دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic ShockThe ACTS Randomized Clinical Trial
Ari Moskowitz, MD; David T. Huang, MD, MPH; Peter C. Hou, MD; et al.
doi : 10.1001/jama.2020.11946
JAMA. 2020;324(7):642-650.
This randomized clinical trial compares the effect of combination hydrocortisone, ascorbic acid, and thiamine (the HAT or Marik protocol) vs placebo on SOFA score–measured organ injury at 72 hours in patients with septic shock.
Effect of a Collaborative Care Model on Depressive Symptoms and Glycated Hemoglobin, Blood Pressure, and Serum Cholesterol Among Patients With Depression and Diabetes in IndiaThe INDEPENDENT Randomized Clinical Trial
Mohammed K. Ali, MD, MSc, MBA; Lydia Chwastiak, MD, MPH; Subramani Poongothai, PhD; et al.
doi : 10.1001/jama.2020.11747
JAMA. 2020;324(7):651-662.
This randomized clinical trial compares the effect of a collaborative care model that integrates management of depression and enhanced diabetes care on depressive symptoms and HbA1c, SBP, and LDL cholesterol measures among individuals with depression and diabetes in India.
Presence of Genetic Variants Among Young Men With Severe COVID-19
Caspar I. van der Made, MD; Annet Simons, PhD; Janneke Schuurs-Hoeijmakers, MD, PhD; et al.
doi : 10.1001/jama.2020.13719
JAMA. 2020;324(7):663-673.
This case series describes rare putative X-chromosomal loss-of-function variants associated with impaired peripheral mononuclear blood cell interferon signaling in 4 young male patients hospitalized with severe coronavirus disease 2019 (COVID-19) in the Netherlands.
Association Between Universal Masking in a Health Care System and SARS-CoV-2 Positivity Among Health Care Workers
Xiaowen Wang, MD; Enrico G. Ferro, MD; Guohai Zhou, PhD; et al.
doi : 10.1001/jama.2020.12897
JAMA. 2020;324(7):703-704.
This study describes SARS-CoV-2 PCR test positivity among health care workers before, during, and after implementation of a policy requiring universal masking of all health care workers and patients in a large health care system in Massachusetts.
Change in the Incidence of Stillbirth and Preterm Delivery During the COVID-19 Pandemic
Asma Khalil, MD; Peter von Dadelszen, PhD; Tim Draycott, MD; et al.
doi : 10.1001/jama.2020.12746
JAMA. 2020;324(7):705-706.
This study compares pregnancy outcomes, including rates of stillbirth (fetal death ?24 weeks’ gestation), preterm and cesarean delivery, and neonatal unit admission in the months preceding vs during the 2020 COVID-19 pandemic at a London university hospital.
Prevalence of Psychotropic and Opioid Prescription Fills Among Community-Dwelling Older Adults With Dementia in the US
Donovan T. Maust, MD, MS; Julie Strominger, MS; Julie P. W. Bynum, MD; et al.
doi : 10.1001/jama.2020.8519
JAMA. 2020;324(7):706-708.
This pharmacoepidemiology study uses Medicare data to estimate US prescription fills for antidepressants, anxiolytics, antipsychotics, opioids, and antiepileptics among community-dwelling older adults with dementia in 2014-2015, and identifies the most commonly prescribed medications.
Behavioral Counseling Interventions to Prevent Sexually Transmitted InfectionsUS Preventive Services Task Force Recommendation Statement
US Preventive Services Task Force
doi : 10.1001/jama.2020.13095
JAMA. 2020;324(7):674-681.
This 2020 US Preventive Services Task Force Recommendation Statement recommends behavioral counseling to prevent sexually transmitted infections (STIs) for all sexually active adolescents and for adults at increased risk for STIs (B recommendation).
Behavioral Counseling Interventions to Prevent Sexually Transmitted InfectionsUpdated Evidence Report and Systematic Review for the US Preventive Services Task Force
Jillian T. Henderson, PhD, MPH; Caitlyn A. Senger, MPH; Michelle Henninger, PhD; et al.
doi : 10.1001/jama.2020.10371
JAMA. 2020;324(7):682-699.
This systematic review to support the 2020 US Preventive Services Task Force Recommendation Statement on behavioral counseling interventions to prevent sexually transmitted infections (STIs) summarizes published evidence on the benefits and harms of behavioral counseling interventions in adolescents and adults at increased risk for the infections.
COVID-19 and DexamethasoneA Potential Strategy to Avoid Steroid-Related Strongyloides Hyperinfection
William M. Stauffer, MD, MSPH; Jonathan D. Alpern, MD; Patricia F. Walker, MD, DTM&H
doi : 10.1001/jama.2020.13170
JAMA. 2020;324(7):623-624.
Anticipating widespread global use of dexamethasone for COVID-19 in the wake of RECOVERY trial findings, this Viewpoint summarizes the theoretical risk of triggering Strongyloides hyperinfection/dissemination syndrome in people with asymptomatic strongyloidiasis, and proposes an algorithm to for assessing and managing the risk in outpatient and hospital settings.
Weighing the Benefits and Risks of Proliferating Observational Treatment AssessmentsObservational Cacophony, Randomized Harmony
Robert M. Califf, MD; Adrian F. Hernandez, MD, MHS; Martin Landray, MBChB
doi : 10.1001/jama.2020.13319
JAMA. 2020;324(7):625-626.
This Viewpoint discusses the role of observational study designs and data in the rapid stand-up of an evidence base for managing the COVID-19 pandemic, proposing ways to position observational research as a foundation for rapid follow-on randomized evaluation without premature overinterpretation of its findings.
