Digestive Diseases and Sciences

Social media (SoMe) can be an effective professional tool for the gastroenterologist or trainee. SoMe can support a gastroenterologist’s efforts to brand themselves, network, learn, educate, and advocate for patients. SoMe for professional use should be approached with specific aims in mind, in order to optimize impact and productivity.

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Endoscopic Ultrasound-Guided Gallbladder Drainage

Zain A. SobaniChristina LingTarun Rustagi

doi : 10.1007/s10620-020-06520-y

Digestive Diseases and Sciences volume 66, pages2154–2161 (2021)

The mainstay of management of acute cholecystitis is surgical. Despite the advances in anesthesia and laparoscopic surgery, there is a significant pool of patients that are not candidates for surgery given their significant comorbidities and limited functional reserve. Historically percutaneous gallbladder drainage has been utilized to temporize these patients. Recently, endoscopic approaches are being explored with transpapillary and transmural drainage. In this article, we discuss the background, current status, technical challenges, adverse events, and outcomes of endoscopic ultrasound-guided gallbladder drainage for management of acute cholecystitis.

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Viral-Attributed Acute Pancreatitis: A Systematic Review

C. Roberto Simons-LinaresZaid ImamPrabhleen Chahal

doi : 10.1007/s10620-020-06531-9

Digestive Diseases and Sciences volume 66, pages2162–2172 (2021)

Infectious etiologies are rare cause of acute pancreatitis (AP). We sought to investigate the frequency of viral-attributed AP (VIAP) and describe its natural course and clinical features. Comprehensive review of PubMed and EMBASE in English until December 31, 2019, was performed. AP diagnosis and severity were defined per the Revised Atlanta Classification. Viral infections were diagnosed by serology and/or histology. A diagnosis of viral infection, with a concurrent AP diagnosis, a temporal resolution of both entities, and the attempt to exclude the most common etiologies of AP defined VIAP. Two independent reviewers reviewed eligible publications. Bias risk was assessed with the Murad tool. A total of 209 cases identified in 128 publications met inclusion criteria. Mean age was 38.9?±?1.28 years. Male-to-female ratio was 2.2:1, and 28% of patients were immunocompromised. Viral hepatitis (A, B, C, D and E) was the most common virus and accounted for 34.4% of cases, followed by coxsackie and echoviruses (14.8%), hemorrhagic fever viruses (12.4%), CMV (12.0%), VZV (10.5%), mumps and measles (3.8%), primary HIV infection (3.8%), HSV (1.9%), EBV (1.9%), and the remainder of cases (2.9%) attributed to adenovirus, influenza H1N1, and multiple viruses. Severity of AP was: 43.1% mild, 11.7% moderately severe, 32.4% severe. Death occurred in 42 (20.1%) patients. A significant portion of VIAP patients were immunocompromised (28.0%) and accounted for 71.4% of mortality cases. Mortality was higher than that reported for AP from other etiologies in the literature.

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CEing More—Assessing Small Bowel Crohn’s with Capsule Endoscopy (CE)

Carlo Calabrese,Nikolas Dussias,Nico Pagano

doi : 10.1007/s10620-021-06966-8

Digestive Diseases and Sciences volume 66, pages2173–2176 (2021)

Small bowel involvement is very common in Crohn’s disease. Ileocolonoscopy, cross-sectional imaging modalities, and video capsule endoscopy are the tools currently used to investigate such involvement.

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Author Spotlight: Nikolas Konstantine Dussias

Nikolas Konstantine Dussias

doi : 10.1007/s10620-021-06964-w

Digestive Diseases and Sciences volume 66, page2177 (2021)

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Strongyloides Superinfection After Liver Transplantion

Andrew Ofosu,John Higgins,Monique T. Barakat

doi : 10.1007/s10620-020-06696-3

Digestive Diseases and Sciences volume 66, pages2178–2182 (2021)

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Author Spotlight: Andrew Ofosu

Andrew Ofosu

doi : 10.1007/s10620-020-06738-w

Digestive Diseases and Sciences volume 66, page2183 (2021)

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Author Spotlight: Joseph S. Frye

Joseph S. Frye

doi : 10.1007/s10620-020-06739-9

Digestive Diseases and Sciences volume 66, page2184 (2021)

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HCC You Cannot See

Vaishnavi Boppana,Sakshi Sahni,Denis M McCarthy

doi : 10.1007/s10620-021-07070-7

Digestive Diseases and Sciences volume 66, pages2185–2189 (2021)

