دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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This Month's Highlights
George Vasquez-Rios and Madhav C. Menon
doi : 10.1681/ASN.2021030385
JASN May 2021, 32 (5) 1009-1011
Kidney Transplant Rejection Clusters and Graft Outcomes: Revisiting Banff in the Era of “Big Data”
George Vasquez-Rios and Madhav C. Menon
doi : 10.1681/ASN.2021030348
JASN May 2021, 32 (5) 1009-1011
Monkeying about with Nephron Formation
Ian M. Smyth
doi : 10.1681/ASN.2021030320
JASN May 2021, 32 (5) 1011-1013
Urinary Vesicles: Are They Ready for Real-World Use?
Robert W. Hunter and James W. Dear
doi : 10.1681/ASN.2021030332
JASN May 2021, 32 (5) 1013-1015
COVID-19 and Dialysis Patients: Unsolved Problems in Early 2021
Alan S. Kliger and Jeffrey Silberzweig
doi : 10.1681/ASN.2020121766
JASN May 2021, 32 (5) 1018-1020
SARS-CoV-2 Vaccines in Kidney Transplant Recipients: Will They Be Safe and Effective and How Will We Know?
Madeleine R. Heldman and Ajit P. Limaye
doi : 10.1681/ASN.2021010023
JASN May 2021, 32 (5) 1021-1024
The Urine Anion Gap: Common Misconceptions
Jaime Uribarri and Man S. Oh
doi : 10.1681/ASN.2020101509
JASN May 2021, 32 (5) 1025-1028
Two papers, one in 1986 and another one in 1988, reported a strong inverse correlation between urinary anion gap (UAG) and urine ammonia excretion (UNH4) in patients with metabolic acidosis and postulated that UAG could be used as an indirect measure of UNH4. This postulation has persisted until now and is widely accepted. In this review, we discuss factors regulating UAG and examine published evidence to uncover errors in the postulate and the design of the original studies. The essential fact is that, in the steady state, UAG reflects intake of Na, K, and Cl. Discrepancy between intake and urinary output of these electrolytes (i.e., UAG) indicates selective extrarenal loss of these electrolytes or nonsteady state. UNH4 excretion, which depends, in the absence of renal dysfunction, mainly on the daily acid load, has no consistent relationship to UAG either theoretically or in reality. Any correlation between UAG and UNH4, when observed, was a fortuitous correlation and cannot be extrapolated to other situations. Furthermore, the normal value of UAG has greatly increased over the past few decades, mainly due to increases in dietary intake of potassium and widespread use of sodium salts with anions other than chloride as food additives. The higher normal values of UAG must be taken into consideration in interpreting UAG.
COVID-19 and AKI: Where Do We Stand?
Paul M. Palevsky
doi : 10.1681/ASN.2020121768
JASN May 2021, 32 (5) 1029-1032
Background The humoral response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the hemodialysis population, including its dynamics over time, remains poorly understood.
Kinetics of Anti–SARS-CoV-2 IgG Antibodies in Hemodialysis Patients Six Months after Infection
Hamza Sakhi, Djamal Dahmane, Philippe Attias, Thomas Kofman, Magali Bouvier, Nathanael Lapidus, Slim Fourati, Khalil El Karoui and Mondor NephroCov Study Group
doi : 10.1681/ASN.2020111618
JASN May 2021, 32 (5) 1033-1036
Deletion of Myeloid Interferon Regulatory Factor 4 (Irf4) in Mouse Model Protects against Kidney Fibrosis after Ischemic Injury by Decreased Macrophage Recruitment and Activation
Kensuke Sasaki, Andrew S. Terker, Yu Pan, Zhilian Li, Shirong Cao, Yinqiu Wang, Aolei Niu, Suwan Wang, Xiaofeng Fan, Ming-Zhi Zhang and Raymond C. Harris
doi : 10.1681/ASN.2020071010
JASN May 2021, 32 (5) 1037-1052
Background AKI is characterized by abrupt and reversible kidney dysfunction, and incomplete recovery leads to chronic kidney injury. Previous studies by us and others have indicated that macrophage infiltration and polarization play key roles in recovery from AKI. The role in AKI recovery played by IFN regulatory factor 4 (IRF4), a mediator of polarization of macrophages to the M2 phenotype, is unclear.
