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Herpes Zoster: A Brief Definitive Review
Cohen, Elisabeth J.; Jeng, Bennie H.
doi : 10.1097/ICO.0000000000002754
Cornea: August 2021 - Volume 40 - Issue 8 - p 943-949
This brief definitive review of herpes zoster (HZ) will cover the current state of knowledge and questions that remain to be answered regarding HZ in general and HZ ophthalmicus in particular. A question-and-answer format will be used to address various important topics related to this common and serious disease. Questions to be addressed relate to common misconceptions, contagiousness of infection, unknowns regarding pathogenesis, rising incidence, risk factors and complications, relationship with temporal arteritis, vaccination, and current and future antiviral treatment. In addition, the importance of the Zoster Eye Disease Study to determine the efficacy of suppressive valacyclovir treatment in preventing complications of HZ ophthalmicus and the need to support enrollment will be discussed.
Conjunctival Vessels in Diabetes Using Functional Slit Lamp Biomicroscopy
Hwang, Jodi; Karanam, Veena; Wang, Jianhua; Feuer, William J.; Garg, Rajesh K.; Tamariz, Leonardo; Galor, Anat
doi : 10.1097/ICO.0000000000002623
Cornea: August 2021 - Volume 40 - Issue 8 - p 950-957
This study used functional slit lamp biomicroscopy (FSLB) to quantify conjunctival microvessel parameters in individuals with and without diabetes and examined whether these metrics could be used as surrogate markers of diabetes-related complications.
Clinical Evaluation of Electrolysis for Reis-Bücklers Corneal Dystrophies and In Vivo Histological Analysis Using Anterior Segment Optical Coherence Tomography
Nishino, Tsubasa; Kobayashi, Akira; Mori, Natsuko; Yokogawa, Hideaki; Sugiyama, Kazuhisa
doi : 10.1097/ICO.0000000000002541
Cornea: August 2021 - Volume 40 - Issue 8 - p 958-962
To report the effectiveness and clinical outcomes of corneal electrolysis for Reis-Bücklers corneal dystrophies (RBCDs) and provide in vivo histological analysis using anterior segment optical coherence tomography (AS-OCT).
Use of Panel-Reactive Antibody Testing in the Planning and Management of Ocular Surface Stem Cell Transplantation
Jeffrey, Joseph H.; Denny, Matthew R.; Cheung, Albert Y.; Sarnicola, Enrica; Wright, Elizabeth; Govil, Amit; Holland, Edward J.
doi : 10.1097/ICO.0000000000002552
Cornea: August 2021 - Volume 40 - Issue 8 - p 963-966
Panel-reactive antibody (PRA) testing has been widely adopted in solid organ transplantation for risk assessment in potential allograft recipients but has not been studied in the context of ophthalmic transplantation. The purpose of this study is to evaluate outcomes in patients undergoing ocular surface stem cell transplantation (OSST) for limbal stem cell deficiency (LSCD) relative to preoperative PRA level.
Limbal Stem Cell Deficiency Associated With Herpes Keratitis
Carreno-Galeano, Jimena Tatiana; Dohlman, Thomas H.; Yin, Jia; Dana, Reza
doi : 10.1097/ICO.0000000000002557
Cornea: August 2021 - Volume 40 - Issue 8 - p 967-971
To describe the demographic features and clinical characteristics of patients with herpes keratitis (HK) and limbal stem cell deficiency (LSCD) and identify possible factors associated with development of LSCD after HK.
Descemet Membrane Endothelial Keratoplasty in Congenital Hereditary Endothelial Dystrophy: Initial Experiences
Mittal, Vikas; Sehdev, Nancy; Mittal, Ruchi
doi : 10.1097/ICO.0000000000002701
Cornea: August 2021 - Volume 40 - Issue 8 - p 972-976
To report our early experiences with Descemet membrane endothelial keratoplasty (DMEK) in congenital hereditary endothelial dystrophy (CHED).
Evaluation of Ocular Surface and Meibomian Glands in Patients With Scleroderma
Adiguzel, Seyma; Palamar, Melis; Yargucu, Figen; Oksel, Fahrettin; Yagci, Ayse
doi : 10.1097/ICO.0000000000002551
Cornea: August 2021 - Volume 40 - Issue 8 - p 977-981
To evaluate the prevalence of dry eye and meibomian gland dysfunction in patients with scleroderma.
Descemet Stripping Endothelial Keratoplasty Outcomes in Patients With Rheumatoid Arthritis
Cinar, Yasin; Delvadia, Bela; Sahin, Alparslan; Hammersmith, Kristin M.; Nagra, Parveen K.; Rapuano, Christopher J.; Syed, Zeba A
doi : 10.1097/ICO.0000000000002504
Cornea: August 2021 - Volume 40 - Issue 8 - p 982-987
To review the graft and visual outcomes in a series of patients with rheumatoid arthritis (RA) who underwent Descemet stripping endothelial keratoplasty (DSEK).
