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Hemorrhagic stroke in children

Hemorrhagic stroke in children
Literature review current through: Jan 2024.
This topic last updated: Nov 03, 2023.

INTRODUCTION — Although less common than in adults, hemorrhagic stroke can affect children, resulting in significant morbidity and mortality.

An overview of hemorrhagic stroke in children beyond the newborn period is provided here. Other clinical aspects of stroke in neonates and children are reviewed elsewhere:

(See "Stroke in the newborn: Classification, manifestations, and diagnosis".)

(See "Stroke in the newborn: Management and prognosis".)

(See "Ischemic stroke in children and young adults: Epidemiology, etiology, and risk factors".)

(See "Ischemic stroke in children: Clinical presentation, evaluation, and diagnosis".)

(See "Ischemic stroke in children: Management and prognosis".)

(See "Acute stroke (ischemic and hemorrhagic) in children and adults with sickle cell disease".)

(See "Prevention of stroke (initial or recurrent) in sickle cell disease".)

(See "Moyamoya disease and moyamoya syndrome: Etiology, clinical features, and diagnosis".)

(See "Cerebral venous thrombosis: Etiology, clinical features, and diagnosis".)

CLASSIFICATION — Hemorrhagic stroke encompasses spontaneous intracerebral hemorrhage (ICH), isolated intraventricular hemorrhage, and nontraumatic subarachnoid hemorrhage [1]. ICH is defined by intraparenchymal hemorrhage or a combination of intraparenchymal and intraventricular hemorrhage (image 1).

Despite its common usage, the term hemorrhagic stroke remains confusing. It has also been used to denote hemorrhagic transformation of arterial ischemic stroke or of cerebral venous thrombosis, but it does not encompass those entities, strictly speaking. (See "Spontaneous intracerebral hemorrhage: Pathogenesis, clinical features, and diagnosis", section on 'Subsequent imaging'.)

EPIDEMIOLOGY — Although stroke in children is relatively rare compared with adults, it is a significant cause of childhood death and lifelong disability. A stroke suffered within the first decades may cause functional sequelae for multiple decades to follow. Hemorrhagic stroke is a notable contributor to childhood morbidity and mortality, as it accounts for about half of all childhood strokes, compared with <20 percent of adult strokes [2,3].

The estimated incidence of all types of stroke (ischemic and hemorrhagic) in children ranges 2 to 13 per 100,000 children per year in the developed world [4,5]. A study of a California-wide hospital discharge database for first stroke admission for children ages 1 month through 19 years found an annual incidence rate of 1.1 per 100,000 children for hemorrhagic stroke and 1.2 per 100,000 children for ischemic stroke [4]. Similarly, a retrospective cohort study of 2.3 million children (age <20 years) followed for more than a decade revealed an average annual incidence rate of 1.4 per 100,000 children for hemorrhagic stroke [6].

Among hemorrhagic stroke subtypes, the estimated annual incidence of intracerebral hemorrhage in developed countries ranges from 1.1 to 5.2 per 100,000 children [4,5], while the estimated annual incidence of subarachnoid hemorrhage is 0.4 per 100,000 children [4].

ETIOLOGY AND RISK FACTORS — Ruptured vascular malformations are the most common cause of intracerebral hemorrhage (ICH) in children. In contrast, hypertension and amyloid angiopathy are the most frequent causes of ICH in adults. (See "Spontaneous intracerebral hemorrhage: Pathogenesis, clinical features, and diagnosis", section on 'Risk factors'.)

Aneurysms are the most common cause of nontraumatic subarachnoid hemorrhage in both adults and children. (See "Aneurysmal subarachnoid hemorrhage: Epidemiology, risk factors, and pathogenesis".)

The etiology and risk factors of perinatal hemorrhagic stroke are reviewed separately. (See "Stroke in the newborn: Classification, manifestations, and diagnosis", section on 'Hemorrhagic stroke'.)

Vascular malformations — Depending on the series, vascular malformations are responsible for 18 to 90 percent of childhood ICH cases [3,7-9], with arteriovenous malformations (AVMs) being the most common type and cavernous malformations and aneurysms found less frequently (image 2) [10].

AVMs consist of abnormal direct connections between arteries and veins without intervening capillaries that give rise to high-flow lesions extremely prone to rupture (see "Brain arteriovenous malformations"). The incidence of cerebral AVMs in adults has been estimated to be 1 per 100,000 person-years [11]. Many AVM lesions are thought to be congenital, so this estimate may reflect the incidence in children as well; however, only a small percentage of AVMs (estimated 8 to 20 percent) become symptomatic under the age of 15 years [12,13]. The risk of hemorrhage from a cerebral AVM in children has been estimated at 2 percent per year [14]. AVMs account for 14 to 46 percent of ICH in children and nearly 50 percent of intraparenchymal hemorrhage [15-17].

Although most AVMs are isolated developmental lesions, there are genetic causes that predispose to multiple AVMs. Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant genetic disorder of vascular dysplasia associated with mucocutaneous telangiectasias and AVMs. AVMs in patients with HHT most often occur in the pulmonary, hepatic, and cerebral circulations [18,19]. Multiplicity of brain AVMs is highly predictive of the diagnosis of HHT [20]. Incidence of HHT is reported to be 1 in 5000 to 8000 individuals per year [21], although this is likely to be an underestimate due to the variability in clinical manifestations. Approximately 20 percent of adults with HHT have cerebrovascular malformations [22]. The prevalence of cerebrovascular malformations in children with HHT is unknown but believed to approximate that of adult [23]. In one of the largest case series of pediatric patients with confirmed HHT, 11 of 115 children had cerebral AVMs and >50 percent developed symptomatic ICH [19].

Arteriovenous fistulas differ from AVMs because there is an absence of a discrete nidus between the arterial feeder and draining vein. Arteriovenous fistulas are worth noting as these also carry a significant risk of hemorrhage of 1.5 percent per year. However, arteriovenous fistulas are much rarer, comprising only 4 percent of pediatric cerebral vascular malformations [24,25].

Cavernous malformations (cavernomas or cavernous angiomas) have an estimated annual incidence of 0.56 per 100,000 people, which is approximately one-half that of AVMs [26]. Cavernous malformations consist of dilated sinusoidal vessels lined by endothelium without intervening neural parenchyma. "Leaking" of blood into surrounding tissue can occur due to dysfunctional endothelial cell connections. These are considered to be low-flow lesions. Cavernous malformations have been found to have a prevalence of 0.5 percent in autopsy studies [27,28] and are estimated to account for 20 to 25 percent of pediatric intraparenchymal hemorrhage [3,16,29]. While symptoms may manifest in all age groups, affected children tend to cluster in two age groups: infants and toddlers under the age of 3 years and children in early puberty, ages 12 to 16 years [30,31]. .

While aneurysms are one of the most common vascular anomalies of the central nervous system, they are far less common in children than in adults, with a reported prevalence ranging from 0.5 to 5 percent of the total prevalence of intracranial aneurysms in the general population [32-39]. Aneurysms in children are felt to be different from those in adults in the following respects [33,39-41]:

Pediatric aneurysms tend to be larger in size

There is a higher incidence of giant aneurysms in children

There tends to be a male predominance in children

The most common cause of nontraumatic subarachnoid hemorrhage in children and adolescents is rupture of a cerebral aneurysm [6]. Ruptured aneurysms can also cause intraparenchymal hemorrhage or can present with nonhemorrhagic symptoms like headaches or seizures.

Hematologic — In reports from developed countries, hematologic abnormalities (including thrombocytopenia or platelet dysfunction, hemophilia and other congenital or acquired coagulopathies, and sickle cell disease) were the major risk factor for pediatric hemorrhagic stroke, found in 10 to 30 percent of cases [42]. In resource-limited countries, ICH secondary to underlying hematologic disorders occurs more frequently than hemorrhage due to vascular malformations. A retrospective study of 50 children with ICH at a single institution in Pakistan demonstrated that 52 percent had bleeding disorders compared with 14 percent with vascular malformations [43]. Similarly, a retrospective analysis of 94 children in China found that a bleeding diathesis, most commonly due to a vitamin K deficiency, was present in 88 percent of patients with hemorrhagic stroke compared with 14 percent with AVM [44].

