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Pregnancy and Stress: Thinking Beyond Seizure Control in Women With Epilepsy.
Rosengard, Jillian L. MD *; Haut, Sheryl R. MD *
doi : 10.1212/WNL.0000000000207391
Volume 100(24) pgs. 1121-1167,e2424-e2520 June 13, 2023
Can an Intervention Be Cost-effective Following a Negative Clinical Trial?.
Ney, John MD, MPH; van der Goes, David Noel PhD
Toward a Patient-Specific Readout of Neurodegeneration: The Case for Spatial Normative Modeling in Alzheimer Disease.
Sinha, Nishant PhD; Gugger, James J. MD, PharmD
Examining Unresponsive Patients: Basics Come First.
Rabinstein, Alejandro A. MD
Life Stressors During Pregnancy in Women With Epilepsy: Results From the Pregnancy Risk Assessment Monitoring System.
Chaudhry, Naveed MD; Bergey, Gregory K. MD; Kaplan, Peter W. MBBS, FRCP; Johnson, Emily L. MD
doi : 10.1212/WNL.0000000000207274
To compare specific life stressors and domestic abuse that pregnant women and others with epilepsy (WWE) experience compared with pregnant women and others without epilepsy (WWoE).
Cost-effectiveness of Prednisolone to Treat Bell Palsy in Children: An Economic Evaluation Alongside a Randomized Controlled Trial.
Xiong, Xiuqin MPH; Huang, Li PhD; Herd, David W. MBBS; Borland, Meredith L. MBBS; Davidson, Andrew MD; Hearps, Stephen MBiostat; Mackay, Mark T. PhD; Lee, Katherine J. PhD; Dalziel, Stuart R. PhD; Dalziel, Kim PhD; Cheek, John A. MBBS; Babl, Franz E. MD
doi : 10.1212/WNL.0000000000207284
AB Background and Objectives: Bell palsy is the third most frequent diagnosis in children with sudden-onset neurologic dysfunction. The cost-effectiveness of treating Bell palsy with prednisolone in children is unknown.
Revealing Individual Neuroanatomical Heterogeneity in Alzheimer Disease Using Neuroanatomical Normative Modeling.
Verdi, Serena MPhil; Kia, Seyed Mostafa PhD; Yong, Keir X.X. PhD; Tosun, Duygu PhD; Schott, Jonathan M. MD; Marquand, Andre F. PhD *; Cole, James H. PhD *
doi : 10.1212/WNL.0000000000207298
Alzheimer disease (AD) is highly heterogeneous, with marked individual differences in clinical presentation and neurobiology. To explore this, we used neuroanatomical normative modeling to index regional patterns of variability in cortical thickness.
Association of the Informant-Reported Memory Decline With Cognitive and Brain Deterioration Through the Alzheimer Clinical Continuum.
Kuhn, Elizabeth PhD; Perrotin, Audrey PhD; La Joie, Renaud PhD; Touron, Edelweiss PhD; Dautricourt, Sophie MD; Vanhoutte, Matthieu PhD; Vivien, Denis PhD; de La Sayette, Vincent MD; Chetelat, Gael PhD; for the Alzheimer's Disease Neuroimaging Initiative
doi : 10.1212/WNL.0000000000207338
Studies are sparse regarding the association between the informant-reported subjective memory decline (informant report) and Alzheimer disease (AD) biomarkers.
Neurocognitive Dysfunction With Neuronal Injury in People With HIV on Long-Duration Antiretroviral Therapy.
