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Perianal Kissing Ulcers: Behçet’s Syndrome (with Video)
Taofeng Jiang & Fu Guan
doi : 10.1007/s10620-024-08656-7
Volume 69, pages 3981–3982, (2024)
A 15-year-old male patient with a 2-year history of recurrent oral ulcers presented with recurrent perianal pain for?>?1 month. Esophagogastroduodenoscopy revealed three oral ulcers, approximately 0.5–0.8 cm in diameter (Fig. 1a; Video 1). Colonoscopy revealed well-demarcated contralateral ulcers in a kissing configuration in the crissum (Fig. 1b; Video 1). Histopathologic examination of the oral biopsy specimens revealed that the mucosal tissue was covered by mildly atypical squamous epithelial hyperplasia, with more stromal infiltration of lymphocytes and plasma cells infiltration and local ulcer formation (Fig. 1c).
5-Aminosalicylic Acid Aggravates Bloody Diarrhoea in Crohn’s Disease
Linyu Sha, Jingli Cao, Yusheng Yang & Jing Wang
doi : 10.1007/s10620-024-08658-5
Volume 69, pages 3983–3985, (2024)
A 56-year-old man was evaluated for abdominal pain and diarrhea. Enhanced computed tomography showed colonic dilatation and considerable enhancement of the mucosal layer throughout the colon. (Fig. 1a). Capsule endoscopy revealed multiple gastric ulcers, inflammation of the small bowel, and numerous colonic ulcers (Fig. 1b). IBD was suspected based on these clinical findings [1]. The patient was prescribed 5-ASA [2], and the patient reported worsening abdominal pain and bloody diarrhea. Colonoscopy showed intestinal inflammation (Fig. 1c, d) with edematous mucosa from the splenic flexure to the sigmoid colon, with mucosal friability, erosions, and longitudinal ulcers (Fig. 2a). and crypt abscesses (Fig. 2b). Bloody diarrhea and abdominal pain ceased after mesalamine withdrawal. A second colonoscopy revealed segmental longitudinal ulcers from the descending colon to the sigmoid colon (Fig. 2c). Postoperative pathology showed infiltration of inflammatory cells with typical epithelioid granulomas (Fig. 2d). We speculate the 5-ASA may have impaired fluid and electrolyte absorption, causing diarrhea [3]
Improved Paired-Kiss Suture Technique for Wound Closure After Colonic Endoscopic Submucosal Dissection (with Video)
Haideng Yang, Xiuxiu Jin, Yi Wang, Xinli Mao, Liping Ye, Lina Fang & Lingling Yan
doi : 10.1007/s10620-024-08645-w
Volume 69, pages 3986–3987, (2024)
Endoscopic submucosal dissection (ESD) is a well-established treatment for early colorectal neoplasms [1], and effective closure of the postoperative wound is key to reducing complications such as delayed bleeding and perforation [2, 3]
Standalone Gall Bladder Ascariasis: An Unusual Sanctuary Site
Sanjeev Sachdeva, Ravi Teja Reddy, Rahul Chittem & Ashok Dalal
doi : 10.1007/s10620-024-08665-6
Volume 69, pages 3988–3989, (2024)
A 67-year-old woman presented with recurrent episodes of right upper abdominal pain for 3 months. Physical examination was unremarkable. Liver function tests were normal. Hemogram showed absolute eosinophil count of 1140/cu.mm. Abdominal ultrasound revealed mobile tubular structure within gall bladder suggestive of round worm (Fig. 1, arrow). Stool microscopy revealed eggs of Ascaris lumbricoides. MRI abdomen with MRCP showed soft tissue intensity tubular structure within the gall bladder indicative of ascariasis (Fig. 1, arrowhead). The patient was treated with 3 days of oral albendazole. Subsequently, she underwent laparoscopic cholecystectomy which revealed presence of dead Ascaris worms (Fig. 2, arrows). Indication of cholecystectomy was recurrent biliary colics.
Acute Onset Vision Loss and Acute Pain Abdomen
Mithu Bhowmick, Sanish Ancil, Ritesh Acharya, Vishali Gupta, Rajesh Gupta & Surinder Singh Rana
doi : 10.1007/s10620-024-08673-6
Volume 69, pages 3990–3992, (2024)
A 26-year-old male presented with acute abdominal pain associated with sudden loss of vision in both eyes following an alcohol binge. Blood investigations revealed markedly elevated serum amylase (2412 IU/L) and C-reactive protein (364 mg/L). Visual acuity was reduced in both eyes with finger counting in the right eye and appreciation of hand movements close to the face in the left eye. True color fundus photograph of both eyes demonstrated polygonal areas of retinal whitening with a clear demarcating line between the affected retina and contiguous retinal vessels suggestive of Purtscher flecken (arrows) (Figs. 1, 2). Overlying these fleckens, retinal hemorrhages (arrowhead) were also seen with more marked changes in the left eye. On the fifth day of illness, contrast-enhanced computed tomography of the abdomen revealed a diffusely enlarged pancreas (Fig. 3) with a peri-pancreatic fluid collection (Fig. 4). The patient was treated with supportive medical management and 1 g/day intravenous methylprednisolone for three days. There was a gradual improvement in the vision and visual acuity after 4 weeks of steroid treatment, which was 6/18 in both eyes.
