Pathogen | Guidance for precaution discontinuation | Reference |
Methicillin-resistant Staphylococcus aureus (MRSA) | Following completion of antibiotic therapy as needed, contact precautions may be discontinued after documentation of 1 to 3 negative weekly surveillance cultures.* Extension of contact precautions may be warranted for patients with a draining wound, ongoing respiratory secretions associated with MRSA infection, or other evidence implicating risk of ongoing transmission. | [1,6] |
Vancomycin-resistant enterococcus (VRE) | Following completion of antibiotic therapy as needed, contact precautions may be discontinued after documentation of 1 to 3 negative weekly stool or rectal swab surveillance cultures.* Extension of contact precautions may be warranted for patients who are highly immunosuppressed, are receiving broad-spectrum antibiotic therapy (without VRE activity), or receiving care in protected environments (such as burn units) or in institutions with high VRE rates. | [1,6] |
Clostridioides difficile | Continue contact precautions for at least 48 hours after resolution of diarrhea. Since persistent shedding of spores is common[3], extension of contact precautions beyond resolution of diarrhea (eg, for remainder of hospitalization) is warranted in some situations, such as for incontinent patients. | [1,3] |
Multi-drug resistant gram-negative (MDR-GN) pathogens | ||
Extended-spectrum beta-lactamase (ESBL) and other MDR-GN pathogens | Continue precautions for duration of hospitalization. Guidelines recommend assessing discontinuation of precautions on a case-by-case basis related to time since onset of infection, need for ongoing antibiotic use, negative rectal screening samples, and specific pathogen (as an example, transmission risk of ESBL-positive Escherichia coli may be relatively limited). | [1] |
Carbapenem-resistant enterobacteriaceae (CRE) and Extremely drug-resistant gram negative (XDR-GN) pathogens | Maintain as long as patients are hospitalized or in a congregate living setting. | [1] |
Influenza | In immunocompetent hosts, the duration of droplet precautions is 7 days after illness onset or until 24 hours after resolution of fever and respiratory symptoms, whichever is longer. The optimal duration for immunocompromised hosts is uncertain. | [2] |
Varicella zoster virus (VZV) infection | ||
Localized zoster | Airborne and contact precautions should be continued until lesions are dry and crusted. For immunocompetent patients whose lesions can be covered, standard precautions are sufficient if health care provider(s) are immune. | [4,5] |
Disseminated zoster | Airborne and contact precautions should be continued until lesions are dry and crusted. | [4,5] |
Herpes simplex virus (HSV) infection | Contact precautions should be continued until lesions are dry and crusted. | [4] |
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