McMahan, Cynthia BS; Dietrich, Devon K. BA; Horne, Elizabeth F. BA; Kelly, Erin BA; Geannopoulos, Katrina MD; Siyahhan Julnes, Peter Selim MD; Ham, Lillian BA; Santamaria, Ulisses BA; Lau, Chuen-Yen MD; Wu, Tianxia PhD; Hsieh, Hsing-Chuan MPH; Ganesan, Anuradha MD; Berjohn, Catherine MD, MPH; Kapetanovic, Suad MD; Reich, Daniel S. MD, PhD; Nair, Govind PhD; Snow, Joseph PhD; Agan, Brian K. MD; Nath, Avindra MD; Smith, Bryan R. MD
doi : 10.1212/WNL.0000000000207339
Neurologic outcomes in people with HIV (PWH) on long-duration antiretroviral therapy (ART) are not fully understood, and the underlying pathophysiology is unclear.
Clinical and Demographic Characteristics, Mechanisms, and Outcomes in Patients With Acute Ischemic Stroke and Newly Diagnosed or Known Active Cancer.
Costamagna, Gianluca MD; Hottinger, Andreas MD; Milionis, Haralampos MD; Lambrou, Dimitris PhD; Salerno, Alexander MD; Strambo, Davide MD; Livio, Francoise MD; Navi, Babak Benjamin MD; Michel, Patrik MD
doi : 10.1212/WNL.0000000000207341
Patients with a new diagnosis of cancer carry an increased risk of acute ischemic stroke (AIS), and this risk varies depending on age, cancer type, stage, and time from diagnosis.
Biological Mechanism of Sex Difference in Stroke Manifestation and Outcomes.
Ryu, Wi-Sun MD, PhD *; Chung, Jinyong PhD *; Schellingerhout, Dawid MD; Jeong, Sang-Wuk MD, PhD; Kim, Hang-Rai MD, PhD; Park, Jung E. MD, PhD; Kim, Beom Joon MD, PhD; Kim, Joon-Tae MD, PhD; Hong, Keun-Sik MD, PhD; Lee, Kyungbok MD, PhD; Park, Tai Hwan MD, PhD; Park, Sang-Soon MD; Park, Jong-Moo MD, PhD; Kang, Kyusik MD, PhD; Cho, Yong-Jin MD, PhD; Park, Hong-Kyun MD, MSc; Lee, Byung-Chul MD, PhD; Yu, Kyung-Ho MD, PhD; Oh, Mi Sun MD, PhD; Lee, Soo Joo MD, PhD; Kim, Jae Guk MD, MSc; Cha, Jae-Kwan MD, PhD; Kim, Dae-Hyun MD, PhD; Lee, Jun MD, PhD; Han, Moon-Ku MD, PhD; Park, Man Seok MD; Choi, Kang-Ho MD, PhD; Lee, Juneyoung PhD; Bae, Hee-Joon MD, PhD; Kim, Dong-Eog MD, PhD
doi : 10.1212/WNL.0000000000207346
Female patients tend to have greater disability and worse long-term outcomes after stroke than male patients. To date, the biological basis of sex difference in ischemic stroke remains unclear.
A Focus on Subtle Signs and Motor Behavior to Unveil Awareness in Unresponsive Brain-Impaired Patients: The Importance of Being Clinical.
Diserens, Karin MD *; Meyer, Ivo A. MD *; Johr, Jane PhD; Pincherle, Alessandro MD; Dunet, Vincent MD; Pozeg, Polona PhD; Ryvlin, Philippe MD, PhD; Muresanu, Dafin F. MD, PhD; Stevens, Robert D. MD; Schiff, Nicholas D. MD
doi : 10.1212/WNL.0000000000207067
AB Brain-injured patients in a state of cognitive motor dissociation (CMD) exhibit a lack of command following using conventional neurobehavioral examination tools but a high level of awareness and language processing when assessed using advanced imaging and electrophysiology techniques.
Bridging the Gap: Tailoring an Approach to Treatment in Febrile Infection-Related Epilepsy Syndrome.
Goh, Yihui MBBS; Tay, Sen Hee MBBS; Yeo, Leonard Leong Litt MBBS; Rathakrishnan, Rahul BM
doi : 10.1212/WNL.0000000000207068
AB Cytokine profiling before immunotherapy is increasingly prevalent in febrile infection-related epilepsy syndrome (FIRES). In this case, an 18-year-old man presented with first-onset seizure after a nonspecific febrile illness.