A Second Colonoscope Helps to Release an Incarcerated Colonoscope in an Inguinal Hernia During Colonoscopy
Qiuyue Tu, Yalin Tong, Huixia Zhang & Bingrong Liu
doi : 10.1007/s10620-024-08675-4
Volume 69, pages 3993–3995, (2024)
Hernia incarceration of colonoscope is a rare complication of colonoscopy, to 2023, nearly 20 cases totally have been reported worldwide [1]. Manual reduction and surgery are known interventions [2, 3]
A Bile Duct Dysplasia at the Duodenal Anastomosis Site
Lijian Wang, Zhenguo Qiao, Xiaolu Yu & Qiufen Yang
doi : 10.1007/s10620-024-08688-z
Volume 69, pages 3996–3997, (2024)
An 87-year-old man presented to our hospital with upper abdominal pain. Many years ago, he had a history of the surgery for intrahepatic bile duct stones, but the specific details were unknown. The magnetic resonance cholangiopancreatography (MRCP) indicated multiple calculi in the bile duct of the left lobe of the liver, and dilatation of the bile duct in and out of the liver. The gastroscopy showed that an anastomosis was visible in the duodenal bulb, and the intrahepatic bile duct was found inside the anastomosis (Fig. 1A). In addition, two mucosal hyperplasia lesions about 1.0 cm in diameter were found in the intrahepatic bile duct (Fig. 1B). Narrow band imaging (NBI) showed a villous structure on the surface of the lesion, with dilated glandular ducts (Fig. 1C). The histopathology of both biopsy specimens showed inflammation with a small amount of necrotic tissue, and also showed a small amount of severe atypical glandular epithelium, accompanied by variously sized, irregular and hyperstaining nuclei (Fig. 1D). Unfortunately, because of the patient’s advanced age, the family of the patient refused to further complete resection due to the risk of surgery. As a result, we were unable to assess the nature and extent of the lesions in more depth.
A Case of Multisite Gastric Hepatoid Adenocarcinoma Mimicking Gastric Stromal Tumors
Yuqi Shi, Huiyuan Gu, Xiao Yuan, Lijuan Qian, Zhenguo Qiao & Airong Wu
doi : 10.1007/s10620-024-08680-7
Volume 69, pages 3998–4000, (2024)
A 64-year-old female was evaluated for mild abdominal pain for 1 year and rising serum AFP. Liver biopsy revealed G1-S2 cirrhosis and bile duct injury. Serum AFP increased to 100.73 ng/mL (normal?<?8.78 ng/mL). An enhanced CT scan (Fig. 1) showed two mildly enhancing lesions originating from the greater curvature of the gastric body and antrum, 3.0 cm and 2.0 cm, respectively. Gastroscopy (Fig. 2) demonstrated a 3.0?×?3.0 cm round submucosal mass with ulceration and erosion. Endoscopic ultrasound revealed a heterogeneous hypoechogenic mass arising from the muscularis propria (Fig. 3a) and another poorly echogenic lesion underneath the serous membrane of the antrum (Fig. 3b). Full-thickness ESD performed of the greater curvature mass revealed poorly differentiated adenocarcinoma with neuroendocrine features (Fig. 4) infiltrating the entire gastric wall with intravascular tumor thrombus. Immunohistochemistry revealed that the neoplastic cells were diffusely positive for AFP, Glypican-3, CK18, and SALL-4. These IHC findings combined with the morphologic features supported a diagnosis of hepatoid adenocarcinoma that was surgically confirmed.
Colonic Perforation Caused by a Monopterus albus
Yi Chen, Jun Wang, Shanshan Lin, Hong Lin, Jiamin Xu & Jinshun Zhang
doi : 10.1007/s10620-024-08685-2
Volume 69, pages 4001–4002, (2024)
A 48-year-old man with severe chronic constipation was evaluated for abdominal pain 10 h after anal insertion of the Asian swamp eel Monopterus albus, a traditional folk remedy for constipation. Physical examination showed marked abdominal direct and rebound tenderness. A computed tomography scan revealed the skeleton of the Monopterus albus (Figs. 1 and 2, yellow arrows). The worm carcass was surgically removed, followed by sigmoidostomy for sigmoid perforation, which was reversed 5 months later. His constipation improved during seven years of follow-up. Constipation is common, attributed to a Western lifestyle and low-residue foods [1]. Due to the failure of conventional therapies, some individuals may resort to unconventional methods [2], including traditional folk remedies, which, in this case, proved dangerous. In such situations, seeking prompt medical treatment is essential, as it is the safest, most effective, and responsible approach to one’s health.