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“Sarc” Attack: Rectal Bleeding in an Elderly Patient with Small Bowel Crohn’s Disease

Dania Hudhud,Guangjing Zhu,Raymond K. Cross

doi : 10.1007/s10620-021-07041-y

Digestive Diseases and Sciences volume 66, pages2190–2193 (2021)

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Challenges and Opportunities in Social Media Research in Gastroenterology

Joy W. ChangEvan S. Dellon

doi : 10.1007/s10620-021-07058-3

Digestive Diseases and Sciences volume 66, pages2194–2199 (2021)

In recent years, social media has transformed how we as gastroenterologists communicate with each other and has grown into an arena of knowledge and peer support for patients. Gastroenterologists commonly use social media for education networking, patient populations use social media for peer support and advocacy, but little is known about how gastroenterologists can use social media to conduct thoughtful and rigorous patient-centered research. Therefore, we aim to introduce the scope of social media research, highlight prominent examples in gastroenterology, and review innovative opportunities and unique challenges to using and studying social media for research.

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Black Race and Public Insurance Are Predictive of Inappropriate Evaluation of Iron Deficiency Anemia and Diarrhea

Adjoa Anyane-Yeboa,Betty Li,David T. Rubin

doi : 10.1007/s10620-020-06434-9

Digestive Diseases and Sciences volume 66, pages2200–2206 (2021)

Socioeconomic status, race, and insurance can impact healthcare delivery and utilization in several chronic disease states. The primary aim of our study was to determine whether race and insurance status are predictors of having an appropriate workup for celiac disease and inflammatory bowel disease (IBD) when presenting with iron deficiency anemia (IDA) and chronic diarrhea.

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Concise Commentary: Ironing Out the Differences–Healthcare Disparities in the Evaluation of IDA and Diarrhea

Sarah Lopatin,Sophie Balzora

doi : 10.1007/s10620-020-06572-0

Digestive Diseases and Sciences volume 66, pages2207–2208 (2021)

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Quality and Content of Online Patient Resources for Celiac Disease

Alison Buseck,Benjamin Lebwohl,Peter H. R. Green

doi : 10.1007/s10620-020-06537-3

Digestive Diseases and Sciences volume 66, pages2209–2215 (2021)

Patient-directed information on celiac disease has been reported to be of variable quality. We assessed the quantity and quality of information on blogs and Web sites intended to inform the layperson of celiac disease information.

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Role of Hospital Teaching Status on Outcomes of Patients with Inflammatory Bowel Disease: A Nationwide Analysis

Sachit Sharma, Simcha Weissman ,Arun Swaminath

doi : 10.1007/s10620-020-06497-8

Digestive Diseases and Sciences (2020)

Data regarding hospitalization outcomes in patients with inflammatory bowel disease (IBD) with respect to hospital teaching status are largely unknown.

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Real-World Use of Colonoscopy in an Older Population: A Nationwide Standard Cohort Study Using a Common Data Model

Ha Il Kim, Jin Young Yoon, Jae Myung Cha

doi : 10.1007/s10620-020-06494-x

Digestive Diseases and Sciences volume 66, pages2227–2234 (2021)

Rapid population aging is considered to be a major factor in increased colonoscopy use in Korea. However, real-world use of colonoscopy in older populations is rarely evaluated using Korean databases.

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Does Provider Type Affect Bone Health Surveillance in Chronic Pancreatitis?

Padmavathi Srivoleti ,Allison L. Yang ,Julia McNabb-Baltar

doi : 10.1007/s10620-020-06542-6

Digestive Diseases and Sciences volume 66, pages2235–2239 (2021)

Bone density screening (DEXA) and vitamin D serum assay (Vit-D) are recommended in chronic pancreatitis, but adherence by providers is unknown.

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Racial and Socioeconomic Disparities in Hospitalization of Pediatrics with Liver Disease from 2005 to 2015

Melissa Martin ,Biyao Zou ,Mindie H. Nguyen

doi : 10.1007/s10620-020-06530-w

Digestive Diseases and Sciences volume 66, pages2240–2249 (2021)

Adult liver-related hospitalizations have recently increased in the USA, but data are limited for the pediatric population.