Clinical Reasoning: Progressive Hemiparesis and White Matter Abnormalities in an HIV-Negative Patient.
Jabbari, Edwin MD, PhD; Ruiz, Fernanda MD; Lee, Simon F.K. MD, PhD; Jabeen, Farrah MD; Brandner, Sebastian MD; Kidd, Desmond P. MD, PhD; Manji, Hadi MD, PhD; Batla, Amit MD, PhD
doi : 10.1212/WNL.0000000000207096
AB A 61-year-old man from India was admitted to hospital after being found unresponsive by the roadside. He was treated with dual-antiplatelet therapy for an acute coronary syndrome. Ten days into admission, he had mild left-sided face, arm, and leg weakness, which progressed significantly over the next 2 months in association with progressive white matter abnormalities on brain MRI.
Teaching NeuroImage: Subacute Quadriparesis From Intramedullary Spinal Cord Infiltrating Glioma With TERT Promoter Mutation.
Gritsch, Simon DrMed, MD; Aghajan, Yasmin MD; Kozanno, Liana MD, PhD; Chiu, Daniel MD, MPH; Jordan, Justin T. MD, MPH; Frosch, Matthew P. MD, PhD; Shankar, Ganesh MD, PhD; Kimberly, W. Taylor MD, PhD
Editors' Note: Pioglitazone Use and Reduced Risk of Dementia in Patients With Diabetes Mellitus With a History of Ischemic Stroke.
Lewis, Ariane MD; Galetta, Steven MD
Reader Response: Pioglitazone Use and Reduced Risk of Dementia in Patients With Diabetes Mellitus With a History of Ischemic Stroke.
Author Response: Pioglitazone Use and Reduced Risk of Dementia in Patients With Diabetes Mellitus With a History of Ischemic Stroke.
Kim, Eosu
Pregnancy and Stress: Thinking Beyond Seizure Control in Women With Epilepsy.
Rosengard, Jillian L. MD *; Haut, Sheryl R. MD *
doi : 10.1212/WNL.0000000000207391
Volume 100(24) pgs. 1121-1167,e2424-e2520 June 13, 2023
Can an Intervention Be Cost-effective Following a Negative Clinical Trial?.
Ney, John MD, MPH; van der Goes, David Noel PhD
Toward a Patient-Specific Readout of Neurodegeneration: The Case for Spatial Normative Modeling in Alzheimer Disease.
Sinha, Nishant PhD; Gugger, James J. MD, PharmD
Examining Unresponsive Patients: Basics Come First.
Rabinstein, Alejandro A. MD
Life Stressors During Pregnancy in Women With Epilepsy: Results From the Pregnancy Risk Assessment Monitoring System.
Chaudhry, Naveed MD; Bergey, Gregory K. MD; Kaplan, Peter W. MBBS, FRCP; Johnson, Emily L. MD
doi : 10.1212/WNL.0000000000207274
To compare specific life stressors and domestic abuse that pregnant women and others with epilepsy (WWE) experience compared with pregnant women and others without epilepsy (WWoE).
Cost-effectiveness of Prednisolone to Treat Bell Palsy in Children: An Economic Evaluation Alongside a Randomized Controlled Trial.
Xiong, Xiuqin MPH; Huang, Li PhD; Herd, David W. MBBS; Borland, Meredith L. MBBS; Davidson, Andrew MD; Hearps, Stephen MBiostat; Mackay, Mark T. PhD; Lee, Katherine J. PhD; Dalziel, Stuart R. PhD; Dalziel, Kim PhD; Cheek, John A. MBBS; Babl, Franz E. MD
doi : 10.1212/WNL.0000000000207284
AB Background and Objectives: Bell palsy is the third most frequent diagnosis in children with sudden-onset neurologic dysfunction. The cost-effectiveness of treating Bell palsy with prednisolone in children is unknown.