Special populations with hematologic abnormalities include children with immune thrombocytopenia (ITP), hemophilia, and sickle cell disease:

With ITP, intracranial hemorrhage is estimated to occur in up to 1 percent. (See "Immune thrombocytopenia (ITP) in children: Clinical features and diagnosis", section on 'Intracranial hemorrhage'.)

With hemophilia, the reported ICH prevalence in children is 3 to 12 percent [45-47]. (See "Clinical manifestations and diagnosis of hemophilia", section on 'Intracranial bleeding'.)

With sickle cell disease (SCD), affected individuals are at risk for ischemic and hemorrhagic stroke. One report suggested that children with SCD had a >200-fold higher risk of hemorrhagic stroke compared with children without SCD [48]. In other reports, specific factors associated with hemorrhage in children with SCD included premorbid hypertension, transfusion within the last 14 days, treatment with glucocorticoids, low steady-state hemoglobin concentration, high steady-state leukocyte count, and late effects of moyamoya-type vasculopathy [49-51]. (See "Acute stroke (ischemic and hemorrhagic) in children and adults with sickle cell disease" and "Moyamoya disease and moyamoya syndrome: Etiology, clinical features, and diagnosis".)

Cancer — A smaller proportion of hemorrhagic stroke in children is attributable to cancer. In one case series of 69 children with intraparenchymal hemorrhage, brain tumors accounted for 13 percent cases [7]. In another case series from a tertiary cancer center, ICH occurred in 3 percent of over 1000 children with brain tumors and in 1 percent of nearly 1600 children with acute leukemia [52-54].

Other — Although much less common than in the adult population, hypertension has also been associated with ICH in children. In one small retrospective cohort study, 45 percent of children with ICH had elevated blood pressure above the 90th percentile at presentation; however, only 14 percent continued to have persistently elevated blood pressure on follow-up, and none required antihypertensive treatment [55].

Another cause of hemorrhagic stroke in childhood is moyamoya disease. Ischemic cerebrovascular events, either transient ischemic attack or infarction, are more prevalent than hemorrhagic events in children with moyamoya, while hemorrhagic stroke is more common in adults. However, moyamoya can cause either ICH or subarachnoid hemorrhage in children. (See "Moyamoya disease and moyamoya syndrome: Etiology, clinical features, and diagnosis", section on 'Clinical presentations'.)

Drugs of abuse, coagulopathies secondary to liver dysfunction, and porphyria are rare causes of hemorrhagic stroke in children.

Cohort studies have shown that 9 to 23 percent of childhood ICH remains cryptogenic without a definitive risk factor identified despite extensive evaluation [8,56,57]. However, some proportion of these cryptogenic cases may be due to vascular malformations that have self-obliterated at the time of the incident hemorrhage [58].

CLINICAL FEATURES AND PRESENTATION — Among all children who present outside the perinatal period, headache is the most common symptom of hemorrhagic stroke, affecting 46 to 80 percent [7,8,10,17]. Other common presenting symptoms in children include:

Nausea and emesis in nearly 60 percent [8]

Seizures (either generalized or focal) in 20 to 40 percent [7,8,59]

Focal neurologic deficits such as hemiparesis or aphasia, which range in frequency from 13 to 50 percent [8,17,55,58]

Neck pain

Altered level of consciousness in 50 percent or more [7,8,56,58]

The clinical presentation of hemorrhagic stroke can vary based upon the age of the child; younger children are most likely to present with only nonspecific features (eg, altered mentation, seizures, vomiting) while older children are more likely to present with headache, mental status change, and focal neurologic deficits. There is overlap between symptoms in pediatric hemorrhagic stroke, pediatric arterial ischemic stroke, and pediatric cerebral sinovenous thrombosis. All can present with headache, altered mental status, focal neurologic deficits, and seizures. Therefore, neuroimaging is required to differentiate among these entities. However, severe sudden headache with rapid alteration in level of consciousness may be more indicative of a hemorrhage.

In a retrospective review of 85 children with nontraumatic intracerebral hemorrhage (ICH) at a tertiary pediatric hospital, the most common clinical signs in young children (<6 years of age) were mental status change, seizures, or vomiting [55]. In contrast, older children (≥6 years of age) often presented with headache and focal neurologic deficits in addition to symptoms of mental status change and nausea/vomiting, allowing clinicians to quickly narrow the differential diagnosis.

Another cohort study found that children younger than three years of age at time of hemorrhage onset (n = 9) presented with vague symptoms of general deterioration, increased crying and sleepiness, irritability, feeding difficulty, vomiting, and sepsis-like symptoms with cold extremities [17].

The onset of clinical symptoms due to hemorrhagic stroke is variable and ranges from rapid occurrence over minutes to insidious progression over several hours to days. In a cohort study of 22 children with ICH, the median time to hospital presentation was 70 minutes, but 23 percent of children presented after 24 hours [8].

A prospective study of 53 children with ICH found that acute symptomatic seizures, defined as those occurring from presentation to seven days after onset, occurred in 36 percent [59]. Thus, acute symptomatic seizures with ICH may be more common in children than in adults, where the corresponding rate is estimated to range from 5 to 30 percent (see "Spontaneous intracerebral hemorrhage: Pathogenesis, clinical features, and diagnosis", section on 'Clinical presentation'). Further, children with ICH may present with seizures more commonly than children with arterial ischemic stroke, in whom seizures at stroke onset have been reported in 22 percent [60]. Cortical involvement of ICH, which is an important predictor of acute symptomatic seizures in adults [61,62], was not related to acute symptomatic seizures in the pediatric ICH cohort [59].

The pace of symptom onset may be related to the underlying etiology, with aneurysm rupture expected to correlate with sudden onset, while other mechanisms may allow for subacute onset, at least in some cases. However, data are sparse. In a small cohort study of children with spontaneous ICH, approximately half had acute onset of symptoms while the other half had a subacute course [17]. Among children with a known onset, there were four with aneurysms, and the presentation was acute in three; among 16 children with arteriovenous malformation and known onset, an acute presentation occurred in 10 cases (63 percent). Other factors that could affect the rapidity of symptom development are size and location of hemorrhage, intraventricular extension, and presence of hydrocephalus.

INITIAL EVALUATION AND DIAGNOSIS — The diagnosis of hemorrhagic stroke requires confirmation by brain imaging with computed tomography (CT) or magnetic resonance imaging (MRI) [63]. Therefore, clinical suspicion for hemorrhage in the setting of a compatible presentation (eg, headache, mental status changes, seizure, vomiting, or focal neurologic deficits) as described above should prompt urgent imaging. (See 'Clinical features and presentation' above.)

For children of school age or older, the acute onset of headache, particularly when severe, (eg, sometimes reported as the "worst headache of life") should prompt evaluation for intracerebral or subarachnoid hemorrhage. However, children may have limited experience with headaches. Younger children may have difficulty describing symptoms, and other children who present to an emergency department for a benign headache may also report symptoms as the worst of their life if prompted. The diagnosis of hemorrhagic stroke in children can also be difficult because the presentation is often nonspecific and subacute. In one small study, most cases with delayed diagnosis (7 of 11) had subacute onset [17].

The initial evaluation should center on rapid diagnosis of the hemorrhage, assessment for presence of elevated intracranial pressure, and identification of easily correctible risk factors such as thrombocytopenia, coagulopathy, or hypertension.

Children with hemorrhagic stroke are also at increased risk of subsequent ischemic stroke due to compression of blood vessels from mass effect from the intracerebral hemorrhage, vasospasm after subarachnoid hemorrhage, or underlying vasculopathy (such as moyamoya or cocaine-induced vasculopathy) [64].

