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Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or ObesityThe STEP 3 Randomized Clinical Trial
Thomas A. Wadden, PhD; Timothy S. Bailey, MD; Liana K. Billings, MD, MMSc; et al.
doi : 10.1001/jama.2021.1831
JAMA. 2021;325(14):1403-1413.
This randomized clinical trial compares the effects of once-weekly subcutaneous semaglutide vs placebo for weight management as an adjunct to intensive behavioral therapy with initial low-calorie diet in adults with overweight or obesity.
Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or ObesityThe STEP 4 Randomized Clinical Trial
Domenica Rubino, MD; Niclas Abrahamsson, MD; Melanie Davies, MD; et al.
doi : 10.1001/jama.2021.3224
JAMA. 2021;325(14):1414-1425.
This randomized trial compares the effects of continuing weekly treatment with subcutaneous semaglutide vs switching to placebo on change in body weight over 48 weeks among adults with overweight or obesity who completed a 20-week run-in period with semaglutide.
Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19A Randomized Clinical Trial
Eduardo L?pez-Medina, MD, MSc; P?o L?pez, MD; Isabel C. Hurtado, MD; et al.
doi : 10.1001/jama.2021.3071
JAMA. 2021;325(14):1426-1435.
This randomized trial compares the effects of ivermectin vs placebo on time to symptom resolution within 21 days among patients with mild COVID-19.
Binding and Neutralization Antibody Titers After a Single Vaccine Dose in Health Care Workers Previously Infected With SARS-CoV-2
Saman Saadat, PhD; Zahra Rikhtegaran Tehrani, PhD; James Logue, BS; et al.
doi : 10.1001/jama.2021.3341
JAMA. 2021;325(14):1467-1469.
This study compares titers of binding and neutralizing antibodies after a single mRNA coronavirus vaccine dose in health care workers previously infected with SARS-CoV-2.
Discriminant Accuracy of the SOFA Score for Determining the Probable Mortality of Patients With COVID-19 Pneumonia Requiring Mechanical Ventilation
Robert A. Raschke, MD; Sumit Agarwal, MBBS, MBA; Pooja Rangan, MBBS, MPH; et al.
doi : 10.1001/jama.2021.1545
JAMA. 2021;325(14):1469-1470.
This cohort study characterizes the accuracy of the Sequential Organ Failure Assessment (SOFA) score to discriminate death from survival in patients with COVID-19 pneumonia receiving oxygen therapy for 4 hours or longer before undergoing endotracheal intubation.
Screening for Vitamin D Deficiency in AdultsUS Preventive Services Task Force Recommendation Statement
US Preventive Services Task Force
doi : 10.1001/jama.2021.3069
JAMA. 2021;325(14):1436-1442.
This 2021 US Preventive Services Task Force Recommendation Statement concludes that current evidence is insufficient to assess the balance of benefits and harms of screening for vitamin D deficiency in asymptomatic adults (I statement).
Screening for Vitamin D Deficiency in AdultsUpdated Evidence Report and Systematic Review for the US Preventive Services Task Force
Leila C. Kahwati, MD, MPH; Erin LeBlanc, MD, MPH; Rachel Palmieri Weber, PhD; et al.
doi : 10.1001/jama.2020.26498
JAMA. 2021;325(14):1443-1463.
This systematic review to support the 2021 US Preventive Services Task Force Recommendation Statement on screening for vitamin D deficiency summarizes published evidence on the benefits and harms of screening and interventions for vitamin D deficiency in asymptomatic, community-dwelling adults.
How the Biden Administration Can Improve Health Equity for Racial and Ethnic Minority Populations
Karen E. Joynt Maddox, MD, MPH; Cara V. James, PhD
doi : 10.1001/jama.2021.3046
JAMA. 2021;325(14):1387-1388.
This Viewpoint outlines actions that the new federal administration could consider related to health care access and quality, and social determinants of health, to meaningfully improve health equity for racial/ethnic minority populations.
COVID-19 in 2021—Continuing Uncertainty
Carlos del Rio, MD; Preeti Malani, MD, MSJ
doi : 10.1001/jama.2021.3760
JAMA. 2021;325(14):1389-1390.
This Viewpoint summarizes the current best evidence about COVID-19 vaccines, immunity, and whether SARS-CoV-2 will become an endemic or seasonal virus.
National Initiatives to Prevent Myocardial Infarction and Stroke
Thomas R. Frieden, MD, MPH; Kathryn E. Foti, PhD, MPH
doi : 10.1001/jama.2021.0905
JAMA. 2021;325(14):1391-1392.
This Viewpoint discusses the Million Hearts initiative, a national effort that aims to prevent a million myocardial infarctions and strokes over 5 years, and proposes actions and strategies federal agencies can take to advance tobacco control, sodium reduction, trans fat elimination, hypertension control, and centering the US health care system on primary care.
On Mentoring
Howard Bauchner, MD
doi : 10.1001/jama.2021.4070
JAMA. 2021;325(14):1393.