Crumbs2 Is an Essential Slit Diaphragm Protein of the Renal Filtration Barrier
Annika M?ller-Kerutt, Juan E. Rodriguez-Gatica, Karin Wacker, Rohan Bhatia, Jan-Peter Siebrasse, Nanda Boon, Veerle Van Marck, Peter Boor, Ulrich Kubitscheck, Jan Wijnholds, Hermann Pavenst?dt and Thomas Weide
doi : 10.1681/ASN.2020040501
JASN May 2021, 32 (5) 1053-1070
Background Crumbs2 is expressed at embryonic stages as well as in the retina, brain, and glomerular podocytes. Recent studies identified CRB2 mutations as a novel cause of steroid-resistant nephrotic syndrome (SRNS).
Anti-CD20 mAb-Induced B Cell Apoptosis Generates T Cell Regulation of Experimental Myeloperoxidase ANCA-Associated Vasculitis
Poh-Yi Gan, Jonathan Dick, Kim M. O’Sullivan, Virginie Oudin, Anne Cao Le, Daniel Koo Yuk Cheong, Raymond Shim, Maliha Alikhan, A. Richard Kitching, Joshua D. Ooi and Stephen R. Holdsworth
doi : 10.1681/ASN.2020060834
JASN May 2021, 32 (5) 1071-1083
Background Myeloperoxidase ANCA-associated vasculitis is a major cause of ESKD. Efficacy of anti-CD20 mAb treatment was tested in a mouse model of the disease.
Data-driven Derivation and Validation of Novel Phenotypes for Acute Kidney Transplant Rejection using Semi-supervised Clustering
Thibaut Vaulet, Gillian Divard, Olivier Thaunat, Evelyne Lerut, Aleksandar Senev, Olivier Aubert, Elisabet Van Loon, Jasper Callemeyn, Marie-Paule Emonds, Amaryllis Van Craenenbroeck, Katrien De Vusser, Ben Sprangers, Maud Rabeyrin, Valérie Dubois, Dirk Kuypers, Maarten De Vos, Alexandre Loupy, Bart De Moor and Maarten Naesens
doi : 10.1681/ASN.2020101418
JASN May 2021, 32 (5) 1084-1096
Background Over the past decades, an international group of experts iteratively developed a consensus classification of kidney transplant rejection phenotypes, known as the Banff classification. Data-driven clustering of kidney transplant histologic data could simplify the complex and discretionary rules of the Banff classification, while improving the association with graft failure.
The Rhesus Macaque Serves As a Model for Human Lateral Branch Nephrogenesis
Meredith P. Schuh, Lyan Alkhudairy, Andrew Potter, S. Steven Potter, Kashish Chetal, Kairavee Thakkar, Nathan Salomonis and Raphael Kopan
doi : 10.1681/ASN.2020101459
JASN May 2021, 32 (5) 1097-1112
Background Most nephrons are added in late gestation. Truncated extrauterine nephrogenesis in premature infants results in fewer nephrons and significantly increased risk for CKD in adulthood. To overcome the ethical and technical difficulties associated with studies of late-gestation human fetal kidney development, third-trimester rhesus macaques served as a model to understand lateral branch nephrogenesis (LBN) at the molecular level.
Protective Role of the M-Sec–Tunneling Nanotube System in Podocytes
Federica Barutta, Shunsuke Kimura, Koji Hase, Stefania Bellini, Beatrice Corbetta, Alessandro Corbelli, Fabio Fiordaliso, Antonella Barreca, Mauro Giulio Papotti, Gian Marco Ghiggeri, Gennaro Salvidio, Dario Roccatello, Valentina Audrito, Silvia Deaglio, Roberto Gambino, Stefania Bruno, Giovanni Camussi, Miriam Martini, Emilio Hirsch, Marilena Durazzo, Hiroshi Ohno and Gabriella Gruden
doi : 10.1681/ASN.2020071076
JASN May 2021, 32 (5) 1114-1130
Background Podocyte dysfunction and loss are major determinants in the development of proteinuria. FSGS is one of the most common causes of proteinuria, but the mechanisms leading to podocyte injury or conferring protection against FSGS remain poorly understood. The cytosolic protein M-Sec has been involved in the formation of tunneling nanotubes (TNTs), membrane channels that transiently connect cells and allow intercellular organelle transfer. Whether podocytes express M-Sec is unknown and the potential relevance of the M-Sec–TNT system in FSGS has not been explored.
