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Associate Editorial Board
doi : 10.1016/S0007-0912(21)00181-1
Volume 126, Issue 5, May 2021, Page ii
Data visualisation and cognitive ergonomics in anaesthesia and healthcare
Craig S. Webster, Jennifer M. Weller
doi : 10.1016/j.bja.2021.01.009
Volume 126, Issue 5, May 2021, Pages 913-915
Preprints in perioperative medicine: immediacy for the greater good
Rupert M. Pearse, Gareth L. Ackland, Takashi Asai, Hugh C. Hemmings
doi : 10.1016/j.bja.2021.02.024
Volume 126, Issue 5, May 2021, Pages 915-918
There is light at the end of the tunnel, but we are still in the tunnel: universal preoperative SARS-CoV-2 testing and precautions remain vital in paediatrics
Adam C. Adler, Elaina E. Lin
doi : 10.1016/j.bja.2021.01.025
Volume 126, Issue 5, May 2021, Pages 919-920
Inhalation or total intravenous anaesthesia and recurrence after colorectal cancer surgery: a propensity score matched Danish registry-based study
Rune P. Hasselager, Jesper Hallas, Ismail G?genur
doi : 10.1016/j.bja.2020.11.019
Volume 126, Issue 5, May 2021, Pages 921-930
During colorectal cancer surgery, the immune-modulating effects of inhalation anaesthesia may create a favourable environment for metastasis formation, leading to increased risk of recurrence. Our aim was to assess the association between inhalation vs intravenous anaesthesia and cancer recurrence in patients undergoing colorectal cancer surgery.
Opioids and premature biochemical recurrence of prostate cancer: a randomised prospective clinical trial
Felipe P. Rangel, José O.C. Auler, Maria J.C. Carmona, Mauricio D. Cordeiro, ... Claudia M. Sim?es
doi : 10.1016/j.bja.2021.01.031
Volume 126, Issue 5, May 2021, Pages 931-939
Prostate cancer is one of the most prevalent neoplasms in male patients, and surgery is the main treatment. Opioids can have immune modulating effects, but their relation to cancer recurrence is unclear. We evaluated whether opioids used during prostatectomy can affect biochemical recurrence-free survival.
Relationship of perioperative anaphylaxis to neuromuscular blocking agents, obesity, and pholcodine consumption: a case-control study
Paul H.M. Sadleir, Russell C. Clarke, Catherine E. Goddard, Conor Day, ... Peter R. Platt
doi : 10.1016/j.bja.2020.12.018
Volume 126, Issue 5, May 2021, Pages 940-948
The observation that patients presenting for bariatric surgery had a high incidence of neuromuscular blocking agent (NMBA) anaphylaxis prompted this restricted case-control study to test the hypothesis that obesity is a risk factor for NMBA anaphylaxis, independent of differences in pholcodine consumption.
First genome-wide association study on rocuronium dose requirements shows association with SLCO1A2
Sirkku Ahlstr?m, Paula Bergman, Ritva Jokela, Linda Ottensmann, ... Eija Kalso
doi : 10.1016/j.bja.2021.01.029
Volume 126, Issue 5, May 2021, Pages 949-957
Rocuronium, a common neuromuscular blocking agent, is mainly excreted unchanged in urine (10–25%) and bile (>70%). Age, sex, liver blood flow, smoking, medical conditions, and ethnic background can affect its pharmacological actions. However, reasons for the wide variation in rocuronium requirements are mostly unknown. We hypothesised that pharmacogenetic factors might explain part of the variation.
Bosutinib reduces endothelial permeability and organ failure in a rat polytrauma transfusion model
Derek J.B. Kleinveld, Liza Botros, M. Adrie W. Maas, Jesper Kers, ... Nicole P. Juffermans
doi : 10.1016/j.bja.2021.01.032
Volume 126, Issue 5, May 2021, Pages 958-966
Trauma-induced shock is associated with endothelial dysfunction. We examined whether the tyrosine kinase inhibitor bosutinib as an adjunct therapy to a balanced blood component resuscitation strategy reduces trauma-induced endothelial permeability, thereby improving shock reversal and limiting transfusion requirements and organ failure in a rat polytrauma transfusion model.
