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Highlights from this issue
Frank Larkin
doi : 10.1136/bjophthalmol-2021-319810
British Journal of Ophthalmology 2021;105:i-ii.
Plague rampant: two sides of the coin
Ludwig M Heindl, Vincent Michel Borderie
doi : 10.1136/bjophthalmol-2021-319687
British Journal of Ophthalmology 2021;105:891-892.
Characteristics of endothelial corneal transplant rejection following immunisation with SARS-CoV-2 messenger RNA vaccine
Maria Phylactou, Ji-Peng Olivia Li, Daniel F P Larkin
doi : 10.1136/bjophthalmol-2021-319338
British Journal of Ophthalmology 2021;105:893-896
We report two cases of endothelial corneal allograft rejection following immunisation with SARS-CoV-2 messenger RNA (mRNA) vaccine BNT162b2 and describe the implications for management of transplant recipients postvaccination for COVID-19.
Clinical spectrum of non-syndromic microphthalmos, anophthalmos and coloboma in the paediatric population: a multicentric study from North India
Shailja Tibrewal, Ketaki Subhedar, Pradnya Sen, Amit Mohan, Shivanand Singh, Chintan Shah, Ken K Nischal, Suma Ganesh, The Bodhya Eye Consortium
doi : 10.1136/bjophthalmol-2020-316910
British Journal of Ophthalmology 2021;105:897-903.
To describe the clinical features, visual acuity and causes of ocular morbidity in children (0–18 years) with microphthalmos, anophthalmos, and coloboma (MAC) from North India.
National approaches to trichiasis surgical follow-up, outcome assessment and surgeon audit in trachoma-endemic countries in Africa
Grace Mwangi, Paul Courtright, Anthony W Solomon
doi : 10.1136/bjophthalmol-2019-315777
British Journal of Ophthalmology 2021;105:904-908.
Poor outcomes of trichiasis surgery, including postoperative trichiasis, are common in many trachoma-endemic countries in Africa. To improve outcomes, WHO recommends regular follow-up and outcome assessment of surgical cases plus audit of trichiasis surgeons.
Assessment of conjunctival flora in eyes with lacrimal passage obstruction before and after successful dacryoendoscopic recanalisation
Takahiro Hiraoka, Sujin Hoshi, Kuniharu Tasaki, Tetsuro Oshika
doi : 10.1136/bjophthalmol-2020-316264
British Journal of Ophthalmology 2021;105:909-913.
To investigate conjunctival bacterial flora in eyes with lacrimal passage obstruction before and after dacryoendoscopic recanalisation with lacrimal tube intubation.
Ocular adnexal lymphoma in Denmark: a nationwide study of 387 cases from 1980 to 2017
Frederik Holm, Lauge Hjorth Mikkelsen, Peter Kamper, Peter Kristian Rasmussen, Thomas Stauffer Larsen, Lene Dissing Sj?, Steffen Heegaard
doi : 10.1136/bjophthalmol-2019-315637
British Journal of Ophthalmology 2021;105:914-920
Nationwide studies of ocular adnexal lymphoma (OAL) are very rare in the literature, and knowledge on incidence, subtype distribution and long-term survival data is limited. This is the largest national study of OAL to date. This study sought to find information on incidence, changes in incidence, clinical findings, distribution of subtypes, survival and prognostic factors.
Proposal and validation of a new grading system for pterygium (SLIT2)
Darren Shu Jeng Ting, Yu-Chi Liu, Moushmi Patil, Angel Jung Se Ji, Xiao Ling Fang, Yih Chung Tham, Yi-Fang Lee, Hla M Htoon, Jodhbir S. Mehta
doi : 10.1136/bjophthalmol-2020-315831
British Journal of Ophthalmology 2021;105:921-924.
To propose and validate a new pterygium grading system based on slit-lamp evaluation.
Determinants of corneal endothelial cell loss after sulcus placement of Ahmed and Baerveldt drainage device surgery
Yumiko Murakami, Kazuyuki Hirooka, Yuki Yuasa, Hideaki Okumichi, Kana Tokumo, Reo Kawano, Yoshiaki Kiuchi
doi : 10.1136/bjophthalmol-2020-316379
British Journal of Ophthalmology 2021;105:925-928.
In patients who underwent multiple intraocular surgeries, we evaluated determinants of decreased corneal endothelial cell density (CECD) after sulcus placement following Ahmed and Baerveldt drainage device surgery.
Anterior segment optical coherence tomography angiography for iris vasculature in pigmented eyes
Marcus Ang, Kavya Devarajan, Anna CS Tan, Mengyuan Ke, Bingyao Tan, Kaiying Teo, Chelvin C.A. Sng, Daniel S Ting, Leopold Schmetterer
doi : 10.1136/bjophthalmol-2020-316930
British Journal of Ophthalmology 2021;105:929-934.
To compare anterior segment optical coherence tomography angiography (AS-OCTA) systems in delineating normal iris vessels and iris neovascularisation (NVI) in eyes with pigmented irides.
