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Editorial Board
doi : 10.1016/S0007-0912(20)31026-6
Volume 126, Issue 2, February 2021, Page ii
No Abstract
Associate Editorial Board
doi : 10.1016/S0007-0912(20)31027-8
Volume 126, Issue 2, February 2021, Page iii
No Abstract
Contents
doi : 10.1016/S0007-0912(20)31029-1
Volume 126, Issue 2, February 2021, Pages v-viii
No Abstract
Seventy-five years since the birth of the Liverpool anaesthetic technique
Jan P. Mulier, Jennifer M. Hunter, Hans D. de Boer
doi : 10.1016/j.bja.2020.10.020
Volume 126, Issue 2, February 2021, Pages 343-347
No Abstract
Fast-track hip and knee arthroplasty...how fast?
Thomas W. Wainwright, Stavros G. Memtsoudis, Henrik Kehlet
doi : 10.1016/j.bja.2020.09.038
Volume 126, Issue 2, February 2021, Pages 348-349
No Abstract
Could anaesthetic technique be blocking successful outcomes in arteriovenous fistula surgery?
Alan J.R. Macfarlane, Mark D. Neuman, Emma Aitken
doi : 10.1016/j.bja.2020.10.014
Volume 126, Issue 2, February 2021, Pages 349-352
No Abstract
Monitoring of nociception: is more always more?
Falk von Dincklage, Thomas Ledowski
doi : 10.1016/j.bja.2020.11.014
Volume 126, Issue 2, February 2021, Pages 352-354
No Abstract
Importance of proper conduct of clinical trials
Andrea Cortegiani, Anthony R. Absalom
doi : 10.1016/j.bja.2020.09.030
Volume 126, Issue 2, February 2021, Pages 354-356
No Abstract
Revisiting postoperative complications after abdominal robot-assisted surgery: applying the Core Outcome Measures in Perioperative and Anaesthetic Care
Kim I. Albers, Gabby Reijnders-Boerboom, Christiaan Keijzer, Gert-Jan Scheffer, ... Michiel C. Warlé
doi : 10.1016/j.bja.2020.10.028
Volume 126, Issue 2, February 2021, Pages 356-360
No Abstract
Controversies in airway management of COVID-19 patients: updated information and international expert consensus recommendations
Huafeng Wei, Bailin Jiang, Elizabeth C. Behringer, Ross Hofmeyr, ... Uwe Klein
doi : 10.1016/j.bja.2020.10.029
Volume 126, Issue 2, February 2021, Pages 361-366
No Abstract
Intraoperative opioids are associated with improved recurrence-free survival in triple-negative breast cancer
Giacomo Montagna, Hersh V. Gupta, Margaret Hannum, Kay See Tan, ... Joshua S. Mincer
doi : 10.1016/j.bja.2020.10.021
Volume 126, Issue 2, February 2021, Pages 367-376
Opioid-induced immunomodulation may be of particular importance in triple-negative breast cancer (TNBC) where an immune response is associated with improved outcome and response to immunotherapy. We evaluated the association between intraoperative opioids and oncological outcomes and explored patterns of opioid receptor expression in TNBC.
Deep neuromuscular block does not improve surgical conditions in patients receiving sevoflurane anaesthesia for laparoscopic renal surgery
G. H. Maarten Honing, Christian H. Martini, Erik Olofsen, Rob F.M. Bevers, ... Martijn Boon
doi : 10.1016/j.bja.2020.09.024
Volume 126, Issue 2, February 2021, Pages 377-385
Deep neuromuscular block is associated with improved working conditions during laparoscopic surgery when propofol is used as a general anaesthetic. However, whether deep neuromuscular block yields similar beneficial effects when anaesthesia is maintained using volatile inhalation anaesthesia has not been systematically investigated. Volatile anaesthetics, as opposed to intravenous agents, potentiate muscle relaxation, which potentially reduces the need for deep neuromuscular block to obtain optimal surgical conditions. We examined whether deep neuromuscular block improves surgical conditions over moderate neuromuscular block during sevoflurane anaesthesia.