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Enteropathogenic Escherichia coli Infection Inhibits Intestinal Ascorbic Acid Uptake via Dysregulation of Its Transporter Expression

Christopher W. Heskett ,Trevor Teafatiller ,Veedamali S. Subramanian

doi : 10.1007/s10620-020-06389-x

Digestive Diseases and Sciences volume 66, pages2250–2260 (2021)

Enteropathogenic Escherichia coli (EPEC) infection causes prolonged, watery diarrhea leading to morbidity and mortality. Although EPEC infection impacts nutrient transporter function and expression in intestinal epithelial cells, the effects of EPEC infection on intestinal absorption of ascorbic acid (AA) have not yet been investigated.

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CircRNA Hsa_circ_0001017 Inhibited Gastric Cancer Progression via Acting as a Sponge of miR-197

Hui Li ,ChangPing Shan, ChengJiu Hu

doi : 10.1007/s10620-020-06516-8

Digestive Diseases and Sciences volume 66, pages2261–2271 (2021)

Gastric cancer (GC) is one of the most common digestive system diseases and yet lacks effective therapeutic regimen.

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MiR-137-3p Inhibits Colorectal Cancer Cell Migration by Regulating a KDM1A-Dependent Epithelial–Mesenchymal Transition

Xiaoling Ding ,Jie Zhang ,Xiaorong Zhou

doi : 10.1007/s10620-020-06518-6

Digestive Diseases and Sciences volume 66, pages2272–2282 (2021)

In colorectal cancer (CRC), miR-137-3p downregulation is associated with disease progression, but the mechanism is not fully understood. KDM1A, also known as LSD1, is upregulated in various cancer and promotes tumor metastasis. Interestingly, miR-137-3p is downregulated by hypoxia, which plays critical roles in tumor metastasis, and KDM1A is a miR-137-3p target gene in brain tumors.

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Pancreas Divisum Increases the Risk of Recurrent Acute Pancreatitis in Patients with rs12338 Polymorphism in the Cathepsin B Gene

Rupjyoti Talukdar ,Mohsin Aslam ,B. Govardhan

doi : 10.1007/s10620-020-06517-7

Digestive Diseases and Sciences volume 66, pages2283–2290 (2021)

Pancreas divisum (PD) as a cause of pancreatitis has been debated. In this study, we report the association of multiple gene polymorphisms on the risk of RAP in the presence of PD.

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Subjective Symptoms in Patients with Eosinophilic Esophagitis Are Related to Esophageal Wall Thickness and Esophageal Body Pressure

Koichi Muroi ,Naomi Kakushima ,Mitsuhiro Fujishiro

doi : 10.1007/s10620-020-06527-5

Digestive Diseases and Sciences volume 66, pages2291–2300 (2021)

Endoscopic ultrasonography (EUS) and high-resolution manometry (HRM) can be used in the evaluation of eosinophilic esophagitis (EoE) for frequent symptoms such as dysphagia. However, the role of these examinations is not clear.

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EoE Down Under Is Still EoE: Variability in Provider Practice Patterns in Australia and New Zealand Among Pediatric Gastroenterologists

Ajay Sharma,Swathi Eluri ,Evan S. Dellon

doi : 10.1007/s10620-020-06534-6

Digestive Diseases and Sciences volume 66, pages2301–2310 (2021)

There is likely variation in approach and management of patient with EoE due to lack of standardized care and variation in guidelines. We aimed to identify current practices regarding diagnosis and treatment in children with eosinophillic esophagitis (EoE) in Australia and New Zealand (ANZ).

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The Prevalence of Barrett’s Esophagus Among a Saudi Arabian Population

Majid Alsahafi ,Hebah Mimish ,Mahmoud Mosli

doi : 10.1007/s10620-020-06503-z

Digestive Diseases and Sciences volume 66, pages2311–2316 (2021)

While gastroesophageal reflux disease (GERD) is common in Middle Eastern countries, little data exists on the epidemiology of Barrett’s esophagus (BE).

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Esophageal Columnar Metaplasia in Childhood: A Population-Based Case Series Analysis

Leah Twohig-Bennett ,Helen G. Coleman ,Brian T. Johnston

doi : 10.1007/s10620-020-06462-5

Digestive Diseases and Sciences volume 66, pages2317–2322 (2021)

Adults with Barrett’s esophagus (BE) are often entered into surveillance for esophageal adenocarcinoma (EAC), although cancer risk is relatively low. BE can be detected in children (<?16 years). Little is known about the epidemiology of pediatric BE, and it is unclear what the optimal surveillance regimes are in children.