Cerebral autoregulation in the operating room and intensive care unit after cardiac surgery
Mitsunori Nakano, Yohei Nomura, Glenn Whitman, Marc Sussman, ... Charles H. Brown
doi : 10.1016/j.bja.2020.12.043
Volume 126, Issue 5, May 2021, Pages 967-974
Cerebral autoregulation monitoring is a proposed method to monitor perfusion during cardiac surgery. However, limited data exist from the ICU as prior studies have focused on intraoperative measurements. Our objective was to characterise cerebral autoregulation during surgery and early ICU care, and as a secondary analysis to explore associations with delirium.
Offline comparison of processed electroencephalogram monitors for anaesthetic-induced electroencephalogram changes in older adults
Sarah L. Eagleman, Caitlin M. Drover, Xi Li, M. Bruce MacIver, David R. Drover
doi : 10.1016/j.bja.2020.12.042
Volume 126, Issue 5, May 2021, Pages 975-984
Several devices record and interpret patient brain activity via electroencephalogram (EEG) to aid physician assessment of anaesthetic effect. Few studies have compared EEG monitors on data from the same patient. Here, we describe a set-up to simultaneously compare the performance of three processed EEG monitors using pre-recorded EEG signals from older surgical patients.
Contributions of synaptic and astrocyte physiology to the anaesthetised encephalogram revealed using a computational model
George Hadjipavlou, Catherine E. Warnaby, James Fitzgerald, Jamie Sleigh
doi : 10.1016/j.bja.2021.01.034
Volume 126, Issue 5, May 2021, Pages 985-995
General anaesthesia is known to enhance inhibitory synaptic transmission to produce characteristic effects on the EEG and reduction in brain metabolism secondary to reduced neuronal activity. Evidence suggests that anaesthesia might have a direct effect on synaptic metabolic processes, and this relates to anaesthesia sensitivity. We explored elements of synaptic transmission looking for possible contributions to the anaesthetised EEG and how it may modulate anaesthesia sensitivity.
Electrophysiological signatures of acute systemic lipopolysaccharide-induced inflammation: potential implications for delirium science
Ziyad W. Sultan, Elizabeth R. Jaeckel, Bryan M. Krause, Sean M. Grady, ... Matthew I. Banks
doi : 10.1016/j.bja.2020.12.040
Volume 126, Issue 5, May 2021, Pages 996-1008
Novel preventive therapies are needed for postoperative delirium, which especially affects older patients. A mouse model is presented that captures inflammation-associated cortical slow wave activity (SWA) observed in patients, allowing exploration of the mechanistic role of prostaglandin-adenosine signalling.
Effect of dexmedetomidine on sevoflurane-induced neurodegeneration in neonatal rats
Jeong-Rim Lee, Bernadin Joseph, Rylon D. Hofacer, Brian Upton, ... Andreas W. Loepke
doi : 10.1016/j.bja.2021.01.033
Volume 126, Issue 5, May 2021, Pages 1009-1021
Structural brain abnormalities in newborn animals after prolonged exposure to all routinely used general anaesthetics have raised substantial concerns for similar effects occurring in millions of children undergoing surgeries annually. Combining a general anaesthetic with non-injurious sedatives may provide a safer anaesthetic technique. We tested dexmedetomidine as a mitigating therapy in a sevoflurane dose-sparing approach.
Association between ionised calcium and severity of postpartum haemorrhage: a retrospective cohort study
Danny Epstein, Neta Solomon, Alexander Korytny, Erez Marcusohn, ... Asaf Miller
doi : 10.1016/j.bja.2020.11.020
Volume 126, Issue 5, May 2021, Pages 1022-1028
Postpartum haemorrhage (PPH) is often complicated by impaired coagulation. We aimed to determine whether the level of ionised calcium (Ca2+), an essential coagulation co-factor, at diagnosis of PPH is associated with bleeding severity.
Minimal clinically important differences in randomised clinical trials on pain management after total hip and knee arthroplasty: a systematic review
Jens Laigaard, Casper Pedersen, Thea N?rgaard R?nsbo, Ole Mathiesen, Anders Peder H?jer Karlsen
doi : 10.1016/j.bja.2021.01.021
Volume 126, Issue 5, May 2021, Pages 1029-1037
Sample size determination is essential for reliable hypothesis testing in clinical trials and should rely on adequate sample size calculations with alpha, beta, variance, and an effect size being the minimal clinically important difference (MCID). This facilitates interpretation of the clinical relevance of statistically significant results. No gold standard for MCIDs exists in postoperative pain research.
