Diagnostic categories of cardiac sarcoidosis based on clinical and imaging findings

Findings suggesting cardiac sarcoidosis
Clinical findings	LVEF <40% Sustained ventricular tachycardia (spontaneous or induced) Mobitz type II 2^nd- or 3^rd-degree atrioventricular block (whether or not shown to be immunosuppressant responsive)
Imaging findings	Cardiac FDG-PET with patchy focal uptake in a pattern consistent with CS CMR imaging with LGE in a pattern consistent with CS
Diagnostic category of cardiac sarcoidosis	Criteria
Definite (100% probability of CS)	Detection of noncaseating granuloma on histologic examination of myocardial tissue (endomyocardial biopsy or other myocardial specimen) with no alternative cause identified
Probable (≥50% probability of CS)	With histologic diagnosis of extracardiac sarcoidosis; requires both of the following criteria: 1 or more of the following types of cardiac findings: Clinical finding suggesting CS (refer to above) Imaging finding by CMR or FDG-PET typical for CS (refer to above) Other potential causes for the clinical and imaging findings have been excluded

LVEF: left ventricular ejection fraction; FDG-PET: ¹⁸F-fluorodeoxyglucose-positron emission tomography; CMR: cardiac magnetic resonance; LGE: late gadolinium enhancement; CS: cardiac sarcoidosis.

Original table modified for this publication. From: Birnie DH, Sauer WH, Bogun F, et al. HRS expert consensus statement on the diagnosis and management of arrhythmias associated with cardiac sarcoidosis. Heart Rhythm 2014; 11:1305. Table used with the permission of Elsevier Inc. All rights reserved.

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Diagnostic categories of cardiac sarcoidosis based on clinical and imaging findings