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Spontaneous Twin Internal Fistulae: A Rare Complication of Acute Pancreatitis
Sanjeev Sachdeva, Ravi Teja Reddy, Rahul Chittem & Keval Vora
doi : 10.1007/s10620-024-08609-0
Volume 69, pages 3575–3576, (2024)
Spontaneous internal fistulae (cystocolonic, cystogastric and cystoenteric) have been described as potential complications of severe acute pancreatitis with pseudocyst or walled off necrosis (WON). Ours is possibly the first ever report of double internal fistulae (pancreatico-gastric and pancreatico-colonic) occurring as a spontaneous complication of acute pancreatitis.
Protein-Losing Enteropathy Combined with Multiple Gastrointestinal Venous Ectasia
Siyuan Chen, Yihao Wu, Ziru Zhou, Jing Sun & Qiang Zhan
doi : 10.1007/s10620-024-08605-4
Volume 69, pages 3577–3578, (2024)
A 38-year-old man, who had been previously diagnosed with protein-losing enteropathy (PLE), was evaluated for recurrent edema, hypoproteinemia, and gastrointestinal symptoms [1]. Elevated alpha1AT was present in the stool. Endoscopic findings revealed multiple lymphatic dilatations and chyle leakage in the distal duodenum (Fig. 1a) and the ileocecal region; histopathological examination demonstrated lymphoid hyperplasia and lymphatic ectasia (Fig. 1b). Interestingly, we observed multiple venous ectasias in the upper esophagus, the small intestine (Fig. 1c), and the rectum, with some appearing as solitary venous dilatation, confirmed by CT enterography (Fig. 1d). Intravenous albumin, dietary protein supplementation, and diuretics improved edema.
Xanthogranulomatous Pancreatitis Showing Morphologic Overlap with Type 1 Autoimmune Pancreatitis
Chika Iguh, David Sin & Caroline Yap
doi : 10.1007/s10620-024-08614-3
Volume 69, pages 3579–3580, (2024)
A 19-year-old female with obesity and diabetes presented with chronic epigastric pain. MRI revealed a large cystic mass involving the pancreas head suspicious for malignancy (Fig. 1a). Pancreaticoduodenectomy several months later revealed a shrunken 1.4 cm solid yellow-tan mass showing histologic features consistent with xanthogranulomatous pancreatitis (XGP) likely arising secondary to extravasated bile (Fig. 1b). Surrounding the lesion were many large areas showing morphologic overlap with type 1 autoimmune pancreatitis (T1AP): storiform fibrosis, extensive plasmocytic infiltration, duct-centric plasmacytosis and partial obliterative fibrosis (Fig. 1c, d). IgG4 immunostaining was focally positive but did not meet T1AP criteria for resected pancreas specimen [1], and subsequent testing revealed low serum IgG4. Morphologic features of IgG4-related disease (IgG4-RD) have rarely been demonstrated with xanthogranulomatous inflammation and could possibly lead to erroneous diagnoses of IgG4-RD [2, 3]. The patient also demonstrated pancreatitis recurrence 23 months following surgery, indicating a need for ongoing clinical monitoring for patients with XGP.
Unexpected Discovery of Anal Canal Apocrine Hidrocystoma Mimicking Neuroendocrine Neoplasia: A Unique Case
Zala Jagodic, Zvezdana Dolenc Strazar, Milan Stefanovic & Sebastian Stefanovic
doi : 10.1007/s10620-024-08611-6
Volume 69, pages 3581–3582, (2024)
We describe a rare benign tumor located in the anal canal called apocrine hidrocystoma
A Case of Hookworm Disease Caused by Swallowing Live Frogs
Fu Guan & Qingqing Zhuo
doi : 10.1007/s10620-024-08613-4
Volume 69, pages 3583–3584, (2024)
A 53-year-old woman was referred to our hospital due to recurrent abdominal pain and diarrhea for more than one month. She previously swallowed 23 live frogs of the size of her thumb. Colonoscopy demonstrated scattered erosions in the terminal ileum and colon (Fig. 1a), with numerous moving worms (Fig. 1a and Fig. 1b, arrows). The worms sent to the laboratory for examination were confirmed to be hookworms. Two hookworm eggs were detected in the fluid in the specimen bottle (Fig. 1c) and successfully hatched into one hookworm larva (Fig. 1d). The patient was diagnosed with hookworm disease. Albendazole treatment alleviated the abdominal pain and diarrhea. Cases of sparganosis mansoni due to ingestion of live frogs have been reported, but hookworm disease due to ingestion of live frogs has rarely been reported 1,2,3]. Hookworms are mainly found in the small intestine and rarely found in the human colon.
Successful Endoscopic Resection of Multiple Colorectal Leiomyosarcomas: The First Case Report
Wei Jiang, Rui Gong, Junxiong Wang, Kaiqi Yang, Lumei Wang, Rui Cheng, Bing Yue, Ye Zong & Yongjun Wang
doi : 10.1007/s10620-024-08632-1
Volume 69, pages 3585–3588, (2024)
A 66-year-old man presented with a 6-month history of abdominal discomfort. Colonoscopy revealed multiple polypoid elevations (Yamada type I–III), ranging from 0.6 to 3.5 cm in size, located at various distances from the anal verge. Biopsy pathology and immunohistochemistry results suggested leiomyosarcoma (LMS). A subsequent PET-CT scan revealed the presence of left renal carcinoma (Fig. 1).
