Distal bile duct cancer TNM staging AJCC UICC 8th edition

Primary tumor (T)
T category	T criteria
TX	Primary tumor cannot be assessed
Tis	Carcinoma in situ/high-grade dysplasia
T1	Tumor invades the bile duct wall with a depth less than 5 mm
T2	Tumor invades the bile duct wall with a depth of 5 to 12 mm
T3	Tumor invades the bile duct wall with a depth greater than 12 mm
T4	Tumor involves the celiac axis, superior mesenteric artery, and/or common hepatic artery
Regional lymph nodes (N)
N category	N criteria
NX	Regional lymph nodes cannot be assessed
N0	No regional lymph node metastasis
N1	Metastasis in one to three regional lymph nodes
N2	Metastasis in four or more regional lymph nodes
Distant metastasis (M)
M category	M criteria
M0	No distant metastasis
M1	Distant metastasis
Prognostic stage groups
When T is...	And N is...	And M is...	Then the stage group is...
Tis	N0	M0	0
T1	N0	M0	I
T1	N1	M0	IIA
T1	N2	M0	IIIA
T2	N0	M0	IIA
T2	N1	M0	IIB
T2	N2	M0	IIIA
T3	N0	M0	IIB
T3	N1	M0	IIB
T3	N2	M0	IIIA
T4	N0	M0	IIIB
T4	N1	M0	IIIB
T4	N2	M0	IIIB
Any T	Any N	M1	IV

TNM: tumor, node, metastasis; AJCC: American Joint Committee on Cancer; UICC: Union for International Cancer Control.

Used with permission of the American College of Surgeons, Chicago, Illinois. The original source for this information is the AJCC Cancer Staging Manual, Eighth Edition (2017) published by Springer International Publishing.

Graphic 110943 Version 8.0

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Distal bile duct cancer TNM staging AJCC UICC 8th edition