Santosh MS *; Agarwal, Manisha MD ++
doi : 10.1097/ICO.0000000000002508
Volume 40(1), January 2021, p 125-130
Purpose: To report a modified sutureless and glue-less technique, termed tuck in femtosecond laser assisted anterior lamellar keratoplasty (T-FALK), and to achieve a good graft-host junction apposition.
Novel Microforceps Technique Developed for Endothelial Surgical Procedures.
Berry, J. Christian MD; Moore, Lee E. MD; Riaz, Kamran M. MD
doi : 10.1097/ICO.0000000000002434
Volume 40(1), January 2021, p 131-132
Purpose: To develop a more efficient and less traumatic method of Descemet membrane removal in endothelial surgery.
Letter to the Editor: "Prospective Clinical Study of Keratoconus Progression in Patients Awaiting Corneal Cross-Linking".
Khan, Selina MBChB, BSc (Hons); Jaycock, Philip MBChB, BSc, FRCOphth, Cert LRS, MD
doi : 10.1097/ICO.0000000000002555
Volume 40(1), January 2021, p e1