A Rare Case of Gastric Perforation During the PEG Tube Placement in a Severe Malnutrition Patient
Yan Yan, Rex-Kam Siu, Yan Bi, Victoria Gomez, Vivek Kumbhari & Yuting Huang
doi : 10.1007/s10620-024-08641-0
Volume 69, pages 3589–3591, (2024)
A 43-year-old malnourished female with upper gastrointestinal tract dilation due to superior mesenteric artery syndrome (Fig. 1) was referred for percutaneous endoscopic gastrojejunostomy (PEG-J) tube placement. Medical history includes lung and kidney transplants and right hemicolectomy 1 month ago. She experienced significant weight loss (13 kg over 6 weeks).
Gastrocolonic Fistula Caused by Buckyballs
Yi Chen, Bingqian Ni, Ningning You & Jinshun Zhang
doi : 10.1007/s10620-024-08608-1
Volume 69, pages 3592–3593, (2024)
A 2-year-old girl was evaluated in the Emergency Department due to the incidental finding of seven ball-shaped foreign bodies present in the gastrointestinal tract in a routine X-ray (Fig. 1). The girl had a history of playing with small brightly-colored strongly magnetic metallic spheres termed “buckyballs” ten days prior. She had no complaints; physical examination was unremarkable. Gastroscopy showed three buckyballs aligned perpendicular to the gastric wall (Fig. 2). The remaining four balls were not visible by enteroscopy. Laparoscopy confirmed the presence of four balls in the transverse colon, transported via a gastrocolic fistula. All balls were easily removed
Early with Terli in Patients with ACLF and AKI Rapidly Reverses Renal Injury
Mahathi Avadhanam & Anand V. Kulkarni
doi : 10.1007/s10620-024-08653-w
Volume 69, pages 3594–3596, (2024
Acute-on-chronic liver failure (ACLF) affects patients worldwide with a prevalence of 35% among patients admitted with decompensated cirrhosis, approaching 65% in hospitalized decompensated cirrhotic patients in South Asia. [1] Of those with ACLF, up to 50% have acute kidney injury (AKI). [1] Managing patients with ACLF and AKI is particularly challenging due to the high risk of concomitant sepsis, cholemic (bile cast) nephropathy, and rapid progression of organ failure, that markedly increase mortality risk. Due to rapid disease progression, there is a narrow window to identify and treat these patients so as to favorably modify their trajectory.
Transition or Transfer Readiness in Young Patients with IBD: What Does It Really Mean?
Johanna C. Escher
doi : 10.1007/s10620-024-08624-1
Volume 69, pages 3597–3598, (2024)
Following the diagnosis of inflammatory bowel disease (IBD) in children, transfer from pediatric to adult healthcare typically occurs some years after the initial diagnosis. This age-related aspect of the disease, as well as its increasing incidence, is probably the reason that much research on transition of care has been done in patients with IBD
Combating Misinformation in Celiac Disease
Priyanka V. Chugh & Ritu Verma
doi : 10.1007/s10620-024-08626-z
Volume 69, pages 3599–3600, (2024)
Celiac disease (CeD), a condition that currently is managed entirely through dietary modification by adopting a strict, lifelong gluten-free diet [1], has historically been plagued by limited healthcare provider knowledge, due in part to restricting expert CeD knowledge to CeD centers. The symptoms of CeD, often vague and nonspecific, can be mistaken for other disease processes, leading to variable practices in diagnosis, patient education, and follow-up care. It is unfortunately commonplace that a patient with symptoms of CeD will report being dismissed by providers or having to see multiple specialists before arriving at the correct diagnosis [2], with patients resorting to seeking information outside of their medical team.
Between Rational Beliefs and the Bedside: Breaking the Boundaries and Bridging the Breach
Harpal Singh Dhaliwal
doi : 10.1007/s10620-024-08636-x
Volume 69, pages 3601–3605, (2024)
Science is privileged to explicate and fully illuminate the single truth of the real, the real being generally an opaque black box with no hitherto available information. In what seem to be ideological arguments posturing as matters of truth, medicine, like all scientific domains, need to evaluate its practices based on proof derived from empiricism employing robust scientific tools. This is the basis for the doctrine of evidence-based medicine (EBM), which essentially refers to objectively evaluating the efficacy, safety and cost of medical practices and procedures with established scientific modelling techniques and basing clinical practice on such inferences. Another concept in clinical medicine, perhaps much older, perennial and pervasive than EBM, is based on “rational beliefs” derived from a combination, in various proportions, of clinical expertise, mechanistic reasoning, and some lower-grade evidence not amounting to EBM in its classical sense (randomized controlled trials, systematic reviews and meta-analyses). This less stringent, down-the-pyramid evidence may involve case studies, nonrandomized case series or observational studies.