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Systematic Review and Meta-Analyses Assessment of the Clinical Efficacy of Bismuth Subsalicylate for Prevention and Treatment of Infectious Diarrhea

Jose M. Brum ,Roger D. Gibb ,Bruce R. Yacyshyn

doi : 10.1007/s10620-020-06509-7

Digestive Diseases and Sciences volume 66, pages2323–2335 (2021)

A large number of studies have evaluated the pharmacology, safety, and/or efficacy of bismuth subsalicylate for the relief of common gastrointestinal symptoms, diarrhea and vomiting due to acute gastroenteritis. In addition, short-term (48 h) medication with bismuth subsalicylate is known to be effective against infectious gastroenteritis such as travelers’ diarrhea.

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Endoscopic Closure Utilizing Endoloop and Endoclips After Gastric Endoscopic Submucosal Dissection for Patients on Antithrombotic Therapy

Mai Ego ,Seiichiro Abe ,Yutaka Saito

doi : 10.1007/s10620-020-06508-8

Digestive Diseases and Sciences volume 66, pages2336–2344 (2021)

Antithrombotic therapy is a well-known independent risk factor for bleeding after endoscopic submucosal dissection (ESD) of early gastric cancer (EGC). A novel method of ulcer base closure using an endoloop and endoclips has been reported. This study aimed to evaluate the effectiveness of endoscopic closure using an endoloop and endoclips in preventing post-ESD bleeding in patients undergoing gastric ESD on antithrombotic therapy.

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Rectal Distension Increased the Rectoanal Gradient in Patients with Normal Rectal Sensory Function

Leila Neshatian ,Mary-Jane O. U. Williams ,Eamonn M. Quigley

doi : 10.1007/s10620-020-06519-5

Digestive Diseases and Sciences (2020)

Frequent observation of abnormal manometric patterns consistent with dyssynergia in healthy volunteers has warranted the need for reassessment of the current methods to enhance the diagnostic value of anorectal manometry in functional defecatory disorders. Whether rectal distention at simulated evacuation will affect anorectal pressure profile and increase rectoanal gradient is not known.

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Management of Less Than 10-mm-Sized Pedunculated (Ip) Polyps with Thin Stalk: Hot Snare Polypectomy Versus Cold Snare Polypectomy

Jun Arimoto ,Hideyuki Chiba ,Atsushi Nakajima

doi : 10.1007/s10620-020-06436-7

Digestive Diseases and Sciences volume 66, pages2353–2361 (2021)

Although the use of cold snare polypectomy (CSP) has spread rapidly, its safety for pedunculated (Ip) polyps remains controversial. In particular, the outcomes of hot snare polypectomy (HSP) and CSP for Ip polyps have not been previously compared.

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Unusual Sites of Necrotic Collections in Acute Necrotizing Pancreatitis: Association with Parenchymal Necrosis and Clinical Outcomes

Pankaj Gupta ,Mandeep Virk ,Rakesh Kochhar

doi : 10.1007/s10620-020-06526-6

Digestive Diseases and Sciences volume 66, pages2362–2367 (2021)

The presence of necrotic collection in acute necrotizing pancreatitis (ANP) at intra-abdominal sites other than the retroperitoneum has not been systematically studied.

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Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies

Hongjuan Fu, Jie Zeng ,Hui Chang

doi : 10.1007/s10620-020-06525-7

Digestive Diseases and Sciences volume 66, pages2368–2379 (2021)

Pancreatic cancer is one of the most fatal malignancies and primary prevention strategies are limited. Epidemiological studies focusing on the association between folate intake and pancreatic cancer risk have reported inconsistent findings.

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Understanding Fatigue in Primary Biliary Cholangitis

Naw April Phaw ,Jessica Katharine Dyson ,David Jones

doi : 10.1007/s10620-020-06502-0

Digestive Diseases and Sciences volume 66, pages2380–2386 (2021)

Fatigue affects 50% of primary biliary cholangitis patients and is severe in approximately 20%, significantly affecting quality of life. The pathogenesis of fatigue in primary biliary cholangitis is poorly understood. This study aimed to explore subgroups of fatigue to support targeting of selected groups in future clinical trials.