Tumor-Like Fecal Mass in a Colonic Diverticulum
Ling-ling Wang, Ying Xu, Li-ping Ye, Ke-yin Jin & Qin Huang
doi : 10.1007/s10620-024-08692-3
Volume 69, pages 4003–4005, (2024)
A 64-year-old man with a one-year history of increased defecation frequency underwent colonoscopy, that revealed a 12 mm hemispherical protrusion in the sigmoid colon with fecal material embedded in a mucosal defect (Fig. 1). Endoscopic ultrasound showed a 7.5 mm?×?10.4 mm inhomogeneous hypoechoic mass in the submucosa (Fig. 2), confirmed with computed tomography (CT) (Fig. 3). During the endoscopic submucosal dissection (ESD), a round yellow feculent mass was embedded within the diverticulum, that was carefully removed (Fig. 4), confirmed as a fecalith within a sigmoid diverticulum (Video1). Colonic diverticula are often due to congenital or acquired muscle defects [1]. Tumor-like fecal masses within diverticula are rare and can be easily misdiagnosed as submucosal tumors. Though diverticula are more commonly found in the right colon among Asian populations [2], this case involved the left colon, manifesting as an intraluminal protrusion rather than the typical mucosal outpouching. Our case highlights the importance of considering fecal impaction in the differential diagnosis to avoid unnecessary surgical interventions. The successful endoscopic removal of the fecalith in this case demonstrates the effectiveness of ESD in managing such rare occurrences
FMT Combined with Vedolizumab for the Treatment of Refractory Ulcerative Colitis
Lanfang Chen, Juan Peng, Yanwei Wang, Yuzhi Liu, Xiangsheng Fu & Jun Li
doi : 10.1007/s10620-024-08666-5
Volume 69, pages 4006–4008, (2024)
We report a 52-year-old male patient who carried a diagnosis of ulcerative colitis (UC) for?>?5 years. He responded poorly to multiple drugs, including vedolizumab (VDZ), infliximab (IFX), and adalimumab (ADA) (Figs. 1A–C, E). Finally, he underwent three cycles of combined fecal microbiota transplantation (FMT) and VDZ, with mucosal healing (Figs. 1D, 1F). Previous studies have shown that combining FMT with routine drugs can improve responses to routine treatments by altering gut microbiota composition [1]. Moreover, the baseline microbiota of pediatric UC patients who responded to (IFX) or (ADA) had higher counts of Actinobacterium and Firmicutes [2, 3]. We used metagenomic sequencing to evaluate the fecal microbiota (Fig. 2A, B). After FMT, the proportions of Firmicutes and Actinobacteria in the patient’s stool gradually increased to approach the donor’s level, which may have enhanced the efficacy of VDZ
A Rare Complication after Endoscopic Transcecal Appendectomy: Acute Massive Cerebral Infarction
Ming Zhou & Fu Guan
doi : 10.1007/s10620-024-08686-1
Volume 69, pages 4009–4010, (2024)
Endoscopic transcecal appendectomy (ETA) is a novel natural orifice transluminal endoscopic surgical procedure that has been developed recently as an extension of endoscopic full-thickness resection to remove appendix and appendiceal lesions via the cecum under colonoscopy [1, 2]. ETA-associated complications are rarely reported. Herein, we report a rare complication of acute massive cerebral infarction after ETA. A 66-year-old woman with intermittent right lower abdominal pain for more than 3 months was admitted to our hospital. She had a history of hypertension and diabetes mellitus. Colonoscopy revealed a 1.5-cm submucosal bulge near the appendiceal orifice (Fig. 1A). The patient and his family refused laparoscopic surgery. The patient underwent an ETA under tracheal intubation anesthesia. The procedure was as follows (Fig. 1B–G): (a) The lesion margins were marked. (b) Full-thickness resection of the lesion. (c) A snare was used for external traction of the root of the appendix. (d) Appendix resection and extraction. (e) The defect was closed with an over-the-scope clip and six hemostatic clips. The uneventful procedure lasted approximately 4 h. Unfortunately, the patient developed a massive cerebral infarction on postoperative day 1 (Fig. 1H, I). Postoperative pathology revealed chronic appendicitis with cyst formation and fecalith in the cystic cavity. Currently, 5 months after surgery, the patient is still receiving rehabilitation treatment, and the speech function and muscle strength of the right limb have mostly recovered. In this patient, diabetes mellitus, hypertension, and old age might be considered as risk factors for complicated cerebral infarction after ETA [3]
Are You Are What You Eat?: Pro-inflammatory Diets and IBS Risk
Dalton A. Norwood
doi : 10.1007/s10620-024-08690-5
Volume 69, pages 4011–4013, (2024)
Irritable Bowel Syndrome (IBS) is one of the most common functional gastrointestinal disorders worldwide, affecting more than 9% of the global population [1]. IBS significantly reduces the quality of life, placing a high burden on healthcare systems. Although it is quite prevalent, the exact mechanisms underlying IBS are not well defined, with genetics, diet, and low-grade inflammation considered important contributors to its pathogenesis [2]. Among these, diet has been one of particular interest since it is so closely associated with the onset of gastrointestinal symptoms in IBS. Therefore, dietary management has become an essential part of the treatment of IBS, although the mechanism behind pro-inflammatory diets leading to IBS remains unclear, warranting further research
Knives Out: Does the Choice of Endoscopic Knife Influence the Outcome of Colorectal Endoscopic Submucosal Dissection?