Determination of equi-analgesic doses of inhaled methoxyflurane versus intravenous fentanyl using the cold pressor test in volunteers: a randomised, double-blinded, placebo-controlled crossover study
Harald Lenz, Lars ?. H?iseth, Marlin Comelon, Tomas Draegni, Leiv A. Rosseland
doi : 10.1016/j.bja.2020.12.045
Volume 126, Issue 5, May 2021, Pages 1038-1045
Inhaled methoxyflurane for acute pain relief has demonstrated an analgesic effect superior to placebo. Data comparing methoxyflurane to an opioid are needed. The aim of this study was to determine the equi-analgesic doses of inhaled methoxyflurane vs i.v. fentanyl. Both drugs have an onset within minutes and an analgesic effect of 20–30 min.
Avatar-based patient monitoring in critical anaesthesia events: a randomised high-fidelity simulation study
Tadzio R. Roche, Sadiq Said, Julia Braun, Elise J.C. Maas, ... David W. Tscholl
doi : 10.1016/j.bja.2021.01.015
Volume 126, Issue 5, May 2021, Pages 1046-1054
Failures in situation awareness cause two-thirds of anaesthesia complications. Avatar-based patient monitoring may promote situation awareness in critical situations.
Effectiveness of intubation devices in patients with cervical spine immobilisation: a systematic review and network meta-analysis
Barry N. Singleton, Fiachra K. Morris, Barbaros Yet, Donal J. Buggy, Zane B. Perkins
doi : 10.1016/j.bja.2020.12.041
Volume 126, Issue 5, May 2021, Pages 1055-1066
Cervical spine immobilisation increases the difficulty of tracheal intubation. Many intubation devices have been evaluated in this setting, but their relative performance remains uncertain.
Lung recruitment in the prone position after cardiac surgery: a randomised controlled study
Andreas Martinsson, Erik Houltz, Andreas Wallinder, Sophie Lindgren, Anders Thorén
doi : 10.1016/j.bja.2020.12.039
Volume 126, Issue 5, May 2021, Pages 1067-1074
Atelectasis after cardiac surgery is common and promotes ventilation/perfusion mismatch, infection, and delayed discharge from critical care. Recruitment manoeuvres are often performed to reduce atelectasis. In severe respiratory failure, recruitment manoeuvres in the prone position may increase oxygenation, survival, or both. We compared the effects of recruitment manoeuvres in the prone vs supine position on lung aeration and oxygenation in cardiac surgical patients.
Realising the full potential of anaesthesiology to promote enhanced recovery after surgery programmes in China
Chaojin Chen, Xiaoyue Li, Gangjian Luo, Shaoli Zhou, Ziqing Hei
doi : 10.1016/j.bja.2021.01.016
Volume 126, Issue 5, May 2021, Pages e157-e159
The UK anaesthesia workforce is in deepening crisis
Lloyd E. Kwanten
doi : 10.1016/j.bja.2021.01.020
Volume 126, Issue 5, May 2021, Pages e159-e161
Nociception monitor-guided opioid administration in radical retropubic prostatectomy. Manufacturer's response to Br J Anaesth 2020; 126: 516–24
Frank J. Overdyk, Rachel Weissbrod
doi : 10.1016/j.bja.2021.01.022
Volume 126, Issue 5, May 2021, Pages e161-e162
Gender differences in the authorship of contemporary anaesthesia literature: a cross-sectional study
Lisa Q. Rong, Faiza M. Khan, Ajita Naik, N. Bryce Robinson, ... Mario Gaudino
doi : 10.1016/j.bja.2021.01.023
Volume 126, Issue 5, May 2021, Pages e162-e164
Transient involuntary fixation on a second language following exposure to general anaesthetics
Craig S. Webster, Robert O.S. Grieve
