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Mechanisms of Mast Cell Activation in Severe Asthma: Beyond IgE
Peter Bradding 1,2
doi : 10.1164/rccm.202110-2322ED Â
Volume 205, Issue 4 | February 15 2022
The Air We Breathe: Respiratory Impact of Indoor Air Quality in Chronic Obstructive Pulmonary Disease
Takudzwa Mkorombindo 1,2, John R. Balmes 3,4, Adnan Custovic 5, and Mark T. Dransfield 1,2
Go with the Flow: Expanding the Definition of Acute Respiratory Distress Syndrome to Include High-Flow Nasal Oxygen
Lorraine B. Ware
Preemptive Noninvasive Ventilation to Facilitate Weaning from Mechanical Ventilation in Obese Patients at High Risk of Reintubation
Domenico Luca Grieco 1,2 and Samir Jaber 3
Long-Term Exposure to Ozone and Small Airways: A Large Impact?
John R. Balmes 1,2
Inequity and the Interstitium: Pushing Back on Disparities in Fibrosing Lung Disease in the United States and Canada
Adam W. Gaffney 1,2 and Anna J. Podolanczuk 3
The Many Roles of Cholesterol in Sepsis: A Review
Daniel A. Hofmaenner 1, Anna Kleyman 1, Adrian Press 2, Michael Bauer 2, and Mervyn Singer 1
doi : 10.1164/rccm.202105-1197TR
The biological functions of cholesterol are diverse, ranging from cell membrane integrity, cell membrane signaling, and immunity to the synthesis of steroid and sex hormones, vitamin D, bile acids, and oxysterols.
Association of Differential Mast Cell Activation with Granulocytic Inflammation in Severe Asthma
Angelica Tiotiu 1,2*, Yusef Badi 1,3*, Nazanin Zounemat Kermani 3, Marek Sanak 4, Johan Kolmert 5,6,7, Craig E. Wheelock 6, Philip M. Hansbro 8, Sven-Erik Dahlén 5,7, Peter J. Sterk 9, Ratko Djukanovic 10, Yike Guo 3, Sharon Mumby 1, Ian M. Adcock 1,3‡, and Kian Fan Chung 1,3‡;
Home Dust Allergen Exposure Is Associated with Outcomes among Sensitized Individuals with Chronic Obstructive Pulmonary Disease
Nirupama Putcha 1, Han Woo 1, Meredith C. McCormack 1, Ashraf Fawzy 1, Karina Romero 1, Meghan F. Davis 2, Robert A. Wise 1, Gregory B. Diette 1, Kirsten Koehler 2, Elizabeth C. Matsui 3, and Nadia N. Hansel 1
doi : 10.1164/rccm.202103-0583OC
Rationale: Environmental exposures have been associated with adverse outcomes in chronic obstructive pulmonary disease (COPD). Approximately one-third of individuals with COPD have allergic sensitization, but it is unknown whether exposure to allergens in the home is associated with outcomes.
Randomized Clinical Trial of Air Cleaners to Improve Indoor Air Quality and Chronic Obstructive Pulmonary Disease Health: Results of the CLEAN AIR Study
Nadia N. Hansel 1,2, Nirupama Putcha 1, Han Woo 1, Roger Peng 3, Gregory B. Diette 1,2, Ashraf Fawzy 1, Robert A. Wise 1, Karina Romero 1, Meghan F. Davis 2, Ana M. Rule 2, Michelle N. Eakin 1, Patrick N. Breysse 2,4, Meredith C. McCormack 1,2, and Kirsten Koehler 2
doi : 10.1164/rccm.202103-0604OC
Rationale: Indoor particulate matter is associated with worse chronic obstructive pulmonary disease (COPD) outcomes. It remains unknown whether reductions of indoor pollutants improve respiratory morbidity.
High-Flow Nasal Oxygen for Severe Hypoxemia: Oxygenation Response and Outcome in Patients with COVID-19
V. Marco Ranieri 1,2, Tommaso Tonetti 1,2, Paolo Navalesi 3,4, Stefano Nava 5,6, Massimo Antonelli 7,8, Antonio Pesenti 9,10, Giacomo Grasselli 9,10, Domenico Luca Grieco 7,8, Luca Salvatore Menga 8, Lara Pisani 5,6, Annalisa Boscolo 4, Nicolò Sella 3,4, Laura Pasin 4, Chiara Mega 1,2, Giacinto Pizzilli 2, Alessio Dell’Olio 1, Roberto Dongilli 11, Paola Rucci 12, and Arthur S. Slutsky 13
doi : 10.1164/rccm.202109-2163OC Â
Rationale: The “Berlin definition� of acute respiratory distress syndrome (ARDS) does not allow inclusion of patients receiving high-flow nasal oxygen (HFNO). However, several articles have proposed that criteria for defining ARDS should be broadened to allow inclusion of patients receiving HFNO.
Beneficial Effects of Noninvasive Ventilation after Extubation in Obese or Overweight Patients: A Post Hoc Analysis of a Randomized Clinical Trial
Arnaud W. Thille 1,2, Rémi Coudroy 1,2, Mai-Anh Nay 3, Arnaud Gacouin 4, Maxens Decavèle 5, Romain Sonneville 6, François Beloncle 7, Christophe Girault 8, Laurence Dangers 9, Alexandre Lautrette 10, Quentin Levrat 11, Anahita Rouzé 12, Emmanuel Vivier 13, Jean-Baptiste Lascarrou 14, Jean-Damien Ricard 15,16, Armand Mekontso-Dessap 17, Guillaume Barberet 18, Christine Lebert 19, Stephan Ehrmann 20, Alexandre Massri 21, Jeremy Bourenne 22, Gael Pradel 23, Pierre Bailly 24, Nicolas Terzi 25, Jean Dellamonica 26, Guillaume Lacave 27, René Robert 1,2, Jean-Pierre Frat 1,2, and Stéphanie Ragot 2;
doi : 10.1164/rccm.202106-1452OC
Rationale: Although noninvasive ventilation (NIV) may prevent reintubation in patients at high risk of extubation failure in ICUs, this oxygenation strategy has not been specifically assessed in obese patients.