Yunho Jung
doi : 10.1007/s10620-024-08617-0
Volume 69, pages 4014–4016, (2024)
Colorectal endoscopic submucosal dissection (ESD) is increasingly utilized not only in East Asian countries but also in Western countries including the United States and in Europe, as an essential method for the resection of large colorectal neoplasms and superficial T1 colorectal cancer. The technique enables the removal of large lesions in one piece (en bloc), which facilitates the pathological assessment of lesion margins while significantly reducing recurrence rates compared with piecemeal endoscopic mucosal resection. Nevertheless, colorectal ESD is a time-consuming and technically challenging procedure, particularly due to the thinner colonic wall and narrower lumen compared to the gastric wall, which increase the risk of perforation [1]. Difficult lesion locations, respiratory movements, the heartbeat, and colon redundancy can further confound the procedure, increasing the risk of complications [2]. To overcome these challenges and become proficient in colorectal ESD, significant hurdles must be surmounted
Need for a More Objective, Inclusive, and Equitable Selection Process for Gastroenterology Fellowships
Vivek V. Gumaste
doi : 10.1007/s10620-024-08592-6
Volume 69, pages 4017–4024, (2024)
Diseases related to the digestive system account for a significant proportion of the diseases burden in the United States and result in 36.8 million ambulatory visits, 3.8 million hospital admissions, and 22.2 million gastrointestinal endoscopies. To meet the challenge that this quantum of gastroenterological disorders poses, we are obligated to select and train competent gastroenterologists. Admission into a Gastroenterology (GI) fellowship program is highly selective. In 2023, only 62.7% of candidates who applied were successful in matching into a fellowship program, making it even more competitive than a cardiology fellowship (match rate of 68.4%). Therefore, it is imperative that we ensure that the selection process is fair and transparent. Additionally, we need to be socially more responsible by emphasizing diversity and inclusivity to produce gastroenterologists who reflect the changing society we live in. An analysis of current practices indicates that the process of selection is not standardized and is more subjective than objective. This review is an attempt to identify deficiencies that can be rectified by the introduction of a standardized system that includes structured interviews, Standard Letters of Recommendation (SLOR), and objective scoring protocols—all of which would make the process of selection more equitable, diverse, and inclusive. Newer methods like Casper exam, Psychometric testing, and Preference Signaling can also be explored to this end
Concise Commentary: Twelve Steps on the Path to Improving Training Programs—Recruiting GI Fellows in 2024 and Beyond
Deborah D. Proctor
doi : 10.1007/s10620-024-08637-w
Volume 69, pages 4025–4026, (2024)
As stated in a report of a conference organized by the University of Toronto, [1] the process for selecting applicants for post-graduate training must be transparent and fair. The appropriate mix of physicians must be trained to serve the diverse populations that exist in given communities and countries. As stated by Gumaste in this issue of Digestive Diseases and Sciences [2], the US process for selecting and training GI fellows is not as standardized as in other countries and is more subjective than objective than its comparators. Furthermore, a recent audit [3] suggests that US training programs are not as diverse and inclusive as they should be
A Comprehensive Examination of ChatGPT's Contribution to the Healthcare Sector and Hepatology
Kabita Kumari, Sharvan Kumar Pahuja & Sanjeev Kumar
doi : 10.1007/s10620-024-08659-4
Volume 69, pages 4027–4043, (2024)
Artificial Intelligence and Natural Language Processing technology have demonstrated significant promise across several domains within the medical and healthcare sectors. This technique has numerous uses in the field of healthcare. One of the primary challenges in implementing ChatGPT in healthcare is the requirement for precise and up-to-date data. In the case of the involvement of sensitive medical information, it is imperative to carefully address concerns regarding privacy and security when using GPT in the healthcare sector. This paper outlines ChatGPT and its relevance in the healthcare industry. It discusses the important aspects of ChatGPT's workflow and highlights the usual features of ChatGPT specifically designed for the healthcare domain. The present review uses the ChatGPT model within the research domain to investigate disorders associated with the hepatic system. This review demonstrates the possible use of ChatGPT in supporting researchers and clinicians in analyzing and interpreting liver-related data, thereby improving disease diagnosis, prognosis, and patient care
Heartaches and Gut Feelings: Exploring Myocarditis in Crohn's Disease
Kiran Motwani, Erica Cohen, John J. Liang & Raymond K. Cross
doi : 10.1007/s10620-024-08674-5
Volume 69, pages 4044–4047, (2024)
Myocarditis is a rare extra-intestinal manifestation of inflammatory bowel disease (IBD) (consisting of Crohn’s disease [CD] and ulcerative colitis [UC]) although its exact association with IBD is not well understood. [1] Furthermore, there is a growing number of therapeutics for IBD that may have unknown systemic side effects. Based on a review of the literature, there have not been any clear associations of anti-interleukin (IL)-12/23 or anti-integrin agents with myocarditis. We present a case of a patient with newly diagnosed CD with subsequent recurrent episodes of myocarditis after receiving ustekinumab and vedolizumab
EoE Recurrence on PPI Maintenance Therapy: You Do Not Know if You Do Not Look!
Ryan Alexander, Blake Kassmeyer, Ryan Lennon, Jeffrey Alexander, Diana Snyder & Karthik Ravi
doi : 10.1007/s10620-024-08676-3
Volume 69, pages 4048–4052, (2024)
Data regarding histologic recurrence of EoE on PPI maintenance therapy are lacking
Prophylactic Proton Pump Inhibitors in Upper Gastrointestinal Bleeding: Impact and Underprescription in a French Multicentric Cohort
Weam El Hajj, Stéphane Nahon, Eddy Fares, Vincent Quentin, Denis Grasset, Jean-Pierre Arpurt, Florence Skinazi, René-Louis Vitte, Laurent Costes, André-Jean Remy, Christophe Locher, Gilles Macaigne on behalf of ANGH for the SANGHRIA Study Group
doi : 10.1007/s10620-024-08663-8
Volume 69, pages 4053–4062, (2024)
Appropriate prescription of Proton pump inhibitors (PPIs) remains an important concern amid the rising overuse. A gap exists in the literature regarding the benefit of PPI prophylaxis and the consequences of underprescription in patients at risk for upper gastrointestinal bleeding (UGIB).