Urgent neuroimaging — Neuroimaging with CT or MRI as the initial study is necessary to determine the cause of the presenting symptoms, distinguish hemorrhagic stroke from ischemic stroke, and distinguish stroke from stroke mimics. In a stable patient, MRI is preferred because of the lack of radiation and the better resolution of the parenchyma. MRI with gradient echo and/or susceptibility-weighted sequences is equally sensitive for acute hemorrhage and more sensitive for chronic hemorrhage than CT [65]. (See "Spontaneous intracerebral hemorrhage: Pathogenesis, clinical features, and diagnosis", section on 'Brain MRI'.)

However, MRI is not universally available and may require sedation [65]. Noncontrast head CT should be performed if a patient with suspected hemorrhage is unstable or if obtaining an MRI might delay diagnosis. CT is quick, widely available, does not require sedation in most cases, and is highly sensitive for acute hemorrhage.

Noncontrast head CT reveals the diagnosis of subarachnoid hemorrhage in more than 90 percent of cases if performed within 24 hours of bleeding onset; the sensitivity of modern head CT for detecting SAH is highest in the first six hours after subarachnoid hemorrhage (nearly 100 percent when interpreted by expert reviewers). Limited data suggest that proton density and fluid-attenuated inversion recovery (FLAIR) sequences on brain MRI may be as sensitive as head CT for the detection of acute subarachnoid hemorrhage. If neuroimaging is negative for blood and there is high clinical concern for subarachnoid hemorrhage, lumbar puncture should be performed to detect red blood cells or xanthochromia if there are no contraindications (eg, mass lesions causing impending herniation). (See "Aneurysmal subarachnoid hemorrhage: Clinical manifestations and diagnosis", section on 'Evaluation and diagnosis'.)

Laboratory studies — First-line laboratory studies should include electrolytes, blood urea nitrogen and creatinine, glucose, complete blood count with platelets, coagulation studies (prothrombin time, international normalized ratio, and activated partial thromboplastin time) [63]. Type and screen should be sent for any child who will undergo surgery.

DIFFERENTIAL DIAGNOSIS — Hemorrhagic stroke must first be differentiated from other types of acute intracerebral vascular events, such as arterial ischemic stroke and cerebral sinovenous thrombosis, both of which may have concomitant hemorrhagic transformation [66]. (See "Ischemic stroke in children and young adults: Epidemiology, etiology, and risk factors" and "Ischemic stroke in children: Clinical presentation, evaluation, and diagnosis" and "Cerebral venous thrombosis: Etiology, clinical features, and diagnosis".)

The differential diagnosis for hemorrhagic stroke (table 1) also includes a broad list of diagnoses that can mimic stroke syndromes. The most common childhood stroke mimics are [67,68]:

Migraine syndromes (see "Types of migraine and related syndromes in children" and "Migraine-associated stroke: risk factors, diagnosis, and prevention", section on 'Forms of migraine with aura')

Postictal (Todd) paralysis (see "Differential diagnosis of transient ischemic attack and acute stroke", section on 'Transient neurologic events')

Bell’s Palsy (see "Facial nerve palsy in children")

Functional neurological disorders (see "Etiology and evaluation of the child with weakness", section on 'Causes of acute weakness')

Other conditions that may mimic stroke include the following:

Brain tumors (see "Clinical manifestations and diagnosis of central nervous system tumors in children")

Posterior reversible encephalopathy syndrome (PRES), also known as reversible posterior leukoencephalopathy syndrome (see "Reversible posterior leukoencephalopathy syndrome")

Intracranial infections including abscess, encephalitis, and meningitis

White matter diseases (algorithm 1) including multiple sclerosis, acute disseminated encephalomyelitis, myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), and leukodystrophies (see "Pathogenesis, clinical features, and diagnosis of pediatric multiple sclerosis" and "Acute disseminated encephalomyelitis (ADEM) in children: Pathogenesis, clinical features, and diagnosis" and "Differential diagnosis of acute central nervous system demyelination in children")

Metabolic derangements such as hypoglycemia (see "Approach to hypoglycemia in infants and children")

Organic or amino acidurias (see "Inborn errors of metabolism: Classification" and "Inborn errors of metabolism: Epidemiology, pathogenesis, and clinical features")

Mitochondrial diseases such as mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) (see "Mitochondrial myopathies: Clinical features and diagnosis", section on 'MELAS')

Methotrexate and other chemotherapeutic agent neurotoxicity (see "Overview of neurologic complications of conventional non-platinum cancer chemotherapy" and "Overview of neurologic complications of platinum-based chemotherapy")

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) (see "Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)")

Musculoskeletal conditions

Neuroimaging is required to diagnose hemorrhagic stroke and to distinguish stroke from mimics. (See 'Initial evaluation and diagnosis' above.)

MANAGEMENT — Once diagnosis of hemorrhagic stroke is confirmed (see 'Initial evaluation and diagnosis' above), the focus should shift to stabilization of the patient, treatment of elevated intracranial pressure (if present), and close monitoring for brain herniation. There are currently no established evidence-based diagnostic or management guidelines for children with hemorrhagic stroke. The American Heart Association (AHA) scientific statement for the management of stroke in infants and children includes recommendations for children with hemorrhagic stroke [69], which are mostly extrapolated from adult guidelines or are based on expert opinion derived from small retrospective pediatric studies.

Immediate consultations — Immediate consultations should be obtained from neurosurgery and neurology; hematology should also be consulted if hematologic abnormalities are present on laboratory studies (eg, activated partial thromboplastin time [aPTT], prothrombin time [PT], international normalized ratio [INR], complete blood count [CBC]) or are suspected. Platelet transfusion may be required if there is thrombocytopenia or concern for platelet dysfunction. Coagulopathy may require intravenous vitamin K and/or fresh frozen plasma, and children with factor VIII or IX deficiency typically require urgent factor replacement. Any child on an anticoagulant medication who presents with hemorrhage should receive blood products, protamine, specific reversal agents, or vitamin K as warranted. (See "Reversal of anticoagulation in intracranial hemorrhage".)

Potential need for decompressive hemicraniectomy, external ventricular drainage, placement of an intracranial pressure monitor, and/or hematoma evacuation should be discussed with neurosurgery. Consultation with interventional neuroradiology may be indicated for children with suspected or identified vascular malformations. (See 'Surgical management' below.)

Supportive measures — Subsequent supportive medical management of children with hemorrhagic stroke centers on preventing the progression of brain injury, with primary goals of reducing metabolic demand on brain tissue and avoiding hematoma expansion [63]. Isotonic fluids without glucose should be immediately started to maintain euvolemia, and normothermia should be maintained with acetaminophen and cooling blankets, as temperature elevation >37.5°C increased the likelihood of poor outcome in adult intraparenchymal hemorrhage [70]. Hyper- and hypoglycemia should be avoided.

Children who present with seizures should be treated with appropriate antiseizure medication (see "Seizures and epilepsy in children: Initial treatment and monitoring"). Prophylactic antiseizure medication treatment is unproven, though there are no high-quality studies of prophylactic antiseizure medication administration in pediatric hemorrhagic stroke. The AHA pediatric stroke guidelines make no recommendations regarding prophylactic antiseizure medication treatment in intracerebral hemorrhage (ICH) [69]. We agree with the AHA guidelines for management of ICH, which recommend against prophylactic antiseizure medications [71].

While treatment of hypertension is a mainstay of hemorrhagic stroke management in adults [63], no evidence for directing management of hypertension after ICH exists in children. It may be a reasonable goal to lower a child's blood pressure to the 95th percentile for age and sex if elevated after hemorrhage to help prevent hematoma expansion. However, this is not evidence based and may cause a reduction in cerebral perfusion, thereby exacerbating secondary brain injury, particularly if there is elevated intracranial pressure or pre-existing hypertension. Any use of antihypertensive medication should be used cautiously.

Intracranial pressure

Medical management — General measures for children with increased intracranial pressure include:

Rapid treatment of hypoxia, hypercarbia, and hypotension

Elevation of the head of the bed to at least 30 degrees

Maintenance of the head and neck midline to facilitate venous drainage

Aggressive treatment of fever with antipyretics and thermoregulation devices

Control of shivering using sedation or muscle relaxants based on respiratory support and neurologic examination needs (see "Initial assessment and management of the adult post-cardiac arrest patient", section on 'Sedation and suppression of shivering')

Maintenance of adequate analgesia to blunt the response to noxious stimuli

Intracranial pressure (ICP) may become precipitously elevated in hemorrhagic stroke due to mass effect from the hemorrhage or from obstructive or communicating hydrocephalus from intraventricular hemorrhage. This contrasts with acute ischemic stroke, in which increased ICP typically develops several days after the incident event as infarcted brain tissue become edematous.