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External Validation of Four Point-of-Care Noninvasive Scores for Predicting Advanced Hepatic Fibrosis in a Predominantly Hispanic NAFLD Population

Maya Balakrishnan ,Aradhna Seth ,Aaron P. Thrift

doi : 10.1007/s10620-020-06501-1

Digestive Diseases and Sciences volume 66, pages2387–2393 (2021)

The development of point-of-care biomarkers of disease has become a major focus of interest in nonalcoholic fatty liver disease (NAFLD). The NAFLD fibrosis score (NFS), BARD, FIB-4, and aspartate aminotransferase-to-platelet ratio index (APRI) are commonly used for advanced NAFLD fibrosis prediction. However, the performance of these scores among in a predominantly Hispanic patient population, a population with the highest prevalence of NAFLD, has not been examined.

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Nonalcoholic Fatty Liver Disease Risk Factors Affect Liver-Related Outcomes After Direct-Acting Antiviral Treatment for Hepatitis C

Jihane N. Benhammou ,Andrew M. Moon ,George N. Ioannou

doi : 10.1007/s10620-020-06457-2

Digestive Diseases and Sciences volume 66, pages2394–2406 (2021)

In hepatitis C (HCV) patients, obesity and/or diabetes may increase the risk of liver-related outcomes. We aimed to determine whether diabetes and/or obesity are associated with adverse outcomes in direct-acting antiviral (DAA)-treated HCV patients.

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Interactive Impacts from Hepatitis C Virus Infection and Mixed Cryoglobulinemia on Complement Levels

Ming-Ling Chang ,Jing-Hong Hu ,Rong-Nan Chien

doi : 10.1007/s10620-020-06507-9

Digestive Diseases and Sciences volume 66, pages2407–2416 (2021)

How hepatitis C virus (HCV) infection and mixed cryoglobulinemia interactively affect complement levels remains elusive, and we aimed to elucidate it.

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Comparison of Tenofovir Disoproxil Fumarate and Entecavir in the Prophylaxis of HBV Reactivation

Bilal Toka ,Aydin Seref Koksal ,Erkan Parlak

doi : 10.1007/s10620-020-06506-w

Digestive Diseases and Sciences volume 66, pages2417–2426 (2021)

Current guidelines recommend starting antiviral prophylaxis to prevent hepatitis B virus (HBV) reactivation in patients receiving immunosuppressive treatments (IST). The aim of this study was to compare the efficacy of entecavir (ETV) and tenofovir disoproxil fumarate (TDF) for prophylaxis.

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Direct-Acting Antivirals Improve Treatment Outcomes in Patients with Hepatitis C Virus-Related Hepatocellular Carcinoma Treated with Transarterial Chemoembolization: A Nationwide, Multi-center, Retrospective Cohort Study

Hye Kyung Hyun ,Eun Ju Cho ,The Korean TACE Study Group

doi : 10.1007/s10620-020-06533-7

Digestive Diseases and Sciences volume 66, pages2427–2438 (2021)

The influence of direct-acting antivirals (DAAs) on chronic hepatitis C (CHC)-related hepatocellular carcinoma (HCC) remains controversial. We investigated the effect of eradicating CHC using DAAs on treatment outcomes in patients with CHC-related HCC treated with transarterial chemoembolization (TACE).

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Incidence of Hepatocellular Carcinoma in Primary Biliary Cholangitis: A Systematic Review and Meta-Analysis

Yamini Natarajan ,Aylin Tansel ,Fasiha Kanwal

doi : 10.1007/s10620-020-06498-7

Digestive Diseases and Sciences volume 66, pages2439–2451 (2021)

The risk and determinants of HCC in patients with primary biliary cholangitis (PBC) are unclear. We conducted a systematic review and meta-analysis of the incidence of HCC and risk factors associated with HCC risk among patients with PBC.

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Volume–Function Analysis (LiMAx Test) in Patients with HCC and Cirrhosis Undergoing TACE—A Feasibility Study

Matthias Christian Reicher ,tAlexander Massmann ,Maciej Malinowski

doi : 10.1007/s10620-020-06535-5

Digestive Diseases and Sciences volume 66, pages2452–2460 (2021)

Transarterial chemoembolization (TACE) is an important therapy for hepatocellular carcinoma (HCC) in cirrhosis. In particular in advanced cirrhosis, post-TACE hepatic failure liver (PTHF) failure may develop. Currently, there is no standardization for the periinterventional risk assessment. The liver maximum capacity (LiMAx) test assesses the functional liver capacity, but has not been investigated in this setting.

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