Overcoming Immunogenicity to Anti-TNF Therapy by Reactively Adding an Immunomodulator
Mark G. Ward
doi : 10.1007/s10620-024-08620-5
Volume 69, pages 3606–3607, (2024)
Anti-tumor necrosis factor (TNF) therapy with the monoclonal antibodies infliximab and adalimumab remains a key pillar in the expanding therapeutic armamentarium in the management of inflammatory bowel disease [1]. This class of advanced therapy is not only highly efficacious in moderate-to-severe Crohn’s disease (CD) and ulcerative colitis (UC), but also the first choice in perianal CD and as rescue therapy in acute severe UC [2, 3]. Unfortunately, immunogenic failure, due to the development of anti-drug antibodies, is frequently observed, occurring in up to 65.3% of patients treated with infliximab and up to 38% of those treated with adalimumab [4]. Once present, anti-drug antibodies can increase drug clearance while diminishing response, or can produce adverse effects. Though concomitant immunomodulation with thiopurines or methotrexate reduces the risk of immunogenic failure and improves durability of response, it is associated with potentially serious adverse effects including opportunistic infection and lymphoma. Immunogenic loss of response often leads to a change in therapy out-of-class, or, where appropriate, change within class to an alternate anti-TNF, in which subsequent immunogenicity can be mitigated with the use of concomitant immunomodulation [5]. Accordingly, strategies to manage immunogenicity can be broadly divided into prevention (proactive) or to management once recognized (reactive)
An ‘Adaptive Treatment Strategy’ for Oral Vancomycin in Patients with the Orphan Disease Primary Sclerosing Cholangitis
Ayesha Shah, James Tabibian, Cynthia Buness & Gerald J. Holtmann
doi : 10.1007/s10620-024-08497-4
Volume 69, pages 3608–3613, (2024)
Decision-making in clinical medicine ideally is based upon evidence from randomized, placebo-controlled trials (RCTs) and subsequent systematic reviews and meta-analyses. However, for orphan diseases, the expectation of having one or multiple RCTs that inform clinical guidelines or justify specific treatments can be unrealistic and subsequent therapeutic nihilism can be detrimental to patients. This article discusses the benefits of therapeutic decision-making in the context of orphan diseases, focusing on primary sclerosing cholangitis (PSC) as an example of an orphan disease with poor clinical outcomes. PSC is a rare disorder characterized by inflammation and progressive fibrosis of the bile ducts. It carries a high risk of liver failure, malignancies, and debilitating symptoms that impair quality of life. Liver transplantation is currently the only life-prolonging intervention for PSC, but it is not a curative option. The article highlights the potential benefits of treating PSC patients with oral vancomycin (OV), which has shown significant clinical responses and improved quality of life in some cases. However, access to OV therapy is limited due to the lack of RCTs supporting its use. The standard requirement of having evidence from RCTs may result in withholding potentially life-altering and/or life-saving treatments for patients with orphan diseases. Conducting RCTs is challenging in these patient populations due to difficulties in recruiting the required patient cohorts and limited commercial returns. A standardized ‘adaptive treatment strategy’ is proposed to address this. This approach leverages the best available evidence for specific treatments, considers individual clinical responses, and adjusts treatment over time.
Fever, Abdominal Pain, and Inflammation in a Young Woman—Appendix, Liver, or Both?
Ahmed Amgad, Augusto Lauro, Silvia Severi, Nicolò Fabbri, Vito D’Andrea & Antonio Pesce
doi : 10.1007/s10620-024-08606-3
Volume 69, pages 3614–3619, (2024)
Fitz-Hugh-Curtis syndrome (FHC) and acute appendicitis pose a diagnostic challenge due to overlapping clinical manifestations, especially in young female patients with acute abdominal pain [1]. Acute appendicitis, which peaks in incidence among individuals aged 10–19, typically progresses from upper abdominal to right lower quadrant pain, resembling gynecologic conditions such as pelvic inflammatory disease (PID) and its severe complication, tubo-ovarian abscess [1, 2]. Symptoms such as right lower quadrant pain associated with fever and leukocytosis, and imaging findings such as appendiceal dilation are indicative of acute appendicitis [2]. Conversely, PID may manifest as vaginal discharge, pelvic tenderness, and urinary symptoms [2, 3]. FHC is often triggered by pathogens similar to those causing PID such as Chlamydia trachomatis or Neisseria gonorrhoeæ, is an inflammation of the liver capsule with adhesion formation accompanied by right upper quadrant pain [2, 3]. Laparoscopy has improved diagnostic accuracy among these conditions, further supported by imaging techniques such as computed tomography (CT) scans, which enhance diagnostic accuracy for both FHC and appendicitis [4]
Ileal Signet Ring Adenocarcinoma in Crohn’s Disease: Unanticipated Diagnosis After Surgical Resection of a Symptomatic
Lindsay M. Clarke, Maria Christina Riascos, Mark S. Redston, Matthew J. Hamilton & Colleen R. Kelly
doi : 10.1007/s10620-024-08621-4
Volume 69, pages 3620–3623, (2024)
A 46-year-old woman with a history of stricturing ileal Crohn’s disease (CD) was evaluated in our Center following transfer of care due to persistent abdominal pain, constipation, and weight loss.
