Nature Reviews Rheumatology




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سفارش

Somatic mutations cause VEXAS syndrome

Sarah Onuora

doi : 10.1038/s41584-020-00559-x

Volume 17, Issue 1, January 2021, Published 01 December 2020

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RA remission maintained after MTX withdrawal

Sarah Onuora

doi : 10.1038/s41584-020-00554-2

Volume 17, Issue 1, January 2021, Published 02 December 2020

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Fasinumab effective for chronic low back pain

Sarah Onuora

doi : 10.1038/s41584-020-00555-1

Volume 17, Issue 1, January 2021, Published 02 December 2020

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Intensive electroacupuncture reduces OA pain

Sarah Onuora

doi : 10.1038/s41584-020-00556-0

Volume 17, Issue 1, January 2021, Published 02 December 2020

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Long-term fatigue relief with secukinumab for AS

Sarah Onuora

doi : 10.1038/s41584-020-00557-z

Volume 17, Issue 1, January 2021, Published 02 December 2020

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Induced Treg cells stay on course

Jessica McHugh

doi : 10.1038/s41584-020-00558-y

Volume 17, Issue 1, January 2021, Published 01 December 2020

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Febuxostat cardiovascular safety revisited

Sarah Onuora

doi : 10.1038/s41584-020-00547-1

Volume 17, Issue 1, January 2021, Published 20 November 2020

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IL-33 is a potential new target in OA

Joanna Clarke

doi : 10.1038/s41584-020-00542-6

Volume 17, Issue 1, January 2021, Published 10 November 2020

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New genetic risk loci found for JIA

Jessica McHugh

doi : 10.1038/s41584-020-00553-3

Volume 17, Issue 1, January 2021, Published 02 December 2020

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NETs revealed as source of carbamylated proteins in RA

Joanna Clarke

doi : 10.1038/s41584-020-00548-0

Volume 17, Issue 1, January 2021, Published 20 November 2020

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Machine learning in precision medicine: lessons to learn

Darren Plant & Anne Barton

doi : 10.1038/s41584-020-00538-2

Volume 17, Issue 1, January 2021, Published 12 November 2020

The ability to predict how a patient might respond to a medication would shift treatment decisions away from trial and error and reduce disease-associated health and financial burdens. Machine learning approaches applied to genomic datasets offer great promise to deliver personalized medicine but their application must first be optimized.

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How well do the new classification criteria for SLE perform?

Guillermo J. Pons-Estel & Graciela S. Alarc?n

doi : 10.1038/s41584-020-00545-3

Volume 17, Issue 1, January 2021, Published 30 November 2020

The new 2019 EULAR–ACR classification criteria for systemic lupus erythematosus (SLE) performed well in the initial derivative and validation cohorts. But do these criteria outperform previous classification criteria across sexes, disease durations or ethnicities?

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How to close the gap between paediatric and adult care

Kirsten Minden

doi : 10.1038/s41584-020-00534-6

Volume 17, Issue 1, January 2021, Published 30 October 2020

For young people with rheumatic diseases, the transition from paediatric to adult rheumatology care is a vulnerable time, and delays or disruption in their care can lead to adverse outcomes. Research into the factors associated with gaps in transitional care could improve the identification and targeting of vulnerable groups.

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How COVID-19 is changing rheumatology clinical practice

Eloisa Bonf?, Laure Gossec, David A. Isenberg, Zhanguo Li & Soumya Raychaudhuri

doi : 10.1038/s41584-020-00527-5

Volume 17, Issue 1, January 2021, Published 02 November 2020

The COVID-19 pandemic led to unprecedented changes in rheumatology clinical practice. In this Viewpoint article, we asked five experts to describe their experiences of the COVID-19 pandemic, how their clinical practice has changed, and the opportunities and challenges that lie ahead.

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Persistent inflammatory and non-inflammatory mechanisms in refractory rheumatoid arthritis

Maya H. Buch, Stephen Eyre & Dennis McGonagle

doi : 10.1038/s41584-020-00541-7

Volume 17, Issue 1, January 2021, Published 08 December 2020

Refractory rheumatoid arthritis (RA) can present with or without signs of ongoing inflammation. A better understanding of the mechanisms behind refractory RA in the presence and absence of inflammation could help to improve the treatment of this condition.

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The evolution of nerve growth factor inhibition in clinical medicine

Barton L. Wise, Matthias F. Seidel & Nancy E. Lane

doi : 10.1038/s41584-020-00528-4

Volume 17, Issue 1, January 2021, Published 20 November 2020

Nerve growth factor has been investigated as a therapeutic target for osteoarthritis and chronic low back pain, yet worries over adverse effects have stalled drug development. This Review provides an update on the current status of nerve growth factor inhibitors.

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Mechanisms and therapeutic implications of cellular senescence in osteoarthritis

Philip R. Coryell, Brian O. Diekman & Richard F. Loeser

doi : 10.1038/s41584-020-00533-7

Volume 17, Issue 1, January 2021, Published 18 November 2020

The development of osteoarthritis (OA) correlates with an increase in the number of senescent cells in joint tissues and the senescence-associated secretory phenotype is implicated in cartilage degradation and OA. Eliminating or altering senescent cells with senolytics or senomorphics could stop OA progression and pathogenesis.

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Non-surgical management of knee osteoarthritis: comparison of ESCEO and OARSI 2019 guidelines

Nigel K. Arden, Thomas A. Perry, Raveendhara R. Bannuru, Olivier Bruyère, Cyrus Cooper, Ida K. Haugen, Marc C. Hochberg, Timothy E. McAlindon, Ali Mobasheri & Jean-Yves Reginster

doi : 10.1038/s41584-020-00523-9

Volume 17, Issue 1, January 2021, Published 28 October 2020

A working group including authors of the latest OARSI and ESCEO recommendations for the management of knee osteoarthritis and independent experts compare and contrast these guidelines, and provide insights into their differences that could help inform application of the recommendations.

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