Long-Term Ozone Exposure and Small Airway Dysfunction: The China Pulmonary Health (CPH) Study
Yue Niu 1*, Ting Yang 2,3,4,5*, Xiaoying Gu 3,4,6,7*, Renjie Chen 1*, Xia Meng 1, Jianying Xu 8, Lan Yang 9, Jianping Zhao 10, Xiangyan Zhang 11, Chunxue Bai 12, Jian Kang 13, Pixin Ran 14,15, Huahao Shen 16, Fuqiang Wen 17, Kewu Huang 18,19, Yahong Chen 20, Tieying Sun 21,22, Guangliang Shan 23, Yingxiang Lin 18,19, Sinan Wu 3,4,6,7, Jianguo Zhu 22, Ruiying Wang 8, Zhihong Shi 9, Yongjian Xu 10, Xianwei Ye 11, Yuanlin Song 12, Qiuyue Wang 13, Yumin Zhou 14,15, Liren Ding 16, Ting Yang 17, Wanzhen Yao 20, Yanfei Guo 21,22, Fei Xiao 22,24, Yong Lu 18,19, Xiaoxia Peng 25, Biao Zhang 23, Dan Xiao 3,4,6,26,27, Zuomin Wang 28, Hong Zhang 18,19, Xiaoning Bu 18,19, Xiaolei Zhang 2,3,4,5, Li An 18,19, Shu Zhang 18,19, Zhixin Cao 18,19, Qingyuan Zhan 2,3,4,5, Yuanhua Yang 18,19, Lirong Liang 29, Bin Cao 2,3,4,5, Huaping Dai 2,3,4,5, Tangchun Wu 30 Jiang He 31, Huichu Li 32, Haidong Kan 1,33‡, and Chen Wang 2,3,4,5,27‡;
doi : 10.1164/rccm.202107-1599OC
Rationale: It remains unknown whether long-term ozone exposure can impair lung function.
Neighborhood-Level Disadvantage Impacts on Patients with Fibrotic Interstitial Lung Disease
Gillian C. Goobie 1,2,3, Christopher J. Ryerson 4,5, Kerri A. Johannson 6, Erin Schikowski 7, Richard H. Zou 8, Nasreen Khalil 4, Veronica Marcoux 9, Deborah Assayag 10, Hélène Manganas 11, Jolene H. Fisher 12, Martin R. J. Kolb 13, Kevin F. Gibson 2,8, Daniel J. Kass 2,8, Yingze Zhang 8, Kathleen O. Lindell 2,14*, and S. Mehdi Nouraie 8* ... Show less
doi : 10.1164/rccm.202109-2065OC
Rationale: Fibrotic interstitial lung disease (fILD) is a group of pathologic entities characterized by scarring of the lungs and high morbidity and mortality. Research investigating how socioeconomic and residential factors impact outcomes in patients with fILD is lacking.
The Lobe That Got Away
Amr J. Alwakeel 1,2, Christian Sirois 3, and Kevin Schwartzman 1,4
Kissing in the Airway: Collateral Damage from Tracheobronchomalacia
Aravind A. Menon and Majid Shafiq
Rapid Phospholipid Turnover after Surfactant Nebulization in Severe COVID-19 Infection: A Randomized Clinical Trial
Anthony D. Postle 1,2*, Howard W. Clark 3,4, Jim Fink 5, Jens Madsen 6, Grielof Koster 2, Madhuriben Panchal 2, Ratko Djukanovic 1,2, David Brealey 7, Michael P. W. Grocott 1,2, and Ahilanandan Dushianthan 2
Prospective Identification of Subclinical Interstitial Lung Disease in a Rheumatoid Arthritis Cohort Is Associated with the MUC5B Promoter Variant
Scott M. Matson 1, Kevin D. Deane 2, Anna L. Peljto 2, Tami J. Bang 2, Peter B. Sachs 2, Avram D. Walts 2, Christopher Collora 2, Shuyu Ye 2, M. Kristen Demoruelle 2, Stephen M. Humphries 3, David A. Schwartz 2, and Joyce S. Lee 2*
Response of Lung Microbiota to Changes of Pulmonary Innate Immunity under Healthy Conditions
Taro Yasuma , Corina N. D’Alessandro-Gabazza , Hajime Fujimoto , Tetsu Kobayashi , and Esteban C. Gabazza *
Reply to Yasuma et al.: Response of Lung Microbiota to Changes of Pulmonary Innate Immunity under Healthy Conditions
Jezreel Pantaleón GarcÃÂa 1, Kevin J. Hinkle 2, Nicole R. Falkowski 2, Scott E. Evans 1*, and Robert P. Dickson 2,3*‡
Time to Tailor the One-Size-Fits-All Approach?
Marnix Kuindersma 1* and Peter E. Spronk 1,2
Reply to Kuindersma and Spronk: Time to Tailor the One-Size-Fits-All Approach?
David M. Furfaro 1,2*, Pratik Sinha 3, Carolyn S. Calfee 4, Daniel Brodie 5, and Max R. O’Donnell 5,6
Treatment of Early-Stage Non–Small Cell Lung Cancer
Yaron Gesthalter , Robert Smyth , and Donald Sullivan
doi : 10.1164/rccm.2054P7