POETry Without Motion: When Per-oral Endoscopic Myotomy (POEM) Fails
Mengyu Zhang, Qianjun Zhuang, Niandi Tan, Yinglian Xiao & George Triadafilopoulos
doi : 10.1007/s10620-024-08622-3
Volume 69, pages 3624–3634, (2024)
Per-oral endoscopic myotomy (POEM), an equivalent of surgical myotomy, is rapidly gaining acceptance globally for the treatment of esophageal achalasia, utilizing the principles of submucosal endoscopy to correct the incomplete relaxation of the esophagogastric junction. Although POEM is a safe and effective option, nearly 15–20% of patients suffer from recurrent symptoms [1]. Clinical failures after POEM are usually due to inadequate myotomy, or gastroesophageal reflux, among others [2]. Thorough consideration of underlying possibilities after suspected POEM failures can facilitate and optimize therapy, as exemplified in the 3 cases presented below:
Gastrointestinal Manifestations of Rosai–Dorfman Disease
Fady Gendy, Michael Makar, Nicole Anderson, Sara E. Monaco, Bradley D. Confer & Molham Abdulsamad
doi : 10.1007/s10620-024-08596-2
Volume 69, pages 3635–3639, (2024)
Rosai–Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a rare benign non-Langerhans cell histiocytic disorder described as an accumulation of histiocytes and usually presents in children and young adults. RDD clinically presents as bilateral painless cervical lymphadenopathy and is associated with fever, weight loss, and night sweats. Patients may also present with extranodal manifestations involving the skeletal system, central nervous system, kidneys, or other organs [1]. Gastrointestinal (GI) involvement is rare with limited reports in the literature. GI manifestations are important to characterize as it carries a 20% mortality rate [1]. RDD is self-limited in most patients. Patients requiring treatment have been managed with steroids, methotrexate, azathioprine, or other immunosuppressive agents [2]. In this case series, we present two different GI manifestations of RDD involving the pancreas and stomach.
A Smooth Transition: Assessing Transition Readiness in Adolescents with Inflammatory Bowel Disease
Shahzaib M. Khan, David Tuchman, Alizeh Imran, Fatima Mustafa Lakdawala, Sana Mansoor & Joseph Abraham
doi : 10.1007/s10620-024-08484-9
Volume 69, pages 3640–3649, (2024)
Inflammatory Bowel Disease (IBD) is an early onset condition that affects individuals of all ages. Approximately 15%–25% of patients present before the age of 20 years, with peak onset occurring during adolescence.
Unauthentic Information About Celiac Disease on Social Networking Pages: Is It a Matter of Concern in Celiac Disease Management?
Anil K. Verma, Sara Quattrini, Yeliz Serin, Chiara Monachesi, Giulia N. Catassi, Simona Gatti, Govind K. Makharia, Elena Lionetti & Carlo Catassi
doi : 10.1007/s10620-024-08486-7
Volume 69, pages 3650–3660, (2024)
Facebook (FB) is the most popular online networking platform. Many celiac disease Facebook (CD-FB) pages spread awareness about celiac disease (CD). To get the latest information, patients with CD frequently follow such pages. However, little is known about whether such pages provide authentic and reliable information.
Patched but Still Leaky: An Update on the Pipeline for Women in Gastroenterology
Nivita D. Sharma, Karen C. Young, Lauren D. Feld & Loren G. Rabinowitz
doi : 10.1007/s10620-024-08587-3
Volume 69, pages 3661–3669, (2024)
Women remain underrepresented in gastroenterology (GI). Studies have identified that a lack of formal mentorship for women contributes to this underrepresentation. While many GI divisions have adopted models for supporting GI fellows and faculty, there is a gap in our knowledge regarding mentorship options for internal medicine (IM) residents interested in GI
Barriers to Engagement with Gastrointestinal Health Management
Kendra Kamp, Katherine Gohres, Lauren K. Tormey, Shoshana H. Bardach, Lauren E. Szkodny & Jessica K. Salwen-Deremer
doi : 10.1007/s10620-024-08585-5
Volume 69, pages 3670–3680, (2024)
Although behavioral interventions have been effective in gastrointestinal (GI) conditions, barriers exist in implementing these interventions into clinical practice. The majority of previously published studies have focused on workforce limitations and have not considered individual and social determinants of health (SDoH) factors that can impact engagement in GI behavioral healthcare
Performance of Computer-Aided Detection and Quality of Bowel Preparation: A Comprehensive Analysis of Colonoscopy Outcomes
Dalton A. Norwood, Shyam Thakkar, Amanda Cartee, Fayez Sarkis, Tatiana Torres-Herman, Eleazar E. Montalvan-Sanchez, Kirk Russ, Patricia Ajayi-Fox, Anam Hameed, Ramzi Mulki, Sergio A. Sánchez-Luna, Douglas R. Morgan & Shajan Peter
doi : 10.1007/s10620-024-08610-7
Volume 69, pages 3681–3689, (2024)
Artificial intelligence (AI) has emerged as a promising tool for detecting and characterizing colorectal polyps during colonoscopy, offering potential enhancements in traditional colonoscopy procedures to improve outcomes in patients with inadequate bowel preparation.
Understanding the Perspectives and Experiences of Patients with Acute Severe Ulcerative Colitis in the Hospital: A Qualitative Analysis
Dustin Romain, Charlotte Larson, Priya Kathuria, Daniel Aintabi, Nicholas Tedesco, Queen Saunyama, Melissa DeJonckheere, Shrinivas Bishu, Shirley Cohen-Mekelburg, Peter D. R. Higgins & Jeffrey A. Berinstein
doi : 10.1007/s10620-024-08633-0
Volume 69, pages 3690–3700, (2024)
Acute severe ulcerative colitis (ASUC) is a life-treating presentation of ulcerative colitis (UC) that requires prompt initiation of treatment to avoid complication. Unfortunately, outcomes for ASUC are suboptimal, with as many as 20–30% of patients requiring colectomy. This can be challenging for patients and highlights the need to understand patient experiences and perspectives navigating ASUC
Natural History and Longitudinal Outcomes of Patients with Mild-to-Moderate Ulcerative Proctitis or Ulcerative Proctosigmoiditis: A Single-Center, Retrospective Study
Kexin Ye, Zhenhe Jin, Qichen chen, Li Cen, Jiaqi Pan, Tianyu Zhou, Wenxi Jiang, Zhaoxue Liu, Linwen Luo & Zhe Shen
doi : 10.1007/s10620-024-08615-2
Volume 69, pages 3701–3709, (2024)
Ulcerative proctitis (UP) and ulcerative proctosigmoiditis (UPS) are special forms of ulcerative colitis. The disease burdens of UP and UPS are increasing. However, the natural history and prognosis of patients with mild-to-moderate UP or UPS have been poorly studied.