Effects of Continuous Positive Airway Pressure Treatment for Obstructive Sleep Apnea–Hypopnea Syndrome on Corneal Morphological Characteristics
Chalkiadaki, Evangelia; Andreanos, Konstantinos; Karmiris, Efthymios; Mani, Aikaterini; Kastanakis, Emmanouil; Amfilochiou, Anastasia; Papaconstantinou, Dimitrios; Koutsandrea, Chrysanthi; Georgalas, Ilias
doi : 10.1097/ICO.0000000000002581
Cornea: August 2021 - Volume 40 - Issue 8 - p 988-994
To evaluate the effects of continuous positive airway pressure (CPAP) therapy on corneal endothelial morphometry and pachymetry in patients with obstructive sleep apnea–hypopnea syndrome (OSAHS).
Prevalence of Ocular Demodicosis in an Older Population and Its Association With Symptoms and Signs of Dry Eye
Cheng, Anny Mansim; Hwang, Jodi; Dermer, Harrison; Galor, Anat
doi : 10.1097/ICO.0000000000002542
Cornea: August 2021 - Volume 40 - Issue 8 - p 995-1001
To evaluate associations between Demodex and its symptoms and ocular surface parameters in individuals with dry eye (DE).
An Unexpected Incidence of Ocular Surface Neoplasia on Pterygium Surgery. A Retrospective Clinical and Histopathological Report
Mej?a, Luis F.; Zapata, Melissa; Gil, Juan C.
doi : 10.1097/ICO.0000000000002586
Cornea: August 2021 - Volume 40 - Issue 8 - p 1002-1006
To report the unexpected finding of ocular surface neoplasia (OSSN) on conjunctival tissue removed during pterygium surgery and subjected to histopathology analysis.
Descemet Membrane Endothelial Keratoplasty in Toxic Anterior Segment Syndrome: A Case Series
Necip, Kara; Oltulu, Refik; Levent, Dogan; Osman, Gundogan Ali
doi : 10.1097/ICO.0000000000002524
Cornea: August 2021 - Volume 40 - Issue 8 - p 1007-1010
To evaluate the outcomes of Descemet membrane endothelial keratoplasty (DMEK) in patients with toxic anterior segment syndrome (TASS).
Topical Erythropoietin as a Novel Treatment for Necrotizing Scleritis After Pterygium Surgery: A Pilot Study
Feizi, Sepehr; Javadi, Mohammad Ali
doi : 10.1097/ICO.0000000000002570
Cornea: August 2021 - Volume 40 - Issue 8 - p 1011-1017
To share our initial experience with the innovative use of topical erythropoietin for the treatment of necrotizing scleritis manifesting immediately after pterygium excision surgery.
Impact of the COVID-19 Pandemic on Keratoplasty and Corneal Eye Banking
Ballouz, Dena; Sawant, Onkar B.; Hurlbert, Susan; Titus, Michael S.; Majmudar, Parag A.; Kumar, Ashok; Zhou, Yunshu; Musch, David C.; Mian, Shahzad I.
doi : 10.1097/ICO.0000000000002748
Cornea: August 2021 - Volume 40 - Issue 8 - p 1018-1023
The purpose of this study was to assess the impact of COVID-19 guidelines for corneal donor tissue screening and the utility of routine postmortem COVID-19 testing of donors intended for surgical use at a single eye bank.
Younger Donor Tissue in Descemet Membrane Endothelial Keratoplasty Surgery: Clinical Outcomes
Hill, Jordan R.; Chen, Shin-Yi; Bauer, Alex J.; Straiko, Megan M. W.; Sanchez, Philip James; Straiko, Michael D.; Terry, Mark A.
doi : 10.1097/ICO.0000000000002582
Cornea: August 2021 - Volume 40 - Issue 8 - p 1024-1030
To determine whether using younger donor tissue for Descemet membrane endothelial keratoplasty (DMEK) surgery influences clinical outcomes.
Trypan-Assisted Automated Endothelial Cell Loss Measurements Compared With Specular Microscopy
Bedard, Peter; Justin, Jeff J.; Hou, Joshua H.
doi : 10.1097/ICO.0000000000002756
Cornea: August 2021 - Volume 40 - Issue 8 - p 1031-1035
The aims of this study were 1) to compare area of cell loss (ACL) on trypan staining with ACL on specular imaging and 2) to evaluate the use of automated software for measuring ACL on trypan staining.
Rose Bengal Photodynamic Antimicrobial Therapy: A Pilot Safety Study
Martinez, Jaime D.; Arrieta, Esdras; Naranjo, Andrea; Monsalve, Pedro; Mintz, Keenan J.; Peterson, Jeffrey; Arboleda, Alejandro; Durkee, Heather; Aguilar, Mariela C.; Pelaez, Daniel; Dubovy, Sander R.; Miller, Darlene; Leblanc, Roger; Amescua, Guillermo; Parel, Jean-Marie
doi : 10.1097/ICO.0000000000002717
Cornea: August 2021 - Volume 40 - Issue 8 - p 1036-1043
To evaluate the in vivo corneal changes after Rose Bengal photodynamic antimicrobial therapy (RB-PDAT) treatment in New Zealand White rabbits.