Psychopathology and the Validity of Gastrointestinal Symptom Reporting as Revealed Through Cluster Analyses of MMPI-2-RF Results
Paris A. Lang, Linda Thomas & Brett A. Lidbury
doi : 10.1007/s10620-024-08629-w
Volume 69, pages 4063–4071, (2024)
Psychological state, self-reported gut symptoms, and somatic complaints are recognized relationships that can impact health assessment and subsequent treatment.
Criterion Validity of Screening Tools and Field-Based Tests for Health-Related Physical Fitness in Inflammatory Bowel Disease
Karlijn Demers, Bart C. Bongers, Sander M. J. van Kuijk, Guy Plasqui, Daisy M. A. E. Jonkers, Marieke J. Pierik & Laurents P. S. Stassen
doi : 10.1007/s10620-024-08682-5
Volume 69, pages 4072–4088, (2024)
Monitoring health-related physical fitness (HRPF) may benefit proactive Inflammatory Bowel Disease (IBD) management. However, knowledge regarding HRPF in patients with IBD is limited and gold standard tests are impractical for widespread use, necessitating simpler methods.
Self-Efficacy, Patient Activation, and the Burden of Inflammatory Bowel Disease on Patients’ Daily Lives
Jessica L. Sheehan, LaVana Greene-Higgs, Kenneth Resnicow, Minal R. Patel, Edward L. Barnes, Akbar K. Waljee, Peter D. R. Higgins & Shirley Cohen-Mekelburg
doi : 10.1007/s10620-024-08712-2
Volume 69, pages 4089–4097, (2024)
The effective management of inflammatory bowel disease (IBD) requires complex self-management behaviors. Both patient activation (the degree to which patients are willing and able to engage in care) and self-efficacy (one’s confidence in performing certain behaviors) are thought to play an important role in chronic disease self-management, but patient activation is a broad concept that can be more difficult to precisely target than self-efficacy. We aimed to describe the relationship between patient activation, self-efficacy, and the burden of IBD on patients’ daily lives
Reduced Proline-Rich Tyrosine Kinase 2 Promotes Tumor Metastasis by Activating Epithelial–Mesenchymal Transition in Colorectal Cancer
Fangquan Wu, Ke Zhang, Zhengyang Song, Qishuo Zhou, Hongxia Sun, Zenglin Tan, Zhenxuan Huang, Fangyan Wang, Zhonglin Wang, Riwei Yang & Yingpeng Huang
doi : 10.1007/s10620-024-08643-y
Volume 69, pages 4098–4107, (2024)
Proline-rich tyrosine kinase 2 (PYK2) is involved in the occurrence, proliferation, migration, and invasion of various tumors. However, few studies have reported the role of PYK2 in colorectal cancer (CRC).
Comparative Analysis of Early Versus Late Feeding Post-percutaneous Endoscopic Gastrostomy Tube Placement: A Systematic Review and Meta-Analysis
Mahesh Gajendran, Eric Smith, Priyadarshini Loganathan, Iqra Kazi, Mohan Babu & Umapathy Chandraprakash
doi : 10.1007/s10620-024-08654-9
Volume 69, pages 4108–4115, (2024)
In clinical practice, tube feedings have been delayed after the percutaneous endoscopic gastrostomy (PEG) tube placement. Previous studies, including a meta-analysis in 2008, have shown that it is safe to start tube feeding???4 h of PEG tube placement. However, it is still a common practice to delay the initiation of tube feeding up to 24 h after PEG tube placement. We have performed an updated analysis of studies comparing early versus delayed tube feedings following PEG placement.
Characteristics of Hospitalized Patients With and Without Celiac Disease on a Gluten-Free Diet
Rachel Eklund, John W. Blackett, Anne R. Lee, Peter H. R. Green & Benjamin Lebwohl
doi : 10.1007/s10620-024-08677-2
Volume 69, pages 4116–4123, (2024)
Most people maintaining a gluten-free diet (GFD) do not have celiac disease (CD). Comorbidities and associated conditions in this population are largely unknown.
