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New Therapies and Management Options for Hepatitis D.
Martin, Paul MD, FACG 1; Jacobson, Ira M. MD, FACG 2
doi : 10.14309/ajg.0000000000002153
Volume 118(7) pgs. 1105-1302 July 2023
A Pragmatic Approach to the Management of Gastric Outlet Obstruction From Pancreaticobiliary Malignancy.
Ma, Michael MD 1; Benias, Petros C. MD 1; Trindade, Arvind J. MD 1,2
Use of the Stethoscope to Diagnose Gastrointestinal and Hepatic Disorders.
Brandt, Lawrence J. MD, MACG, AGAF, FASGE, NYSGEF 1,2
Paralysis of the Left Hemidiaphragm With Organ Distortion.
Zheng, Ting MD 1; Camilleri, Michael MD, DSc 1
Do Not Eat.
Hamidu, Rukaiya Bashir MD 1,2; Kalachi, Kourosh MD 1,2; Raufman, Jean-Pierre MD 1,2
"Open a Can of Worms": Eosinophilic Liver Infiltration Due to Clonorchis sinensis Infection.
Lan, Tian MD 1,2; Tai, Yang MD, PhD 1,2; Tang, Chengwei MD, PhD 1,2
Spontaneous Fistulization of Walled-Off Pancreatic Necrosis Into the Stomach.
Elfert, Khaled MD 1,2; Ho, Sammy MD 1,3
Neonatal Meckel's Diverticula With Perforation.
Shen, Yong MD 1; Lin, Yu MD 1; Ling, Wen MD 2; Zhuang, XiaoJin MD 3; Chen, Fei MD 1; Wu, DianMing MD 1; Fang, YiFan MD 1
Combined Anteroretrograde Endoscopic Rendezvous Approach for Placing a Colonic Stent in a Short Bowel Syndrome.
Fugazza, Alessandro MD 1; Andreozzi, Marta MD 1; Colombo, Matteo MD 1; Koleth, Glenn MD 1; Massimi, Davide MD 1; Spadaccini, Marco MD 1; Repici, Alessandro MD 1,2
Large Recurrent Lateral-Spreading Tumor Resected En Bloc With a Soft Bipolar Snare.
Yamamoto, Shunsuke MD, PhD, FJGES 1; Matsushima, Kensuke MD 1; Sakakibara, Yuko MD 1; Sakamori, Ryotaro MD, PhD 1; Mita, Eiji MD, PhD 1
Continuing Medical Education Questions: July 2023.
Hoppmann, Nicholas A. MD
doi : 10.14309/ajg.0000000000002341
AB Article Title: American College of Gastroenterology Acute Liver Failure Guidelines (C) The American College of Gastroenterology 2023. All Rights Reserved.
Continuing Medical Education Questions: July 2023.
Skeans, Jacob M. MD
doi : 10.14309/ajg.0000000000002343
AB Article Title: Diagnosis and Management of Cyclic Vomiting Syndrome: A Critical Review (C) The American College of Gastroenterology 2023. All Rights Reserved.
Acute Liver Failure Guidelines.
Shingina, Alexandra MD, MSc 1; Mukhtar, Nizar MD 2; Wakim-Fleming, Jamile MD, FACG 3; Alqahtani, Saleh MBChB, MS 4,5; Wong, Robert J. MD, MS, FACG 6; Limketkai, Berkeley N. MD, PhD, FACG 7; Larson, Anne M. MD 8; Grant, Lafaine MD 9
It Is Time for a Paradigm Shift in Design, Execution, and Publishing of Comparative Helicobacter pylori Treatment Trials.
Graham, David Y. MD, MACG 1
Diagnosis and Management of Cyclic Vomiting Syndrome: A Critical Review.
Frazier, Rosita MD 1; Li, B.U.K. MD 2; Venkatesan, Thangam MD 3
doi : 10.14309/ajg.0000000000002216
AB Cyclic vomiting syndrome (CVS) is a chronic disorder of gut-brain interaction characterized by recurrent disabling episodes of nausea, vomiting, and abdominal pain. CVS affects both children and adults with a prevalence of approximately 2% in the United States.