Prospective clinical validation of the Eleveld propofol pharmacokinetic-pharmacodynamic model in general anaesthesia
Remco Vellinga, Laura N. Hannivoort, Michele Introna, Daan J. Touw, ... Michel M.R. F. Struys
doi : 10.1016/j.bja.2020.10.027
Volume 126, Issue 2, February 2021, Pages 386-394
Target-controlled infusion (TCI) systems incorporating pharmacokinetic (PK) or PK-pharmacodynamic (PK-PD) models can be used to facilitate drug administration. Existing models were developed using data from select populations, the use of which is, strictly speaking, limited to these populations. Recently a propofol PK-PD model was developed for a broad population range. The aim of the study was to prospectively validate this model in children, adults, older subjects, and obese adults undergoing general anaesthesia.
Engaging patients as partners in a multicentre trial of spinal versus general anaesthesia for older adults
Jennifer Hruslinski, Diane A. Menio, Robert A. Hymes, J. Douglas Jaffe, ... Miriam Treggiari
doi : 10.1016/j.bja.2020.09.052
Volume 126, Issue 2, February 2021, Pages 395-403
Engaging patients—defined broadly as individuals with lived experience of a given condition, family members, caregivers, and the organisations that represent them—as partners in research is a priority for policymakers, funders, and the public. Nonetheless, formal efforts to engage patients are absent from most studies, and models to support meaningful patient engagement in clinical anaesthesia research have not been previously described.
Intelligent checklists improve checklist compliance in the intensive care unit: a prospective before-and-after mixed-method study
Ashley J.R. De Bie, Eveline Mestrom, Wilma Compagner, Shan Nan, ... Erik H.H.M. Korsten
doi : 10.1016/j.bja.2020.09.044
Volume 126, Issue 2, February 2021, Pages 404-414
We examined whether a context and process-sensitive ‘intelligent’ checklist increases compliance with best practice compared with a paper checklist during intensive care ward rounds.
Polypharmacy and emergency readmission to hospital after critical illness: a population-level cohort study
Angus J. Turnbull, Eddie Donaghy, Lisa Salisbury, Pamela Ramsay, ... Nazir Lone
doi : 10.1016/j.bja.2020.09.035
Volume 126, Issue 2, February 2021, Pages 415-422
Polypharmacy is common and closely linked to drug interactions. The impact of polypharmacy has not been previously quantified in survivors of critical illness who have reduced resilience to stressors. Our aim was to identify factors associated with preadmission polypharmacy and ascertain whether polypharmacy is an independent risk factor for emergency readmission to hospital after discharge from a critical illness.
Improving perioperative brain health: an expert consensus review of key actions for the perioperative care team
Carol J. Peden, Thomas R. Miller, Stacie G. Deiner, Roderic G. Eckenhoff, ... Robert A. Whittington
doi : 10.1016/j.bja.2020.10.037
Volume 126, Issue 2, February 2021, Pages 423-432
Delirium and postoperative neurocognitive disorder are the commonest perioperative complications in patients more than 65 yr of age. However, data suggest that we often fail to screen patients for preoperative cognitive impairment, to warn patients and families of risk, and to take preventive measures to reduce the incidence of perioperative neurocognitive disorders.
Prospectively assessed neurodevelopmental outcomes in studies of anaesthetic neurotoxicity in children: a systematic review and meta-analysis
Caleb Ing, William M. Jackson, Michael J. Zaccariello, Terry E. Goldberg, ... David O. Warner
doi : 10.1016/j.bja.2020.10.022
Volume 126, Issue 2, February 2021, Pages 433-444
Whether exposure to a single general anaesthetic (GA) in early childhood causes long-term neurodevelopmental problems remains unclear.
Effects of noxious stimulation on the electroencephalogram during general anaesthesia: a narrative review and approach to analgesic titration
Paul S. Garc?a, Matthias Kreuzer, Darren Hight, James W. Sleigh
doi : 10.1016/j.bja.2020.10.036
Volume 126, Issue 2, February 2021, Pages 445-457
Electroencephalographic (EEG) activity is used to monitor the neurophysiology of the brain, which is a target organ of general anaesthesia. Besides its use in evaluating hypnotic states, neurophysiologic reactions to noxious stimulation can also be observed in the EEG.