To help reduce or prevent elevated ICP, the head of the bed should be elevated to at least 30 degrees, and the neck should be maintained in a midline position to promote venous drainage. Signs and symptoms of elevated ICP should be frequently reassessed, including presence of positional headache, vomiting, irritability or combativeness, declining mental status, sixth nerve palsies, decreased pupillary light responses, and papilledema. While Cushing's triad (ie, hypertension, reflexive bradycardia, and respiratory depression) is highly suggestive of elevated ICP, this is typically a late finding.

For any neurologic deterioration, a head computed tomography (CT) should be obtained promptly to assess for worsening hemorrhage, hydrocephalus, edema, or herniation. Direct ongoing measurement of ICP may require placement of an intraventricular catheter, which can also aid in ICP reduction via direct cerebrospinal fluid drainage, or a subdural bolt if an intraventricular catheter is not technically feasible due to small size of a child's ventricles or other reasons.

Nonsurgical interventions for management of increased ICP include hyperosmolar therapy with intravenous mannitol (bolus 1 g/kg, given as an intravenous infusion through an in-line filter over 20 to 30 minutes, followed by infusions of 0.25 to 0.5 g/kg as needed, generally every six to eight hours) or hypertonic saline to promote osmotic diuresis (see "Elevated intracranial pressure (ICP) in children: Management", section on 'Hyperosmolar therapy'). If hyperosmolar therapy is administered, close monitoring of plasma osmoles and electrolytes is required to avoid hypovolemia, hypotension, and kidney failure. Glucocorticoids should be avoided because they did not improve outcomes in randomized controlled trials of adults with ICH [72,73], and the resultant hyperglycemia may lead to worse outcomes [74,75]. For intubated patients, as a bridge to a surgical intervention or hyperosmolar therapy, hyperventilation to PCO2 of 25 to 30 mmHg (if the child is intubated) can be used. However, hyperventilation decreases cerebral perfusion and cannot be used as an ongoing therapy.

Surgical management — Ultimately, medical interventions for elevated ICP are only temporizing measures, and surgical evacuation of a parenchymal hematoma or decompressive craniectomy may be necessary to control refractory elevations in ICP and/or mass effect. Surgical hemorrhage evacuation for supratentorial ICH is controversial, and no high-quality studies in children have evaluated early surgical hematoma evacuation or hemicraniectomy. In adults, randomized trials have not conclusively demonstrated benefit. (See "Spontaneous intracerebral hemorrhage: Acute treatment and prognosis", section on 'Surgical approaches for selected patients'.)

As children typically lack the baseline cerebral atrophy found in older adults that permits expansion of the hematoma without consequent compression of the surrounding parenchyma, it is biologically plausible that children may benefit from hematoma evacuation to reduce ICP. If a child is undergoing resection of an underlying vascular malformation that is at high risk for acute rebleeding, it may be optimal to concurrently evacuate the hematoma. Surgical evaluation also might be warranted if a child is comatose, has elevated intracranial pressure that is refractory to medical management, or a worsening neurological examination. As in adults, cerebellar hemorrhages >3 cm in diameter in a child who is deteriorating or in whom brainstem compression and/or hydrocephalus is developing due to compression on the ventricular system should also be considered for surgical evacuation. If a cerebellar hemorrhage is evacuated, suboccipital craniectomy is typically performed at the same time.

While hemicraniectomy has not been studied in the setting of pediatric hemorrhagic stroke, there are some series in which hemicraniectomy was associated with improved function and survival in pediatric arterial ischemic stroke [76,77]. In a child who undergoes surgical hematoma evacuation due to a supratentorial hemorrhage causing elevated intracranial pressure that is refractory to medical management, the surgeon may elect to perform a concomitant hemicraniectomy, particularly if the intracranial pressure remains elevated after hematoma evacuation or if there is herniation out of the craniotomy defect.

Identifying the etiology — Obtaining dedicated cerebrovascular imaging in the acute setting is critical to guide appropriate interventions given the high rate of vascular malformations underlying hemorrhagic stroke in children. Cerebral angiography is a minimally invasive modality that may be used for diagnosis and treatment of vascular causes of ICH [78]. While conventional cerebral angiography remains the gold standard, many institutions opt to first use noninvasive modalities. One retrospective study found that a combination of magnetic resonance imaging (MRI), magnetic resonance angiography (MRA), and magnetic resonance venography (MRV) images accurately identified the cause of ICH in 66 percent of subjects, which was statistically equivalent to the diagnostic yield of conventional cerebral angiography alone (61 percent) [79]. However, another retrospective case series of children with nontraumatic ICH reported identification of the cause of bleeding in 97 percent of children who underwent conventional cerebral angiography compared with 80 percent of children who did not have angiography [7].

Another alternative is CT angiography (CTA), which can be rapidly obtained without the need for sedation in some children, is more widely available than MRA, and may offer superior angioarchitectural visualization compared with MRA [80]. CTA also has a higher sensitivity for detecting aneurysms up to 2 mm in size. However, CTA exposes the child to both ionizing radiation and an iodinated contrast agent, requires a large bore intravenous line, and may be nondiagnostic if the child moves during the study. In a meta-analysis of 11 studies that assessed the utility of noninvasive vascular imaging for adults and children with ICH, CTA was 95 percent sensitive and 99 percent specific, while MRA was 98 percent sensitive and 99 percent specific [81]. However, there were limited numbers of children assessed, as well as variable size of lesions and times from onset to imaging, in the studies that were included.

For children with hemorrhagic stroke and no identified cause despite a thorough evaluation, including appropriate noninvasive vascular imaging, we suggest conventional cerebral angiography. As an acute hemorrhage with large hematoma and significant cerebral edema can obscure visualization of an underlying vascular malformation, vascular studies that are initially nondiagnostic should be repeated weeks to months later once the clot has been reabsorbed if no other cause for the hemorrhage (eg, tumor, coagulopathy) is found [78].

The yield of an extensive evaluation for a bleeding diathesis in children with hemorrhagic stroke is not well-studied. A rational approach is to obtain the screening laboratory studies suggested above (see 'Laboratory studies' above) (ie, a complete blood count with platelets, coagulation studies, prothrombin time, international normalized ratio, and activated partial thromboplastin time) and to pursue additional testing if the screening studies are abnormal or if an underlying vascular lesion or tumor is not found. Higher-level studies may include factor VIII, IX, and XIII levels and von Willebrand disease studies and should be ordered in consultation with a hematologist. (See "Approach to the child with bleeding symptoms" and "Approach to the child with unexplained thrombocytopenia" and "Clinical manifestations and diagnosis of hemophilia" and "Clinical presentation and diagnosis of von Willebrand disease".)

Treatment of vascular lesions — Endovascular and/or surgical management of vascular malformations may be required in the acute setting depending on the location and vascular anatomy of the lesion in conjunction with the clinical status of the child. Multidisciplinary consultation with neurosurgery, interventional radiology, and neurology is advised to choose the optimal approach to treatment of these lesions [69].

Vascular malformations other than aneurysm typically have a low risk of acute rebleeding (although they may rebleed at later times) [82-84]. Therefore, many centers will await hematoma resolution prior to definitive treatment so that the full extent of the vascular malformation can be elucidated. However, if hematoma evacuation is needed, a vascular malformation may be addressed at the same time. Some arteriovenous malformations that cannot be treated with endovascular or surgical techniques may be amenable to gamma knife or proton beam therapy once the hematoma has retracted.

Aneurysms have a higher rate of acute rebleeding [85]. Therefore, aneurysm repair typically occurs in the acute setting. AVMs with an aneurysmal component that may cause acute rebleeding also may require earlier intervention.