Renal Inflammation Induces Salt Sensitivity in Male db/db Mice through Dysregulation of ENaC
Luciana C. Veiras, Justin Z. Y. Shen, Ellen A. Bernstein, Giovanna C. Regis, DuoYao Cao, Derick Okwan-Duodu, Zakir Khan, David R. Gibb, Fernando P. Dominici, Kenneth E. Bernstein and Jorge F. Giani
doi : 10.1681/ASN.2020081112
JASN May 2021, 32 (5) 1131-1149
Background Hypertension is considered a major risk factor for the progression of diabetic kidney disease. Type 2 diabetes is associated with increased renal sodium reabsorption and salt-sensitive hypertension. Clinical studies show that men have higher risk than premenopausal women for the development of diabetic kidney disease. However, the renal mechanisms that predispose to salt sensitivity during diabetes and whether sexual dimorphism is associated with these mechanisms remains unknown.
Association between Longer Travel Distance for Transplant Care and Access to Kidney Transplantation and Graft Survival in the United States
Adrian M. Whelan, Kirsten L. Johansen, Sandeep Brar, Charles E. McCulloch, Deborah B. Adey, Garrett R. Roll, Barbara Grimes and Elaine Ku
doi : 10.1681/ASN.2020081242
JASN May 2021, 32 (5) 1151-1161
Background Transplant candidates may gain an advantage by traveling to receive care at a transplant center that may have more favorable characteristics than their local center. Factors associated with longer travel distance for transplant care and whether the excess travel distance (ETD) is associated with access to transplantation or with graft failure are unknown.
Safety and Efficacy of Daratumumab in Patients with Proliferative GN with Monoclonal Immunoglobulin Deposits
Ladan Zand, S. Vincent Rajkumar, Nelson Leung, Sanjeev Sethi, Mireille El Ters and Fernando C. Fervenza
doi : 10.1681/ASN.2020101541
JASN May 2021, 32 (5) 1163-1173
Background Treatment of proliferative GN with monoclonal Ig deposits (PGNMID) is not established. A monoclonal anti-CD38 antibody (daratumumab) is effective in treating multiple myeloma. Abnormal plasma cell clones may play a role in the pathogenesis of PGNMID.
Kidney Failure Prediction Models: A Comprehensive External Validation Study in Patients with Advanced CKD
Chava L. Ramspek, Marie Evans, Christoph Wanner, Christiane Drechsler, Nicholas C. Chesnaye, Maciej Szymczak, Magdalena Krajewska, Claudia Torino, Gaetana Porto, Samantha Hayward, Fergus Caskey, Friedo W. Dekker, Kitty J. Jager, Merel van Diepen and the EQUAL Study Investigators
doi : 10.1681/ASN.2020071077
JASN May 2021, 32 (5) 1174-1186
Background Various prediction models have been developed to predict the risk of kidney failure in patients with CKD. However, guideline-recommended models have yet to be compared head to head, their validation in patients with advanced CKD is lacking, and most do not account for competing risks.
Podometrics in Japanese Living Donor Kidneys: Associations with Nephron Number, Age, and Hypertension
Kotaro Haruhara, Takaya Sasaki, Natasha de Zoysa, Yusuke Okabayashi, Go Kanzaki, Izumi Yamamoto, Ian S. Harper, Victor G. Puelles, Akira Shimizu, Luise A. Cullen-McEwen, Nobuo Tsuboi, Takashi Yokoo and John F. Bertram
doi : 10.1681/ASN.2020101486
JASN May 2021, 32 (5) 1187-1199
Background Podocyte depletion, low nephron number, aging, and hypertension are associated with glomerulosclerosis and CKD. However, the relationship between podometrics and nephron number has not previously been examined.