Exome Sequencing and Clinical Diagnosis
Jan M. Friedman, MD, PhD; Kenneth Lyons Jones, MD; John C. Carey, MD, MPH
doi : 10.1001/jama.2020.11126
JAMA. 2020;324(7):627-628.
This Viewpoint describes indications and proper clinical use and interpretation of exome sequencing, explaining that the testing is not diagnostic in itself but requires correlation with patients’ history and presentation in the context of a comprehensive clinical evaluation.
Evidence-Based Practice for Public Health Emergency Preparedness and ResponseRecommendations From a National Academies of Sciences, Engineering, and Medicine Report
Ned Calonge, MD; Lisa Brown, MPH; Autumn Downey, PhD
doi : 10.1001/jama.2020.12901
JAMA. 2020;324(7):629-630.
This Viewpoint summarizes recommendations from a 2020 National Academies of Sciences, Engineering, and Medicine (NASEM) report on transforming the infrastructure, funding, and methods of public health emergency preparedness and response (PHEPR) research to ensure it is grounded in the best science about what works where, why, and for whom.
Integrating Personalized Medicine With Population Health ManagementThe Path Forward
David C. Grossman, MD, MPH; Eric B. Larson, MD, MPH; Harold C. Sox, MD
doi : 10.1001/jama.2020.1406
JAMA. 2020;324(7):631-632.
This Viewpoint discusses genome-wide sequencing (GWS) as a potential pathway not only to personalized medicine but also to population health, and proposes 5 dimensions health care organizations might consider when deciding on markers to screen for as they move toward genomic approaches to caring for their patient populations.
Dressing Up
Erica J. Harris, MD
doi : 10.1001/jama.2020.12779
JAMA. 2020;324(7):633-634.
In this narrative medicine essay, an emergency department physician faces her daily dread of donning PPE during the COVID-19 pandemic by recalling her grandfather’s gear when diving into Idaho mine shafts and compares his heroism fighting for miners’ rights to safety and wonders what he would think of calling health care workers on the frontlines heroes.
Universal Masking to Prevent SARS-CoV-2 Transmission—The Time Is Now
John T. Brooks, MD; Jay C. Butler, MD; Robert R. Redfield, MD
doi : 10.1001/jama.2020.13107
JAMA. 2020;324(7):635-637.
Molecular Underpinnings of Severe Coronavirus Disease 2019
Robert M. Plenge, MD, PhD
doi : 10.1001/jama.2020.14015
JAMA. 2020;324(7):638-639.
Behavioral Counseling for Sexually Transmitted Infection Risk Reduction
Jeanne Marrazzo, MD, MPH; Ina Park, MD, MS
doi : 10.1001/jama.2020.12324
JAMA. 2020;324(7):640-641.
Using Latent Class Analysis to Identify Hidden Clinical Phenotypes
Makoto Mori, MD; Harlan M. Krumholz, MD, SM; Heather G. Allore, PhD
doi : 10.1001/jama.2020.2278
JAMA. 2020;324(7):700-701
This JAMA Guide to Statistics and Methods summarizes latent class analysis, a statistical technique that estimates the probability of patients belonging to a discrete group that shares specific combinations of observed variables, and explains how the technique is used and can be interpreted in observational research.
Social Isolation—the Other COVID-19 Threat in Nursing Homes
Jennifer Abbasi
doi : 10.1001/jama.2020.13484
JAMA. 2020;324(7):619-620.
This Medical News article discusses the mental and physical effects of infection-control lockdowns on nursing home residents during the novel coronavirus pandemic.
Outpatient Treatment Option for Patients With Blood Cancer
Mary Chris Jaklevic, MSJ
doi : 10.1001/jama.2020.14427
JAMA. 2020;324(7):622.
First Tobacco Product Receives “Reduced Exposure” Authorization
Mary Chris Jaklevic, MSJ
doi : 10.1001/jama.2020.13907
JAMA. 2020;324(7):622.
A Plan to Use Modern Data Tools to Fight Foodborne Illness
Mary Chris Jaklevic, MSJ
doi : 10.1001/jama.2020.14428
JAMA. 2020;324(7):622.
Long-Acting PrEP Shows Promise
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2020.13412
JAMA. 2020;324(7):621.
Customized Injection Guidelines Reduce Nurses’ Errors
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2020.14432
JAMA. 2020;324(7):621.
Surge in Child Abuse, Harm During COVID-19 Pandemic Reported
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2020.14433
JAMA. 2020;324(7):621.
Behavioral Counseling to Reduce Sexually Transmitted Infections
Jill Jin, MD, MPH
doi : 10.1001/jama.2020.12570
JAMA. 2020;324(7):718.
This JAMA Patient Page reviews the 2020 US Preventive Services Task Force’s recommendation in favor of behavioral counseling to reduce sexually transmitted infections (STIs) for all sexually active adolescents and for adults at increased risk of STIs (B recommendation).
Uncemented vs Cemented Hemiarthroplasty for Hip Fracture
Yang Yu, MD, PhD; Shitao Lu, MD, PhD; Jianzhong Xu, MD
doi : 10.1001/jama.2020.9061
JAMA. 2020;324(7):709-710.
Uncemented vs Cemented Hemiarthroplasty for Hip Fracture—Reply
Kanu Okike, MD, MPH; Priscilla H. Chan, MS; Heather A. Prentice, PhD, MPH
doi : 10.1001/jama.2020.9067
JAMA. 2020;324(7):710-711.
Physicians and Social Determinants of Health
Paul Rousseau, MD
doi : 10.1001/jama.2020.9052
JAMA. 2020;324(7):711.
Physicians and Social Determinants of Health—Reply
Thomas L. Schwenk, MD
doi : 10.1001/jama.2020.9072
JAMA. 2020;324(7):711.
