Ende, Holly B. 1; Rathmell, James P. 2; Wanderer, Jonathan P. 3
Todd, Michael M. M.D. 1; Kopman, Aaron F. M.D. 2
Sleigh, Jamie W. M.D. 1; Voss, Logan Ph.D. 2
Bowdle, T. Andrew M.D., Ph.D., F.A.S.E. 1; Haththotuwegama, Kishanee J. B.S. 2; Jelacic, Srdjan M.D., F.A.S.E. 3; Nguyen, Sharon T. B.S. 4; Togashi, Kei M.D., M.P.H. 5; Michaelsen, Kelly E. M.D., Ph.D. 6
doi : 10.1097/ALN.0000000000004578
The dose of sugammadex recommended by the manufacturer for reversal of rocuronium is 2 mg/kg when the train-of-four count is 2 or more and 4 mg/kg when it is less than 2 but there is a posttetanic count of at least 1.
Meissner, Konrad M.D. 1; Dahan, Albert M.D., Ph.D. 2; Olofsen, Erik Ph.D. 3; Gopfert, Christine M.D. 4; Blood, Jane R.N., B.S.N. 5; Wieditz, Johannes Ph.D. 6; Kharasch, Evan D. M.D., Ph.D. 7
doi : 10.1097/ALN.0000000000004567
Balancing between opioid analgesia and respiratory depression continues to challenge clinicians in perioperative, emergency department, and other acute care settings.
Matava, Clyde T. M.B.Ch.B., M.Med., M.H.S.C. 1; Tighe, Nathaniel T. G. M.D., M.M. 2; Baertschiger, Reto M.D., Ph.D. 3; Wilder, Robert T. M.D., Ph.D. 4; Correll, Lynnie M.D., Ph.D. 5; Staffa, Steven J. M.S. 6; Zurakowski, David M.S., Ph.D. 7; Kato, Meredith A. M.D. 8; Meier, Petra M. M.D. 9; Raman, Vidya M.D., M.B.A. 10; Reddy, Srijaya K. M.D., M.B.A. 11; Roque, Remigio A. M.D. 12; Peterson, Melissa Brooks M.D. 13; Zhong, John M.D. 14; Edala, Thejovathi M.D. 15; Greer, Timothy J. M.B.B.S. 16; von Ungern-Sternberg, Britta S. M.D, Ph.D. 17; Cravero, Joseph M.D. 18; Simpao, Allan F. M.D., M.B.I. 19; for the PEACOC Collaborators; Ali, Anita Akbar M.D.; Al-Rabbat, Mohamad F. M.D.; Brzenski, Alyssa B. M.D.; Casey, William F. M.D., B.Ch., F.F.A.R.C.S.I.; Chhabada, Surendrasingh M.D.; Collin, Michael M.B.B.S., F.R.A.C.S.; Dhumak, Vipul J. M.D., M.P.H.; D'Mello, Ajay M.D.; Echeverry, Piedad C. M.D.; Ellison, Pavithra R. M.D., M.M.M.; Fernandez, Allison M. M.D., M.B.A.; Fisher, Jake A. M.D.; Fuller, Clinton L. M.D.; Glover, Chris D. M.D.; Guruswamy, Velu M.B.B.S., D.A., F.R.C.A., F.F.A.R.C.S.I., M.B.A.; Hesselink, Emily B. M.D.; Hunyady, Agnes I. M.D.; Lorinc, Amanda N. M.D.; King, Michael M.D.; Mihaila, Lavinia B.A.; Nelson, Jonathon H. M.D.; Ng, Ann S. M.D.; Ramjist, Joshua K. M.D., M.Sc.; Ravula, Nirop R. M.B.B.S., F.R.C.A.; Beel, Elizabeth Rossmann M.D., M.P.H.; Rugnathx, Rahil M.D.; Shaw, Robert E. M.D.; Sheth, Michelle M. M.D.; Sinha, Tripiti M.D.; Sommerfield, Aine B.Sc., Ph.D., M.Sc.; Soneru, Codruta M.D.; Templeton, Thomas W. M.D.; Williams, R.J. M.A.
doi : 10.1097/ALN.0000000000004570
COVID-19 forced healthcare systems to make unprecedented changes in clinical care processes. The authors hypothesized that the COVID-19 pandemic adversely impacted timely access to care, perioperative processes, and clinical outcomes for pediatric patients undergoing primary appendectomy.
Chang, Andrew S. M.S. 1; Wirak, Gregory S. Ph.D. 2; Li, Duan Ph.D. 3; Gabel, Christopher V. Ph.D. 4; Connor, Christopher W. M.D., Ph.D. 5
doi : 10.1097/ALN.0000000000004579
Suppression of behavioral and physical responses defines the anesthetized state. This is accompanied, in humans, by characteristic changes in electroencephalogram patterns.
Spencer, Kira A. Ph.D. 1; Woods, Christian B. B.S. 2; Worstman, Hailey M. B.A. 3; Johnson, Simon C. Ph.D. 4; Ramirez, Jan-Marino Ph.D. 5; Morgan, Philip G. M.D. 6; Sedensky, Margaret M. M.D. 7
doi : 10.1097/ALN.0000000000004577
A variety of molecular targets for volatile anesthetics have been suggested, including the anesthetic-sensitive potassium leak channel, TREK-1. Knockout of TREK-1 is reported to render mice resistant to volatile anesthetics, making TREK-1 channels compelling targets for anesthetic action.
Mihalko, Emily P. Ph.D. 1; Srinivasan, Amudan J. M.D. 2; Rahn, Katelin C. B.S. 3; Seheult, Jansen N. M.D. 4; Spinella, Philip C. M.D. 5; Cap, Andrew P. M.D., Ph.D. 6; Triulzi, Darrell J. M.D. 7; Yazer, Mark H. M.D. 8; Neal, Matthew D. M.D. 9; Shea, Susan M. Ph.D. 10
doi : 10.1097/ALN.0000000000004574
The use of low-titer group O whole blood is increasing. To reduce wastage, unused units can be converted to packed red blood cells. Supernatant is currently discarded post-conversion; however, it could be a valuable transfusable product.
Blitz, Jeanna D. M.D., F.A.S.A., D.F.P.M. 1
Goldstein, Joseph C. M.D. 1; Goldstein, Heidi V. M.D. 2
Mpody, Christian M.D., Ph.D., M.P.H., M.B.A. 1; Beltran, Ralph M.D.; Hayes, Seth M.D.; Nafiu, Olubukola O. M.D., F.R.C.A., M.S.; Tobias, Joseph D. M.D.
Lassola, Sergio M.D. 1; Miori, Sara M.D.; Sanna, Andrea M.D.; Umbrello, Michele M.D.; De Rosa, Silvia M.D., F.C.C.N.; Bellani, Giacomo M.D., Ph.D.
Ilfeld, Brian M. M.D., M.S. 1; Wagner, Rochelle Ph.D.
Feldman, Jeffrey M. M.D., M.S.E. 1
Fiadjoe, John M.D. 1; Sequera-Ramos, Luis M.D.; Kovatsis, Pete M.D.
Priebe, Hans-Joachim M.D. 1
Roth, Steven M.D., F.A.R.V.O. 1; Moss, Heather E. M.D., Ph.D.; Vajaranant, Thasarat Sutabutr M.D.; Sweitzer, BobbieJean M.D., F.A.C.P., S.A.M.B.A.-F., F.A.S.A.
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