Follow-up imaging — Due to the high risk of recurrence, we suggest follow-up imaging for most children with hemorrhagic stroke due to a vascular malformation. In addition, we suggest follow-up imaging in cases where a vascular cause is not found but is suspected.

Even when complete resection of an arteriovenous malformation is achieved, there is a substantial risk of recurrence. In one retrospective report of 28 children who underwent surgical resection of arteriovenous malformations, 4 had recurrence leading to repeat resections [86]. Of note, two of the children in this cohort had arteriovenous malformations that were not detected until 17.7 and 25 months after the incident hemorrhage.

While the frequency and modality of follow-up imaging is center-dependent, our suggested protocol is to obtain brain MRI with MRA at three to six months after the first hemorrhage, and/or a conventional angiogram between three and six months. Additional follow-up imaging at later points is typically necessary. In children with an unresected cavernous malformation, periodic imaging with MRI is suggested if the child is having frequent symptoms such as headaches or seizures.

Genetic screening — Genetic screening may be reasonable if multiple vascular malformations are found on imaging or if there is a suggestive family history [69].

The most common genetic cause of brain AVMs is hereditary hemorrhagic telangiectasia (HHT), an autosomal dominant condition. Patients with HHT may have cerebral or spinal cord involvement with telangiectasias, brain AVMs, aneurysms, or cavernous malformations. (See "Clinical manifestations and diagnosis of hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome)", section on 'Genetic testing'.)

Familial cases of cavernous malformation are associated with genetic variants of CCM1, CCM2, and CCM3. (See "Vascular malformations of the central nervous system", section on 'Cavernous malformations'.)

PROGNOSIS — The estimated mortality rate for children with hemorrhagic stroke ranges from 5 to 33 percent, and many studies (largely retrospective) report that neurologic outcomes are poor in approximately 25 to 57 percent of children, as discussed in the sections that follow.

Mortality — Older studies show that hemorrhagic stroke has a significantly higher mortality than arterial ischemic stroke in children [3,29,87,88] but lower mortality compared with that in the adult population [89]. In a 2005 report, pooled data from multiple heterogeneous studies suggested an average mortality rate of 25 percent in children with hemorrhagic stroke [90]; later studies reported mortality rates ranging from 5 to 33 percent [8,91-93].

Neurologic outcome — Neurologic outcome after hemorrhagic stroke has not been well studied in children. Most data are derived from small retrospective cohort studies or case series. Some data suggest neurologic deficits may persist in up to approximately 75 percent, and disability may be present in more than half of survivors [8,93-95]. As an example, a prospective cohort study of pediatric intracerebral hemorrhage (ICH) included 22 children from a single tertiary care center [8]. At follow-up (median 3.5 months), clinically significant disability (defined as moderate disability or worse, with patients unable to function normally and requiring additional care) was present in 57 percent, and neurologic deficits were present in 71 percent.

Scholastic performance is frequently impaired in survivors of ICH [8]. In one cohort including 30 survivors of ICH (age 6 to 17 years), most returned to school within a year of onset, but less than one half were attending age-appropriate classes and the remainder required additional educational support [96]. In a retrospective study of 128 children with childhood stroke, of whom 82 had hemorrhagic stroke, 36 percent required special educational services at long-term follow up (median 43 months) [95].

Epilepsy at two years occurred in 13 percent of children in a prospective study of 53 children with ICH [59]. Elevated intracranial pressure that required urgent intervention during the acute hospitalization was a risk factor for a first remote symptomatic seizure and for developing epilepsy. Children with a diagnosis of epilepsy following stroke have worse parent-reported scores of health status than those without this diagnosis [97].

Outcome predictors — In adult ICH, initial hematoma volume is the strongest predictor of mortality and functional outcome, and the level of consciousness at presentation is also an important prognostic factor. The 30-day mortality is approximately 90 percent if the size of the hemorrhage exceeds 60 cm3 and the Glasgow coma scale (GCS) is <9 at presentation. This compares with an estimated 19 percent mortality when the hemorrhage volume is <30 cm3 and the GCS is ≥9 [98]. (See "Spontaneous intracerebral hemorrhage: Acute treatment and prognosis", section on 'Risk factors for poor outcomes'.)

Similarly, clinical and imaging features of the acute ICH associated with poor functional outcome in children include [8,93]:

ICH volume

Altered mental status

Length of stay in an intensive care unit

Hemorrhage volume must be taken in the context of percentage of total brain volume (TBV) to account for the markedly varying brain sizes of children of different ages. In a retrospective report of 30 consecutive children, the strongest association with outcome was the intraparenchymal component of ICH expressed as a percentage of TBV; intraparenchymal hemorrhage ≥4 percent of TBV was independently associated with poor outcome, defined as severe disability or death (odds ratio [OR] 22.5, 95% CI 1.4-354) [56]. The odds of poor outcome at 30 days increased significantly for every 10 cm3 of additional hemorrhage volume.

Other predictors of poor outcome from retrospective studies include initial GCS ≤8, coagulopathy, and older age (11 to 18 years) [9,99].

Studies in adults suggest that posterior fossa hemorrhage and presence of intraventricular hemorrhage are predictors of poor outcome (see "Spontaneous intracerebral hemorrhage: Acute treatment and prognosis", section on 'Risk factors for poor outcomes'). However, data from small pediatric cohort studies have not confirmed that these factors predict poor outcome in children [8,56,92,100].

Prediction scores

Pediatric ICH score – The adult ICH score [101] is the most commonly used clinical grading scale for predicting mortality and functional outcome following adult ICH (see "Spontaneous intracerebral hemorrhage: Acute treatment and prognosis", section on 'Clinical prediction scores'). A similar pediatric ICH score was developed to assist with risk stratification in children following ICH. While the pediatric ICH score mirrors its adult counterpart, several components required alterations. Hemorrhage volume was expressed as a percent of TBV to account for the varying brain sizes of children of different ages. Due to the lack of availability of GCS scores in most children, the presence of herniation was used. Isolated intraventricular hemorrhage had not been predictive of outcome in previous studies and was present in about 40 percent of children, so this variable was replaced with hydrocephalus [102]. Thus, the pediatric ICH score is comprised of the following components:

Intraparenchymal hemorrhage volume as percentage of TBV

-<2 percent = 0 points

-2 to 3.99 percent = 1 point

-≥4 percent = 2 points

Hydrocephalus?

-No = 0 points

-Yes = 1 point

Herniation?

-No = 0 points

-Yes = 1 point

Infratentorial location?

-No = 0 points

-Yes = 1 point

Therefore, the total pediatric ICH score ranges from 0 to 5 points.

In one prospective cohort of 60 children with ICH, a pediatric ICH score ≥2 was sensitive for predicting severe disability or death and a score ≥1 was sensitive for predicting moderate disability or worse [102]. However, the pediatric ICH score has not been established as generally valid in independent populations.

Modified pediatric ICH score – The modified pediatric ICH (mPICH) score incorporated early altered mental status, a reported predictor of worse outcome following ICH [8], and intraventricular hemorrhage into the pediatric ICH score to improve prediction sensitivity for moderate or severe disability [103]. The modified pediatric ICH (mPICH) score (range, 0 to 13) is assigns points for presence of six variables as follows:

Forebrain herniation, 4 points

Altered mental status at initial presentation, 3 points

Hydrocephalus, 2 points

Infratentorial ICH, 2 points

Intraventricular hemorrhage, 1 point

ICH volume >2 percent of TBV, 1 point

Using a retrospectively selected validation cohort of 43 children, an mPICH score of >4 was sensitive for predicting moderate disability or worse, a score >5 was sensitive for predicting severe disability or worse, and a score >6 was sensitive for predicting vegetative state or death [103].