Revealing Individual Neuroanatomical Heterogeneity in Alzheimer Disease Using Neuroanatomical Normative Modeling.
Verdi, Serena MPhil; Kia, Seyed Mostafa PhD; Yong, Keir X.X. PhD; Tosun, Duygu PhD; Schott, Jonathan M. MD; Marquand, Andre F. PhD *; Cole, James H. PhD *
doi : 10.1212/WNL.0000000000207298
Alzheimer disease (AD) is highly heterogeneous, with marked individual differences in clinical presentation and neurobiology. To explore this, we used neuroanatomical normative modeling to index regional patterns of variability in cortical thickness.
Association of the Informant-Reported Memory Decline With Cognitive and Brain Deterioration Through the Alzheimer Clinical Continuum.
Kuhn, Elizabeth PhD; Perrotin, Audrey PhD; La Joie, Renaud PhD; Touron, Edelweiss PhD; Dautricourt, Sophie MD; Vanhoutte, Matthieu PhD; Vivien, Denis PhD; de La Sayette, Vincent MD; Chetelat, Gael PhD; for the Alzheimer's Disease Neuroimaging Initiative
doi : 10.1212/WNL.0000000000207338
Studies are sparse regarding the association between the informant-reported subjective memory decline (informant report) and Alzheimer disease (AD) biomarkers.
Neurocognitive Dysfunction With Neuronal Injury in People With HIV on Long-Duration Antiretroviral Therapy.
McMahan, Cynthia BS; Dietrich, Devon K. BA; Horne, Elizabeth F. BA; Kelly, Erin BA; Geannopoulos, Katrina MD; Siyahhan Julnes, Peter Selim MD; Ham, Lillian BA; Santamaria, Ulisses BA; Lau, Chuen-Yen MD; Wu, Tianxia PhD; Hsieh, Hsing-Chuan MPH; Ganesan, Anuradha MD; Berjohn, Catherine MD, MPH; Kapetanovic, Suad MD; Reich, Daniel S. MD, PhD; Nair, Govind PhD; Snow, Joseph PhD; Agan, Brian K. MD; Nath, Avindra MD; Smith, Bryan R. MD
doi : 10.1212/WNL.0000000000207339
Neurologic outcomes in people with HIV (PWH) on long-duration antiretroviral therapy (ART) are not fully understood, and the underlying pathophysiology is unclear.
Clinical and Demographic Characteristics, Mechanisms, and Outcomes in Patients With Acute Ischemic Stroke and Newly Diagnosed or Known Active Cancer.
Costamagna, Gianluca MD; Hottinger, Andreas MD; Milionis, Haralampos MD; Lambrou, Dimitris PhD; Salerno, Alexander MD; Strambo, Davide MD; Livio, Francoise MD; Navi, Babak Benjamin MD; Michel, Patrik MD
doi : 10.1212/WNL.0000000000207341
Patients with a new diagnosis of cancer carry an increased risk of acute ischemic stroke (AIS), and this risk varies depending on age, cancer type, stage, and time from diagnosis.
Biological Mechanism of Sex Difference in Stroke Manifestation and Outcomes.