Prognosis of Transplant-Ineligible Patients with Cirrhosis and Acute Kidney Injury Who Initiate Renal Replacement Therapy
Paige McLean Diaz, Danielle L. Saly, Nora Horick, Romela Petrosyan, Zachary Gitto, Teresa Indriolo, Lucinda Li, Olivia Kahn-Boesel, John Donlan, Blair Robinson, Lindsay Dow, Annie Liu, Areej El-Jawahri, Xavier Vela Parada, Sara Combs, Joao Teixeira, Raymond Chung, Andrew S. Allegretti & Nneka N. Ufere
doi : 10.1007/s10620-024-08623-2
Volume 69, pages 3710–3720, (2024)
Data to guide dialysis decision-making for transplant-ineligible patients with cirrhosis are lacking
Missed and Delayed Diagnoses of Chronic Liver Disease in Primary Care Patients with Cirrhosis
Kush M. Patel, Jingwen Zhang, Justin Marsden, Chloe Bays, Patrick D. Mauldin & Andrew D. Schreiner
doi : 10.1007/s10620-024-08601-8
Volume 69, pages 3721–3728, (2024)
Chronic liver diseases (CLD), cirrhosis, and hepatocellular carcinoma (HCC) cause significant morbidity and mortality. Unfortunately, patients with CLD often go undiagnosed until progression to cirrhosis and HCC. We aimed to determine the proportion of primary care patients with severe liver disease outcomes that had missed or delayed CLD diagnoses
A Family of Cyclic Lipopeptides Found in Human Isolates of Bacillus Ameliorates Acute Colitis via Direct Agonism of Toll-Like Receptor 2 in a Murine Model of Inflammatory Bowel Disease
Edward Horwell, Maria Vittoria, Huynh A. Hong, Philip Bearn & Simon M. Cutting
doi : 10.1007/s10620-024-08534-2
Volume 69, pages 3729–3741, (2024)
The Bacillus-derived cyclic lipopeptides (surfactin, iturin, and fengycin) form potent Heterogeneous Lipopeptide Micelle (HeLM) complexes. HeLM is a small molecule that has been shown to have immunomodulatory effects. However, how HeLM regulates inflammation is not clear, moreover its application to Inflammatory Bowel Disease (IBD), specifically Ulcerative Colitis (UC), has not been tested before.
Homocysteine Promotes Intestinal Inflammation in Colitis Mice Through the PGE2/STAT3 Signaling Pathway
Akang Shao, Qiu Zhao & Min Chen
doi : 10.1007/s10620-024-08588-2
Volume 69, pages 3742–3752, (2024)
Our previous study indicated that Hcy exacerbated DSS-induced colitis by facilitating the differentiation of intestinal T helper cell 17 (Th17), but the precise mechanism remains unidentified. Therefore, our current research aims to elucidate the signaling pathway through which Hcy promotes the differentiation of Th17 cells.
Lacidipine Inhibits NF-?B and Notch Pathways and Mitigates DSS-Induced Colitis
Xuezhao Yu, Cheng Li, Yu Tao, Tingting Xia & Zhenyu Jia
doi : 10.1007/s10620-024-08618-z
Volume 69, pages 3753–3759, (2024)
Ulcerative colitis (UC) is a chronic inflammatory condition affecting the colon, with a global incidence that is rising. Despite the increasing prevalence, effective treatment options for UC remain limited.
ZIP8 A391T Crohn’s Disease-Linked Risk Variant Induces Colonic Metal Ion Dyshomeostasis, Microbiome Compositional Shifts, and Inflammation
Julianne C. Yang, Matthew Zhao, Diana Chernikova, Nerea Arias-Jayo, Yi Zhou, Jamilla Situ, Arjun Gutta, Candace Chang, Fengting Liang, Venu Lagishetty & Jonathan P. Jacobs
doi : 10.1007/s10620-024-08647-8
Volume 69, pages 3760–3772, (2024)
The pathogenesis of Crohn’s disease involves genetic and environmental factors, with the gut microbiome playing a crucial role. The Crohn’s disease-associated variant rs13107325 in the SLC39A8 gene results in an A391T substitution in the ZIP8 metal ion transporter and has previously been linked to alterations in the colonic microbiome in variant carriers. We hypothesized that the A391T substitution alters metal ion homeostasis in the colonic mucosal–luminal interface, thereby inducing dysbiosis which may promote intestinal inflammation.