Quality of life in patients with uveitis: data from the ULISSE study (Uveitis: cLInical and medico-economic evaluation of a Standardised Strategy for the Etiological diagnosis)
Pierre-jean Bertrand, Yvan Jamilloux, Laurent Kodjikian, Marie-Helene Errera, Laurent Perard, Gregory Pugnet, Nathalie Tieulie, Marc Andre, Philip Bielefeld, Alain M Bron, Evelyne Decullier, Sylvie Bin, Pascal Seve
doi : 10.1136/bjophthalmol-2020-315862
British Journal of Ophthalmology 2021;105:935-940.
To assess vision-related (VR-QOL) and health-related quality of life (HR-QOL) in a large series of patients with de novo uveitis at baseline and 6-month follow-up.
Standardisation of optical coherence tomography angiography nomenclature in uveitis: first survey results
Francesco Pichi, Ester Carre?o Salas, Marc D de Smet, Vishali Gupta, Manfred Zierhut, Marion R Munk
doi : 10.1136/bjophthalmol-2020-316881
British Journal of Ophthalmology 2021;105:941-947.
To standardise the nomenclature for reporting optical coherence angiography (OCT-A) findings in the field of uveitis.
Intraocular pressure and circumpapillary retinal nerve fibre layer thickness in the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA): distributions and associations
Paul McCann, Ruth Hogg, David M Wright, Usha Chakravarthy, Tunde Peto, Sharon Cruise, Bernardette McGuinness, Ian S Young, Frank Kee, Augusto Azuara-Blanco
doi : 10.1136/bjophthalmol-2020-316499
British Journal of Ophthalmology 2021;105:948-956.
To describe the distributions of and associations with intraocular pressure (IOP) and circumpapillary retinal nerve fibre layer (cRNFL) thickness in a population-based study.
Diagnostic validity of optic nerve head colorimetric assessment and optical coherence tomography angiography in patients with glaucoma
Carmen Mendez-Hernandez, Surina Wang, Paula Arribas-Pardo, Liseth Salazar-Qui?ones, Noemi Güemes-Villahoz, Cristina Fernandez-Perez, Julian Garcia-Feijoo
doi : 10.1136/bjophthalmol-2020-316455
British Journal of Ophthalmology 2021;105:957-963.
The aim of this study was to assess the optic nerve head (ONH) and macular vessel density with optical coherence tomography angiography (OCT-A) and the ONH haemoglobin (ONH Hb) amount with Laguna ONhE program in open-angle glaucoma (OAG) patients.
Relationship between peripapillary vessel density and visual field in glaucoma: a broken-stick model
Min Kyung Song, Joong Won Shin, Younhye Jo, Hun Jae Won, Michael S Kook
doi : 10.1136/bjophthalmol-2020-315973
British Journal of Ophthalmology 2021;105:964-969.
To determine the tipping point at which peripapillary vessel density (pVD), measured using optical coherence tomography angiography (OCT-A), is associated with detectable visual field (VF) loss in cases of open-angle glaucoma (OAG).
Association of anterior segment parameters and 5-year incident narrow angles: findings from an older Chinese population
Yu Jiang, Wei Wang, Lanhua Wang, Mingguang He
doi : 10.1136/bjophthalmol-2020-315852
British Journal of Ophthalmology 2021;105:970-976.
To assess the association of anterior segment optical coherence tomography (AS-OCT) parameters and 5-year incident narrow angle in China.
Outcomes of gonioscopy-assisted transluminal trabeculotomy in pseudoexfoliative glaucoma: 24-month follow-up
Eamon Sharkawi, Daniel Josef Lindegger, Paul H Artes, Lydia Lehmann-Clarke, Mohamad El Wardani, Marie Misteli, Jérôme Pasquier, Adriano Guarnieri
doi : 10.1136/bjophthalmol-2020-315954
British Journal of Ophthalmology 2021;105:977-982.
To report on outcomes of gonioscopy-assisted transluminal trabeculotomy (GATT) in eyes with pseudoexfoliative glaucoma (PXG).
Evaluation of the clinical utility of optical coherence tomography angiography in age-related macular degeneration
Melina Cavichini, Kunny C Dans, Mahima Jhingan, Manuel J Amador-Patarroyo, Shyamanga Borooah, Dirk-Uwe Bartsch, Eric Nudleman, William R Freeman
doi : 10.1136/bjophthalmol-2020-316622
British Journal of Ophthalmology 2021;105:983-988.
To evaluate the ability of optical coherence tomography angiography (OCTA) to identify the presence or absence of choroidal neovascularisation (CNV) and CNV activity in age-related macular degeneration (AMD).
Progression of diffuse chorioretinal atrophy among patients with high myopia: a 4-year follow-up study
Zhixi Li, Ran Liu, Ou Xiao, Xinxing Guo, Jian Zhang, Decai Wang, Monica Jong, Padmaja Sankaridurg, Kyoko Ohno-Matsui, Mingguang He
doi : 10.1136/bjophthalmol-2020-316691
British Journal of Ophthalmology 2021;105:989-994.