Yield of Repeat Endoscopy for Barrett's Esophagus After Normal Index Endoscopy.
Rubenstein, Joel H. MD, MS 1,2,3,4; Burns, Jennifer A. MHSA 1; Arasim, Maria E. MPT 1; Firsht, Elizabeth M. BSW 1; Harbrecht, Matthew MD 2; Widerquist, Marilla MSW 1; Evans, Richard R. MS 1; Inadomi, John M. MD 5; Chang, Joy W. MD, MS 2; Hazelton, William D. PhD 6; Hur, Chin MD, MPH 7; Kurlander, Jacob E. MD, MS 1,2,4; Lim, Francesca MS 7; Luebeck, Georg PhD 6; Macdonald, Peter W. MMath 8; Reddy, Chanakyaram A. MD 9; Saini, Sameer D. MD, MS 1,2,4; Tan, Sarah Xinhui BS 7; Waljee, Akbar K. MD, MS 1,2,4; Lansdorp-Vogelaar, Iris PhD 10
doi : 10.14309/ajg.0000000000002204
Guidelines suggest 1-time screening with esophagogastroduodenoscopy (EGD) for Barrett's esophagus (BE) in individuals at an increased risk of esophageal adenocarcinoma (EAC).
Curative Management After Endoscopic Resection for Esophageal Squamous Cell Carcinoma Invading Muscularis Mucosa or Shallow Submucosal Layer-Multicenter Real-World Survey in Japan.
Katada, Chikatoshi MD, PhD 1,2; Yokoyama, Tetsuji MD, PhD 3; Hirasawa, Dai MD 4; Iizuka, Toshiro MD, PhD 5; Kikuchi, Daisuke MD, PhD 5; Yano, Tomonori MD, PhD 6; Hombu, Takuya MD 6; Yoshio, Toshiyuki MD, PhD 7; Yoshimizu, Shoichi MD 7; Ono, Hiroyuki MD, PhD 8; Yabuuchi, Yohei MD 9; Terai, Shuji MD, PhD 10; Hashimoto, Satoru MD, PhD 10; Takahashi, Kazuya MD, PhD 10; Tanaka, Shinji MD, PhD 11; Urabe, Yuji MD, PhD 12; Arima, Miwako MD 13; Tanabe, Satoshi MD, PhD 14; Wada, Takuya MD 15; Furue, Yasuaki MD, PhD 15; Oyama, Tsuneo MD, PhD 16; Takahashi, Akiko MD 16; Sakamoto, Yasutoshi PhD 17; Muto, Manabu MD, PhD 1
doi : 10.14309/ajg.0000000000002106
Curative management after endoscopic resection (ER) for esophageal squamous cell carcinoma (ESCC), which invades the muscularis mucosa (pMM-ESCC) or shallow submucosal layer (pSM1-ESCC), has been controversial.
Hybrid, High-Dose Dual and Bismuth Quadruple Therapies for First-Line Treatment of Helicobacter pylori Infection in Taiwan: A Multicenter, Open-Label, Randomized Trial.
Hsu, Ping-I MD 1; Chen, Kuan-Yang MD 2; Tai, Wei-Chen MD 3; Yang, Jyh-Chin MD, PhD 4; Tsay, Feng-Woei MD 5; Liu, Yu-Hwa MD 6; Chen, Chien-Lin MD 7; Lee, Chia-Long MD 8; Yeh, Hong-Zen MD 9; Kuo, Chao-Hung MD, PhD 10; Chuah, Seng-Kee MD 3; Lee, Hsi-Chang MD 2; Shie, Chang-Bih MD 1; Shiu, Sz-Iuan MD 9; Kao, John Y. MD, PhD 11; Yamaoka, Yoshio MD, PhD 12,13; Graham, David Y. MD, PhD 13,14; Wu, Deng-Chyang MD, PhD 10,15,16
doi : 10.14309/ajg.0000000000002255
The study aimed to compare the efficacies and safety of 14-day hybrid therapy, 14-day high-dose dual therapy, and 10-day bismuth quadruple therapy in the first-line treatment of Helicobacter pylori infections.