Association between plasma tau and postoperative delirium incidence and severity: a prospective observational study
Tyler Ballweg, Marissa White, Margaret Parker, Cameron Casey, ... Robert D. Sanders
doi : 10.1016/j.bja.2020.08.061
Volume 126, Issue 2, February 2021, Pages 458-466
Postoperative delirium is associated with increases in the neuronal injury biomarker, neurofilament light (NfL). Here we tested whether two other biomarkers, glial fibrillary acidic protein (GFAP) and tau, are associated with postoperative delirium.
Association between cerebrospinal fluid biomarkers of neuronal injury or amyloidosis and cognitive decline after major surgery
Mattias Danielson, Andreas Wiklund, Fredrik Granath, Kaj Blennow, ... Lars I. Eriksson
doi : 10.1016/j.bja.2020.09.043
Volume 126, Issue 2, February 2021, Pages 467-476
Postoperative neurocognitive decline is a frequent complication in adult patients undergoing major surgery with increased risk for morbidity and mortality. The mechanisms behind cognitive decline after anaesthesia and surgery are not known. We studied the association between CSF and blood biomarkers of neuronal injury or brain amyloidosis and long-term changes in neurocognitive function.
Desflurane and sevoflurane differentially affect activity of the subthalamic nucleus in Parkinson's disease
Yu-Chen Chen, Shin-Yuan Chen, Tsung-Ying Chen, Jiann-I Pan, Sheng-Tzung Tsai
doi : 10.1016/j.bja.2020.09.041
Volume 126, Issue 2, February 2021, Pages 477-485
Desflurane and sevoflurane are commonly used during inhalational anaesthesia, but few studies have investigated their effects on deep cerebral neuronal activity. In addition, the association between subthalamic nucleus (STN) neurophysiology and general anaesthesia induced by volatile anaesthetics are not yet identified. This study aimed to identify differences in neurophysiological characteristics of the STN during comparable minimal alveolar concentration (MAC) desflurane and sevoflurane anaesthesia for deep brain stimulation (DBS) in patients with Parkinson's disease.
Infant isoflurane exposure affects social behaviours, but does not impair specific cognitive domains in juvenile non-human primates
Viola Neudecker, Jose F. Perez-Zoghbi, Kristine Coleman, Martha Neuringer, ... Ansgar M. Brambrink
doi : 10.1016/j.bja.2020.10.015
Volume 126, Issue 2, February 2021, Pages 486-499
Clinical studies show that children exposed to anaesthetics for short times at young age perform normally on intelligence tests, but display altered social behaviours. In non-human primates (NHPs), infant anaesthesia exposure for several hours causes neurobehavioural impairments, including delayed motor reflex development and increased anxiety-related behaviours assessed by provoked response testing. However, the effects of anaesthesia on spontaneous social behaviours in juvenile NHPs have not been investigated. We hypothesised that multiple, but not single, 5 h isoflurane exposures in infant NHPs are associated with impairments in specific cognitive domains and altered social behaviours at juvenile age.
Epidural analgesia, intrapartum hyperthermia, and neonatal brain injury: a systematic review and meta-analysis
Sarah Morton, Justin Kua, Christopher J. Mullington
doi : 10.1016/j.bja.2020.09.046
Volume 126, Issue 2, February 2021, Pages 500-515
Epidural analgesia is associated with intrapartum hyperthermia, and chorioamnionitis is associated with neonatal brain injury. However, it is not known if epidural hyperthermia is associated with neonatal brain injury. This systematic review and meta-analysis investigated three questions: (1) does epidural analgesia cause intrapartum hyperthermia, (2) is intrapartum hyperthermia associated with neonatal brain injury, and (3) is epidural-induced hyperthermia associated with neonatal brain injury?
Nociception level-guided opioid administration in radical retropubic prostatectomy: a randomised controlled trial
Sandra Funcke, Hans O. Pinnschmidt, Charlotte Brinkmann, Stefan Wesseler, ... Rainer Nitzschke
doi : 10.1016/j.bja.2020.09.051
Volume 126, Issue 2, February 2021, Pages 516-524
This RCT investigated the effect of opioid titration by three different nociception monitoring devices or clinical signs during general anaesthesia.