In this narrative medicine essay, JAMA’s editor in chief remembers his career mentors and their selflessness as they guided him in his early and mid-career and later became friends and colleagues.
The Near-Term Future of Health Care Reform
Ezekiel J. Emanuel, MD, PhD
doi : 10.1001/jama.2021.1472
JAMA. 2021;325(14):1394-1397.
Crucial Questions for US Health Policy in the Next Decade
John Z. Ayanian, MD, MPP
doi : 10.1001/jama.2021.1470
JAMA. 2021;325(14):1397-1399.
Confronting Challenges in the US Health Care SystemPotential Opportunity in a Time of Crisis
Melinda B. Buntin, PhD
doi : 10.1001/jama.2021.1471
JAMA. 2021;325(14):1399-1400.
The USPSTF 2021 Recommendations on Screening for Asymptomatic Vitamin D Deficiency in AdultsThe Challenge for Clinicians Continues
Sherri-Ann M. Burnett-Bowie, MD, MPH; Anne R. Cappola, MD, ScM
doi : 10.1001/jama.2021.2227
JAMA. 2021;325(14):1401-1402.
Identifying COVID-19 Risk Through Observational Studies to Inform Control Measures
Mark W. Tenforde, MD, PhD; Kiva A. Fisher, PhD, MPH; Manish M. Patel, MD, MSc
doi : 10.1001/jama.2021.1995
JAMA. 2021;325(14):1464-1465.
This JAMA Insights Clinical Update from the CDC’s COVID-19 Response Team discusses the importance of observational data for identifying behaviors associated with SARS-CoV-2 transmission, and presents data suggesting that indoor eating or drinking poses the highest risk, presumably because of prolonged exposure to unmasked, non–physically distanced companions.
How the US Failed to Prioritize SARS-CoV-2 Variant Surveillance
Jennifer Abbasi
doi : 10.1001/jama.2021.3368
JAMA. 2021;325(14):1380-1382.
This Medical News article discusses genomic sequencing to detect and track virus variants during the COVID-19 pandemic.
Time to Rethink Nursing Homes
Stuart M. Butler, PhD
doi : 10.1001/jama.2021.2567
JAMA. 2021;325(14):1383-1384.
COVID-19 Precautions Are Scarce in Non–Health Care Workplaces
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2021.4844
JAMA. 2021;325(14):1386.
Disparities in Suicide Persist Despite Overall Dip in US Rate
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2021.4131
JAMA. 2021;325(14):1386.
Data Leak Exposes Early COVID-19 Vaccine Manufacturing Hiccups
Jennifer Abbasi
doi : 10.1001/jama.2021.5002
JAMA. 2021;325(14):1385.
Teplizumab Improves Beta Cell Function, Delays Type 1 Diabetes
Jennifer Abbasi
doi : 10.1001/jama.2021.4628
JAMA. 2021;325(14):1385.
Wearable Bilirubin Measurement Device for Neonatal Jaundice
Jennifer Abbasi
doi : 10.1001/jama.2021.5004
JAMA. 2021;325(14):1385.
COVID-19 Postage Stamps—Messages in a Message
Bertrand Lefrère, Msc; Amélie Recoing, PharmD, MSc; Hervé Delacour, PharmD, MSc
doi : 10.1001/jama.2021.2139
JAMA. 2021;325(14):1377-1379.
This Arts and Medicine feature presents global postage and commemorative stamps issued by countries and nongovernmental organizations in 2020 featuring coronavirus pandemic-related themes.
Screening for Vitamin D Deficiency in Adults
Jill Jin, MD, MPH
doi : 10.1001/jama.2021.4606
JAMA. 2021;325(14):1480.
This JAMA Patient Page summarizes the US Preventive Services Task Force’s 2021 recommendation that current evidence is insufficient to assess the balance of benefits and harms of screening for vitamin D deficiency in asymptomatic adults (I statement).
Effect of Early Recombinant Human Erythropoietin on Neurodevelopmental Outcomes at Age 5 Years
Hannelore Ehrenreich, MD, DVM; Achim-Peter Neubauer, MD; Kamilla Miskowiak, PhD
doi : 10.1001/jama.2021.0833
JAMA. 2021;325(14):1470-1471.
Effect of Early Recombinant Human Erythropoietin on Neurodevelopmental Outcomes at Age 5 Years—Reply
Giancarlo Natalucci, MD; Hans Ulrich Bucher, MD; Jean-Claude Fauchère, MD
doi : 10.1001/jama.2021.0836
JAMA. 2021;325(14):1471-1472.
Review of Gastroesophageal Reflux Disease
Raaj S. Mehta, MD; Kyle Staller, MD, MPH; Andrew T. Chan, MD, MPH
doi : 10.1001/jama.2021.1438
JAMA. 2021;325(14):1472.
Review of Gastroesophageal Reflux Disease—Reply
John Maret-Ouda, MD, PhD; Sheraz R. Markar, MD, PhD; Jesper Lagergren, MD, PhD
doi : 10.1001/jama.2021.1444
JAMA. 2021;325(14):1472-1473.