Hemorrhagic stroke recurrence — Data from pooled studies suggest that recurrence risk after hemorrhagic stroke in childhood is approximately 10 percent [90], but the length of follow-up in these studies was highly variable. Limited data suggest that the risk of recurrence depends mainly on etiology; children with untreated or incompletely treated vascular malformations and those with hematologic disorders appear to have the highest risk of recurrence [29,104]. In a population-based retrospective cohort study of 116 children with nontraumatic hemorrhagic stroke in northern California who were followed for a mean of 4.2 years, a recurrent hemorrhagic stroke affected 11 children at a median of approximately three months (range 7 days to 5.7 years) [64]. The highest risk period was the first six months. The estimated five-year cumulative recurrence rate was 10 percent (95% CI 5-18 percent). Among the 11 recurrent hemorrhagic strokes, there were 5 due to cavernous malformations, 2 caused by to arteriovenous malformation, 2 attributed to tumor, 1 with hypertension, and 1 with idiopathic thrombocytopenia. Among the 9 children with a second hemorrhage and a structural cause (vascular malformation or tumor), the lesion was untreated in 6 and partially treated in 2 (partially resected tumor and second cavernous malformation which was not the cause of first hemorrhage). There were no recurrences among 29 children with idiopathic hemorrhagic stroke.

Another study monitored adults and children with brain arteriovenous malformations (AVMs) for a total of 3620 person-years in the adult group and 996 person-years in the childhood group, starting from initial presentation [14]. The unadjusted rates of subsequent ICH were similar for children and adults (2.0 and 2.2 percent, respectively) However, compared with adults, children with AVMs were more likely to present with hemorrhage, and after adjusting for the higher proportion of hemorrhagic presentation in children, the risk of a subsequent ICH was lower for children (hazard ratio 0.1, 95% CI 0.01-0.86). These results suggest that cerebral AVMs in children do not need to be treated more aggressively than those in adults. However, although their annualized risk of hemorrhage is similar to adults, their cumulative risk is greater given their greater number of years left to live.

SOCIETY GUIDELINE LINKS — Links to society and government-sponsored guidelines from selected countries and regions around the world are provided separately. (See "Society guideline links: Stroke in children".)

SUMMARY AND RECOMMENDATIONS

Classification – Hemorrhagic stroke encompasses spontaneous intracerebral hemorrhage (ICH), isolated intraventricular hemorrhage, and nontraumatic subarachnoid hemorrhage. ICH is defined by intraparenchymal hemorrhage with or without associated intraventricular hemorrhage. (See 'Classification' above.)

Epidemiology – Hemorrhagic stroke accounts for approximately one-half of all childhood strokes. The annual incidence rate is approximately 1 per 100,000 children. (See 'Epidemiology' above.)

Etiologies – Hemorrhagic stroke in children living in developed countries is most commonly due to ruptured vascular malformations. Hematologic abnormalities, cancer, and hypertension are less common causes. Aneurysms are the most common cause of nontraumatic subarachnoid hemorrhage. (See 'Etiology and risk factors' above.)

Clinical features – The most common presenting symptom of hemorrhagic stroke in children is headache. Other common presenting symptoms include nausea and emesis, seizures, neck pain, focal neurologic deficits, and altered level of consciousness. (See 'Clinical features and presentation' above.)

Diagnosis – The diagnosis of hemorrhagic stroke requires confirmation by brain imaging with computed tomography (CT) or magnetic resonance imaging (MRI). (See 'Urgent neuroimaging' above.)

Differential diagnosis and evaluation – The differential diagnosis for hemorrhagic stroke includes a broad list of diagnoses that can mimic stroke syndromes (table 1), with the most common being migraine syndromes and postictal (Todd) paralysis. (See 'Differential diagnosis' above.)

Testing to identify underlying causes includes dedicated cerebrovascular imaging and screening laboratory studies. (See 'Identifying the etiology' above.)

Management – The goals of acute hemorrhagic stroke management include stabilization of the patient, treatment of elevated intracranial pressure (if present), and close monitoring for brain herniation. (See 'Management' above.)

We suggest multidisciplinary consultation to choose the optimal endovascular and/or surgical approach of vascular malformations. (See 'Treatment of vascular lesions' above.)

Follow-up imaging is warranted in cases where a vascular lesion is suspected but not found during the acute evaluation as well as for most children with hemorrhagic stroke due to a vascular malformation due to the risk of recurrence. (See 'Follow-up imaging' above.)

Prognosis – The estimated mortality rate for children with hemorrhagic stroke ranges from 5 to 33 percent. Neurologic deficits may persist in up to approximately 75 percent, and disability may be present in more than half of ICH survivors. (See 'Prognosis' above.)

ACKNOWLEDGMENT — The UpToDate editorial staff acknowledges Evelyn K Shih, MD, PhD, who contributed to earlier versions of this topic review.

