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خرید پکیج

تعداد آیتم قابل مشاهده باقیمانده : 3 مورد

Differential diagnosis between angiolymphoid hyperplasia with eosinophilia and Kimura disease

Differential diagnosis between angiolymphoid hyperplasia with eosinophilia and Kimura disease

	Angiolymphoid hyperplasia with eosinophilia	Kimura disease
Age of onset	All ages, peak incidence second to fourth decade
Clinical features
Sex	No sex predilection	Predominantly in males
Ethnicity	Any	Asian
Body location	Head and neck most common
Clinical appearance	Cutaneous papules and nodules	Large subcutaneous mass
Regional lymphadenopathy	Rare	Common
Systemic involvement	None	Associated with renal disease in approximately 20% of cases
Clinical course	Chronic, persistent
Laboratory tests
Peripheral eosinophilia	Uncommon (20%)	Common
Serum IgE levels	Normal	Increased
Histopathology
Depth	Dermal/subcutaneous	Subcutaneous
Main findings	Proliferation of blood vessels of varying sizes lined by plump endothelial cells Mild fibrous stromal reaction	Florid lymphoid follicles with germinal center formation Hyperplastic small blood vessels lined by flat or cuboidal endothelial cells Prominent stromal fibrosis
Infiltrate	Mixed, lymphocytes and variable number of eosinophils	Dense inflammatory infiltrate of lymphocytes, plasma cells, histiocytes, eosinophils Eosinophilic microabscesses
Lymph nodes	N/A	Preserved nodal architecture, follicular hyperplasia with reactive germinal centers, IgE deposition in the germinal centers

IgE: immunoglobulin E.

References:

Guo R, Gavino AC. Angiolymphoid hyperplasia with eosinophilia. Arch Pathol Lab Med 2015; 139:683.
Olsen TG, Helwig EB. Angiolymphoid hyperplasia with eosinophilia. A clinicopathologic study of 116 patients. J Am Acad Dermatol 1985; 12:781.

Graphic 119439 Version 2.0

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