doi : 10.1016/j.bja.2021.01.024
Volume 126, Issue 5, May 2021, Pages e164-e167
Identification of lung overdistension caused by tidal volume and positive end-expiratory pressure increases based on electrical impedance tomography
Zhanqi Zhao, Ling Sang, Yimin Li, Inéz Frerichs, ... Feng Fu
doi : 10.1016/j.bja.2021.01.026
Volume 126, Issue 5, May 2021, Pages e167-e170
Calculating positive and negative predictive values. Comment on Br J Anaesth 2021; 126: 564-7
Erik Olofsen, Albert Dahan
doi : 10.1016/j.bja.2021.02.001
Volume 126, Issue 5, May 2021, Pages e170-e171
Posterior femoral cutaneous nerve block improves regional anaesthesia for below-knee surgery
Xing Xiuhua, Qian Zhiqiang, Zhou Quanhong
doi : 10.1016/j.bja.2021.02.002
Volume 126, Issue 5, May 2021, Pages e171-e172
Clinical validation of pharmacokinetic and pharmacodynamic models for propofol infusion. Comment on Br J Anaesth 2021; 126: 386–94
Thomas W. Schnider, Charles F. Minto, Talmage D. Egan, Miodrag Filipovic
doi : 10.1016/j.bja.2021.02.004
Volume 126, Issue 5, May 2021, Pages e172-e174
Relationship between variations in cardiac output and end-tidal CO2 after phenylephrine infusion in anaesthetised patients
Hugues de Courson, Delphine Georges, Philippe Boyer, Emmanuel Futier, Matthieu Biais
doi : 10.1016/j.bja.2021.02.007
Volume 126, Issue 5, May 2021, Pages e174-e176
Carbon dioxide partial pressure and oxygen saturation in venous blood from the upper body compared with mixed venous blood
Franco Cavaliere, Francesca Bevilacqua, Bruno M. Cesana, Maria Calabrese, ... Andrea Scapigliati
doi : 10.1016/j.bja.2021.01.018
Volume 126, Issue 5, May 2021, Pages e177-e179
Mechanistic insights into spinal neurones involved in neuraxial opioid-induced pruritus
Eileen Nguyen, Grace Lim, Sarah E. Ross
doi : 10.1016/j.bja.2021.02.009
Volume 126, Issue 5, May 2021, Pages e179-e181
Mandatory preoperative SARS-CoV-2 infection screening policies for paediatric surgery
Anne-Emmanuelle Colas, Mehdi Azale, Fanny Ayanmanesh, Celine Tran, ... Souhayl Dahmani
doi : 10.1016/j.bja.2021.01.007
Volume 126, Issue 5, May 2021, Pages e182-e184
Trends in personal protective equipment use by clinicians performing airway procedures for patients with coronavirus disease 2019 in the USA from the intubateCOVID registry
Timothy G. Gaulton, Mark D. Neuman, Timothy Gaulton, Mark Neuman, ... Meir Dashevksy
doi : 10.1016/j.bja.2021.01.019
Volume 126, Issue 5, May 2021, Pages e184-e186
SARS-CoV-2 in perioperative medicine: lessons learnt
Aisling N? Eochag?in, Jonathan G. Hardman, Donal J. Buggy
doi : 10.1016/j.bja.2021.02.005
Volume 126, Issue 5, May 2021, Pages e187-e188
Putative antiviral effects of propofol in COVID-19
Penghui Wei, Qiang Zheng, Haotian Ye, Wenyuan Lyu, ... Jian-jun Yang
doi : 10.1016/j.bja.2021.02.006
Volume 126, Issue 5, May 2021, Pages e188-e191
Characterising the pulmonary response to prone positioning. Comment on Br J Anaesth 2021; 126: 48-55
Thomas Chad
doi : 10.1016/j.bja.2021.02.008
Volume 126, Issue 5, May 2021, Pages e191-e192
Physical Diagnosis of Pain: Atlas of Signs and Symptoms of Pain, 4th ed Steven Waldman, editor Elsevier (Philadelphia, PS, USA) £153.99, pp. 468, ISBN No: 9780323712606
Patrice Forget
doi : 10.1016/j.bja.2021.01.027
Volume 126, Issue 5, May 2021, Page 1075
Acknowledgement of Assessors
doi : 10.1016/j.bja.2021.03.001
Volume 126, Issue 5, May 2021, Pages 1076-1080
