US: ultrasound; BI-RADS: Breast Imaging-Reporting and Data System; CNB: core needle biopsy; FNA: fine needle aspiration; PE: physical examination.
* The risk of future breast cancer can be estimated using one of the validated models such as the Gail or the Tyrer-Cuzick model. Refer to UpToDate topic on genetic counseling and testing for those at risk of hereditary breast and ovarian cancer for details.