BP in Young Adults with CKD and Associations with Cardiovascular Events and Decline in Kidney Function
Alexander J. Kula, David K. Prince, Joseph T. Flynn and Nisha Bansal
doi : 10.1681/ASN.2020081156
JASN May 2021, 32 (5) 1200-1209
Background BP is an important modifiable risk factor for cardiovascular events and CKD progression in middle-aged or older adults with CKD. However, studies describing the relationship between BP with outcomes in young adults with CKD are limited.
Comparing Approaches to Normalize, Quantify, and Characterize Urinary Extracellular Vesicles
Charles J. Blijdorp, Omar A. Z. Tutakhel, Thomas A. Hartjes, Thierry P. P. van den Bosch, Martijn H. van Heugten, Juan Pablo Rigalli, Rob Willemsen, Usha M. Musterd-Bhaggoe, Eric R. Barros, Roger Carles-Fontana, Cristian A. Carvajal, Onno J. Arntz, Fons A. J. van de Loo, Guido Jenster, Marian C. Clahsen-van Groningen, Cathy A. Cuevas, David Severs, Robert A. Fenton, Martin E. van Royen, Joost G. J. Hoenderop, René J. M. Bindels and Ewout J. Hoorn
doi : 10.1681/ASN.2020081142
JASN May 2021, 32 (5) 1210-1226
Background Urinary extracellular vesicles (uEVs) are a promising source for biomarker discovery, but optimal approaches for normalization, quantification, and characterization in spot urines are unclear.
IgM Autoantibodies to Complement Factor H in Atypical Hemolytic Uremic Syndrome
Massimo Cugno, Silvia Berra, Federica Depetri, Silvana Tedeschi, Samantha Griffini, Elena Grovetti, Sonia Caccia, Donata Cresseri, Piergiorgio Messa, Sara Testa, Fabio Giglio, Flora Peyvandi and Gianluigi Ardissino
doi : 10.1681/ASN.2020081224
JASN May 2021, 32 (5) 1227-1235
Background Atypical hemolytic uremic syndrome (aHUS), a severe thrombotic microangiopathy, is often related to complement dysregulation, but the pathomechanisms remain unknown in at least 30% of patients. Researchers have described autoantibodies to complement factor H of the IgG class in 10% of patients with aHUS but have not reported anti-factor H autoantibodies of the IgM class.
Impact of the COVID-19 Pandemic on Nephrology Fellow Training and Well-Being in the United States: A National Survey
Kurtis A. Pivert, Suzanne M. Boyle, Susan M. Halbach, Lili Chan, Hitesh H. Shah, Joshua S. Waitzman, Ali Mehdi, Sayna Norouzi and Stephen M. Sozio
doi : 10.1681/ASN.2020111636
JASN May 2021, 32 (5) 1236-1248
Background The coronavirus disease 2019 (COVID-19) pandemic’s effects on nephrology fellows’ educational experiences, preparedness for practice, and emotional wellbeing are unknown.
Protocadherin 7–Associated Membranous Nephropathy
Sanjeev Sethi, Benjamin Madden, Hanna Debiec, Johann Morelle, M. Cristine Charlesworth, LouAnn Gross, Vivian Negron, David Buob, Sidharth Chaudhry, Michel Jadoul, Fernando C. Fervenza and Pierre Ronco
doi : 10.1681/ASN.2020081165
JASN May 2021, 32 (5) 1249-1261
Background Membranous nephropathy (MN) results from deposition of antigen-antibody complexes along the glomerular basement membrane (GBM). PLA2R, THSD7A, NELL1, and SEMA3B account for 80%–90% of target antigens in MN.
Procurement Biopsy Data Quality Limits Comparability of United States and French Deceased Donor Kidney Biopsies
S. Ali Husain and Sumit Mohan
doi : 10.1681/ASN.2020121788
JASN May 2021, 32 (5) 1263-1264
Authors’ Reply
Peter. P. Reese, Olivier Aubert and Alexandre Loupy
doi : 10.1681/ASN.2021020207
JASN May 2021, 32 (5) 1264-1265
Receptor-Mediated Endocytosis and Differentiation in Proximal Tubule Cell Systems
Marine Berquez, Patrick Krohn, Alessandro Luciani and Olivier Devuyst
doi : 10.1681/ASN.2021020253
JASN May 2021, 32 (5) 1265-1267