  1. Saver JL, Warach S, Janis S, et al. Standardizing the structure of stroke clinical and epidemiologic research data: the National Institute of Neurological Disorders and Stroke (NINDS) Stroke Common Data Element (CDE) project. Stroke 2012; 43:967.
  2. Broderick JP, Phillips SJ, Whisnant JP, et al. Incidence rates of stroke in the eighties: the end of the decline in stroke? Stroke 1989; 20:577.
  3. Broderick J, Talbot GT, Prenger E, et al. Stroke in children within a major metropolitan area: the surprising importance of intracerebral hemorrhage. J Child Neurol 1993; 8:250.
  4. Fullerton HJ, Wu YW, Zhao S, Johnston SC. Risk of stroke in children: ethnic and gender disparities. Neurology 2003; 61:189.
  5. Giroud M, Lemesle M, Gouyon JB, et al. Cerebrovascular disease in children under 16 years of age in the city of Dijon, France: a study of incidence and clinical features from 1985 to 1993. J Clin Epidemiol 1995; 48:1343.
  6. Jordan LC, Johnston SC, Wu YW, et al. The importance of cerebral aneurysms in childhood hemorrhagic stroke: a population-based study. Stroke 2009; 40:400.
  7. Al-Jarallah A, Al-Rifai MT, Riela AR, Roach ES. Nontraumatic brain hemorrhage in children: etiology and presentation. J Child Neurol 2000; 15:284.
  8. Beslow LA, Licht DJ, Smith SE, et al. Predictors of outcome in childhood intracerebral hemorrhage: a prospective consecutive cohort study. Stroke 2010; 41:313.
  9. Adil MM, Qureshi AI, Beslow LA, et al. Factors Associated With Increased In-Hospital Mortality Among Children With Intracerebral Hemorrhage. J Child Neurol 2015; 30:1024.
  10. Liu J, Wang D, Lei C, et al. Etiology, clinical characteristics and prognosis of spontaneous intracerebral hemorrhage in children: A prospective cohort study in China. J Neurol Sci 2015; 358:367.
  11. Al-Shahi R, Warlow C. A systematic review of the frequency and prognosis of arteriovenous malformations of the brain in adults. Brain 2001; 124:1900.
  12. Zhao J, Wang S, Li J, et al. Clinical characteristics and surgical results of patients with cerebral arteriovenous malformations. Surg Neurol 2005; 63:156.
  13. Di Rocco C, Tamburrini G, Rollo M. Cerebral arteriovenous malformations in children. Acta Neurochir (Wien) 2000; 142:145.
  14. Fullerton HJ, Achrol AS, Johnston SC, et al. Long-term hemorrhage risk in children versus adults with brain arteriovenous malformations. Stroke 2005; 36:2099.
  15. Chung B, Wong V. Pediatric stroke among Hong Kong Chinese subjects. Pediatrics 2004; 114:e206.
  16. Giroud M, Lemesle M, Madinier G, et al. Stroke in children under 16 years of age. Clinical and etiological difference with adults. Acta Neurol Scand 1997; 96:401.
  17. Meyer-Heim AD, Boltshauser E. Spontaneous intracranial haemorrhage in children: aetiology, presentation and outcome. Brain Dev 2003; 25:416.
  18. Plauchu H, de Chadarévian JP, Bideau A, Robert JM. Age-related clinical profile of hereditary hemorrhagic telangiectasia in an epidemiologically recruited population. Am J Med Genet 1989; 32:291.
  19. Saleh M, Carter MT, Latino GA, et al. Brain arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia: clinical presentation and anatomical distribution. Pediatr Neurol 2013; 49:445.
  20. Putman CM, Chaloupka JC, Fulbright RK, et al. Exceptional multiplicity of cerebral arteriovenous malformations associated with hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome). AJNR Am J Neuroradiol 1996; 17:1733.
  21. Begbie ME, Wallace GM, Shovlin CL. Hereditary haemorrhagic telangiectasia (Osler-Weber-Rendu syndrome): a view from the 21st century. Postgrad Med J 2003; 79:18.
  22. Fulbright RK, Chaloupka JC, Putman CM, et al. MR of hereditary hemorrhagic telangiectasia: prevalence and spectrum of cerebrovascular malformations. AJNR Am J Neuroradiol 1998; 19:477.
  23. Morgan T, McDonald J, Anderson C, et al. Intracranial hemorrhage in infants and children with hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome). Pediatrics 2002; 109:E12.
  24. Tomlinson FH, Rüfenacht DA, Sundt TM Jr, et al. Arteriovenous fistulas of the brain and the spinal cord. J Neurosurg 1993; 79:16.
  25. Cooke D, Tatum J, Farid H, et al. Transvenous embolization of a pediatric pial arteriovenous fistula. J Neurointerv Surg 2012; 4:e14.
  26. Al-Shahi R, Bhattacharya JJ, Currie DG, et al. Prospective, population-based detection of intracranial vascular malformations in adults: the Scottish Intracranial Vascular Malformation Study (SIVMS). Stroke 2003; 34:1163.
  27. Gross BA, Smith ER, Goumnerova L, et al. Resection of supratentorial lobar cavernous malformations in children: clinical article.. J Neurosurg Pediatr 2013; 12:367.
  28. Gault J, Sarin H, Awadallah NA, et al. Pathobiology of human cerebrovascular malformations: basic mechanisms and clinical relevance. Neurosurgery 2004; 55:1.
  29. Lanthier S, Carmant L, David M, et al. Stroke in children: the coexistence of multiple risk factors predicts poor outcome. Neurology 2000; 54:371.
  30. Mottolese C, Hermier M, Stan H, et al. Central nervous system cavernomas in the pediatric age group. Neurosurg Rev 2001; 24:55.
  31. Fortuna A, Ferrante L, Mastronardi L, et al. Cerebral cavernous angioma in children. Childs Nerv Syst 1989; 5:201.
  32. Gerosa M, Licata C, Fiore DL, Iraci G. Intracranial aneurysms of childhood. Childs Brain 1980; 6:295.
  33. Meyer FB, Sundt TM Jr, Fode NC, et al. Cerebral aneurysms in childhood and adolescence. J Neurosurg 1989; 70:420.
  34. Patel AN, Richardson AE. Ruptured intracranial aneurysms in the first two decades of life. A study of 58 patients. J Neurosurg 1971; 35:571.
  35. Roche JL, Choux M, Czorny A, et al. [Intracranial arterial aneurysm in children. A cooperative study. Apropos of 43 cases]. Neurochirurgie 1988; 34:243.
  36. Sedzimir CB, Robinson J. Intracranial hemorrhage in children and adolescents. J Neurosurg 1973; 38:269.
  37. Locksley HB, Sahs AL, Knowler L. Report on the cooperative study of intracranial aneurysms and subarachnoid hemorrhage. Section II. General survey of cases in the central registry and characteristics of the sample population. J Neurosurg 1966; 24:922.
  38. Locksley HB. Natural history of subarachnoid hemorrhage, intracranial aneurysms and arteriovenous malformations. Based on 6368 cases in the cooperative study. J Neurosurg 1966; 25:219.
  39. Gemmete JJ, Toma AK, Davagnanam I, et al. Pediatric cerebral aneurysms. Neuroimaging Clin N Am 2013; 23:771.
  40. Alawi A, Edgell RC, Elbabaa SK, et al. Treatment of cerebral aneurysms in children: analysis of the Kids' Inpatient Database. J Neurosurg Pediatr 2014; 14:23.
  41. Huang J, McGirt MJ, Gailloud P, Tamargo RJ. Intracranial aneurysms in the pediatric population: case series and literature review. Surg Neurol 2005; 63:424.
  42. Jordan LC, Hillis AE. Hemorrhagic stroke in children. Pediatr Neurol 2007; 36:73.
  43. Abbas Q, Merchant QU, Nasir B, et al. Spectrum of Intracerebral Hemorrhage in Children: A Report from PICU of a Resource Limited Country. Crit Care Res Pract 2016; 2016:9124245.
  44. Wang JJ, Shi KL, Li JW, et al. Risk factors for arterial ischemic and hemorrhagic stroke in childhood. Pediatr Neurol 2009; 40:277.
  45. Klinge J, Auberger K, Auerswald G, et al. Prevalence and outcome of intracranial haemorrhage in haemophiliacs--a survey of the paediatric group of the German Society of Thrombosis and Haemostasis (GTH). Eur J Pediatr 1999; 158 Suppl 3:S162.
  46. Revel-Vilk S, Golomb MR, Achonu C, et al. Effect of intracranial bleeds on the health and quality of life of boys with hemophilia. J Pediatr 2004; 144:490.
  47. Yoffe G, Buchanan GR. Intracranial hemorrhage in newborn and young infants with hemophilia. J Pediatr 1988; 113:333.
  48. Earley CJ, Kittner SJ, Feeser BR, et al. Stroke in children and sickle-cell disease: Baltimore-Washington Cooperative Young Stroke Study. Neurology 1998; 51:169.
  49. Strouse JJ, Hulbert ML, DeBaun MR, et al. Primary hemorrhagic stroke in children with sickle cell disease is associated with recent transfusion and use of corticosteroids. Pediatrics 2006; 118:1916.
  50. Ohene-Frempong K, Weiner SJ, Sleeper LA, et al. Cerebrovascular accidents in sickle cell disease: rates and risk factors. Blood 1998; 91:288.
  51. Dobson SR, Holden KR, Nietert PJ, et al. Moyamoya syndrome in childhood sickle cell disease: a predictive factor for recurrent cerebrovascular events. Blood 2002; 99:3144.
  52. Kyrnetskiy EE, Kun LE, Boop FA, et al. Types, causes, and outcome of intracranial hemorrhage in children with cancer. J Neurosurg 2005; 102:31.