Ursodeoxycholic Acid Treatment-Induced GLOBE Score Changes Are Associated With Liver Transplantation-Free Survival in Patients With Primary Biliary Cholangitis.
de Veer, Rozanne C. MD 1; van Hooff, Maria C. MD 1; Corpechot, Christophe MD, PhD 2; Thorburn, Douglas MD, PhD 3; Invernizzi, Pietro MD, PhD 4,5; Lammers, Willem J. MD, PhD 1; Janssen, Harry L.A. MD, PhD 1,6; Battezzati, Pier M. MD, PhD 7; Nevens, Frederik MD, PhD 8; Lindor, Keith D. MD, PhD 8,9,10; Floreani, Annarosa MD, PhD 11,12; Ponsioen, Cyriel Y. MD, PhD 13; Mayo, Marlyn J. MD, PhD 14; Pares, Albert MD, PhD 15; Mason, Andrew L. MD, PhD 16; Kowdley, Kris V. MD, PhD 17; Trivedi, Palak J. MD, PhD 18; Hirschfield, Gideon M. MD, PhD 6,18; Goet, Jorn C. MD, PhD 1; Bruns, Tony MD, PhD 19,20; Dalekos, George N. MD, PhD 21,22; Gatselis, Nikolaos K. MD, PhD 21,22; Verhelst, Xavier MD, PhD 23; Hansen, Bettina E. MD, PhD 1,6; Harms, Maren H. MD, PhD 1; van der Meer, Adriaan J. MD, PhD 1
doi : 10.14309/ajg.0000000000002128
Treatment of primary biliary cholangitis (PBC) can improve the GLOBE score. We aimed to assess the association between changes in the GLOBE score ([DELTA]GLOBE) and liver transplantation (LT)-free survival in patients with PBC who were treated with ursodeoxycholic acid (UDCA).
Exercise Training Is Associated With Treatment Response in Liver Fat Content by Magnetic Resonance Imaging Independent of Clinically Significant Body Weight Loss in Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.
Stine, Jonathan G. MD, MSc 1,2,3,4; DiJoseph, Kara DO 1; Pattison, Zach DO 1; Harrington, Alex MLIS 5; Chinchilli, Vernon M. PhD 2; Schmitz, Kathryn H. PhD 2,4,6,7; Loomba, Rohit MD, MHSc 8,9,10
doi : 10.14309/ajg.0000000000002098
Exercise training is crucial in the management of nonalcoholic fatty liver disease (NAFLD); however, whether it can achieve clinically meaningful improvement in liver fat is unclear.
Randomized Trial of Tenofovir With or Without Peginterferon Alfa Followed by Protocolized Treatment Withdrawal in Adults With Chronic Hepatitis B.
Terrault, Norah A. MD, MPH 1; Lok, Anna S. MD 2; Wahed, Abdus S. PhD 3; Ghany, Marc G. MD 4; Perrillo, Robert P. MD 5; Fried, Michael W. MD 6; Wong, David K. MD 7; Khalili, Mandana MD, MAS 8; Lau, Daryl T.Y. MD 9; Sterling, Richard K. MD 10; Di Bisceglie, Adrian M. MD 11; Lisker-Melman, Mauricio MD 12; Cooper, Stewart L. MD 13; Chung, Ray T. MD 14; Patel, Keyur MD 7; Roberts, Lewis R. MD 15; Belle, Steven H. PhD 3; Janssen, Harry L.A. MD 7; for the Hepatitis B Research Network
doi : 10.14309/ajg.0000000000002125
Hepatitis B surface antigen (HBsAg) loss is associated with improved long-term outcomes of patients with chronic hepatitis B but is infrequently achieved with current monotherapies.
Withdrawal of Long-Term Nucleotide Analog Therapy in Chronic Hepatitis B: Outcomes From the Withdrawal Phase of the HBRN Immune Active Treatment Trial.