Low-Grade Activation of the Extrinsic Coagulation Pathway in Patients with Ulcerative Colitis
Ioannis Drygiannakis, Vassilis Valatas, Eirini Filidou, Niki Tzenaki, Evangelia Archontoulaki, Nikolas Dovrolis, Leonidas Kandilogiannakis, Georgios Kefalogiannis, Prodromos Sidiropoulos, George Kolios & Ioannis E. Koutroubakis
doi : 10.1007/s10620-024-08640-1
Volume 69, pages 3773–3785, (2024)
Ulcerative colitis (UC) increases the risk for venous thromboembolism. Tissue factor (TF) initiates the extrinsic coagulation pathway (ECP).
ACTL8 Promotes the Progression of Gastric Cancer Through PI3K/AKT/mTOR Signaling Pathway
Wenhao Yu, Qi Zhang, Muhammad Ali, Bangquan Chen, Qiannan Sun & Daorong Wang
doi : 10.1007/s10620-024-08649-6
Volume 69, pages 3786–3798, (2024)
Actin-like protein 8 (ACTL8) significantly correlates with tumor growth and prognosis across various cancer types. Nevertheless, the potential relationship between ACTL8 and gastric cancer (GC) remains uncertain.
CRYAB Promotes Colorectal Cancer Progression by Inhibiting Ferroptosis Through Blocking TRIM55-Mediated ?-Catenin Ubiquitination and Degradation
Haiyan Xia, Jingwen Chen, Wenbo Zhang, Ying Xu, Yongjun Nai & Xiaowei Wei
doi : 10.1007/s10620-024-08584-6
Volume 69, pages 3799–3809, (2024)
?-Crystallin B (CRYAB) is a chaperone member of the HSPs family that protects proteins with which it interacts from degradation. This study aims to investigate the effect of CRYAB on the progression of colorectal cancer (CRC) and its underlying mechanism.
Single-Cell Transcriptomic Profiling of Cholangiocyte Organoids Derived from Bile Ducts of Primary Sclerosing Cholangitis Patients
Anna Katharina Frank, Brian K. Chung, Miguel Larraz Lopez De Novales, Lise Katrine Engesæter, Henry William Hoyle, Jonas Øgaard, James Heslop, Tom H. Karlsen, Olivia Tysoe, Teresa Brevini, Jan S. Tchorz, Ludovic Vallier, Irina Mohorianu, Fotios Sampaziotis & Espen Melum
doi : 10.1007/s10620-024-08570-y
Volume 69, pages 3810–3823, (2024)
Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disorder without effective medical treatment which is characterized by inflammation and fibrotic structures around the bile ducts. Biliary epithelial cells (cholangiocytes) are the target and potential disease drivers in PSC, yet little is known if cholangiocytes from PSC patients differ from non-PSC controls. To characterize cholangiocytes at early rather than end-stage disease, cholangiocyte organoids (COs) were derived from diseased bile ducts of PSC patients and compared to organoids generated from disease controls.
Does Gastroesophageal Reflux Disease Increase the Risk of Sepsis and Its 28-day Mortality? A Causal Study Using a Mendelian Randomization Approach
Runquan Zhou, Wenjuan Li, Fan Wu, Yuanhui Sheng, Shan Xu, Yi Liu, Dan Zhang & Mingxing Wang
doi : 10.1007/s10620-024-08625-0
Volume 69, pages 3824–3834, (2024)
Gastroesophageal reflux disease (GERD) is a prevalent gastrointestinal disorder. Recent studies indicate that GERD may exert systemic effects, potentially elevating the risk of severe infections, including sepsis. Nevertheless, the causal relationship between GERD and sepsis, as well as sepsis-related 28-day mortality, remains uncertain.
Timing of Endoscopic Intervention for Esophageal Food Impaction and Its Impact on Patient Outcomes
Mark S. Obri, Momin Samad, Suhib Alhaj, Ammad Chaudhary, Sheema Rehman, M. Ramzi Almajed, Courtney Rose, Lonni Schultz, Kevin Harris & Suraj Suresh
doi : 10.1007/s10620-024-08600-9
Volume 69, pages 3835–3843, (2024)
Esophageal food impaction (EFI) is a common complaint of patients presenting to the emergency department. EFI requires urgent evaluation by the gastroenterology service and often necessitates esophagogastroduodenoscopy (EGD) for management. Timing of EGD in patients with EFI that does not improve with medical management remains a point of contention. We aim to evaluate outcomes of EFI in the context of time to intervention
Performing Esophageal Biopsies Is Safe During Upper Endoscopy for Food Impaction but Are Underperformed in Certain Populations
Trevor S. Barlowe, Walker D. Redd, Angela Z. Xue, Akshatha Kiran, Justin D. McCallen, Swathi Eluri, Craig C. Reed & Evan S. Dellon
doi : 10.1007/s10620-024-08590-8
Volume 69, pages 3844–3852, (2024)
Despite recommendations to perform esophageal biopsies during esophagogastroduodenoscopy (EGD) for esophageal food impaction to evaluate for eosinophilic esophagitis (EoE), endoscopists often forgo biopsies. There are minimal data on the risks of biopsies in this setting.
Odynophagia and Retrosternal Pain Are Common in Eosinophilic Esophagitis and Associated with an Increased Overall Symptom Severity
Jeanine Karpf, Ekaterina Safroneeva, Jean-Benoit Rossel, Florian Hildenbrand, Catherine Saner, Thomas Greuter, Gerhard Rogler, Alex Straumann, Alain Schoepfer, Luc Biedermann, Fritz R. Murray & Philipp Schreiner
doi : 10.1007/s10620-024-08586-4
Volume 69, pages 3853–3862, (2024)
Dysphagia is the hallmark symptom in eosinophilic esophagitis (EoE). However, data are limited regarding the overall prevalence and potential implications of atypical symptoms like odynophagia and retrosternal pain.