  53. LaRovere KL, Riggs BJ, Poussaint TY, et al. Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome. JAMA Neurol 2021; 78:536.
  54. Coronado Munoz A, Tasayco J, Morales W, et al. High incidence of stroke and mortality in pediatric critical care patients with COVID-19 in Peru. Pediatr Res 2022; 91:1730.
  55. Lo WD, Lee J, Rusin J, et al. Intracranial hemorrhage in children: an evolving spectrum. Arch Neurol 2008; 65:1629.
  56. Jordan LC, Kleinman JT, Hillis AE. Intracerebral hemorrhage volume predicts poor neurologic outcome in children. Stroke 2009; 40:1666.
  57. Gumer LB, Del Vecchio M, Aronoff S. Strokes in children: a systematic review. Pediatr Emerg Care 2014; 30:660.
  58. Beslow LA, Heuer GG, Jordan LC. Nontraumatic Intracerebral Hemorrhage and Subarachnoid Hemorrhage. In: Pediatric Neurocritical Care, Abend NS, Helfaer MA (Eds), Demos Medical, New York 2012. p.195.
  59. Beslow LA, Abend NS, Gindville MC, et al. Pediatric intracerebral hemorrhage: acute symptomatic seizures and epilepsy. JAMA Neurol 2013; 70:448.
  60. Abend NS, Beslow LA, Smith SE, et al. Seizures as a presenting symptom of acute arterial ischemic stroke in childhood. J Pediatr 2011; 159:479.
  61. Beghi E, D'Alessandro R, Beretta S, et al. Incidence and predictors of acute symptomatic seizures after stroke. Neurology 2011; 77:1785.
  62. De Herdt V, Dumont F, Hénon H, et al. Early seizures in intracerebral hemorrhage: incidence, associated factors, and outcome. Neurology 2011; 77:1794.
  63. Greenberg SM, Ziai WC, Cordonnier C, et al. 2022 Guideline for the Management of Patients With Spontaneous Intracerebral Hemorrhage: A Guideline From the American Heart Association/American Stroke Association. Stroke 2022; 53:e282.
  64. Fullerton HJ, Wu YW, Sidney S, Johnston SC. Recurrent hemorrhagic stroke in children: a population-based cohort study. Stroke 2007; 38:2658.
  65. Kidwell CS, Chalela JA, Saver JL, et al. Comparison of MRI and CT for detection of acute intracerebral hemorrhage. JAMA 2004; 292:1823.
  66. Hutchinson ML, Beslow LA. Hemorrhagic Transformation of Arterial Ischemic and Venous Stroke in Children. Pediatr Neurol 2019; 95:26.
  67. Mackay MT, Yock-Corrales A, Churilov L, et al. Differentiating Childhood Stroke From Mimics in the Emergency Department. Stroke 2016; 47:2476.
  68. Shellhaas RA, Smith SE, O'Tool E, et al. Mimics of childhood stroke: characteristics of a prospective cohort. Pediatrics 2006; 118:704.
  69. Ferriero DM, Fullerton HJ, Bernard TJ, et al. Management of Stroke in Neonates and Children: A Scientific Statement From the American Heart Association/American Stroke Association. Stroke 2019; 50:e51.
  70. Schwarz S, Häfner K, Aschoff A, Schwab S. Incidence and prognostic significance of fever following intracerebral hemorrhage. Neurology 2000; 54:354.
  71. Hemphill JC 3rd, Greenberg SM, Anderson CS, et al. Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke 2015; 46:2032.
  72. Poungvarin N, Bhoopat W, Viriyavejakul A, et al. Effects of dexamethasone in primary supratentorial intracerebral hemorrhage. N Engl J Med 1987; 316:1229.
  73. Tellez H, Bauer RB. Dexamethasone as treatment in cerebrovascular disease. 1. A controlled study in intracerebral hemorrhage. Stroke 1973; 4:541.
  74. Passero S, Ciacci G, Ulivelli M. The influence of diabetes and hyperglycemia on clinical course after intracerebral hemorrhage. Neurology 2003; 61:1351.
  75. Weir CJ, Murray GD, Dyker AG, Lees KR. Is hyperglycaemia an independent predictor of poor outcome after acute stroke? Results of a long-term follow up study. BMJ 1997; 314:1303.
  76. Smith SE, Kirkham FJ, Deveber G, et al. Outcome following decompressive craniectomy for malignant middle cerebral artery infarction in children. Dev Med Child Neurol 2011; 53:29.
  77. Omay SB, Carrión-Grant GM, Kuzmik GA, et al. Decompressive hemicraniectomy for ischemic stroke in the pediatric population. Neurosurg Rev 2013; 36:21.
  78. Harrar DB, Sun LR, Goss M, Pearl MS. Cerebral Digital Subtraction Angiography in Acute Intracranial Hemorrhage: Considerations in Critically Ill Children. J Child Neurol 2022; 37:693.
  79. Liu AC, Segaren N, Cox TS, et al. Is there a role for magnetic resonance imaging in the evaluation of non-traumatic intraparenchymal haemorrhage in children? Pediatr Radiol 2006; 36:940.
  80. Truwit CL. CT angiography versus MR angiography in the evaluation of acute neurovascular disease. Radiology 2007; 245:362.
  81. Josephson CB, White PM, Krishan A, Al-Shahi Salman R. Computed tomography angiography or magnetic resonance angiography for detection of intracranial vascular malformations in patients with intracerebral haemorrhage. Cochrane Database Syst Rev 2014; :CD009372.
  82. Kondziolka D, McLaughlin MR, Kestle JR. Simple risk predictions for arteriovenous malformation hemorrhage. Neurosurgery 1995; 37:851.
  83. Graf CJ, Perret GE, Torner JC. Bleeding from cerebral arteriovenous malformations as part of their natural history. J Neurosurg 1983; 58:331.
  84. Ondra SL, Troupp H, George ED, Schwab K. The natural history of symptomatic arteriovenous malformations of the brain: a 24-year follow-up assessment. J Neurosurg 1990; 73:387.
  85. Winn HR, Richardson AE, Jane JA. The long-term prognosis in untreated cerebral aneurysms: I. The incidence of late hemorrhage in cerebral aneurysm: a 10-year evaluation of 364 patients. Ann Neurol 1977; 1:358.
  86. Lang SS, Beslow LA, Bailey RL, et al. Follow-up imaging to detect recurrence of surgically treated pediatric arteriovenous malformations. J Neurosurg Pediatr 2012; 9:497.
  87. Schoenberg BS, Mellinger JF, Schoenberg DG. Cerebrovascular disease in infants and children: a study of incidence, clinical features, and survival. Neurology 1978; 28:763.
  88. Livingston JH, Brown JK. Intracerebral haemorrhage after the neonatal period. Arch Dis Child 1986; 61:538.
  89. Qureshi AI, Tuhrim S, Broderick JP, et al. Spontaneous intracerebral hemorrhage. N Engl J Med 2001; 344:1450.
  90. Lynch JK, Han CJ. Pediatric stroke: what do we know and what do we need to know? Semin Neurol 2005; 25:410.
  91. Fox CK, Johnston SC, Sidney S, Fullerton HJ. High critical care usage due to pediatric stroke: results of a population-based study. Neurology 2012; 79:420.
  92. Lo WD, Hajek C, Pappa C, et al. Outcomes in children with hemorrhagic stroke. JAMA Neurol 2013; 70:66.
  93. Porcari GS, Beslow LA, Ichord RN, et al. Neurologic Outcome Predictors in Pediatric Intracerebral Hemorrhage: A Prospective Study. Stroke 2018; 49:1755.
  94. Greenham M, Gordon A, Anderson V, Mackay MT. Outcome in Childhood Stroke. Stroke 2016; 47:1159.
  95. Yvon E, Lamotte D, Tiberghien A, et al. Long-term motor, functional, and academic outcome following childhood ischemic and hemorrhagic stroke: A large rehabilitation center-based retrospective study. Dev Neurorehabil 2018; 21:83.
  96. Hawks C, Jordan LC, Gindville M, et al. Educational Placement After Pediatric Intracerebral Hemorrhage. Pediatr Neurol 2016; 61:46.
  97. Smith SE, Vargas G, Cucchiara AJ, et al. Hemiparesis and epilepsy are associated with worse reported health status following unilateral stroke in children. Pediatr Neurol 2015; 52:428.
  98. Broderick JP, Brott TG, Duldner JE, et al. Volume of intracerebral hemorrhage. A powerful and easy-to-use predictor of 30-day mortality. Stroke 1993; 24:987.
  99. Huang X, Cheng Z, Xu Y, et al. Associations of Clinical Characteristics and Etiology With Death in Hospitalized Chinese Children After Spontaneous Intracerebral Hemorrhage: A Single-Center, Retrospective Cohort Study. Front Pediatr 2020; 8:576077.
  100. Kleinman JT, Beslow LA, Engelmann K, et al. Evaluation of intraventricular hemorrhage in pediatric intracerebral hemorrhage. J Child Neurol 2012; 27:526.
  101. Hemphill JC 3rd, Bonovich DC, Besmertis L, et al. The ICH score: a simple, reliable grading scale for intracerebral hemorrhage. Stroke 2001; 32:891.
  102. Beslow LA, Ichord RN, Gindville MC, et al. Pediatric intracerebral hemorrhage score: a simple grading scale for intracerebral hemorrhage in children. Stroke 2014; 45:66.
  103. Guédon A, Blauwblomme T, Boulouis G, et al. Predictors of Outcome in Patients with Pediatric Intracerebral Hemorrhage: Development and Validation of a Modified Score. Radiology 2018; 286:651.
  104. Nelson MD Jr, Maeder MA, Usner D, et al. Prevalence and incidence of intracranial haemorrhage in a population of children with haemophilia. The Hemophilia Growth and Development Study. Haemophilia 1999; 5:306.
Topic 107995 Version 16.0

References

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