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Distinguishing clinical features between primary (essential) and secondary pediatric hypertension

Distinguishing clinical features between primary (essential) and secondary pediatric hypertension
Clinical features Primary HTN Secondary HTN
Age
Prepubertal   Secondary HTN is more likely in younger children, especially those less than 6 years of age
Postpubertal Older children and adolescents are more likely to have primary HTN  
Diastolic HTN*   Diastolic HTN is more likely to be associated with secondary HTN
Nocturnal HTN*   Nocturnal HTN is more likely to be associated with secondary HTN
Overweight/obesity Overweight or obese children/adolescents are more likely to have primary HTN  
Family history of HTN Children with a positive family history of primary HTN are more likely to have primary HTN Family history may be positive in some cases of secondary HTN due to a monogenic cause (eg, autosomal dominant polycystic kidney disease)
Symptoms of underlying disorder Patients with primary HTN are typically asymptomatic Patients with secondary HTN often have other symptoms related to the underlying cause (eg, headache, sweating, and tachycardia due to catecholamine excess in patients with pheochromocytoma)

HTN: hypertension.

* Nocturnal and diastolic HTN are usually detected by ambulatory blood pressure monitoring.
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