Vonoprazan vs. Proton Pump Inhibitors for Treatment and Prevention of Gastric and/or Duodenal Ulcers: A Systematic Review with Meta-Analysis
Daniel Martin Simadibrata, Elvira Lesmana, Muhammad Iqbal Adi Pratama, Adrianus Jonathan Sugiharta, Ayers Gilberth Ivano Kalaij, Arzita Diandra Diva Fadhilla, Pojsakorn Danpanichkul, Ari Fahrial Syam & Marcellus Simadibrata
doi : 10.1007/s10620-024-08593-5
Volume 69, pages 3863–3874, (2024)
Although Vonoprazan, a potassium-competitive acid blocker, is superior to proton pump inhibitors (PPIs) in treating Helicobacter pylori and erosive esophagitis, its efficacy for treating gastric and/or duodenal ulcers remains controversial. This meta-analysis summarizes the efficacy and safety of Vonoprazan vs. PPI for treating and preventing gastric and/or duodenal ulcers.
Whole Gut Transit Scintigraphy for the Assessment of Patients with Symptoms of Chronic Constipation
Abraham Ifrah, Jay Kanaparthi, Rachel Fromer, Alec Harrison Gayner, Alan H. Maurer, Simin Dadparvar & Henry P. Parkman
doi : 10.1007/s10620-024-08564-w
Volume 69, pages 3875–3881, (2024)
Whole gut transit scintigraphy (WGTS) can detect delayed colonic transit (CT), different types of CT delays, and assess upper GI tract transit
Endoscopic Management of Lower Gastrointestinal Tract Anastomosis Strictures: A Meta-Analysis and Systematic Review of the Literature
Parth Patel, Manav Patel, Mohamad Ayman Ebrahim, Priyadarshini Loganathan & Douglas G. Adler
doi : 10.1007/s10620-024-08627-y
Volume 69, pages 3882–3893, (2024)
Anastomotic strictures following colectomy and proctectomy are a significant cause of benign lower gastrointestinal tract (LGIT) obstruction, with a reported incidence of up to 30%. Endoscopic interventions such as balloon dilation, stricturotomy, mechanical dilation, electrocautery incision, and stent placement are utilized for management. This meta-analysis aimed to evaluate the efficacy and safety of endoscopic interventions for the management of benign LGIT anastomotic strictures.
Acquired Low Factor XIII Activity Is Associated with an Increased Need for Blood Transfusions in Patients with Gastrointestinal Bleedings
Anna Traninger, Andreas Blesl, Andrea Borenich, Stefan Fürst, Thomas Wagner, Reinhard Bernd Raggam, Andrea Berghold & Christoph Högenauer
doi : 10.1007/s10620-024-08651-y
Volume 69, pages 3894–3900, (2024)
We aimed to investigate the relevance of factor XIII activity on the outcome of patients with gastrointestinal bleedings
Assessment of Endoscopy-Based Scoring Systems for Prognostication in Ulcerative Colitis: A Comparative Analysis
Pingxin Zhang, Chuhan Zhang, Baili Chen, Yao He, Zhirong Zeng, Ren Mao, Yun Qiu & Minhu Chen
doi : 10.1007/s10620-024-08582-8
Volume 69, pages 3901–3910, (2024)
Endoscopy-based scoring systems, including Mayo Endoscopic Score (MES), Modified Mayo Endoscopic Score (MMES), and Degree of Ulcerative Colitis Burden of Luminal Inflammation (DUBLIN) Score, have been introduced to evaluate UC prognosis. This study aims to compare their predictive capacity for clinical outcomes in UC patients.
Response to Upadacitinib in Patients with Inflammatory Bowel Disease Previously Treated with Tofacitinib
Tarek Odah, Christian Karime, Aakash Desai, Michael F. Picco, Jami A. Kinnucan, Jana G. Hashash & Francis A. Farraye
doi : 10.1007/s10620-024-08630-3
Volume 69, pages 3911–3919, (2024)
Upadacitinib is an oral selective Janus kinase (JAK) inhibitor approved in the United States for ulcerative colitis (UC) and Crohn’s disease (CD). However, data regarding its use following prior treatment with the JAK inhibitor tofacitinib is sparse. As such, we aimed to evaluate the effectiveness of upadacitinib therapy following tofacitinib exposure.
Reactive Immunomodulator Addition to Infliximab Monotherapy Restores Clinical Response in Inflammatory Bowel Disease: A Meta-Analysis
Jeffrey A. Lowell, Garvita Sharma, Vincent Chua, Shomron Ben-Horin, Arun Swaminath & Keith Sultan
doi : 10.1007/s10620-024-08515-5
Volume 69, pages 3920–3931, (2024)
Patients with inflammatory bowel disease (IBD) receiving infliximab (IFX) commonly experience immunogenic loss of response (LOR) by formation of anti-drug antibodies (ADAs). An immunomodulator (IMM) used in combination with initial IFX induction is known to reduce ADA development and improve clinical outcomes. We aimed to assess the impact of reactively adding an IMM to patients on IFX monotherapy.