Ryu, Wi-Sun MD, PhD *; Chung, Jinyong PhD *; Schellingerhout, Dawid MD; Jeong, Sang-Wuk MD, PhD; Kim, Hang-Rai MD, PhD; Park, Jung E. MD, PhD; Kim, Beom Joon MD, PhD; Kim, Joon-Tae MD, PhD; Hong, Keun-Sik MD, PhD; Lee, Kyungbok MD, PhD; Park, Tai Hwan MD, PhD; Park, Sang-Soon MD; Park, Jong-Moo MD, PhD; Kang, Kyusik MD, PhD; Cho, Yong-Jin MD, PhD; Park, Hong-Kyun MD, MSc; Lee, Byung-Chul MD, PhD; Yu, Kyung-Ho MD, PhD; Oh, Mi Sun MD, PhD; Lee, Soo Joo MD, PhD; Kim, Jae Guk MD, MSc; Cha, Jae-Kwan MD, PhD; Kim, Dae-Hyun MD, PhD; Lee, Jun MD, PhD; Han, Moon-Ku MD, PhD; Park, Man Seok MD; Choi, Kang-Ho MD, PhD; Lee, Juneyoung PhD; Bae, Hee-Joon MD, PhD; Kim, Dong-Eog MD, PhD
doi : 10.1212/WNL.0000000000207346
Female patients tend to have greater disability and worse long-term outcomes after stroke than male patients. To date, the biological basis of sex difference in ischemic stroke remains unclear.
A Focus on Subtle Signs and Motor Behavior to Unveil Awareness in Unresponsive Brain-Impaired Patients: The Importance of Being Clinical.
Diserens, Karin MD *; Meyer, Ivo A. MD *; Johr, Jane PhD; Pincherle, Alessandro MD; Dunet, Vincent MD; Pozeg, Polona PhD; Ryvlin, Philippe MD, PhD; Muresanu, Dafin F. MD, PhD; Stevens, Robert D. MD; Schiff, Nicholas D. MD
doi : 10.1212/WNL.0000000000207067
AB Brain-injured patients in a state of cognitive motor dissociation (CMD) exhibit a lack of command following using conventional neurobehavioral examination tools but a high level of awareness and language processing when assessed using advanced imaging and electrophysiology techniques.
Bridging the Gap: Tailoring an Approach to Treatment in Febrile Infection-Related Epilepsy Syndrome.
Goh, Yihui MBBS; Tay, Sen Hee MBBS; Yeo, Leonard Leong Litt MBBS; Rathakrishnan, Rahul BM
doi : 10.1212/WNL.0000000000207068
AB Cytokine profiling before immunotherapy is increasingly prevalent in febrile infection-related epilepsy syndrome (FIRES). In this case, an 18-year-old man presented with first-onset seizure after a nonspecific febrile illness.
Clinical Reasoning: Progressive Hemiparesis and White Matter Abnormalities in an HIV-Negative Patient.
Jabbari, Edwin MD, PhD; Ruiz, Fernanda MD; Lee, Simon F.K. MD, PhD; Jabeen, Farrah MD; Brandner, Sebastian MD; Kidd, Desmond P. MD, PhD; Manji, Hadi MD, PhD; Batla, Amit MD, PhD
doi : 10.1212/WNL.0000000000207096
AB A 61-year-old man from India was admitted to hospital after being found unresponsive by the roadside. He was treated with dual-antiplatelet therapy for an acute coronary syndrome. Ten days into admission, he had mild left-sided face, arm, and leg weakness, which progressed significantly over the next 2 months in association with progressive white matter abnormalities on brain MRI.
Teaching NeuroImage: Subacute Quadriparesis From Intramedullary Spinal Cord Infiltrating Glioma With TERT Promoter Mutation.
Gritsch, Simon DrMed, MD; Aghajan, Yasmin MD; Kozanno, Liana MD, PhD; Chiu, Daniel MD, MPH; Jordan, Justin T. MD, MPH; Frosch, Matthew P. MD, PhD; Shankar, Ganesh MD, PhD; Kimberly, W. Taylor MD, PhD
Editors' Note: Pioglitazone Use and Reduced Risk of Dementia in Patients With Diabetes Mellitus With a History of Ischemic Stroke.
Lewis, Ariane MD; Galetta, Steven MD
Reader Response: Pioglitazone Use and Reduced Risk of Dementia in Patients With Diabetes Mellitus With a History of Ischemic Stroke.
Author Response: Pioglitazone Use and Reduced Risk of Dementia in Patients With Diabetes Mellitus With a History of Ischemic Stroke.
Kim, Eosu