Efficacy and Safety of a Low-FODMAP Diet in Combination with a Gluten-Free Diet for Adult Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis
Jing Zhang, Ping Yu, Yang Xu, Xiao Yun Lu, Yan Xu, Jun Hang & Yu Zhang
doi : 10.1007/s10620-024-08671-8
Volume 69, pages 4124–4132, (2024)
Common gastrointestinal disease irritable bowel syndrome (IBS) is marked by symptoms like changed bowel habits, bloating, and stomach ache. A low-FODMAP combined gluten-free diet (LF-GFD) has been suggested as a possible therapy for IBS symptoms management
Comparison of Endoscopic Ultrasound and CT Scan in the Diagnosis of Esophageal Duplication Cysts
Eve Ronkainen, Nina Barner-Rasmussen, Kirsi Volmonen, Martti Färkkilä, Perttu Arkkila & Andrea Tenca
doi : 10.1007/s10620-024-08655-8
Volume 69, pages 4133–4139, (2024)
Esophageal duplication cysts (EDCs) are rare congenital malformations, often discovered incidentally during endoscopy or on computed tomography (CT) scans. The role of endoscopic ultrasound (EUS) and CT scan in the diagnosis of these lesions and indications for surgical treatment are underreported. The aim of this study was to investigate these topics in a cohort of patients
Proinflammatory Diet Increases the Risk of Irritable Bowel Syndrome: A Prospective Study of 129,408 UK Biobank Participants and Mendelian Randomization Analysis
Laifu Li, Yan Ran, Yan Zhuang, Ying Xu, Lianli Wang, Lele Chen, Yating Sun, Fangchen Ye, Lin Mei & Fei Dai
doi : 10.1007/s10620-024-08638-9
Volume 69, pages 4140–4151, (2024)
Patients with irritable bowel syndrome (IBS) often have chronic low-grade inflammation in the intestinal mucosa. Some dietary components are known to be associated with inflammation. However, there is currently limited research on the relationship between dietary inflammatory potential and the risk of IBS
Efficacy and Safety of Endoscopic Stricturotomy in Inflammatory Bowel Disease-Related Strictures: A Systematic Review and Meta-Analysis
Fouad Jaber, Laith Numan, Mohammed Ayyad, Mohamed Abuelazm, Muhammad Imran, Majd M. AlBarakat, Aya M. Aboutaleb, Ubaid Khan, Saqr Alsakarneh & Mohammad Bilal
doi : 10.1007/s10620-024-08533-3
Volume 69, pages 4152–4166, (2024)
Luminal strictures, common in inflammatory bowel disease (IBD), especially Crohn’s disease (CD), are typically treated with endoscopic balloon dilatation (EBD). The newer endoscopic stricturotomy (ESt) approach shows promise, but data is limited. This systematic review and meta-analysis assess the effectiveness and safety of ESt in IBD-related strictures
Progression of Crohn’s Disease in Newly Diagnosed Patients: Results from an Observational Study Using US Claims Data
Yanni Fan, Ling Zhang, Negar Omidakhsh, Rhonda L. Bohn, Kathleen Putnam, A. Shola Adewale & Gil Y. Melmed
doi : 10.1007/s10620-024-08591-7
Volume 69, pages 4167–4177, (2024)
Patients with Crohn’s disease (CD) experience disease progression over time, including strictures/stenoses, penetrating fistulae, and abscesses.
Pro-motility Preparation Protocol May Reduce the Rates of Failed Patency Capsule Among Patients with Crohn’s Disease in Clinical Remission
Offir Ukashi, Arad Dotan, Tom Borkovsky, Adi Talan Asher, Tamar Thurm, Ayal Hirsch, Nitsan Maharshak, Eva Niv, Moshe Leshno, Rami Eliakim, Shomron Ben-Horin, Uri Kopylov & Liat Deutsch
doi : 10.1007/s10620-024-08670-9
Volume 69, pages 4178–4186, (2024)
Patency capsule (PC) ingestion is commonly used to minimize capsule retention in high-risk patients with Crohn’s disease (CD). However, false-positive rates remain high, precluding the use of video capsule endoscopy (VCE). We aimed to compare the efficacy of two preparation protocols in reducing failed PC rates in patients with CD
Risk Factors for Gallstones in Crohn’s Disease: A Systematic Review and Meta-Analysis
Yan Gong, Yishu He, Mengting Wan & Hong Chen
doi : 10.1007/s10620-024-08597-1
Volume 69, pages 4187–4202, (2024)
Crohn’s disease (CD) have an increased risk of gallstone disease. We aimed to systematically evaluate the prevalence rate and relevant risk factors of gallstones in CD patients
Prevalence of Malnutrition and Micronutrient Deficiencies in Older Adults with Ulcerative Colitis
Zoe Memel, Anna Thiemann, Cooper Dort, Uma Mahadevan & Kendall R. Beck
doi : 10.1007/s10620-024-08650-z
Volume 69, pages 4203–4213, (2024)
The nutritional status and consequences of malnutrition among older adults with ulcerative colitis (UC) are not known.
