- Empiric evidence for efficacy in improving sleep onset, largely in children with neurodevelopmental disorders; fewer studies in typically developing children
- Minimal effects on sleep architecture
- Acceptability to caregivers
- Generally low side effect profile
- Widely available
- Low cost
- Low-dose and liquid preparations available
| - Long-term side effects uncertain (eg, pubertal development)
- Few or no studies in psychiatric populations (eg, anxiety, mood disorders)
- Dosing timing is important and depends on clinical use (several hours before bedtime for circadian rhythm effects or shortly before bedtime for sleep-onset insomnia)
- Studies of extended-release formulation (prescription only, not available in United States) suggest efficacy for sleep-maintenance insomnia in autism
- Reliability of over-the-counter preparations highly variable; products with a third-party verification seal (eg, US Pharmacopeia [USP] Verified Mark) may provide a more reliable preparation
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