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Psychometric properties of developmental-behavioral screening tests

Psychometric properties of developmental-behavioral screening tests
Property Definition[1] Considerations for developmental-behavioral screening tests
Sensitivity
  • Probability of test giving a positive result when the condition is present. (What percentage of children with developmental delay will be flagged by this test?)
  • ≥70%[2] is generally accepted.
Specificity
  • Probability of the test giving a negative result when the condition is not present. (What percentage of children without developmental delay will "pass" this test?)
  • ≥70%[2] is generally accepted.
Positive predictive value (PPV)
  • Probability of the condition being present in a positive test. (What percentage of children who are flagged by this test have the developmental delay for which it screens?)
  • If the condition is serious and a follow-up test can distinguish true and false positives, then low PPV (meaning a high number of false positives) may be acceptable.
  • PPV is higher if the condition is more common (eg, language delay versus cognitive delay).
  • PPV and NPV are less useful in rare or low-prevalence conditions.[3]
Negative predictive value (NPV)
  • Probability of the condition being absent in a negative test. (What percentage of children who "pass" this test do not have the developmental delay for which it screens?)
Likelihood ratio (LR)
  • Likelihood that a "flagged" test indicates the presence of the condition compared to its absence. (How much more likely is a "failed" screen to occur in a child with a developmental delay than without a delay?)
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Concurrent validity
  • Correlation of the test results to the "gold standard" or reference test results at the same point in time. (If this child has a comprehensive evaluation now, how will it correlate with the screening test?)
  • Childhood development is dynamic. Concurrent validity fails to account for the expected trajectory; some mild delays resolve while others become more marked.
Predictive validity
  • Correlation of the test results to the "gold standard" or reference test results given at a later point in time. (If this child has a comprehensive evaluation sometime in the future, how will it correlate with the screening test?)
  • Predictive validity can be misleading. The screening test results may affect experiences before the "gold standard" evaluation. Developmental-behavioral evaluations sometimes occur months to years after a screening test, and various medical or psychosocial interventions may have occurred between the two time points.[2]
Data from:
  1. Boslaugh S, Watters PA. Statistics in a nutshell: A desktop quick reference. O'Reilly Media, Inc, 2008. p. 480.
  2. Marks K, Glascoe FP, Aylward GP, et al. The thorny nature of predictive validity studies on screening tests for developmental-behavioral problems. Pediatrics 2008; 122:866.
  3. Carvajal DN, Rowe PC. Research and statistics: Sensitivity, specificity, predictive values, and likelihood ratios. Pediatr Rev 2010; 31:511.
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