Efficacy of Two Kinds of Scissor-Type Knives for Colorectal Endoscopic Submucosal Dissection: A Retrospective Comparative Study
Jianhua Shen, Naohisa Yoshida, Reo Kobayashi, Ken Inoue, Ryohei Hirose, Osamu Dohi, Hideyuki Konishi, Yuri Tomita & Yoshito Itoh
doi : 10.1007/s10620-024-08525-3
Volume 69, pages 4214–4223, (2024)
Scissor-type knives are spreading as safe devises in endoscopic submucosal dissection (ESD). We evaluated the efficacy of two kinds of scissor-type knives (Clutch Cutter: CC, Fujifilm Co. and SB Knife Jr2: SB, SB-KAWASUMI Laboratories. Inc.) in colorectal ESD
Comparison of TC-325 Hemostatic Powder with Standard Endoscopic Treatments for Malignancy-Related Upper Gastrointestinal Bleeding: Meta-Analysis of Randomized Controlled Trials
Aamir Saeed, Saira Yousuf, Muhammad Hashim Hayat, Marjan Haider, Muhammad Aziz, Umar Hayat, Christian Salcedo, Zahid Ijaz Tarar, Umer Farooq, Sachit Sharma, Muhammad Ali Khan & Faisal Kamal
doi : 10.1007/s10620-024-08644-x
Volume 69, pages 4224–4230, (2024)
TC-325 powder has been successfully used in the management of malignancy-related upper gastrointestinal bleeding (UGIB) with favorable results. We conducted a meta-analysis of randomized controlled trials (RCTs) comparing TC-325 hemostatic powder with standard endoscopic treatments in the management of malignancy-related UGIB
A Multi-task Neural Network for Image Recognition in Magnetically Controlled Capsule Endoscopy
Ting Xu, Yuan-Yi Li, Fang Huang, Min Gao, Can Cai, Song He & Zhi-Xuan Wu
doi : 10.1007/s10620-024-08681-6
Volume 69, pages 4231–4239, (2024)
Physicians are required to spend a significant amount of reading time of magnetically controlled capsule endoscopy. However, current deep learning models are limited to completing a single recognition task and cannot replicate the diagnostic process of a physician. This study aims to construct a multi-task model that can simultaneously recognize gastric anatomical sites and gastric lesions
Prognostic Accuracy of Transient Elastography-Based Predictors in Diabetes and Obesity: A Multicenter International Cohort Study
Venkata Sai Jayakrishna Jasty, Esteban Urias, Kai Le Ashley Tiong, Majd Bassam Aboona, Michael Song, Claire Faulkner, Pooja Devan, Jean Ee Neo, Karn Wijarnpreecha, Yu Jun Wong & Vincent Lingzhi Chen
doi : 10.1007/s10620-024-08635-y
Volume 69, pages 4240–4249, (2024)
Liver stiffness measurement (LSM) by vibration-controlled transient elastography (VCTE) is recommended for risk stratification of patients with nonalcoholic fatty liver disease (NAFLD). More recently, AGILE3?+?and AGILE4 have combined LSM with clinical parameters to identify patients with advanced fibrosis and cirrhosis, respectively. However, there are limited data on prognostic performance of these scores in key at-risk subgroups such as those with diabetes and obesity compared to LSM alone.
Serial Liver Stiffness Measurement and Fibrosis-4 Scores in Metabolic Dysfunction-Associated Steatotic Liver Disease
Tanvi Goyal, Michael W. Song, Deepika Suresh, Venkata S. J. Jasty, Esteban Urias, Karn Wijarnpreecha, Yu Jun Wong & Vincent L. Chen
doi : 10.1007/s10620-024-08683-4
Volume 69, pages 4250–4258, (2024)
In patients with metabolic dysfunction-associated steatotic liver disease (MASLD), there are limited data on how changes in FIB4 and liver stiffness measurement (LSM) correlate in non-biopsy cohorts
AFP-DIAM Score to Predict Survival in Patients with Hepatocellular Carcinoma Before TACE: A French Multicenter Study
Estelle Rebillard, Nicolas De Abreu, Benjamin Buchard, Léon Muti, Mathieu Boulin, Bruno Pereira, Benoit Magnin & Armand Abergel
doi : 10.1007/s10620-024-08639-8
Volume 69, pages 4259–4267, (2024)
Transarterial chemoembolization (TACE) is recommended as a palliative treatment for patients of the B stage of the Barcelona Clinic Liver Cancer (BCLC) classification.
Hepatocellular Carcinoma in Acute Hepatic Porphyria: A Meta-Analysis of Observational Studies
Ashwani K. Singal, Rewanth K. Reddy, Mohan C. Gudiwada, Jaswant J. Jasti & Karl E. Anderson
doi : 10.1007/s10620-024-08661-w
Volume 69, pages 4268–4274, (2024)
Hepatocellular carcinoma (HCC) is a long-term complication of acute hepatic porphyria (AHP) inclusive of acute intermittent porphyria [AIP], variegate porphyria [VP], or hereditary coproporphyria [HCP]. Data on HCC risk in AHP patients are limited and heterogeneous. We performed this meta-analysis with aims to (a) determine incidence of HCC in AHP and specific subtypes of AHP and (b) examine high-risk groups for HCC
Diagnostic Yield of Endoscopic Ultrasound in Common Bile Duct Dilation: A Real Breakthrough
A. I. Ferreira, S. Xavier, F. Dias de Castro, J. Magalhães, S. Leite & J. Cotter
doi : 10.1007/s10620-024-08628-x
Volume 69, pages 4275–4282, (2024)
Endoscopic ultrasound (EUS) is important for the evaluation of patients with common bile duct (CBD) dilation
Trisectoral Metal Stenting Using Combined Stent-by-Stent and Stent-in-Stent Method for Malignant Hilar Biliary Obstruction: A Prospective Pilot Study
Tadahisa Inoue, Rena Kitano, Mayu Ibusuki, Tomoya Kitada, Kazumasa Sakamoto, Satoshi Kimoto, Jun Arai & Kiyoaki Ito
doi : 10.1007/s10620-024-08566-8
Volume 69, pages 4283–4289, (2024
Endoscopic trisectoral metal stent (MS) placement for malignant hilar biliary obstruction (MHBO) poses technical challenges, although it may prolong survival and stent patency. Combined stent-by-stent and stent-in-stent (SBSIS) methods can reduce technical difficulty. This study aimed to examine the use of the SBSIS in patients with Bismuth type III or IV MHBO.