Feld, Jordan J. MD, MPH 1,2; Wahed, Abdus S. PhD 3,4; Fried, Michael MD 5; Ghany, Marc G. MD 6; Di Bisceglie, Adrian M. MD 7; Perrillo, Robert P. MD 8; Khalili, Mandana MD 9; Yang, Xue PhD 3; Belle, Steven H. PhD 3,4; Janssen, Harry L.A. MD, PhD 1,2; Terrault, Norah MD 10; Lok, Anna S. MD 11; for the Hepatitis B Research Network (HBRN)
doi : 10.14309/ajg.0000000000002176
Withdrawal of nucleos(t)ide analog therapy is increasingly being evaluated in chronic hepatitis B infection as a strategy to induce hepatitis B surface antigen (HBsAg) loss.
Real-World Evidence of Tofacinitib in Ulcerative Colitis: Short-Term and Long-Term Effectiveness and Safety.
Chaparro, Maria MD, PhD 1,*; Acosta, Diana Sc 1,*; Rodriguez, Cristina MD 2; Mesonero, Francisco MD 3; Vicuna, Miren MD 2; Barreiro-de Acosta, Manuel MD, PhD 4; Fernandez-Clotet, Agnes MD 5; Hernandez Martinez, Alvaro MD, PhD 6; Arroyo, Maite MD, PhD 7; Vera, Isabel MD, PhD 8; Ruiz-Cerulla, Alexandra MD 9; Sicilia, Beatriz MD, PhD 10; Cabello Tapia, M. Jose MD, PhD 11;
doi : 10.14309/ajg.0000000000002145
The objective of this study was to assess the durability, short-term and long-term effectiveness, and safety of tofacitinib in ulcerative colitis (UC) in clinical practice.
Effect of Biologics on the Risk of Advanced-Stage Inflammatory Bowel Disease-Associated Intestinal Cancer: A Nationwide Study.
Seishima, Ryo MD, PhD 1; Okabayashi, Koji MD 1; Ikeuchi, Hiroki MD, PhD 2; Uchino, Motoi MD, PhD 2; Futami, Kitaro MD, PhD 3; Noguchi, Tatsuki MD, PhD 4; Ohge, Hiroki MD, PhD 5; Iseki, Yasuhito MD, PhD 6; Watanabe, Kazuhiro MD, PhD 7; Itabashi, Michio MD, PhD 8; Okamoto, Kinya MD, PhD 9; Toiyama, Yuji MD, PhD 10; Ogino, Takayuki MD, PhD 11; Nakamura, Masafumi MD, PhD 12; Yamada, Kazutaka MD, PhD 13; Wakai, Toshifumi MD, PhD 14; Sato, Yu MD, PhD 15;
doi : 10.14309/ajg.0000000000002149
The aim of this study was to evaluate the effect of biologics on the risk of advanced-stage inflammatory bowel disease (IBD)-associated intestinal cancer from a nationwide multicenter data set.
The Short-Term Efficacy of Bifidobacterium Quadruple Viable Tablet in Patients With Diarrhea-Predominant Irritable Bowel Syndrome: Potentially Mediated by Metabolism Rather Than Diversity Regulation.
Bai, Tao PhD 1,*; Xu, Zhiyue MD 1,*; Xia, Peijun PhD 2; Feng, Yichao PhD 3; Liu, Bing PhD 4; Liu, Hongling PhD 5; Chen, Yunwang PhD 6; Yan, Guangjun PhD 7; Lv, Bin PhD 8; Yan, Zaihong PhD 9; Dai, Ning PhD 10; Long, Yanqin PhD 10; Wei, Wei PhD 11; Shi, Zhihong PhD 12; Li, Xiaoqing PhD 13; Fang, Xiucai MD, PhD 13; Gao, Huibin PhD 14; Qi, Lingzhi PhD 15; Hou, Xiaohua MD, PhD 1
doi : 10.14309/ajg.0000000000002147
The therapeutic effect of probiotics for irritable bowel syndrome (IBS) was controversial. This study aims to evaluate the short-term efficacy of Bifidobacterium quadruple viable tablet in patients with diarrhea-predominant IBS and explore factors associated with response to probiotics.
Cardiac Vagal Regulation Is Impeded in Children With Cyclic Vomiting Syndrome.