Role of Reverse Transcriptase Polymerase Chain Reaction in Cornea Donors During the COVID-19 Pandemic
Arora, Ritu; Sharda, Shipra; Sahu, Jigyasa; Manchanda, Vikas; Jain, Parul; Gupta, Isha; Gotmare, Nikhil; Bharti, Nisha
doi : 10.1097/ICO.0000000000002742
Cornea: August 2021 - Volume 40 - Issue 8 - p 1044-1047
The purpose of this study was to report the analysis of reverse transcriptase polymerase chain reaction (RT-PCR) of nasopharyngeal (NP) samples of cornea donors dying because of causes unrelated to severe acute respiratory coronavirus (SARS-CoV-2).
Transient Reticular Cystic Corneal Epithelial Edema With Topical Netarsudil: A Case Series and Review
LoBue, Stephen A.; Moustafa, Giannis A.; Vu, Anderson; Amin, Mira; Nguyen, Thanh; Goyal, Himani
doi : 10.1097/ICO.0000000000002621
Cornea: August 2021 - Volume 40 - Issue 8 - p 1048-1054
To describe cases in which netarsudil ophthalmic solution 0.02% precipitated reversible, reticular cystic epithelial edema.
Herpes Simplex Virus–Related Conjunctivitis Resistant to Aciclovir: A Case Report and Review of the Literature
Esra, Nira; Hollhumer, Roland
doi : 10.1097/ICO.0000000000002613
Cornea: August 2021 - Volume 40 - Issue 8 - p 1055-1058
To report a rare case of herpes virus type 2–related conjunctivitis, resistant to aciclovir (ACV).
Treatment of Dry Eye from Laser-Assisted In Situ Keratomileusis With Recombinant Human Nerve Growth Factor (Cenegermin)
Habibi, Roya N.; Lee, Michele D.
doi : 10.1097/ICO.0000000000002554
Cornea: August 2021 - Volume 40 - Issue 8 - p 1059-1061
To describe 2 patients with neurotrophic keratitis after laser-assisted in situ keratomileusis surgery who were treated with recombinant human nerve growth factor (cenegermin) and the treatment course.
Severe Keratitis and Corneal Perforation by Paenibacillus glucanolyticus
Hassan, Ali; Rampat, Radhika; Vasquez-Perez, Alfonso
doi : 10.1097/ICO.0000000000002584
Cornea: August 2021 - Volume 40 - Issue 8 - p 1062-1064
To report the first case of Paenibacillus glucanolyticus, a spore-forming bacteria, to be isolated in a human ocular infection.
Solitary Conjunctivocorneal Plasmacytoma Arising After Cataract Surgery
Davidson, Max; Shah, Vallari; Shah, Chirag; Shahnazaryan, David; Jones, Sophie
doi : 10.1097/ICO.0000000000002569
Cornea: August 2021 - Volume 40 - Issue 8 - p 1065-1066
To report a case of solitary plasmacytoma of the conjunctiva with corneal encroachment and to review the literature of all published cases.
Late Corneal Stromal Deposits After COVID-19
Pareja-R?os, Alicia; Bonaque-Gonz?lez, Sergio
doi : 10.1097/ICO.0000000000002757
Cornea: August 2021 - Volume 40 - Issue 8 - p 1067-1069
We present 2 cases of striking stromal corneal infiltrates months after COVID-19 infection. While we cannot prove that these infiltrates are caused by or directly related to COVID-19, we did not find any other plausible cause that could explain these ophthalmic signs. In these cases, the ongoing process was detected in relatively early stages due to scheduled visits with patients and responded positively to prednisolone acetate 1% ophthalmic suspension. However, we do not know the response to treatment in more advanced cases.
Keratoplasty Rejection After the BNT162b2 messenger RNA Vaccine
Wasser, Lauren M.; Roditi, Eduardo; Zadok, David; Berkowitz, Liron; Weill, Yishay
doi : 10.1097/ICO.0000000000002761
Cornea: August 2021 - Volume 40 - Issue 8 - p 1070-1072
The aim of this report was to report 2 patients who presented with acute corneal graft rejection 2 weeks after receiving the BNT162b2 messenger RNA (mRNA) vaccine for severe acute respiratory syndrome coronavirus 2.
A Novel Technique for Donor Insertion and Unfolding in Descemet Membrane Endothelial Keratoplasty
Fogla, Rajesh; Thazethaeveetil, Indumathy Ramachandran
doi : 10.1097/ICO.0000000000002698
Cornea: August 2021 - Volume 40 - Issue 8 - p 1073-1078
To describe a novel technique for insertion and unfolding of donor Descemet membrane (DM) scroll during DM endothelial keratoplasty (DMEK).
Mini-Descemet Stripping–Automated Endothelial Keratoplasty for Macro Corneal Perforations
Vasquez-Perez, Alfonso; Din, Nizar; Phylactou, Maria; Kriman Nunez, Jaime; Allan, Bruce
doi : 10.1097/ICO.0000000000002713
Cornea: August 2021 - Volume 40 - Issue 8 - p 1079-1084
We present a technique that preserves good vision in paracentral macroperforations and avoids challenges of tectonic lamellar or penetrating keratoplasty in eyes with poor visual potential.