Association Between Body Composition Measured by Artificial Intelligence and Long-Term Sequelae After Acute Pancreatitis
Pedro Cortés, Tyler Mistretta, Brittany Jackson, Caroline G. Olson, Ahmed M. Salih, Fernando F. Stancampiano, Panagiotis Korfiatis, Jason R. Klug, Dana M. Harris, JDan Echols, Rickey E. Carter, Baoan Ji, Heather D. Hardway, Michael B. Wallace, Vivek Kumbhari & Yan Bi
doi : 10.1007/s10620-024-08684-3
Volume 69, pages 4290–4301, (2024)
The clinical utility of body composition in the development of complications of acute pancreatitis (AP) remains unclear. We aimed to describe the associations between body composition and the recurrence of AP
Identification of Endosonographic Features that Compromise EUS-FNB Diagnostic Accuracy in Pancreatic Masses
Hsueh-Chien Chiang, Chien-Jui Huang, Yao-Shen Wang, Chun-Te Lee, Meng-Ying Lin & Wei-Lun Chang
doi : 10.1007/s10620-024-08691-4
Volume 69, pages 4302–4310, (2024)
Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) is highly accurate for diagnosing pancreatic mass. However, making diagnosis is challenging in 5–20% of patients. This study investigated the challenging features associated with reduced diagnostic performance in EUS-FNB and potential rescue methods that can improve the diagnostic rate
ISO Clarifications on Albumin Use and Pulmonary Complications
Deepak Sasikumar, Vikramaditya Rawat, Saiprasad Lad, Meghraj Ingle, Vinay Borkar, Shivani Chopra, Yatin Lunagariya & Rohit Wagh
doi : 10.1007/s10620-024-08513-7
Volume 69, pages 4311–4312, (2024)
We would like to express our appreciation for the recent article on “Early Versus Standard Initiation of Terlipressin for Acute Kidney Injury in ACLF: A Randomised controlled trial (eTerli study)” [1]. The study provides valuable insight into the potential benefit of early initiation of terlipressin for HRS AKI in ACLF patients. However, we would like to seek a clarification on few points
Early Terlipressin for HRS-AKI in ACLF
Ankur Jindal & Shiv Kumar Sarin
doi : 10.1007/s10620-024-08662-9
Volume 69, page 4313, (2024)
We thank Sasikumar and colleagues [1] for showing interest in our manuscript. The important issues raised by the authors need clarification. The response to twenty per cent albumin (1 g/kg/day for 2 days infused over six-hour duration) is recommended for diagnosis of hepatorenal syndrome (HRS-AKI) [2]. However, we have observed and recently published that standard dose albumin infusion (1 g/kg/day) is not tolerated by Indian patients and is associated with pulmonary complications, particularly the volume overload [3]. Moreover, the reduced dose albumin (0.5–0.75 g/kg/day) was found to be safe and equally effective. However, we agree that the effectiveness of standard dose albumin infused over more prolonged periods, as compared to reduced dose albumin, should be evaluated in further studies.
Screening Ability of Non-invasive Markers for Detecting Hepatic Fibrosis
Tomoyuki Kawada
doi : 10.1007/s10620-024-08668-3
Volume 69, pages 4314–4315, (2024)
Thrift et al. examined to check the ability of some indicators for predicting hepatic fibrosis. A total of 344 participants underwent Fibroscan® examination to measure liver fat and liver stiffness measurement [LSM], which was used as a dependent variable [1]. Any hepatic fibrosis and significant hepatic fibrosis were defined as LSM?>?7 kPa and?>?8 kPa, respectively. A total of 34 and 15 participants were judged as any hepatic fibrosis and significant hepatic fibrosis. By using body mass index (BMI)?>?33, Fibrosis-4 index (FIB-4)?>?1, and diabetes, the area under the curve (AUC) [95% confidence interval (CI)] for predicting any hepatic fibrosis was 0.75 (0.67–0.84), with negative predictive value (NPV) of 91.5% and positive predictive value (PPV) of 40.0%. By setting BMI???30 kg/m2 and FIB-4???1.45, AUC (95% CI), NPV and PPV were 0.65 (0.54–0.75), 91.3% and 50.0%, respectively. The same trend was observed by using significant hepatic fibrosis as a dependent variable. I have some comments about their study.
Correction to: Feel the Burn: RFA for Chronic Radiation Proctitis
Gabriele De Sena, Federico Maria Mongardini, Danilo Porpora, Maria Mauro, Davide Bentivoglio, Davide Centore, Luigi Brusciano, Claudio Gambardella, Augusto Lauro, Ludovico Docimo & Vincenzo Napolitano
doi : 10.1007/s10620-024-08660-x
Volume 69, page 4316, (2024)
In the original publication of the article, the title was incorrectly given as ‘DDS–SIRC Cooperative Conferences Feel the Burn: RFA for Chronic Radiation Proctitis’ but should have been ‘Feel the burn: RFA for chronic radiation proctitis’.