Kolacz, Jacek PhD 1,2,*; Kovacic, Katja MD 3,*; Dang, Linh BS 1,4; Li, B U.K. MD 3; Lewis, Gregory F. PhD 2; Porges, Stephen W. PhD 2,5
doi : 10.14309/ajg.0000000000002207
The pathophysiology underlying cyclic vomiting syndrome (CVS) remains undefined. Scant data and distinct clinical features point to altered autonomic nervous system function.
Alpha-Gal Sensitization in a US Screening Population Is Not Associated With a Decreased Meat Intake or Gastrointestinal Symptoms.
McGill, Sarah K. MD, MSc 1; Commins, Scott P. MD, PhD 2; Peery, Anne F. MD, MSCR 1; Galanko, Joseph PhD 1; Keku, Temitope O. PhD 1; Shaheen, Nicholas J. MD, MPH 1; Anderson, Chelsea MPH, PhD 1; Sandler, Robert S. MD, MPH 1
doi : 10.14309/ajg.0000000000002219
Patients with alpha-gal syndrome, a delayed reaction to mammalian meat, can present with isolated gastrointestinal (GI) symptoms.
Electronic Health Record Burden Among Gastroenterology Providers Associated With Subspecialty and Training.
Bali, Aman S. MD 1; Hashash, Jana G. MD, MSc 2; Picco, Michael F. MD, PhD 2; Kinnucan, Jami A. MD 2; Farraye, Francis A. MD, MSc 2
doi : 10.14309/ajg.0000000000002254
Use of the electronic health record (EHR) has become increasingly widespread. Higher EHR burden is associated with burnout, but this has not been specifically investigated among gastroenterology (GI) providers.
Patients With Crohn's Disease and Permanent Ileostomy Are Universally Excluded From Clinical Trials: A Systematic Review.
Vuyyuru, Sudheer K. MD 1; Rieder, Florian MD 2,3; Solitano, Virginia MD 1; Nguyen, Tran M. MSc 4; Crowley, Eileen MD 5; Narula, Neeraj MD 6; Singh, Siddharth MD 7; Ma, Christopher MD 8,9; Jairath, Vipul MBChB, DPhil 1,4,10
doi : 10.14309/ajg.0000000000002215
We performed a systematic review to investigate whether patients with Crohn's disease (CD) and permanent ileostomy (PI) have been included in clinical trials evaluating biologics and small molecules.
Incidence of Cirrhosis Among Recent Immigrants and Refugees to Ontario, Canada.
Sayed, Nawid MD 1; Selzner, Nazia MD, PhD 2; Djerboua, Maya MSc 3; Muaddi, Hala MD, PhD 4; Neves, Paula PhD 5; Flemming, Jennifer A. MD, MAS, FRCPC 1,3,6
Clinical Presentation of Alpha-Gal Syndrome in Pediatric Gastroenterology and Response to Mammalian Dietary Elimination.
Busing, Jordan D. MD 1; Stone, Cosby A. Jr MD, MPH 2; Nicholson, Maribeth R. MD, MPH 1
doi : 10.14309/ajg.0000000000002268
Alpha-gal syndrome is an immunoglobulin E (IgE)-mediated delayed hypersensitivity reaction to nonprimate mammalian products, which has a newly established gastrointestinal (GI) phenotype in adults.
Measuring and Interpreting Ammonia Levels in Cirrhosis.
Ballester, Maria Pilar MPB, MD, PhD 1,2; Rose, Christopher F. 3; Carbonell-Asins, Juan-Antonio PhD 2; Jalan, Rajiv 4,5
Response to Ballester et al.
Deutsch-Link, Sasha MD 1; Moon, Andrew M. MD, MPH 1
Does Single Fasting Methane Levels Really Detect Intestinal Methanogen Overgrowth?.
Mion, Francois MD, PhD 1; Subtil, Fabien MD, PhD 2; Ropert, Alain MD, PhD 3; Jouet, Pauline MD, PhD 4
Response to Mion et al.
Takakura, Will MD 1; Rezaie, Ali MD, MSc 2,3