Few and feasible preoperative variables can identify high-risk surgical patients: derivation and validation of the Ex-Care risk model
Claudia S. Gutierrez, S?vio C. Passos, Stela M.J. Castro, Lucas S.M. Okabayashi, ... Luciana C. Stefani
doi : 10.1016/j.bja.2020.09.036
Volume 126, Issue 2, February 2021, Pages 525-532
The development of feasible preoperative risk tools is desirable, especially for low-middle income countries with limited resources and complex surgical settings. This study aimed to derive and validate a preoperative risk model (Ex-Care model) for postoperative mortality and compare its performance with current risk tools.
Ventilation and outcomes following robotic-assisted abdominal surgery: an international, multicentre observational study
Assessment of Ventilation during general AnesThesia for Robotic surgery (AVATaR) Study Investigators, for the PROtective VEntilation (PROVE) Network, Veronica N.F. Queiroz, Luis Guilherme V. da Costa, ... Lindsey Woods
doi : 10.1016/j.bja.2020.08.058
Volume 126, Issue 2, February 2021, Pages 533-543
International data on the epidemiology, ventilation practice, and outcomes in patients undergoing abdominal robotic-assisted surgery (RAS) are lacking. The aim of the study was to assess the incidence of postoperative pulmonary complications (PPCs), and to describe ventilator management after abdominal RAS.
Minimising exposure to droplet and aerosolised pathogens: a computational fluid dynamics study
Paolo Perella, Mohammad Tabarra, Ertan Hataysal, Amir Pournasr, Ian Renfrew
doi : 10.1016/j.bja.2020.09.047
Volume 126, Issue 2, February 2021, Pages 544-549
Hazardous pathogens are spread in either droplets or aerosols produced during aerosol-generating procedures (AGP). Adjuncts minimising exposure of healthcare workers to hazardous pathogens released during AGP may be beneficial. We used state-of-the-art computational fluid dynamics (CFD) modelling to optimise the performance of a custom-designed shield.
Bayesian predictive probabilities: a good way to monitor clinical trials
David Ferreira, Pierre-Olivier Ludes, Pierre Diemunsch, Eric Noll, ... Nicolas Meyer
doi : 10.1016/j.bja.2020.08.062
Volume 126, Issue 2, February 2021, Pages 550-555
Bayesian methods, with the predictive probability (PredP), allow multiple interim analyses with interim posterior probability (PostP) computation, without the need to correct for multiple looks at the data. The objective of this paper was to illustrate the use of PredP by simulating a sequential analysis of a clinical trial.
Fresh gas flows, filters, heat and moisture exchangers, and humidification. Comment on Br J Anaesth 2020; 125: 773–778
Rhys Thomas
doi : 10.1016/j.bja.2020.09.027
Volume 126, Issue 2, February 2021, Page e53
Goal-directed fluid therapy for oesophagectomy surgery
Alexandre Joosten, Philippe Van der Linden, Jean-Louis Vincent, Jacques Duranteau
doi : 10.1016/j.bja.2020.10.025
Volume 126, Issue 2, February 2021, Pages e54-e55
A randomised pilot trial of combined cognitive and physical exercise prehabilitation to improve outcomes in surgical patients
Kimberly F. Rengel, Nitin Mehdiratta, Susan W. Vanston, Kristin R. Archer, ... Christopher G. Hughes
doi : 10.1016/j.bja.2020.11.004
Volume 126, Issue 2, February 2021, Pages e55-e57
Succinylcholine rescue for sugammadex-induced laryngospasm. Comment on Br J Anaesth 2020; 125: 423–5
Amit Jain, Jaya Batra, Massimo Lamperti, D.John Doyle
doi : 10.1016/j.bja.2020.11.001
Volume 126, Issue 2, February 2021, Pages e58-e59
Perioperative automation: Time to become artificial intelligence literate? Response to Br J Anaesth 2020; 125: 843–6
Heidi V. Goldstein, Joseph C. Goldstein
doi : 10.1016/j.bja.2020.10.033
Volume 126, Issue 2, February 2021, Pages e59-e61
Variability in experimental pain studies: nuisance or opportunity?