To investigate the progression pattern of diffuse chorioretinal atrophy (DCA) among Chinese participants with high myopia.
Ultra-wide-field scanning laser ophthalmoscopy and optical coherence tomography in FEVR: findings and its diagnostic ability
Ting Zhang, Zhirong Wang, Limei Sun, Songshan Li, Li Huang, Chengxi Liu, Chonglin Chen, Xiaoling Luo, Bilin Yu, Xiaoyan Ding
doi : 10.1136/bjophthalmol-2020-316226
British Journal of Ophthalmology 2021;105:995-1001.
To describe some novel vitreoretinal microstructural findings in patients with mild familial exudative vitreoretinopathy (FEVR) on ultra-wide-field scanning laser ophthalmoscopy (UWF-SLO) and UWF optical coherence tomography (UWF-OCT) and to evaluate their clinical significance.
Parafoveal atrophy after human amniotic membrane graft for macular hole in patients with high myopia
Der-Chong Tsai, Yu-Hsuan Huang, Shih-Jen Chen
doi : 10.1136/bjophthalmol-2019-315603
British Journal of Ophthalmology 2021;105:1002-1010.
To report the surgical outcome and postoperative hypopigmented change around fovea among patients with high myopia who received human amniotic membrane (hAM) graft transplantation for macular hole (MH).
Heritability of macular ganglion cell inner plexiform layer thickness as determined by optical coherence tomography: the Healthy Twin Study
Mingui Kong, Sungsoon Hwang, Hyeonyoung Ko, Ga-In Lee, Moonil Kang, Joohon Sung, Yun-Mi Song, Don-Il Ham
doi : 10.1136/bjophthalmol-2020-316512
British Journal of Ophthalmology 2021;105:1011-1015.
To evaluate genetic influence on macular ganglion cell inner plexiform layer (GCIPL) thickness.
Is intravitreal topotecan toxic to retinal function?
Jennifer Nadelmann, Jasmine H Francis, Scott E Brodie, Engjel Muca, David H Abramson
doi : 10.1136/bjophthalmol-2020-316588
British Journal of Ophthalmology 2021;105:1016-1018.
Intravitreal injections of topotecan are used in the management of retinoblastoma with vitreous seeds. This study evaluated whether intravitreal topotecan was associated with retinal toxicity.
Subclinical dysthyroid optic neuropathy: tritan deficiency as an early sign of dysthyroid optic neuropathy
Aylin Garip-Kuebler, Kathrin Halfter, Lukas Reznicek, Annemarie Klingenstein, Siegfried Priglinger, Christoph R Hintschich
doi : 10.1136/bjophthalmol-2020-316433
British Journal of Ophthalmology 2021;105:1019-1023.
The aim of this research was to investigate the subclinical findings of dysthyroid optic neuropathy (DON) and to look for early indicators for optic nerve compression in patients with Graves’ orbitopathy.
Prospective study to evaluate incidence and indicators for early detection of ethambutol toxicity
Sohini Mandal, Rohit Saxena, Rebika Dhiman, Anant Mohan, Srikanta Kumar Padhy, Swati Phuljhele, Pradeep Sharma, Randeep Guleria
doi : 10.1136/bjophthalmol-2020-316897
British Journal of Ophthalmology 2021;105:1024-1028.
To evaluate incidence of toxic optic neuropathy in patients receiving ethambutol (EMB) for 6 months and to identify its early indicators.
Higher aqueous levels of matrix metalloproteinases indicated visual impairment in patients with retina vein occlusion after anti-VEGF therapy
Yong Luo, Jianbo Wan, Chang Luo, HengWei Liu, YuFan Zhou, Heping Xu, Zhongping Chen
doi : 10.1136/bjophthalmol-2019-315358
British Journal of Ophthalmology 2021;105:1029-1034.
To investigate the levels of matrix metalloproteinases (MMPs) in aqueous humour of patients with retinal vein occlusion (RVO) and the relationship between intraocular MMP levels and retinal lesion and visual prognosis.
Identification of TIE2 as a susceptibility gene for neovascular age-related macular degeneration and polypoidal choroidal vasculopathy
Zhen Ji Chen, Li Ma, Marten E Brelen, Haoyu Chen, Motokazu Tsujikawa, Timothy Y Lai, Mary Ho, Kaori Sayanagi, Chikako Hara, Noriyasu Hashida, Pancy OS Tam, Alvin L Young, Kohji Nishida, Clement C Tham, Chi Pui Pang, Li Jia Chen
doi : 10.1136/bjophthalmol-2019-315746
British Journal of Ophthalmology 2021;105:1035-1040.
The endothelial and cell-specific angiopoietin-Tie pathway plays an important regulatory role in angiogenesis. In this study, we investigated the associations of the TIE2 (tyrosine kinase, endothelial, TEK) gene with neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV), using haplotype-tagging single-nucleotide polymorphisms (SNPs) analysis.