Absence of Paneth Cell Metaplasia to Predict Clinical Relapse in Ulcerative Colitis with Endoscopically Quiescent Mucosa
Kazuki Horiuchi, Masaaki Higashiyama, Hiroyuki Tahara, Yuta Yoshidome, Kana Ayaki, Hiroyuki Nishimura, Akira Tomioka, Kazuyuki Narimatsu, Shunsuke Komoto, Kengo Tomita & Ryota Hokari
doi : 10.1007/s10620-024-08581-9
Volume 69, pages 3932–3941, (2024)
Paneth cells play multiple roles in maintaining intestinal homeostasis. However, the clinical role of Paneth cell metaplasia (PCM) in ulcerative colitis (UC) remains unclear. We aimed to investigate the relationship between PCM and relapse in patients with UC and compare the usefulness of PCM with other histological indexes, including mucin depletion (MD) and basal plasmacytosis (BP).
Derivation of Splenic Stiffness in Subjects with Normal Liver Stiffness and No Vascular Liver Disease Using Transient Elastography with a Spleen-Dedicated Module: A Large Cross Sectional Study
Ankur Jindal, Guresh Kumar, Manoj Kumar Sharma, Chitranshu Vashishtha & Shiv Kumar Sarin
doi : 10.1007/s10620-024-08634-z
Volume 69, pages 3942–3951, (2024)
Liver and splenic stiffness measurements (LSM and SSM) are useful to predict varices and clinical decompensation in cirrhosis. SSM values are highly variable and overlapping and no guidelines exists on what constitutes normal SSM, that might limit interpretation of results
Differentiating Ischemic Hepatitis from Acetaminophen Overdose in Acute Liver Failure: Role of Acetaminophen Adducts—Ischemic Hepatitis vs Acetaminophen Overdose
Jody A. Rule, Faith Ajayi, Laura P. James, Shannan R. Tujios, Norman L. Sussman, Jorge L. Rakela, Daniel Ganger, Norman L. Bass, Adrian Reuben, R. Todd Stravitz, William M. Lee & The Acute Liver Failure
doi : 10.1007/s10620-024-08602-7
Volume 69, pages 3952–3961, (2024)
Acetaminophen (APAP) hepatotoxicity and ischemic hepatic injury (IH) demonstrate remarkably similar biochemical patterns. Deciding between these two etiologies in the setting of acute liver failure (ALF) can be challenging. We reviewed all cases in the Acute Liver Failure Study Group (ALFSG) registry where these diagnoses were considered, to determine reasons for, and frequency of, difficulties making these diagnoses. We hypothesized that the newly developed APAP-CYS adduct assay could help in discerning the correct diagnosis
Precut Over a Pancreatic Duct Stent Versus Transpancreatic Precut Sphincterotomy for Difficult Biliary Cannulation in Endoscopic Retrograde Cholangiopancreatography: A Retrospective Cohort Study
Yang Qi, Qianyi Li, Wenfei Yao, Yuquan Wu & Nengping Li
doi : 10.1007/s10620-024-08603-6
Volume 69, pages 3962–3969, (2024)
Precut over a pancreatic duct stent (PPDS) and transpancreatic precut sphincterotomy (TPS) with immediate pancreatic duct stent placement are techniques employed to promote biliary access during endoscopic retrograde cholangiopancreatography (ERCP) in cases of challenging biliary cannulation. However, limited data are available to compare the efficacy of these two pancreatic stent-assisted precut sphincterotomy techniques
Incidence of Post-ERCP Pancreatitis in Patients Receiving Rectal Indomethacin vs. Compounded Rectal Diclofenac Prophylaxis
Laurens P. Janssens, Aishwarya Yamparala, John Martin, John O’Meara, William S. Harmsen, Thanmay Sathi, Elizabeth Lemke, Barham K. Abu Dayyeh, Aliana Bofill-Garcia, Bret T. Petersen, Andrew C. Storm, Mark Topazian, Eric J. Vargas, Vinay Chandrasekhara & Ryan J. Law
doi : 10.1007/s10620-024-08604-5
Volume 69, pages 3970–3978, (2024)
Endoscopic retrograde cholangiopancreatography (ERCP) carries a 3–15% risk of post-ERCP pancreatitis (PEP). Rectal indomethacin reduces the risk of PEP, but its cost has increased more than 20-fold over the past decade. Rectal diclofenac is also used to prevent PEP but is not commercially available in the United States. The aim of this study is to compare the incidence of PEP after administration of commercially available rectal indomethacin versus compounded rectal diclofenac and assess financial implications
Correction to: miR?9?5p Suppresses Malignant Biological Behaviors of Human Gastric Cancer Cells by Negative Regulation of TNFAIP8L3
Yanyun Fan, Ying Shi, Zhenhe Lin, Xiaoxiao Huang, Jinying Li, Wei Huang, Dongyan Shen, Guohong Zhuang & Wenming Liu
doi : 10.1007/s10620-024-08599-z
Volume 69, pages 3979–3980, (2024)
After publication, the authors noted errors in Fig. 2. During the assembling of the figures, the authors included incorrect images for the migration transwell assay images of the miR-9-5p mimic (Fig. 2B) and miR-9-5p inhibitor (Fig. 2E). The correct figures are shown below (Fig. 2). The authors contend that these corrections do not change the data interpretation or conclusions of the article