Victoria J. Madden, Peter R. Kamerman, Mark J. Catley, Valeria Bellan, ... G. Lorimer Moseley
doi : 10.1016/j.bja.2020.11.005
Volume 126, Issue 2, February 2021, Pages e61-e64
Nociception level-guided fentanyl titration: potential impact of multimodal anaesthesia and false positives. Comment on Br J Anaesth 2020; 125: 1070–8
Sean Coeckelenbergh, Hugo E.M. Vereecke, Philippe Richebé
doi : 10.1016/j.bja.2020.10.030
Volume 126, Issue 2, February 2021, Pages e64-e65
Nociception level monitoring for personalized analgesic treatment. Response to Br J Anaesth 2020; 125: 1070-8
Fleur Meijer, Maarten Honing, Tessa Roor, Samantha Toet, ... Albert Dahan
doi : 10.1016/j.bja.2020.11.015
Volume 126, Issue 2, February 2021, Pages e65-e66
Doing more and doing better: improving racial and ethnic disparities research in anaesthesiology
Julia M. Rosenbloom, Michael R. King, Thomas A. Anderson
doi : 10.1016/j.bja.2020.11.003
Volume 126, Issue 2, February 2021, Pages e66-e68
A student's perspective on the relevance of anaesthesia and critical care to the medical school curriculum. Response to Br J Anaesth 2018; 121: 993–6
Aditya Krishnan
doi : 10.1016/j.bja.2020.11.013
Volume 126, Issue 2, February 2021, Pages e68-e69
Haemodynamic impact of positive end-expiratory pressure in SARS-CoV-2 acute respiratory distress syndrome: oxygenation versus oxygen delivery
Romain Barthélémy, Victor Beaucoté, Raphaëlle Bordier, Magalie Collet, ... Benjamin G. Chousterman
doi : 10.1016/j.bja.2020.10.026
Volume 126, Issue 2, February 2021, Pages e70-e72
Potential for personalised application of inhaled nitric oxide in COVID-19 pneumonia
Benjamin Garfield, Charles McFadyen, Charlotte Briar, Caroline Bleakley, ... Laura C. Price
doi : 10.1016/j.bja.2020.11.006
Volume 126, Issue 2, February 2021, Pages e72-e75
Hypoxaemia does not necessitate tracheal intubation in COVID-19 patients. Comment on Br J Anaesth 2021; 126: 44-7
Martin J. Tobin, Amal Jubran, Franco Laghi
doi : 10.1016/j.bja.2020.11.007
Volume 126, Issue 2, February 2021, Pages e75-e76
Optical gas imaging of carbon dioxide at tracheal extubation: a novel technique for visualising exhaled breath
Brian Murphy, Ronan Cahill, Conan McCaul, Donal Buggy
doi : 10.1016/j.bja.2020.11.016
Volume 126, Issue 2, February 2021, Pages e77-e78
Perioperative analgesia for colorectal cancer patients
E. Gill, C. Thomas, S. Sonwalkar, S. Howell
doi : 10.1016/j.bja.2020.11.010
Volume 126, Issue 2, February 2021, Page e79
Effects of 6-hydroxymelatonin in human macrophage model of inflammasome activation in conditions mimicking sepsis
E. Musatti, N. Webster, H. Wilson, H. Galley
doi : 10.1016/j.bja.2020.11.011
Volume 126, Issue 2, February 2021, Pages e79-e80
Myocardial inflammation after major non-cardiac thoracic surgery
E. Murphy, A. Glass, P. McCall, B. Shelley
doi : 10.1016/j.bja.2020.11.012
Volume 126, Issue 2, February 2021, Pages e80-e81
Leadership in Anaesthesia. Five Pioneers of the Deadly Quest for Surgical Insensibility Berend Mets Published by Cambridge Scholars Publishing, Newcastle upon Tyne, UK, 2020, pp. 340. Price £64.99. ISBN9781527555969.
Christine Ball
doi : 10.1016/j.bja.2020.11.002
Volume 126, Issue 2, February 2021, Pages 556-557
